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You searched for: Publication year rev 7985-2015 Remove constraint Publication year rev: 7985-2015 Subject term caffeine Remove constraint Subject term: caffeine
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1. A 3-year study on occurrence of emerging contaminants in an urban stream of São Paulo State of Southeast Brazil

Author:
Mariele B. Campanha; Almas Taj Awan; Diana N. R. de Sousa; Guilherme M. Grosseli; Antonio A. Mozeto; Pedro S. Fadini
Source:
Environmental science and pollution research international 2015 v.22 no.10 pp. 7936-7947
ISSN:
0944-1344
Subject:
acetaminophen; aquatic ecosystems; caffeine; data collection; estrone; liquid chromatography; public policy; rivers; sewage; solid phase extraction; streams; surface water; tandem mass spectrometry; urban areas; wastewater treatment; water pollution; water quality; Brazil
Abstract:
... This manuscript reports a 3-year study on occurrence of pharmaceuticals, hormones, and triclosan in surface waters of a central urban region of São Paulo State of Southeast Brazil (the Monjolinho River in São Carlos). Water samples collected once at every 2 months were pre-concentrated by solid-phase extraction (SPE) and analyzed by liquid chromatography coupled with tandem mass spectrometry (LC-M ...
DOI:
10.1007/s11356-014-3929-x

2. A Candidate Short-Term Toxicity Test Using Ampelisca brevicornis to Assess Sublethal Responses to Pharmaceuticals Bound to Marine Sediments

Author:
L. A. Maranho; L. B. Moreira; R. M. Baena-Nogueras; P. A. Lara-Martín; T. A. DelValls; M. L. Martín-Díaz
Source:
Archives of environmental contamination and toxicology 2015 v.68 no.2 pp. 237-258
ISSN:
0090-4341
Subject:
Amphipoda; DNA; DNA damage; acetylcholinesterase; adverse effects; antioxidants; bioassays; bioavailability; biomarkers; caffeine; environmental assessment; enzyme activity; genotoxicity; ibuprofen; indicator species; lipid peroxidation; marine sediments; metabolism; mortality; neurotoxicity; oxidative stress; propranolol; sediment contamination; toxicity testing
Abstract:
... Lethal and sublethal responses related to different phases of metabolism (phases I and II enzymatic activities), neurotoxicity (acetylcholinesterase activity), oxidative stress (lipid peroxidation and antioxidant enzyme activities), and genetic damage (DNA strand breaks) were analysed to assess the possible adverse effects of pharmaceuticals bound to marine sediments. The crustacean amphipod Ampel ...
DOI:
10.1007/s00244-014-0080-0

3. A Combination of Glucosyl Hesperidin and Caffeine Exhibits an Anti‐obesity Effect by Inhibition of Hepatic Lipogenesis in Mice

Author:
Tatsuya Ohara; Koutarou Muroyama; Yoshihiro Yamamoto; Shinji Murosaki
Source:
Phytotherapy research 2015 v.29 no.2 pp. 310-316
ISSN:
0951-418X
Subject:
low fat diet; caffeine; refeeding; liver; tissue weight; adipose tissue; triacylglycerols; DNA microarrays; mice; lipogenesis; genes; hesperidin; obesity; fatty-acid synthase
Abstract:
... To develop an anti‐obesity agent, we examined the combination effect of glucosyl hesperidin (G‐hesperidin) and caffeine on obesity in mice. High‐fat diet‐induced obese KK mice were fed a low‐fat diet with or without G‐hesperidin, caffeine, or their combination for 2 weeks. Decreases in body weight and significantly lower adipose tissue weight were observed in the combination‐fed mice but not in th ...
DOI:
10.1002/ptr.5258

4. A Conceptual Demonstration of Decaffeination via Nanofiltration

Author:
Ong Yee Kang; Ng Hui Ting; Chung Tai-Shung
Source:
Industrial & Engineering Chemistry Research 2015 v.54 no.31 pp. 7737-7742
ISSN:
1520-5045
Subject:
caffeine; decaffeination; engineering; models; molecular weight; nanofiltration; temperature
Abstract:
... This study aims to evaluate the feasibility of using novel nanofiltration (NF) membranes for decaffeination of coffee wherein caffeine present in the feed solution is recovered at the permeate of the membrane. The NF hollow fiber membranes were fabricated and tested with model solutions to evaluate the recovery of caffeine as functions of molecular weight/size of organic molecules, caffeine concen ...
DOI:
10.1021/acs.iecr.5b01737

5. A Cup Today or a Pot Later: On the Discounting of Delayed Caffeinated Beverages

Author:
David P. Jarmolowicz; Shea M. Lemley; Dylan Cruse; Michael J. Sofis
Source:
Journal of agricultural & food industrial organization 2015 v.13 no.1 pp. 101-111
ISSN:
1542-0485
Subject:
beverages; caffeine; cocaine; drug abuse; obesity; questionnaires
Abstract:
... Delay discounting describes how the subjective value of a given commodity decreases as the delay to receiving that commodity increases. Decades of behavioral economic research have found that individuals suffering from a range of clinical conditions (e.g., drug addiction, obesity) tend to devalue delayed rewards more quickly than individuals without said clinical conditions and that such individua ...
DOI:
10.1515/jafio-2015-0021

6. A beating heart cell model to predict cardiotoxicity: Effects of the dietary supplement ingredients higenamine, phenylethylamine, ephedrine and caffeine

Author:
Richard Calvert; Sanah Vohra; Martine Ferguson; Paddy Wiesenfeld
Source:
Food and chemical toxicology 2015 v.78 pp. 207-213
ISSN:
0278-6915
Subject:
blood; caffeine; calcium; cardiomyocytes; dietary supplements; dose response; ephedrine; humans; in vitro studies; ingredients; intravenous injection; models; toxicity; toxicology
Abstract:
... Some dietary supplements may contain cardiac stimulants and potential cardiotoxins. In vitro studies may identify ingredients of concern. A beating human cardiomyocyte cell line was used to evaluate cellular effects following phenylethylamine (PEA), higenamine, ephedrine or caffeine treatment. PEA and higenamine exposure levels simulated published blood levels in humans or animals after intravenou ...
DOI:
10.1016/j.fct.2015.01.022

7. A green route for the synthesis of a bitter-taste dipeptide combining biocatalysis, heterogeneous metal catalysis and magnetic nanoparticles

Author:
Vitor A. Ungaro; Cleber W. Liria; Carolina D. Romagna; Natália J. S. Costa; Karine Philippot; Liane M. Rossi; M. Teresa Machini
Source:
RSC advances 2015 v.5 no.46 pp. 36449-36455
ISSN:
2046-2069
Subject:
acetonitrile; biocatalysis; bitterness; caffeine; catalysts; chymotrypsin; dipeptides; enzyme activity; esterases; food additives; food industry; hydrochloric acid; hydrogenation; hydrolysis; iron oxides; magnetism; methanol; nanoparticles; stereoselectivity; sustainable technology; thermolysin
Abstract:
... There is increasing demand for green technologies to produce high-solubility and low-toxicity compounds with potential application in the food industry. This study aimed to establish a clean, synthetic route for preparing the bitter-taste dipeptide Ala-Phe, a potential substitute for caffeine as a food additive. Synthesis of Z-Ala-Phe-OMe starting from Z-Ala-OH and HCl·Phe-OMe was catalysed by the ...
DOI:
10.1039/c5ra02641e

8. A multi-ingredient, pre-workout supplement is apparently safe in healthy males and females

Author:
Jordan M. Joy; Ryan P. Lowery; Paul H. Falcone; Roxanne M. Vogel; Matt M. Mosman; Chih-Yin Tai; Laura R. Carson; Dylan Kimber; David Choate; Michael P. Kim; Jacob M. Wilson; Jordan R. Moon
Source:
Food & nutrition research 2015 v.59 no.1 pp. 27470
ISSN:
1654-661X
Subject:
albumins; athletes; blood glucose; blood platelets; females; heart; hemoglobin; ingredients; liver; males; renal function; sodium
Abstract:
... Pre-workout supplements (PWS) have become increasingly popular with recreational and competitive athletes. While many ingredients used in PWS have had their safety assessed, the interactions when combined are less understood. The purpose of this study was to examine the safety of 1 and 2 servings of a PWS. Forty-four males and females (24.4±4.6 years; 174.7±9.3 cm; 78.9±18.6 kg) from two laborator ...
DOI:
10.3402/fnr.v59.27470

9. A novel electrochemical method to detect theophylline utilizing silver ions captured within abasic site-incorporated duplex DNA

Author:
Jun Ki Ahn; Ki Soo Park; Byoung Yeon Won; Hyun Gyu Park
Source:
Biosensors & bioelectronics 2015 v.67 pp. 590-594
ISSN:
0956-5663
Subject:
DNA; biosensors; blood serum; caffeine; cytosine; electrochemistry; electrodes; gold; humans; ions; silver; theobromine; theophylline
Abstract:
... We herein describe a novel and label-free electrochemical system to detect theophylline. The system was constructed by immobilizing duplex DNA containing an abasic site opposite cytosine on the gold electrode surface. In the absence of theophylline in a sample, silver ions freely bind to the empty abasic site in the duplex DNA leading to the highly elevated electrochemical signal by the redox reac ...
DOI:
10.1016/j.bios.2014.09.056

10. A pilot study on the assessment of trace organic contaminants including pharmaceuticals and personal care products from on-site wastewater treatment systems along Skaneateles Lake in New York State, USA

Author:
Bikram Subedi; Neculai Codru; David M. Dziewulski; Lloyd R. Wilson; Jingchuan Xue; Sehun Yun; Ellen Braun-Howland; Christine Minihane; Kurunthachalam Kannan
Source:
Water research 2015 v.72 pp. 28-39
ISSN:
0043-1354
Subject:
Enterococcus; beta-adrenergic antagonists; biofilters; caffeine; detection limit; effluents; fabrics; households; lakes; mass flow; mass transfer; nutrient content; perfluorooctane sulfonic acid; perfluorooctanoic acid; personal care products; polybrominated diphenyl ethers; polychlorinated biphenyls; septic systems; surface water; surfactants; tap water; tracer techniques; wastewater; wastewater treatment; water pollution; New York
Abstract:
... On-site wastewater treatment systems (OWTSs or septic systems) are designed to treat and dispose effluents on the same property that produces the wastewater. Approximately 25% of the U.S. population is served by such facilities. Nevertheless, studies on the treatment efficiency and discharge of organic contaminants through septic effluents are lacking. This pilot study showed the occurrence of org ...
DOI:
10.1016/j.watres.2014.10.049

11. A quantitative radioluminographic imaging method for evaluating lateral diffusion rates in skin

Author:
Allison K. Rush; Matthew A. Miller; Edward D. Smith; Gerald B. Kasting
Source:
Journal of controlled release 2015 v.216 pp. 1-8
ISSN:
0168-3659
Subject:
anti-infective agents; bioavailability; caffeine; carbon; diffusivity; image analysis; microorganisms; radiolabeling; radionuclides; surfactants; testosterone; zinc
Abstract:
... A method is presented for measuring the lateral diffusion coefficients of exogenously applied compounds on excised skin. The method involves sequential high resolution imaging of the spatial distribution of β-radiation associated with [¹⁴C]-labeled compounds to monitor the development of the concentration profile on the skin surface. It is exemplified by measurements made on three radiolabeled tes ...
DOI:
10.1016/j.jconrel.2015.07.032

