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- Choi, Young Hae, et al. Show all 5 Authors
- Journal of natural products 2015 v.78 no.10 pp. 2355-2363
- Bacillus subtilis; Streptomyces; antibacterial properties; antineoplastic agents; genome mining; metabolomics; microorganisms; multigene family; proteomics; screening; streptomycin; tryptophan
- ... Actinomycetes are a major source of antimicrobials, anticancer compounds, and other medically important products, and their genomes harbor extensive biosynthetic potential. Major challenges in the screening of these microorganisms are to activate the expression of cryptic biosynthetic gene clusters and the development of technologies for efficient dereplication of known molecules. Here we report t ...