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- Isupov, Michail N., et al. Show all 11 Authors
- The FEBS journal 2015 v.282 no.15 pp. 2879-2894
- Rhodococcus erythropolis; crystal structure; drugs; epoxides; ethylene glycol; genetic databases; genomic libraries; hot springs; hydrolases; melting; metagenomics; mutagenesis; nucleotide sequences; polyethylene glycol; substrate specificity; temperature
- ... The epoxide hydrolases (EHs) represent an attractive option for the synthesis of chiral epoxides and 1,2‐diols which are valuable building blocks for the synthesis of several pharmaceutical compounds. A metagenomic approach has been used to identify two new members of the atypical EH limonene‐1,2‐epoxide hydrolase (LEH) family of enzymes. These two LEHs (Tomsk‐LEH and CH55‐LEH) show EH activities ...