12. A review of commercially important African medicinal plants

Author:
B.-E. Van Wyk
Source:
Journal of ethnopharmacology 2015 v.176 pp. 118-134
ISSN:
0378-8741
Subject:
Adansonia digitata; Agathosma betulina; Aloe vera; Boswellia papyrifera; Boswellia sacra; Catha edulis; Catharanthus roseus; Centella asiatica; Citrullus lanatus; Coffea arabica; Cyclopia genistoides; Griffonia simplicifolia; Harpagophytum procumbens; Hibiscus sabdariffa; Hoodia gordonii; Hypoxis hemerocallidea; Lessertia; Momordica charantia; Mondia whitei; Pausinystalia johimbe; Pelargonium sidoides; Ricinus communis; Sceletium tortuosum; Senegalia senegal; Sesamum indicum; Strophanthus; Sutherlandia; Tamarindus indica; Trigonella foenum-graecum; Tylosema esculentum; Withania somnifera; caffeine; clinical trials; commercialization; dietary supplements; flora; functional foods; international trade; inventories; medicinal plants; new crops; new products; raw materials; research planning; traditional medicine; world markets; world wide web; yohimbine; Africa; Asia; Europe
Abstract:
... Data on the relative importance and research status of commercially relevant African medicinal plants are needed for developing new research strategies in order to stimulate much-needed ethnopharmacological research and to promote the commercialization of African plants.To present an illustrated bird’s eye view and comparative analysis of the relative popularity and importance of commercialized Af ...
DOI:
10.1016/j.jep.2015.10.031

13. A review of the bioactivity of coffee, caffeine and key coffee constituents on inflammatory responses linked to depression

Author:
Susan Hall; Ben Desbrow; Shailendra Anoopkumar-Dukie; Andrew K. Davey; Devinder Arora; Catherine McDermott; Matthew M. Schubert; Anthony V. Perkins; Milton J. Kiefel; Gary D. Grant
Source:
Food research international 2015 v.76 pp. 626-636
ISSN:
0963-9969
Subject:
animal models; antioxidant activity; beverages; caffeic acid; caffeine; chlorogenic acid; cohort studies; ferulic acid; humans; inflammation; polyphenols; relative risk
Abstract:
... Coffee is a widely consumed beverage containing numerous biologically active constituents predominantly belonging to the polyphenol and alkaloid classes. It has been established that coffee has a beneficial effect on numerous disease states including depression. A number of prospective and retrospective cohort studies have assessed the effects of coffee consumption on the relative risk of developi ...
DOI:
10.1016/j.foodres.2015.07.027

14. A single serving of caffeinated coffee impairs postprandial glucose metabolism in overweight men

Author:
Tracey M. Robertson; Michael N. Clifford; Simon Penson; Gemma Chope; M. Denise Robertson
Source:
British journal of nutrition 2015 v.114 no.8 pp. 1218-1225
ISSN:
1475-2662
Subject:
acute effects; analysis of variance; blood sampling; caffeine; cross-over studies; dose response; glucose; glycemic control; glycemic effect; insulin; males; men; overweight
Abstract:
... Previous studies regarding the acute effects of coffee on glycaemic control have used a single large dose of coffee, typically containing the caffeine equivalent of 2–4 servings of coffee. This study investigates whether the acute effects of coffee are dose-dependent, starting with a single serving. A total of ten healthy overweight males participated in a two-part randomised double-blind cross-ov ...
DOI:
10.1017/S0007114515002640
PubMed:
26316273

15. A study on quality components and sleep-promoting effects of GABA black tea

Author:
Wenfang Zhao; Yun Li; William Ma; Yazhong Ge; Yahui Huang
Source:
Food & function 2015 v.6 no.10 pp. 3393-3398
ISSN:
2042-650X
Subject:
black tea; body weight; caffeine; drying; flavanols; free amino acids; gamma-aminobutyric acid; mice; pentobarbital; polyphenols; sleep; sodium
Abstract:
... The aims of this study were to analyze the changes in quality components of gamma (γ)-aminobutyric acid (GABA) black tea during processing, and to investigate the effect of three dosages of GABA black tea on sleep improvement. The results showed that the GABA content was increased significantly up to 2.70 mg g⁻¹ after vacuum anaerobic and aerobic treatment. In addition, the content of GABA after d ...
DOI:
10.1039/c5fo00265f

16. Acrylamide inhibits cellular differentiation of human neuroblastoma and glioblastoma cells

Author:
Jong-Hang Chen; Chin-Cheng Chou
Source:
Food and chemical toxicology 2015 v.82 pp. 27-35
ISSN:
0278-6915
Subject:
acrylamides; butyric acid; caffeine; cell differentiation; cell proliferation; dose response; humans; mitogen-activated protein kinase; neurogenesis; non-specific protein-tyrosine kinase; phosphorylation; retinoic acid; toxicology
Abstract:
... This study explores human neuroblastoma (SH-SY5Y) and human glioblastoma (U-1240 MG) cellular differentiation changes under exposure to acrylamide (ACR). Differentiation of SH-SY5Y and U-1240 MG cells were induced by retinoic acid (RA) and butyric acid (BA), respectively. Morphological observations and MTT assay showed that the induced cellular differentiation and cell proliferation were inhibited ...
DOI:
10.1016/j.fct.2015.04.030

17. Acute consumption of a caffeinated energy drink enhances aspects of performance in sprint swimmers

Author:
Beatriz Lara; Diana Ruiz-Vicente; Francisco Areces; Javier Abián-Vicén; Juan José Salinero; Cristina Gonzalez-Millán; César Gallo-Salazar; Juan Del Coso
Source:
British journal of nutrition 2015 v.114 no.6 pp. 908-914
ISSN:
1475-2662
Subject:
adverse effects; blood; blood sampling; caffeine; energy drinks; headache; ingestion; lactic acid; males; muscles; placebos; sleep disorders; swimming
Abstract:
... This study investigated the effect of a caffeinated energy drink on various aspects of performance in sprint swimmers. In a randomised and counterbalanced order, fourteen male sprint swimmers performed two acute experimental trials after the ingestion of a caffeinated energy drink (3 mg/kg) or after the ingestion of the same energy drink without caffeine (0 mg/kg; placebo). After 60 min of ingesti ...
DOI:
10.1017/S0007114515002573
PubMed:
26279580

18. Acute effectiveness of a “fat-loss” product on substrate utilization, perception of hunger, mood state and rate of perceived exertion at rest and during exercise

Author:
Ahmad Alkhatib; Marcos Seijo; Eneko Larumbe; Fernando Naclerio
Source:
Journal of the International Society of Sports Nutrition 2015 v.12 no.1 pp. 44
ISSN:
1550-2783
Subject:
Eleutherococcus senticosus; Paullinia cupana; Serenoa repens; analysis of variance; beta oxidation; caffeine; calorimetry; emotions; ethics; exercise; females; green tea; hunger; males; placebos; satiety; seed extracts; sports nutrition; yerba mate; yohimbine
Abstract:
... BACKGROUND: Achieving fat-loss outcomes by ingesting multi-ingredient mixtures may be further enhanced during exercise. This study tested the acute thermogenic effectiveness of a commercially available multi-ingredient product (Shred-Matrix®), containing Green Tea Extract, Yerba Maté, Guarana Seed Extract, Anhydrous caffeine, Saw palmetto, Fo-Ti, Eleuthero root, Cayenne Pepper, and Yohimbine HCI, ...
DOI:
10.1186/s12970-015-0105-8
PubMed:
26612980
PubMed Central:
PMC4660661

19. Acute effects of coffee consumption on self-reported gastrointestinal symptoms, blood pressure and stress indices in healthy individuals

Author:
Emilia Papakonstantinou; Ioanna Kechribari; Κyriaki Sotirakoglou; Petros Tarantilis; Theodora Gourdomichali; George Michas; Vassiliki Kravvariti; Konstantinos Voumvourakis; Antonis Zampelas
Source:
Nutrition journal 2015 v.15 no.1 pp. 26
ISSN:
1475-2891
Subject:
acute effects; alpha-amylase; anxiety; blood pressure; caffeine; clinical trials; cold; cortisol; gastrins; gastrointestinal system; gender; instant coffee; men; questionnaires; sympathetic nervous system; temperature; women
Abstract:
... BACKGROUND: It has been suggested that coffee may affect the gut-brain axis with conflicting outcomes. Moreover, there is insufficient evidence to determine whether the type or temperature of coffee consumed will have a different impact on the gut-brain axis. The purpose of this study was to investigate the effects of acute coffee consumption on the following: 1. self-reported GI symptoms and sali ...
DOI:
10.1186/s12937-016-0146-0
PubMed:
26979712
PubMed Central:
PMC4791892

20. Allosteric interactions between agonists and antagonists within the adenosine A₂A receptor-dopamine D₂ receptor heterotetramer

Author:
Jordi Bonaventura; Gemma Navarro; Verònica Casadòó-Anguera; Karima Azdad; William Rea; Estefanòóía Moreno; Marc Brugarolas; Josefa Mallol; Enric I. Canela; Carme Lluòóíís; Antoni Cortòóííés; Nora D. Volkow; Serge N. Schiffmann; Sergi Ferròóííéé; Vicent Casadòóííééó
Source:
Proceedings of the National Academy of Sciences of the United States of America 2015 v.112 no.27 pp. E3609
ISSN:
0027-8424
Subject:
adenosine; agonists; antagonists; bioluminescence; brain; caffeine; dopamine; energy transfer; fluorescence; models
Abstract:
... Adenosine A ₂A receptor (A ₂AR)-dopamine D ₂ receptor (D ₂R) heteromers are key modulators of striatal neuronal function. It has been suggested that the psychostimulant effects of caffeine depend on its ability to block an allosteric modulation within the A ₂AR-D ₂R heteromer, by which adenosine decreases the affinity and intrinsic efficacy of dopamine at the D ₂R. We describe novel unsuspected al ...
DOI:
10.1073/pnas.1507704112
PubMed:
26100888
PubMed Central:
PMC4500251

21. An optimized and validated SPE-LC–MS/MS method for the determination of caffeine and paraxanthine in hair

Author:
Pieter M.M. De Kesel; Willy E. Lambert; Christophe P. Stove
Source:
Talanta 2015 v.144 pp. 62-70
ISSN:
0039-9140
Subject:
buffers; caffeine; cleaning; decontamination; drugs; guidelines; isotope labeling; metabolites; pH; phenotype; proteinases; spectrometers
Abstract:
... Caffeine is the probe drug of choice to assess the phenotype of the drug metabolizing enzyme CYP1A2. Typically, molar concentration ratios of paraxanthine, caffeine’s major metabolite, to its precursor are determined in plasma following administration of a caffeine test dose. The aim of this study was to develop and validate an LC–MS/MS method for the determination of caffeine and paraxanthine in ...
DOI:
10.1016/j.talanta.2015.05.084

22. Analysis of caffeine and paraxanthine in human saliva with ultra-high-performance liquid chromatography for CYP1A2 phenotyping

