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- Jong, Yuh-Jyh, et al. Show all 4 Authors
- Analytical chemistry 2015 v.87 no.12 pp. 6228-6232
- DNA; ascorbic acid; copper; exons; fluorescence; genes; genotype; genotyping; muscular dystrophy; nanoparticles; patients; polymerase chain reaction
- ... Real applications in clinical diagnosis of label-free fluorescent copper nanoclusters (CuNCs) are demonstrated. Double-strand DNA (dsDNA) can act as an effective template for the formation of CuNCs, which can be used to distinguish the deletion or duplication genotypes of Duchenne muscular dystrophy (DMD) due to different fluorescent intensities. After PCR, the DMD amplicons reacted with copper io ...