Author:
Nan Yeun Jordan; Jolet Y. Mimpen; Willie J.M. van den Bogaard; Frits M. Flesch; Michiel H.M. van de Meent; Javier Sastre Torano
Source:
Journal of Chromatography B 2015 v.995-996 pp. 70-73
ISSN:
1570-0232
Subject:
caffeine; cytochrome P-450; detection limit; ethyl acetate; humans; liquid-liquid extraction; pharmacokinetics; phenotype; saliva; ultra-performance liquid chromatography
Abstract:
... Cytochrome P450 1A2 (CYP1A2) plays an important role in drug metabolism. Caffeine (CAF) is converted into paraxanthine (PX) by this enzyme and is used as a xenobiotic substrate to determine the CYP1A2 phenotype in humans. A method for the quantification of CAF and PX in saliva was developed using liquid–liquid extraction with ethyl acetate and analysis with ultra-high-performance liquid chromatogr ...
DOI:
10.1016/j.jchromb.2015.05.020

23. Analysis of cocaine and its adulterants in drugs for international trafficking seized by the Brazilian Federal Police

Author:
Silvio Fernandes Lapachinske; Guilherme Gonçalves Okai; Ariana dos Santos; André Valle de Bairros; Mauricio Yonamine
Source:
Forensic science international 2015 v.247 pp. 48-53
ISSN:
0379-0738
Subject:
active ingredients; adulterated products; airports; caffeine; centrifugation; cocaine; drugs; gas chromatography-mass spectrometry; levamisole; lidocaine; methanol; nitrogen; phosphorus; police; Brazil
Abstract:
... Here, gas chromatography with nitrogen phosphorous detector (GC–NPD) method was developed and validated for the quantification of cocaine and adulterants (caffeine, 4-dimethylaminoantipyrine, levamisole, lidocaine and phenacetin) in illicit samples. The method was based on direct dilution of samples in methanol, sonication for 5min and centrifugation. After appropriate dilution, an aliquot was inj ...
DOI:
10.1016/j.forsciint.2014.11.028

24. Analysis of organo-chlorine pesticides residue in raw coffee with a modified “quick easy cheap effective rugged and safe” extraction/clean up procedure for reducing the impact of caffeine on the gas chromatography–mass spectrometry measurement

Author:
Bruno Bresin; Maria Piol; Denis Fabbro; Maria Antonietta Mancini; Bruno Casetta; Clorinda Del Bianco
Source:
Journal of chromatography 2015 v.1376 pp. 167-171
ISSN:
0021-9673
Subject:
Coffea; European Union; caffeine; coffee (beverage); gas chromatography-mass spectrometry; microextraction; monitoring; pesticide residues; pesticides; protocols; Italy
Abstract:
... The control of pesticide residues on raw coffee is a task of great importance due to high consumption of this beverage in Italy and in many other countries. High caffeine content can hamper extraction and measurement of any pesticide residue. A tandem extraction protocol has been devised by exploiting the quick easy cheap effective rugged and safe (QuEChERS) scheme for extraction, coupled to a dis ...
DOI:
10.1016/j.chroma.2014.12.016

25. Analysis of tea catechins in vegetable oils by high‐performance liquid chromatography combined with liquid–liquid extraction

Author:
Xin Zhang; Zufang Wu; Peifang Weng; Yang Yang
Source:
International journal of food science & technology 2015 v.50 no.4 pp. 885-891
ISSN:
0950-5423
Subject:
caffeine; flavanols; high performance liquid chromatography; industry; liquid-liquid extraction; methanol; soybean oil; sunflower oil; tea; vegetable oil
Abstract:
... In this study, a method was developed for the determination of various tea catechins in vegetable oils. Firstly, vegetable oils including tea seed oil, sunflower seed oil and soya bean oil were extracted by methanol/water (40:60, v/v), and then, a high‐performance liquid chromatography (HPLC) method was developed for the simultaneous determination of GA, caffeine, EGC, EGCG, EC, ECG, GC, GCG, C an ...
DOI:
10.1111/ijfs.12726

26. Analysis of ‘legal high’ substances and common adulterants using handheld spectroscopic techniques

Author:
S. Assi; A. Guirguis; S. Halsey; S. Fergus; J. L. Stair
Source:
Analytical methods 2015 v.7 no.2 pp. 736-746
ISSN:
1759-9679
Subject:
Fourier transform infrared spectroscopy; Internet; Raman spectroscopy; algorithms; caffeine; carbohydrates; cutting agents; fluorescence; lidocaine; models; near-infrared spectroscopy; reflectance; wavelengths
Abstract:
... The identification of ‘legal highs’ is challenging as they often do not match their label claim and contain a wide range of impurities and/or adulterants. In addition, there is a need for techniques to be on-site, rapid and non-destructive. The feasibility of using the in-built algorithms of handheld near-infrared (NIR), Raman and attenuated total reflectance Fourier transform-infrared (ATR-FT-IR) ...
DOI:
10.1039/c4ay02169j

27. Antioxidative potential of different coffee substitute brews affected by milk addition

Author:
Draženka Komes; Arijana Bušić; Aleksandra Vojvodić; Ana Belščak-Cvitanović; Mirjana Hruškar
Source:
European food research & technology 2015 v.241 no.1 pp. 115-125
ISSN:
1438-2377
Subject:
antioxidant activity; antioxidants; barley; caffeine; chicory; coffee (beverage); flavanols; food research; gallic acid; ingredients; milk; principal component analysis; proanthocyanidins; sensory properties
Abstract:
... Due to the specific sensory properties, a rich bioactive composition, attributed to different ingredients used for their production, as well as the absence of caffeine, coffee substitutes are becoming increasingly popular alternatives to usual coffee brews. The objective of this study was to determine the content of polyphenolic compounds and antioxidant capacity of 10 coffee substitute brews with ...
DOI:
10.1007/s00217-015-2440-z

28. Application of POCIS for exposure assessment of munitions constituents during constant and fluctuating exposure

Author:
Jason B. Belden; Guilherme R. Lotufo; James M. Biedenbach; Kristal K. Sieve; Gunther Rosen
Source:
Environmental toxicology and chemistry 2015 v.34 no.5 pp. 959-967
ISSN:
0730-7268
Subject:
atrazine; caffeine; exposure assessment; samplers; trinitrotoluene
Abstract:
... The present study examined the potential use of polar organic chemical integrative samplers (POCIS) for exposure assessment of munitions constituents, including 2,4,6‐trinitrotoluene (TNT) and hexahydro‐1,3,5‐trinitro‐1,3,5‐triazine (RDX), and their breakdown products (aminodinitrotoluenes [ADNTs], diaminonitrotoluenes [DANTs], and hexahydro‐1,3,5‐trinitroso‐1,3,5‐triazine [TNX]). Loss of munition ...
DOI:
10.1002/etc.2836

29. Application of gas chromatography-mass spectrometry and chemometrics methods for assessing volatile profiles of Pu-erh tea with different processing methods and ageing years

Author:
Shidong Lv; Yuanshuang Wu; Jifu Wei; Ming Lian; Chen Wang; Xuemei Gao; Qingxiong Meng
Source:
RSC advances 2015 v.5 no.107 pp. 87806-87817
ISSN:
2046-2069
Subject:
beta-ionone; caffeine; cedrol; chemometrics; cluster analysis; gas chromatography-mass spectrometry; headspace analysis; linalool; manufacturing; multivariate analysis; odors; palmitic acid; principal component analysis; solid phase microextraction; tea; volatile compounds
Abstract:
... Volatile changes and the post-fermentation ageing process of tea remain largely unknown. Additionally, the understanding of ageing and storage processes of tea mostly rely on sensory experience and lack the support of scientific and accurate data. In this paper, a method was developed based on head-space solid phase microextraction/gas chromatography-mass spectrometry (HS-SPME/GC-MS) combined with ...
DOI:
10.1039/c5ra15381f

30. Aqueous Biphasic System Containing Long Chain Anion-Functionalized Ionic Liquids for High-Performance Extraction

Author:
Xie Yuanbang; Xing Huabin; Yang Qiwei; Bao Zongbi; Su Baogen; Ren Qilong
Source:
ACS sustainable chemistry 2015 v.3 no.12 pp. 3365-3372
ISSN:
2168-0485
Subject:
anions; bioactive compounds; biocompatibility; biomass; caffeine; carbon; cations; crystal structure; detection limit; hydrogen bonding; hydrophobicity; ionic liquids; liquid crystals; phenylalanine; tryptophan; volatile organic compounds
Abstract:
... Ionic liquid-based aqueous biphasic systems (IL-based ABSs) offer a benign alternative process for conventional extraction systems with volatile organic solvents to separate biomass. Designing an IL-based ABS with excellent phase splitting ability, remarkable extraction efficiency, and good biocompatibility remains challenging. In this work, we report a series of novel ABSs using biocompatible ILs ...
DOI:
10.1021/acssuschemeng.5b01068

31. Arabica coffee extract shows antibacterial activity against Staphylococcus epidermidis and Enterococcus faecalis and low toxicity towards a human cell line

Author:
Giulia Runti; Sabrina Pacor; Silvia Colomban; Renato Gennaro; Luciano Navarini; Marco Scocchi
Source:
Lebensmittel-Wissenschaft + Technologie 2015 v.62 no.1 pp. 108-114
ISSN:
0023-6438
Subject:
Coffea arabica; Enterococcus faecalis; Gram-positive bacteria; Staphylococcus aureus; Staphylococcus epidermidis; adenocarcinoma; antibacterial properties; caffeine; cytotoxicity; exposure duration; human cell lines
Abstract:
... The antimicrobial activity of a regular and decaffeinated Arabica coffee extract was evaluated against three different Gram-positive bacteria and two Gram-negatives, including pathogenic Staphylococci strains. The antimicrobial activity was shown to be independent from caffeine content and was more pronounced against the Gram-positive strains. The regular coffee extract exhibited a significant bac ...
DOI:
10.1016/j.lwt.2014.12.039

32. Are coffee silverskin extracts safe for topical use? An in vitro and in vivo approach

Author:
F. Rodrigues; C. Pereira; F.B. Pimentel; R.C. Alves; M. Ferreira; B. Sarmento; M. Helena Amaral; M. Beatriz P.P. Oliveira
Source:
Industrial crops and products 2015 v.63 pp. 167-174
ISSN:
0926-6690
Subject:
animal use alternatives; bioassays; caffeine; chlorogenic acid; cornea; cosmetics; epidermis (animal); face; histology; humans; hydroxymethylfurfural; in vitro studies; in vivo studies; ingredients; models; mucosa; prediction; raw materials; topical application
Abstract:
... Recent changes in regulatory requirements and social views on animal testing have incremented the development of reliable alternative tests for predicting skin and ocular irritation potential of products based on new raw materials. In this regard, botanical ingredients used in cosmetic products are among those materials, and should be carefully reviewed concerning the potential presence of irritan ...
DOI:
10.1016/j.indcrop.2014.10.014

33. Are standard tests sensitive enough to evaluate effects of human pharmaceuticals in aquatic biota? Facing changes in research approaches when performing risk assessment of drugs

Author:
G.V. Aguirre-Martínez; M.A. Owuor; C. Garrido-Pérez; M.J. Salamanca; T.A. Del Valls; M.L. Martín-Díaz
Source:
Chemosphere 2015 v.120 pp. 75-85
ISSN:
0045-6535
Subject:
Isochrysis galbana; Paracentrotus lividus; Selenastrum capricornutum; Vibrio fischeri; acute toxicity; adverse effects; aquatic environment; bacteria; bioassays; bioluminescence; caffeine; dimethyl sulfoxide; environmental exposure; environmental impact; freshwater; guidelines; humans; ibuprofen; microalgae; novobiocin; risk; risk characterization; teratogenicity
Abstract:
... Nowadays, the presence of pharmaceutical products in aquatic environments is not only common, but is also of significant concern regarding the adverse effect they may produce to aquatic biota. In order to determine the adverse effects of caffeine (CAF), ibuprofen (IBU), carbamazepine (CBZ) and novobiocin (NOV), at environmental occurring concentrations, standardized endpoints applied in current gu ...
DOI:
10.1016/j.chemosphere.2014.05.087

34. Assessing dietary exposure to caffeine from beverages in the U.S. population using brand-specific versus category-specific caffeine values

Author:
Diane C. Mitchell; Jon Hockenberry; Robyn Teplansky; Terryl J. Hartman
Source:
Food and chemical toxicology 2015 v.80 pp. 247-252
ISSN:
0278-6915
Subject:
adults; caffeine; coffee (beverage); dietary exposure; markets; soft drinks; tea; toxicology; United States
Abstract:
... Recent reports on caffeine intakes in the United States have highlighted the importance of obtaining accurate and valid measures of caffeine exposure. The objective of this study is to compare two methods of assigning caffeine values to beverages: brand-specific values versus an aggregate single value representing a broader range of products within a beverage category (i.e., category-specific). Th ...
DOI:
10.1016/j.fct.2015.03.024

35. Assessment of caffeine intake in the Korean population

Author:
Ho Soo Lim; Ju Young Hwang; Jae Chon Choi; Meehye Kim
Source:
Food additives & contaminants 2015 v.32 no.11 pp. 1786-1798
ISSN:
1944-0057
Subject:
National Health and Nutrition Examination Survey; adults; caffeine; carbonated beverages; high performance liquid chromatography; markets; Korean Peninsula
Abstract:
... An improved method for the analysis of caffeine in foods by HPLC was validated by measuring several analytical parameters. The caffeine contents of 1202 products available from Korean markets were analysed. A consumption study was conducted by using data from the Korea National Health and Nutrition Examination Survey (KNHANES), 2010–12, to estimate the caffeine intakes of the Korean population. Th ...
DOI:
10.1080/19440049.2015.1077396

36. Assessment of ichthyotoxicity and anthropogenic contamination in the surface waters of Kenting National Park, Taiwan

Author:
Te-Hao Chen; Yi-Ling Chen; Chia-Yang Chen; Pi-Jen Liu; Jing-O Cheng; Fung-Chi Ko
Source:
Environmental monitoring and assessment 2015 v.187 no.5 pp. 265
ISSN:
0167-6369
Subject:
Danio rerio; ammonia; bioassays; caffeine; chemical analysis; correlation; deet; drugs; fish; heart rate; larvae; national parks; nitrites; personal care products; sewage; surface water; survival rate; swimming; tourists; toxicity; Taiwan
Abstract:
... Millions of tourists visit Kenting National Park (KNP) in southern Taiwan every year, causing great amount of sewage discharges in this area. This study aimed to assess the impact of sewage on KNP surface waters using zebrafish embryo-larval bioassays combined with chemical analyses of pharmaceuticals and personal care products (PPCPs). Surface water samples were collected monthly from May to Octo ...
DOI:
10.1007/s10661-015-4511-9

37. Associations of chemical tracers and faecal indicator bacteria in a tropical urban catchment

Author:
E. Ekklesia; P. Shanahan; L.H.C. Chua; H.S. Eikaas
Source:
Water research 2015 v.75 pp. 270-281
ISSN:
0043-1354
Subject:
acetaminophen; active ingredients; boron; caffeine; cholesterol; coprostanol; data collection; detergents; drainage water; feces; human health; humans; ibuprofen; indicator species; land use; methylene blue; phthalates; residential areas; saccharin; sewage; sucralose; surface water; tracer techniques; wastewater; water pollution; water quality; watersheds
Abstract:
... Surface water contamination by human faecal wastes is a widespread hazard for human health. Faecal indicator bacteria (FIB) are the most widely used indicators to assess surface water quality but are less-human-specific and have the potential to survive longer and/or occur naturally in tropical areas. In this study, 13 wastewater chemicals (chloride, boron, orthosphophate, detergents as methylene ...
DOI:
10.1016/j.watres.2015.02.037

38. Attenuation of trace organic compounds (TOrCs) in bioelectrochemical systems

Author:
Craig M. Werner; Christiane Hoppe-Jones; Pascal E. Saikaly; Bruce E. Logan; Gary L. Amy
Source:
Water research 2015 v.73 pp. 56-67
ISSN:
0043-1354
Subject:
acetates; atrazine; biocides; bioelectrochemistry; biotransformation; caffeine; carbon; deet; electric current; electrodes; electrolysis; energy; hydrogen; hydrophilicity; microbial fuel cells; microorganisms; municipal wastewater; pH; phosphates; sorption; trimethoprim; wastewater treatment
Abstract:
... Microbial fuel cells (MFCs) and microbial electrolysis cells (MECs) are two types of microbial bioelectrochemical systems (BESs) that use microorganisms to convert chemical energy in wastewaters into useful energy products such as (bio)electricity (MFC) or hydrogen gas (MEC). These two systems were evaluated for their capacity to attenuate trace organic compounds (TOrCs), commonly found in municip ...
DOI:
10.1016/j.watres.2015.01.013

39. Automated Lab-on-a-Chip Technology for Fish Embryo Toxicity Tests Performed under Continuous Microperfusion (μFET)

Author:
Zhu Feng; Wigh Adriana; Friedrich Timo; Devaux Alain; Bony Sylvie; Nugegoda Dayanthi; Kaslin Jan; Wlodkowic Donald
Source:
Environmental Science & Technology 2015 v.49 no.24 pp. 14570-14578
ISSN:
1520-5851
Subject:
Danio rerio; automation; bioassays; caffeine; chemical hazards; copper sulfate; dimethyl sulfoxide; ecotoxicology; ethanol; fish; lighting; mechatronics; models; nicotine; phenol; risk assessment; standard operating procedures; toxicity; toxicity testing
Abstract:
... The fish embryo toxicity (FET) biotest has gained popularity as one of the alternative approaches to acute fish toxicity tests in chemical hazard and risk assessment. Despite the importance and common acceptance of FET, it is still performed in multiwell plates and requires laborious and time-consuming manual manipulation of specimens and solutions. This work describes the design and validation of ...
DOI:
10.1021/acs.est.5b03838

40. Bioprocess of robusta cherry coffee with polyphenol oxidase and quality enhancement

Author:
Ritika Mathur; P. N. Navya; K. Basavaraj; Pushpa S. Murthy
Source:
European food research & technology 2015 v.240 no.2 pp. 319-325
ISSN:
1438-2377
Subject:
Coffea arabica; Coffea canephora; Pleurotus florida; Pleurotus ostreatus; ammonium sulfate; beans; bioprocessing; bitterness; caffeine; catechol oxidase; chemical reactions; coffee beans; consumer satisfaction; food research; foods; fruiting bodies; molecular weight; pH; phenolic compounds; polyacrylamide gel electrophoresis; proteins; temperature
Abstract:
... Flavor plays an important role in consumer satisfaction and influences further consumption of foods. Robusta coffee is rich in caffeine and phenolics and is undesirable for coffee connoisseurs compared to arabica coffee. The exogenous polyphenol oxidase (4,000 U/ml) was extracted from the fruiting bodies of Pleurotus florida otherwise referred as the oyster mushroom. The polyphenol oxidase (PPO) w ...
DOI:
10.1007/s00217-014-2331-8

41. Blockade of phosphodiesterase 4 reverses morphine-induced ventilatory disturbance without loss of analgesia

Author:
Satoko Kimura; Yoshiaki Ohi; Akira Haji
Source:
Life sciences 2015 v.127 pp. 32-38
ISSN:
0024-3205
Subject:
adenosine; adverse effects; analgesia; caffeine; cyclic AMP; enzyme inhibitors; morphine; narcotics; nerve tissue; neurons; rats
Abstract:
... Ventilatory disturbance is a fatal side-effect of opioid analgesics. Separation of analgesia from ventilatory depression is important for therapeutic use of opioids. It has been suggested that opioid-induced ventilatory depression results from a decrease in adenosine 3′,5′-cyclic monophosphate content in the respiratory-related neurons. Therefore, we examined the effects of caffeine, a methylxanth ...
DOI:
10.1016/j.lfs.2015.02.006

42. COSMO-SAC Sigma Profile Generation with Conceptual Segment Concept

Author:
Islam Md Rashedul; Chen Chau-Chyun
Source:
Industrial & Engineering Chemistry Research 2015 v.54 no.16 pp. 4441-4454
ISSN:
1520-5045
Subject:
acetaminophen; aspirin; caffeine; chemical structure; engineering; hydrophilicity; hydrophobicity; industry; lovastatin; models; prediction; product development; quantum mechanics; solubility; thermodynamics
Abstract:
... Solvation thermodynamics-based models for predicting liquid-phase nonidealities and fluid-phase equilibria are gaining attention in modern chemical process and product development. Among this class of thermodynamic models, COSMO-RS and COSMO-SAC are two variants used extensively in industry. A key input to these models is the so-called sigma profile, i.e., a histogram of charge density distributio ...
DOI:
10.1021/ie503829b

43. Caffeine Intake from Food and Beverage Sources and Trends among Children and Adolescents in the United States: Review of National Quantitative Studies from 1999 to 2011

Author:
Namanjeet Ahluwalia; Kirsten Herrick
Source:
Advances in food and nutrition research 2015 v.6 no.1 pp. 102-111
ISSN:
1043-4526
Subject:
National Health and Nutrition Examination Survey; Whites; adolescents; adverse effects; caffeine; children; dietary nutrient sources; energy drinks; guidelines; monitoring; national surveys; sociodemographic characteristics; tea; youth; United States
Abstract:
... There is increasing concern about potential adverse effects of caffeine in children. Our understanding of caffeine intake relies on studies dating to the late 1990s. This article synthesizes information from national studies since then to describe caffeine consumption, its association with sociodemographic factors, key dietary sources including caffeine-containing energy drinks (CCEDs), and trends ...
DOI:
10.3945/an.114.007401
PubMed:
25593149
PubMed Central:
PMC4288269

44. Caffeine acts through neuronal adenosine A₂A receptors to prevent mood and memory dysfunction triggered by chronic stress

Author:
Manuella P. Kaster; Nuno J. Machado; Henrique B. Silva; Ana Nunes; Ana Paula Ardais; Magda Santana; Younis Baqi; Christa E. Müller; Ana Lúcia S. Rodrigues; Lisiane O. Porciúncula; Jiang Fan Chen; ́Ângelo R. Tomé; Paula Agostinho; Paula M. Canas; Rodrigo A. Cunha
Source:
Proceedings of the National Academy of Sciences of the United States of America 2015 v.112 no.25 pp. 7833-7838
ISSN:
0027-8424
Subject:
adenosine; animal models; caffeine; emotions; epidemiological studies; memory; protective effect; receptors
Abstract:
... The consumption of caffeine (an adenosine receptor antagonist) correlates inversely with depression and memory deterioration, and adenosine A ₂A receptor (A ₂AR) antagonists emerge as candidate therapeutic targets because they control aberrant synaptic plasticity and afford neuroprotection. Therefore we tested the ability of A ₂AR to control the behavioral, electrophysiological, and neurochemical ...
DOI:
10.1073/pnas.1423088112
PubMed:
26056314
PubMed Central:
PMC4485143

45. Caffeine ameliorates high energy diet-induced hepatic steatosis: sirtuin 3 acts as a bridge in the lipid metabolism pathway

Author:
Shi-Jie Zhang; Yi-Fang Li; Guo-En Wang; Rui-Rong Tan; Bun Tsoi; Gao-Wei Mao; Yu-Jia Zhai; Ling-Fang Cao; Min Chen; Hiroshi Kurihara; Qi Wang; Rong-Rong He
Source:
Food & function 2015 v.6 no.8 pp. 2578-2587
ISSN:
2042-650X
Subject:
adenosine diphosphate; adenosine triphosphate; alanine transaminase; aspartate transaminase; body weight; caffeine; cyclic AMP; energy; fatty liver; high energy diet; human cell lines; lipid metabolism; lipids; liver; mice; phosphorylation; small interfering RNA; staining
Abstract:
... The beneficial effect of caffeine-containing food on non-alcoholic fatty liver disease (NAFLD) has been widely reported. The aim of this study was to explore the effect of caffeine on hepatic steatosis. C57BL/6 mice were randomly assigned to a normal diet or a high energy diet (HED). Caffeine was given to HED mice by oral gavage. Body weights, lipids in the liver and liver damage were measured. Me ...
DOI:
10.1039/c5fo00247h

46. Caffeine content of conventional and non conventional foods on the Hungarian market

Author:
A. Lugasi; G. Kádár; K. Alb; E. Schreiber Molnár; É. Martos
Source:
Acta alimentaria 2015 v.44 no.1 pp. 86-94
ISSN:
0139-3006
Subject:
breakfast cereals; caffeine; chocolate; coffee beans; energy drinks; high performance liquid chromatography; ice cream; instant coffee; markets; milk; powders
Abstract:
... Caffeine content of 377 food samples obtained from the Hungarian market was measured by a validated HPLC technique. The highest caffeine levels were observed in different instant coffees (3954±2355 mg/100 g) and ground coffee beans (1634±389 mg/100 g). Significant amount of caffeine could be detected in energy drinks (119 mg in 100 ml at the highest end). The caffeine content of different coffee d ...
DOI:
10.1556/AAlim.44.2015.1.8

47. Caffeine dimerization: effects of sugar, salts, and water structure

Author:
Seishi Shimizu
Source:
Food & function 2015 v.6 no.10 pp. 3228-3235
ISSN:
2042-650X
Subject:
additives; bitterness; caffeine; dimerization; models; salts; sugars; thermodynamics
Abstract:
... Sugars and salts strongly affect the dimerization of caffeine in water. Such a change of dimerization, considered to be crucial for bitter taste suppression, has long been rationalized by the change of “water structure” induced by the additives; “kosmotropic” (water structure enhancing) salts and sugars promote dimerization, whereas “chaotropic” (water structure breaking) salts suppress dimerizati ...
DOI:
10.1039/c5fo00610d

48. Caffeine increases sugar-sweetened beverage consumption in a free-living population: a randomised controlled trial

Author:
Russell S. J. Keast; Boyd A. Swinburn; Dhoungsiri Sayompark; Susie Whitelock; Lynn J. Riddell
Source:
British journal of nutrition 2015 v.113 no.2 pp. 366-371
ISSN:
1475-2662
Subject:
ad libitum feeding; caffeine; flavor; food additives; food records; hedonic scales; high energy foods; obesity; randomized clinical trials; sugar sweetened beverages
Abstract:
... Excessive sugar-sweetened beverage (SSB) consumption has been associated with overweight and obesity. Caffeine is a common additive to SSB, and through dependence effects, it has the potential to promote the consumption of caffeine-containing foods. The objective of the present study was to assess the influence that caffeine has on the consumption of SSB. Participants (n 99) were blindly assigned ...
DOI:
10.1017/S000711451400378X
PubMed:
25567475

49. Caffeine ingestion does not affect afternoon muscle power and fatigue during the Wingate test in elite judo players

Author:
Makram Souissi; Asma Aloui; Hamdi Chtourou; Hassen Ben Aouicha; Rim Atheymen; Zouhair Sahnoun
Source:
Biological rhythm research 2015 v.46 no.2 pp. 291-298
ISSN:
1744-4179
Subject:
anxiety; biological rhythms; caffeine; ingestion; muscles; placebos; vigor
Abstract:
... The purpose of the present study was to evaluate the effect of caffeine ingestion on elite judo players’ mood states, simple reaction time, and muscle power during the Wingate test in the afternoon. Ten elite judo players (age: 21.08 ± 1.16 years, body mass: 83.75 ± 20.2 kg, height: 1.76 ± 0.07 m) took part in this study. The performance variables were measured during two test sessions scheduled a ...
DOI:
10.1080/09291016.2014.994857

50. Caffeine inhibits hepatitis C virus replication in vitro

Author:
Mariana N. Batista; Bruno M. Carneiro; Ana Cláudia S. Braga; Paula Rahal
Source:
Archives of virology 2015 v.160 no.2 pp. 399-407
ISSN:
0304-8608
Subject:
Hepatitis C virus; biochemistry; caffeine; dose response; fibrosis; genotype; hepatitis C; hepatoma; liver; liver function; virus replication
Abstract:
... Hepatitis C is considered the major cause of cirrhosis and hepatocellular carcinoma. Conventional treatment is not effective against some hepatitis C virus (HCV) genotypes; therefore, new treatments are needed. Coffee and, more recently, caffeine, have been found to have a beneficial effect in several disorders of the liver, including those manifesting abnormal liver biochemistry, cirrhosis and he ...
DOI:
10.1007/s00705-014-2302-1

51. Caffeine intake in pregnancy: Relationship between internal intake and effect on birth weight

Author:
F. Partosch; H. Mielke; R. Stahlmann; U. Gundert-Remy
Source:
Food and chemical toxicology 2015 v.86 pp. 291-297
ISSN:
0278-6915
Subject:
birth weight; blood; caffeine; epidemiological studies; fetus; kinetics; pregnancy; pregnant women; risk; simulation models; toxicology
Abstract:
... We used a physiologically based kinetic model to simulate caffeine blood concentration-time profiles in non-pregnant and pregnant women. The model predicted concentration-time profile was in good accordance with experimental values. With 200 mg, the safe dose per occasion in non-pregnant women, AUC and peak concentration in pregnant women were nearly twice that of non-pregnant women. In order to d ...
DOI:
10.1016/j.fct.2015.11.005

52. Caffeine is responsible for the bloodglucose-lowering effects of green tea and Puer tea extractsin BALB/c mice

Author:
Chong-Ye FANG; Xuan-Jun WANG; Ye-Wei HUANG; Shu-Mei HAO; Jun SHENG
Source:
Chinese journal of natural medicines 2015 v.13 no.8 pp. 595-601
ISSN:
1875-5364
Subject:
Oriental traditional medicine; adipocytes; blood glucose; caffeine; drinking water; epigallocatechin gallate; genes; green tea; males; mice; noninsulin-dependent diabetes mellitus
Abstract:
... The present study was designed to determine the effects of Puer tea and green tea on blood glucose level. Male BALB/c mice were administered green tea extract (GTE) or Puer tea extract (PTE), either intragastrically or in their drinking water. The major components of these teas are epigallocatechin gallate (EGCG) and caffeine, respectively. Blood glucose measurement results showed that mice fed in ...
DOI:
10.1016/S1875-5364(15)30055-8

53. Caffeine stimulates in vitro pituitary LH secretion in lipopolysaccharide-treated ewes

Author:
Andrzej Przemysław Herman; Anna Herman; Janina Skipor; Agata Krawczyńska; Joanna Bochenek; Dorota Tomaszewska-Zaremba
Source:
Reproductive Biology 2015 v.15 no.1 pp. 20-26
ISSN:
1642-431X
Subject:
anterior pituitary; caffeine; endotoxins; ewes; explants; gene expression; gonadotropin-releasing hormone; in vitro studies; lipopolysaccharides; luteinizing hormone; receptors; secretion
Abstract:
... The study was designed to determine the effects of caffeine on luteinizing hormone (LH) secretion and gene expression of caffeine-associated receptors in anterior pituitary (AP) explants obtained from saline- and lipopolysaccharide (LPS)-treated ewes. Animals had been treated with LPS or saline daily for seven days. Three hours after the last injection of LPS/saline, the AP were collected and divi ...
DOI:
10.1016/j.repbio.2014.12.001

54. Caffeine’s Antioxidant Potency Optically Sensed with Double-Stranded DNA-Encased Single-Walled Carbon Nanotubes

Author:
Zhao Edward H.; Ergul Busra; Zhao Wei
Source:
Journal of physical chemistry 2015 v.119 no.10 pp. 4068-4075
ISSN:
1520-5207
Subject:
DNA; ascorbic acid; caffeine; carbon nanotubes; hydrogen peroxide; hydroxyl radicals; oxidative stress; physical chemistry; uric acid
Abstract:
... There is great interest in developing a sensitive method being able to quantitatively measure and compare antioxidant potencies of samples of interest against multiple reactive oxygen species (ROS) whose imbalance could cause oxidative stress. Here, a sensitive nanoprobe, double-stranded DNA encased single-walled carbon nanotubes (SWNTs) has been developed to determine antioxidant potencies of sel ...
DOI:
10.1021/acs.jpcb.5b00708

55. Can Energy Drinks Increase the Desire for More Alcohol?

Author:
Cecile A Marczinski
Source:
Advances in food and nutrition research 2015 v.6 no.1 pp. 96-101
ISSN:
1043-4526
Subject:
alcohol abuse; alcohol drinking; alcohols; binging; caffeine; energy drinks; epidemiological studies; humans; markets; mixers; public health; risk
Abstract:
... Energy drinks, the fastest growing segment in the beverage market, have become popular mixers with alcohol. The emerging research examining the use of alcohol mixed with energy drinks (AmEDs) indicates that the combination of caffeine-containing energy drinks with alcohol may be riskier than the use of alcohol alone. The public health concerns arising from AmED use are documented in different rese ...
DOI:
10.3945/an.114.007393
PubMed:
25593148
PubMed Central:
PMC4288285

56. Central adenosine A1 and A2A receptors mediate the antinociceptive effects of neuropeptide S in the mouse formalin test

Author:
A.D. Victor Holanda; Laila Asth; Adair R Santos; Remo Guerrini; Vanessa de P. Soares-Rachetti; Girolamo Calo’; Eunice André; Elaine C Gavioli
Source:
Life sciences 2015 v.120 pp. 8-12
ISSN:
0024-3205
Subject:
adenosine; analgesic effect; antagonists; caffeine; formalin; formalin test; indomethacin; mice; neuropeptides; nociception; purinergic receptors
Abstract:
... The present study aimed to investigate the intraplantar (ipl) and central (icv) effects of neuropeptide S (NPS) in the formalin test and to evaluate the role of adenosine receptors, mainly A1 and A2A, in mediating such effects.The ipl injection of formalin was used to assess the nociceptive activity. Moreover, by pretreating mice with non-selective and selective antagonists of adenosine receptors, ...
DOI:
10.1016/j.lfs.2014.10.021

57. Changes in the Aromatic Profile of Espresso Coffee as a Function of the Grinding Grade and Extraction Time: A Study by the Electronic Nose System

Author:
C. Severini; I. Ricci; M. Marone; A. Derossi; T. De Pilli
Source:
Journal of agricultural and food chemistry 2015 v.63 no.8 pp. 2321-2327
ISSN:
0021-8561
Subject:
caffeine; coffee (beverage); electronic nose; grinding; organic acids and salts; particle size distribution
Abstract:
... The changes in chemical attributes and aromatic profile of espresso coffee (EC) were studied taking into account the extraction time and grinding level as independent variables. Particularly, using an electronic nose system, the changes of the global aromatic profile of EC were highlighted. The results shown as the major amounts of organic acids, solids, and caffeine were extracted in the first 8 ...
DOI:
10.1021/jf505691u

58. Characterisation of microcontaminants in Darwin Harbour, a tropical estuary of northern Australia undergoing rapid development

Author:
Veronica A. French; Susan Codi King; Anu Kumar; Grant Northcott; Keith McGuinness; David Parry
Source:
Science of the total environment 2015 v.536 pp. 639-647
ISSN:
0048-9697
Subject:
acesulfame potassium; acetaminophen; anthropogenic activities; aquatic environment; bioassays; caffeine; cholesterol; deet; ecotoxicology; estradiol; estrogenic properties; estuaries; freshwater; habitats; herbicides; human health; industrialization; metals; personal care products; sewage effluent; surface water; urbanization; wastewater; watersheds; Australia
Abstract:
... The detection of microcontaminants in aquatic environments raises concerns about their potential to exert ecotoxicological effects and impact human health. In contrast to freshwater habitats, little information is available on environmental concentrations in urban estuarine and marine environments. This study investigated an extensive range of organic and inorganic microcontaminants in the Darwin ...
DOI:
10.1016/j.scitotenv.2015.07.114

59. Characterization of cefalexin degradation capabilities of two Pseudomonas strains isolated from activated sludge

Author:
Bokun Lin; Jinling Lyu; Xian-jin Lyu; Han-qing Yu; Zhong Hu; James C.W. Lam; Paul K.S. Lam
Source:
Journal of hazardous materials 2015 v.282 pp. 158-164
ISSN:
0304-3894
Subject:
Pseudomonas; activated sludge; bacteria; caffeine; chloramphenicol; drugs; salicylic acid; sulfamethoxazole
Abstract:
... Pharmaceuticals have recently been regarded as contaminants of emerging concern. To date, there is limited knowledge about antibiotic-degrading microorganisms in conventional activated sludge treatment systems and their characteristics toward antibiotic degradation especially in the presence of a pharmaceutical mixture. As such, antibiotic-degrading microorganisms were investigated and isolated fr ...
DOI:
10.1016/j.jhazmat.2014.06.080

60. Characterizing Drug Release from Nonfouling Polyampholyte Hydrogels

Author:
Barcellona Marcos N.; Johnson Nicholas; Bernards Matthew T.
Source:
Langmuir 2015 v.31 no.49 pp. 13402-13409
ISSN:
1520-5827
Subject:
bioactive compounds; caffeine; chlorides; drugs; enzyme-linked immunosorbent assay; hydrogels; ionic strength; methylene blue; pH; tissue repair
Abstract:
... Controlled delivery of bioactive signaling molecules and drugs is essential for the development of the next generation of tissue regeneration scaffolds. However, these molecules must be delivered from a nonfouling platform, so that the therapeutic role is not masked by the naturally occurring foreign body response. Therefore, the purpose of this study is to characterize the release profiles of thr ...
DOI:
10.1021/acs.langmuir.5b03597

61. Children's and parents' health perception of different soft drinks

Author:
Tamara Bucher; Michael Siegrist
Source:
British journal of nutrition 2015 v.113 no.3 pp. 526-535
ISSN:
1475-2662
Subject:
adults; artificial sweeteners; boys; caffeine; grapefruit juice; multidimensional scaling; nutritive value; parents; school children; soft drinks; squashes; sugar content
Abstract:
... Beverages are among the first independent product choices that school-aged children will make and unhealthy choices can be a threat to children's health. The present study investigated which beverage attributes shape adults' and children's health perceptions. For this purpose, 100 children (fifty-two boys; mean age 8·8 (sd 1·1) years) and their parents were invited to independently perform a bever ...
DOI:
10.1017/S0007114514004073
PubMed:
25612601

62. Chronic caffeine treatment enhances the resilience to social defeat stress in mice

Author:
Yong-Qin Yin; Chun Zhang; Jian-Xin Wang; Jia Hou; Xu Yang; Jing Qin
Source:
Food & function 2015 v.6 no.2 pp. 479-491
ISSN:
2042-650X
Subject:
antagonism; caffeine; dopamine; dopamine receptors; locomotion; mice; social behavior; sucrose
Abstract:
... Strong evidence has shown that caffeine exerts antidepressant-like effects in chronic stress situations by increasing dopamine levels. However, whether caffeine mediates the dopaminergic system and interferes with the resilience to social defeat stress in mice is unknown. The aim of this study is to investigate the role of caffeine in the behavioral responses to social defeat stress and the possib ...
DOI:
10.1039/c4fo00702f

63. Coffee Extracts Suppress Tryptophan Breakdown in Mitogen-Stimulated Peripheral Blood Mononuclear Cells

Author:
Johanna M. Gostner; Sebastian Schroecksnadel; Marcel Jenny; Angela Klein; Florian Ueberall; Harald Schennach; Dietmar Fuchs
Source:
Journal of the American College of Nutrition 2015 v.34 no.3 pp. 212-223
ISSN:
1541-1087
Subject:
biochemical pathways; biosynthesis; caffeic acid; caffeine; carcinogenesis; cardiovascular diseases; cell viability; chlorogenic acid; cytokines; dose response; emotions; gallic acid; humans; immunosuppression; indoleamine 2,3-dioxygenase; interferon-gamma; kynurenine; mechanism of action; mononuclear leukocytes; neoplasms; neopterin; neurotransmitters; phytohemagglutinin; quality of life; serotonin; tryptophan
Abstract:
... Objectives: Coffee consumption is considered to exert an influence on mood, the immune system, cardiovascular disease, and cancer development, but the mechanisms of action of coffee and its compounds are only partly known and understood. Methods: Immunomodulatory effects of filtered extracts of coffee and decaffeinated coffee as well as coffee compounds were investigated in human peripheral blood ...
DOI:
10.1080/07315724.2014.907756

64. Coffee Silverskin: Characterization, Possible Uses, and Safety Aspects

Author:
Tullia Gallina Toschi; Vladimiro Cardenia; Giorgio Bonaga; Mara Mandrioli; Maria Teresa Rodriguez-Estrada
Source:
Journal of agricultural and food chemistry 2014 v.62 no.44 pp. 10836-10844
ISSN:
0021-8561
Subject:
caffeine; cellulose; coffee products; dietary fiber; humans; industry; linoleic acid; livestock; ochratoxin A; oxidation; phytosterols; polyphenols; risk
Abstract:
... The reuse of coffee silverskin (CS), the main waste product of the coffee-roasting industry, could be an alternative to its environmental disposal. However, CS could also contain undesirable compounds, such as ochratoxin A (OTA) and phytosterol oxidation products (POPs). A study on the composition of CS (caffeine, moisture, dietary fibers, carbohydrates, and polyphenol contents) was carried out, w ...
DOI:
10.1021/jf503200z

65. Coffee and spent coffee extracts protect against cell mutagens and inhibit growth of food-borne pathogen microorganisms

Author:
Carmen Monente; Jimena Bravo; Ana Isabel Vitas; Leire Arbillaga; M. Paz De Peña; Concepción Cid
Source:
Journal of functional foods 2015 v.12 pp. 365-374
ISSN:
1756-4646
Subject:
Ames test; Candida albicans; Gram-positive bacteria; Listeria monocytogenes; Staphylococcus aureus; anti-infective properties; antioxidant activity; bioactive compounds; brewing; byproducts; caffeine; chlorogenic acid; coffee (beverage); food pathogens; food spoilage; functional foods; growth retardation; ingredients; melanoidins; mutagenicity; phenolic acids; risk; spoilage microorganisms; yeasts
Abstract:
... Coffee consumption decreases the risk of oxidative stress-related diseases. The by-product obtained after brewing process (spent coffee) also has antioxidant capacity. Spent coffee and coffee brews (filter and espresso) extracts were obtained from Arabica and Robusta coffees, respectively. Spent coffee showed slightly high amounts in chlorogenic acids, but caffeine content was similar to their res ...
DOI:
10.1016/j.jff.2014.12.006

66. Coffee enriched with willow (Salix purpurea and Salix myrsinifolia) bark preparation – Interactions of antioxidative phytochemicals in a model system

Author:
Agata Durak; Urszula Gawlik-Dziki; Danuta Sugier
Source:
Journal of functional foods 2015 v.18 pp. 1106-1116
ISSN:
1756-4646
Subject:
Salix purpurea; active ingredients; antioxidant activity; bark; caffeine; chlorogenic acid; coffee (beverage); hydroxyl radicals; lipids; oxidation; phytopharmaceuticals; raw materials; synergism
Abstract:
... Coffee and willow are known to be valuable sources of biologically active phytochemicals such as chlorogenic acid, caffeine and salicin. The aim of this study was to determine the interactions between the active compounds from coffee and willow bark (Salix purpurea and Salix myrsinifolia). Raw materials and their mixtures were characterized by multidirectional antioxidant activities; however, bioa ...
DOI:
10.1016/j.jff.2014.06.012

67. Coffee, tea, and caffeine consumption and prevention of late-life cognitive decline and dementia: A systematic review

Author:
Francesco Panza; V. Solfrizzi; M. R. Barulli; C. Bonfiglio; V. Guerra; A. Osella; D. Seripa; C. Sabbà; A. Pilotto; G. Logroscino
Source:
journal of nutrition, health & aging 2015 v.19 no.3 pp. 313-328
ISSN:
1279-7707
Subject:
Alzheimer disease; brain; caffeine; cognition; disease prevention; dose response; drugs; long term effects; men; nutrition; protective effect; risk factors; systematic review; tea; women
Abstract:
... A prolonged preclinical phase of more than two decades before the onset of dementia suggested that initial brain changes of Alzheimer’s disease (AD) and the symptoms of advanced AD may represent a unique continuum. Given the very limited therapeutic value of drugs currently used in the treatment of AD and dementia, preventing or postponing the onset of AD and delaying or slowing its progression ar ...
DOI:
10.1007/s12603-014-0563-8

68. Cognitive Performance and Mood Following Ingestion of a Theacrine-Containing Dietary Supplement, Caffeine, or Placebo by Young Men and Women

Author:
Daniel J. Kuhman; Keanan J. Joyner; Richard J. Bloomer
Source:
Nutrients 2015 v.7 no.11 pp. 9618-9632
ISSN:
2072-6643
Subject:
Camellia sinensis var. assamica; blood pressure; caffeine; cognition; dietary supplements; emotions; energy; heart rate; leaves; men; placebos; women
Abstract:
... Theacrine is a purine alkaloid found primarily in the leaves of the Camellia Kucha plant and is now included within dietary supplements. To compare the effects of a theacrine-containing dietary supplement with caffeine and placebo on energy and mood, as well as objective measures of cognitive performance, heart rate, and blood pressure, 10 healthy men (20.8 ± 0.7 years) and 10 healthy women (22.2 ...
DOI:
10.3390/nu7115484
PubMed:
26610558
PubMed Central:
PMC4663612

69. Comparing antioxidant capacity of purine alkaloids: A new, efficient trio for screening and discovering potential antioxidants in vitro and in vivo

Author:
Bun Tsoi; Ruo-Nan Yi; Ling-Fang Cao; Shan-Bing Li; Rui-Rong Tan; Min Chen; Xiao-Xiao Li; Chen Wang; Yi-Fang Li; Hiroshi Kurihara; Rong-Rong He
Source:
Food chemistry 2015 v.176 pp. 411-419
ISSN:
0308-8146
Subject:
antioxidants; apoptosis; caffeine; chickens; chicks; chorioallantoic membrane; cost effectiveness; models; oxygen radical absorbance capacity; screening
Abstract:
... The most commonly applied strategies for the evaluation of antioxidant capacity are the chemical- or cell-based approaches. However, the results obtained from these methods might not reflect the antioxidant ability of test samples within organisms. In this study, we propose a combination of experiments, including oxygen radical absorbance capacity (ORAC), cellular antioxidant activity assay (CAA), ...
DOI:
10.1016/j.foodchem.2014.12.087

70. Comparison of intensities and binary interactions of four basic tastes between an electronic tongue and a human tongue

Author:
Huaixiang Tian; Tao Feng; Zuobing Xiao; Shiqing Song; Zhiyu Li; Qiang Liu; Deshou Mao; Fenghua Li
Source:
Food science and biotechnology 2015 v.24 no.5 pp. 1711-1715
ISSN:
1226-7708
Subject:
caffeine; citric acid; correlation; electronic tongue; flavor; humans; mathematical models; sodium chloride; sucrose; taste; tongue
Abstract:
... For detection of single taste intensities and binary interactions using an electronic tongue (E-tongue) and the human tongue (H-tongue), the 4 basic flavor substances of sucrose, caffeine, citric acid, and sodium chloride were used. A linear fit was performed using response values of the E-tongue and concentrations of the basic tastes. The taste intensity of the E-tongue was positively correlated ...
DOI:
10.1007/s10068-015-0222-9

71. Comparison of three strategies for the isolation of black tea thearubigins with a focus on countercurrent chromatography

Author:
Ulf W. Stodt; Janina Stark; Ulrich H. Engelhardt
Source:
Journal of food composition and analysis 2015 v.43 pp. 160-168
ISSN:
0889-1575
Subject:
black tea; caffeine; countercurrent chromatography; fractionation; liquid-liquid extraction; reversed-phase high performance liquid chromatography; solvents
Abstract:
... Three different methods from the literature for the fractionation and isolation of thearubigins in black tea (Roberts’ fractionation via liquid–liquid extraction, caffeine precipitation and high-speed countercurrent chromatography) were compared. The fractions were analyzed by both normal phase high-performance liquid chromatography (HPLC) on a diol-column and reverse phase HPLC. The methods were ...
DOI:
10.1016/j.jfca.2015.07.002

72. Comparison of trapping profiles between d-peptides and glutathione in the identification of reactive metabolites

Author:
Jaana E. Laine; Merja R. Häkkinen; Seppo Auriola; Risto O. Juvonen; Markku Pasanen
Source:
Toxicology reports 2015 v.2 pp. 1024-1032
ISSN:
2214-7500
Subject:
Lewis acids; amino acid sequences; biocatalysts; caffeine; glutathione; gold; humans; ibuprofen; liver microsomes; metabolites; mice; toxicity; toxicology
Abstract:
... Qualitative trapping profile of reactive metabolites arising from six structurally different compounds was tested with three different d-peptide isomers (Peptide 1, gly–tyr–pro–cys–pro–his-pro; Peptide 2, gly–tyr–pro–ala–pro–his–pro; Peptide 3, gly–tyr–arg–pro–cys–pro–his–lys–pro) and glutathione (GSH) using mouse and human liver microsomes as the biocatalyst. The test compounds were classified ei ...
DOI:
10.1016/j.toxrep.2015.07.002

73. Conductive diamond electrochemical oxidation of caffeine-intensified biologically treated urban wastewater

Author:
María J. Martín de Vidales; María Millán; Cristina Sáez; José F. Pérez; Manuel A. Rodrigo; Pablo Cañizares
Source:
Chemosphere 2015 v.136 pp. 281-288
ISSN:
0045-6535
Subject:
ammonium compounds; caffeine; electrochemistry; hydrogen peroxide; nitrates; oxidants; oxidation; perchlorates; sulfates; wastewater
Abstract:
... In this work, the usefulness of Conductive Diamond Electrochemical Oxidation (CDEO) to degrade caffeine in real urban wastewater matrixes was assessed. The oxidation of actual wastewater intensified with caffeine (from 1 to 100mgL−1) was studied, paying particular attention to the influence of the initial load of caffeine and the differences observed during the treatment of caffeine in synthetic w ...
DOI:
10.1016/j.chemosphere.2015.05.077

74. Consuming a multi-ingredient thermogenic supplement for 28 days is apparently safe in healthy adults

Author:
Roxanne M. Vogel; Jordan M. Joy; Paul H. Falcone; Matt M. Mosman; Michael P. Kim; Jordan R. Moon
Source:
Food & nutrition research 2015 v.59 no.1 pp. 27999
ISSN:
1654-661X
Subject:
adults; blood; blood pressure; blood sampling; body mass index; body weight; caffeine; carbon dioxide; cayenne; chlorides; creatinine; energy expenditure; exercise; fasting; globulins; glomerular filtration rate; green tea; heart rate; high density lipoprotein; ingredients; markets; t-test
Abstract:
... Thermogenic (TRM) supplements are often used by people seeking to decrease body weight. Many TRM supplements are formulated with multiple ingredients purported to increase energy expenditure and maximize fat loss. However, in the past some TRM ingredients have been deemed unsafe and removed from the market. Therefore, it is important to verify the safety of multi-ingredient TRM supplements with ch ...
DOI:
10.3402/fnr.v59.27999

75. Correlation between nitrogen application to tea flushes and quality of green and black teas

Author:
Po-An Chen; Shu-Yen Lin; Chiou-Fang Liu; Yen-Shuo Su; Hun-Yuan Cheng; Jian-Hsing Shiau; Iou-Zen Chen
Source:
Scientia horticulturae 2015 v.181 pp. 102-107
ISSN:
0304-4238
Subject:
black tea; caffeine; cultivars; flavanols; green tea; leaves; linear models; nitrogen; nitrogen content; nitrogen fertilizers; shoots
Abstract:
... We treated the tea cultivar TTES No. 12 with different nitrogen fertilizers and prepared black and green teas from these tea flushes. Analyses of nitrogen content and levels of catechins and caffeine of shoots with two leaves and a bud were conducted to understand the influence of these factors on tea quality. Only the nitrogen content showed consistent effects on tea quality, whereas the effects ...
DOI:
10.1016/j.scienta.2014.10.050

76. Corrigendum to “Sorption/desorption of non-hydrophobic and ionisable pharmaceutical and personal care products from reclaimed water onto/from a natural sediment” Sci Total Environ 472 (2014) 273–281

Author:
Virtudes Martínez-Hernández; Raffaella Meffe; Sonia Herrera; Elena Arranz; Irene de Bustamante
Source:
Science of the total environment 2015 v.505 pp. 1232-1233
ISSN:
0048-9697
Subject:
acetaminophen; caffeine; carbon; desorption; inorganic ions; ionization; organic matter; personal care products; rain; sandy loam soils; sediments; sulfamethoxazole
Abstract:
... In the present work, the sorption of pharmaceutical and personal care products (PPCPs) (acetaminophen, atenolol, carbamazepine, caffeine, naproxen and sulphamethoxazole) onto the natural organic matter (NOM) and the inorganic surfaces of a natural sandy loam sediment was quantified separately. The quantification was based on the PPCP charge, their degree of ionisation, their octanol-water partitio ...
DOI:
10.1016/j.scitotenv.2014.10.104

77. DINO (Diet In Nutrients Out) – an integrated dietary assessment system

Author:
Emily Fitt; Darren Cole; Nida Ziauddeen; David Pell; Elizabeth Stickley; Anna Harvey; Alison M Stephen
Source:
Public health nutrition 2015 v.18 no.2 pp. 234-241
ISSN:
1475-2727
Subject:
added sugars; caffeine; cheeses; dietary recommendations; education programs; fish; food composition; food groups; fruits; issues and policy; meat; national surveys; nutrients; nutrition assessment; nutrition monitoring; nutrition research; portion size; quality control; vegetables; vitamin K; whole grain foods; Gambia; United Kingdom
Abstract:
... The current paper describes Diet In Nutrients Out (DINO), an integrated dietary assessment system incorporating dietary data entry and nutritional analysis within one platform for use in dietary assessment in small-scale intervention studies to national surveys. DINO contains >6000 food items, mostly aggregated composites of branded foods, across thirty-one main food groups divided into 151 subsid ...
DOI:
10.1017/S1368980014000342
PubMed:
24674815

78. Determination of pesticide multi-residues in green tea using a modified QuEChERS extraction and liquid chromatography tandem mass spectrometry technique

Author:
S. C. Tran; H. Th. Le; T. H. Thai-Nguyen
Source:
Acta alimentaria 2015 v.44 no.3 pp. 409-419
ISSN:
1588-2535
Subject:
caffeine; graphene; green tea; lead acetate; liquid chromatography; pesticides; pigments; tandem mass spectrometry
Abstract:
... A modified QuEChERS method was developed and validated for determination of pesticide multi-residues in green tea by liquid chromatography tandem mass spectrometry. Lead acetate was first time used together with primary secondary amine and graphite carbon black to eliminate tannin, caffeine, and other pigments in tea and thus reduced the matrix effects. The method was compared to the original QuEC ...
DOI:
10.1556/066.2015.44.0012

79. Determination of phytochemicals, antioxidant activity and total phenolic content in Andrographis paniculata using chromatographic methods

Author:
Marzanna Kurzawa; Anna Filipiak-Szok; Ewa Kłodzińska; Edward Szłyk
Source:
Journal of Chromatography B 2015 v.995-996 pp. 101-106
ISSN:
1570-0232
Subject:
2,2-diphenyl-1-picrylhydrazyl; Andrographis paniculata; analysis of variance; antioxidant activity; caffeine; cluster analysis; dietary supplements; gas chromatography-mass spectrometry; high performance liquid chromatography; leaves; phytopharmaceuticals; principal component analysis; strychnine; theobromine; theophylline; yohimbine
Abstract:
... Antioxidant activity, total phenolics content and selected phytochemicals (alkaloids and andrographolides) were determined in Andrographis paniculata and in dietary supplements containing this plant. Antioxidant activity was measured by FRAP, CUPRAC and DPPH procedures and ranged from 503.36 to 6164.09μmol TE/100g d.m. depending on methods, part of plant and kind of dietary supplement. The total p ...
DOI:
10.1016/j.jchromb.2015.05.021

80. Development and validation of a rapid derivative spectrophotometric method for simultaneous determination of acetaminophen, ibuprofen and caffeine

Author:
Effat Souri; Seyed Adel Mousavi Nasab; Massoud Amanlou; Maliheh Barazandeh Tehrani
Source:
Journal of analytical chemistry 2015 v.70 no.3 pp. 333-338
ISSN:
1061-9348
Subject:
acetaminophen; caffeine; drug formulations; ibuprofen; quality control; spectrophotometers; wavelengths
Abstract:
... A zero-crossing derivative spectrophotometric method was used for the simultaneous determination of acetaminophen, ibuprofen and caffeine. The derivative spectra of standard solutions of each compound were obtained at different orders to find out the suitable zero-crossing points. Under the optimized conditions, determination of acetaminophen was performed at wavelengths of 311 and 270 nm using th ...
DOI:
10.1134/S1061934815030041

81. Development of a Stationary Phase Optimised Selectivity Liquid Chromatography based screening method for adulterations of food supplements for the treatment of pain

Author:
E. Deconinck; A. Kamugisha; P. Van Campenhout; P. Courselle; J.O. De Beer
Source:
Talanta 2015 v.138 pp. 240-246
ISSN:
0039-9140
Subject:
adulterated products; analgesics; caffeine; codeine; dietary supplements; diodes; guidelines; hydrophilicity; hydrophobicity; liquid chromatography; mass spectrometry; pain; screening; veterinary medicine
Abstract:
... Illegally adulterated dietary supplements are an increasing problem worldwide. One of the important groups of often adulterated products are the dietary supplements, sold for the treatment of pain. These often contain analgesics, a heterogeneous group of molecules, containing both hydrophilic and hydrophobic compounds. The development of a screening method for these components, especially when mas ...
DOI:
10.1016/j.talanta.2015.03.010

82. Development of a predictive framework to assess the removal of trace organic chemicals by anaerobic membrane bioreactor

Author:
Kaushalya C. Wijekoon; James A. McDonald; Stuart J. Khan; Faisal I. Hai; William E. Price; Long D. Nghiem
Source:
Bioresource technology 2015 v.189 pp. 391-398
ISSN:
0960-8524
Subject:
bacteria; bioreactors; caffeine; hydrophilicity; hydrophobicity; linuron; nitrogen; sludge; sulfur; wastewater treatment
Abstract:
... This study aims to develop a predictive framework to assess the removal and fate of trace organic chemicals (TrOCs) during wastewater treatment by anaerobic membrane bioreactor (AnMBR). The fate of 27 TrOCs in both the liquid and sludge phases during AnMBR treatment was systematically investigated. The results demonstrate a relationship between hydrophobicity and specific molecular features of TrO ...
DOI:
10.1016/j.biortech.2015.04.034

83. Development of urine standard reference materials for metabolites of organic chemicals including polycyclic aromatic hydrocarbons, phthalates, phenols, parabens, and volatile organic compounds

Author:
Michele M. Schantz; Bruce A. Benner Jr.; N. Alan Heckert; Lane C. Sander; Katherine E. Sharpless; Stacy S. Vander Pol; Y. Vasquez; M. Villegas; Stephen A. Wise; K. Udeni Alwis; Benjamin C. Blount; Antonia M. Calafat; Zheng Li; Manori J. Silva; Xiaoyun Ye; Éric Gaudreau; Donald G. Patterson Jr; Andreas Sjödin
Source:
Analytical and bioanalytical chemistry 2015 v.407 no.11 pp. 2945-2954
ISSN:
1618-2642
Subject:
National Health and Nutrition Examination Survey; analytical methods; caffeine; cotinine; creatinine; humans; ibuprofen; metabolites; monitoring; national surveys; nicotine; normal values; phenols; phthalates; pollution; polycyclic aromatic hydrocarbons; quality control; theobromine; urine; volatile organic compounds
Abstract:
... Two new Standard Reference Materials (SRMs), SRM 3672 Organic Contaminants in Smokers’ Urine (Frozen) and SRM 3673 Organic Contaminants in Non-Smokers’ Urine (Frozen), have been developed in support of studies for assessment of human exposure to select organic environmental contaminants. Collaborations among three organizations resulted in certified values for 11 hydroxylated polycyclic aromatic h ...
DOI:
10.1007/s00216-014-8441-0
PubMed:
25651899
PubMed Central:
PMC5137188

84. Differences of Biochemical Constituents and Contents of Eight Cultivars Flowers of Camellia sinensis

Author:
Hao Wang; Xiaoxuan Cui; Xiaogai Zhao; Shan Gao; Jianan Zhao; Zuli Yuan
Source:
Journal of essential oil-bearing plants 2015 v.18 no.2 pp. 320-328
ISSN:
0976-5026
Subject:
Camellia sinensis; aldehydes; alkanes; alkenes; amino acids; caffeine; colorimetry; cultivars; distillation; flowers; gas chromatography-mass spectrometry; ketones; phthalates; polyphenols; proteins; solvents; spectrophotometers; sugars; tea
Abstract:
... For better use of tea plant (Camellia sinensis) flower resources, biochemical components and contents of eight tea cultivars flowers were investigated. Volatile aromatic compounds were extracted by simultaneous distillation and solvent extraction (SDE) and determined using Gas Chromatography (GC) and Gas Chromatography/Mass Spectrometry (GC-MS). The contents of tea polyphenols, amino acids, caffei ...
DOI:
10.1080/0972060X.2014.961036

85. Differential regulation of caffeine metabolism in Coffea arabica (Arabica) and Coffea canephora (Robusta)

Author:
Charlène Perrois; Susan R. Strickler; Guillaume Mathieu; Maud Lepelley; Lucie Bedon; Stéphane Michaux; Jwanro Husson; Lukas Mueller; Isabelle Privat
Source:
Planta 2015 v.241 no.1 pp. 179-191
ISSN:
0032-0935
Subject:
Coffea canephora; amino acids; beans; beverages; caffeine; coffee beans; doubled haploids; gene expression; genes; haploidy; leaves; metabolism; metabolites; phylogeny; purine nucleotides; transcription (genetics)
Abstract:
... Caffeine is a metabolite of great economic importance, especially in coffee, where it influences the sensorial and physiological impacts of the beverage. Caffeine metabolism in the Coffea species begins with the degradation of purine nucleotides through three specific N-methyltransferases: XMT, MXMT and DXMT. A comparative analysis was performed to clarify the molecular reasons behind differences ...
DOI:
10.1007/s00425-014-2170-7
PubMed:
25249475
PubMed Central:
PMC4282694

86. Differentiation of degrees of ripeness of Catuai and Tipica green coffee by chromatographical and statistical techniques

Author:
Samo Smrke; Ivana Kroslakova; Alexia N. Gloess; Chahan Yeretzian
Source:
Food chemistry 2015 v.174 pp. 637-642
ISSN:
0308-8146
Subject:
caffeine; chlorogenic acid; farms; gas chromatography; gel chromatography; headspace analysis; high performance liquid chromatography; hydrophilic interaction chromatography; mass spectrometry; principal component analysis; sucrose; volatile compounds
Abstract:
... The quality of green coffee is influenced by the degree of ripeness of the fruit at harvest. The aim of this study was to identify chemical markers differentiating between degrees of ripeness. Two coffee varieties, Catuai and Tipica, from the same farm were analysed using the following parameters and methods: caffeine and chlorogenic acid content using high-performance liquid chromatography (HPLC) ...
DOI:
10.1016/j.foodchem.2014.11.060

87. Differing chemical compositions of three teas may explain their different effects on acute blood pressure in spontaneously hypertensive rats

Author:
Shan‐Bing Li; Yi‐Fang Li; Zhong‐Fu Mao; Hui‐Hua Hu; Shu‐Hua Ouyang; Yan‐Ping Wu; Bun Tsoi; Pin Gong; Hiroshi Kurihara; Rong‐Rong He
Source:
Journal of the science of food and agriculture 2015 v.95 no.6 pp. 1236-1242
ISSN:
0022-5142
Subject:
acute effects; caffeine; diastolic blood pressure; epinephrine; heart rate; intragastric administration; leaves; norepinephrine; people; rats; systolic blood pressure; tea; theobromine
Abstract:
... BACKGROUND: Heavy tea consumption is suggested to be unsuitable for hypertensive people. However, the bioactive substances in different varieties of tea leaves are very different. This study compares the effects of three Chinese teas – C. sinensis, C. ptilophylla and C. assamica var. kucha – on blood pressure (BP) and heart rate in spontaneously hypertensive rats (SHRs). RESULTS: Intragastric admi ...
DOI:
10.1002/jsfa.6811

88. Direct injection of tissue extracts in liquid chromatography/tandem mass spectrometry for the determination of pharmaceuticals and other contaminants of emerging concern in mollusks

Author:
Stéphane Bayen; Elvagris Segovia Estrada; Guillaume Juhel; Barry C. Kelly
Source:
Analytical and bioanalytical chemistry 2015 v.407 no.19 pp. 5553-5558
ISSN:
1618-2642
Subject:
Perna viridis; Polymesoda; atrazine; caffeine; clams; coastal water; detection limit; drugs; endocrine-disrupting chemicals; isotope labeling; liquid chromatography; monitoring; mussels; solvents; tandem mass spectrometry; Singapore
Abstract:
... In the present study, a straightforward approach was validated for the analysis of pharmaceutically active compounds and endocrine-disrupting chemicals in the mollusk tissues, with a focus on two species commonly consumed in Southeast Asia (green mussels: Perna viridis; lokan clams: Polymesoda expansa). This approach relied on a simple solvent extraction (shaker table) followed by direct injection ...
DOI:
10.1007/s00216-015-8760-9

89. Discrimination and quantification of cocaine and adulterants in seized drug samples by infrared spectroscopy and PLSR

Author:
Tatiane S. Grobério; Jorge J. Zacca; Élvio D. Botelho; Marcio Talhavini; Jez W.B. Braga
Source:
Forensic science international 2015 v.257 pp. 297-306
ISSN:
0379-0738
Subject:
adulterated products; benzocaine; caffeine; cocaine; drugs; flame ionization; infrared spectroscopy; least squares; lidocaine; police; prediction; qualitative analysis; seizures
Abstract:
... Middle infrared spectroscopy and multivariate analysis have been applied for the development of methods to perform both quantitative and qualitative analysis of real drug samples seized by the Brazilian Police Federal (BPF). Currently, quantification of cocaine and determination of adulterants in seizures is performed using gas chromatography with flame ionization detection. However, this techniqu ...
DOI:
10.1016/j.forsciint.2015.09.012

90. Dissection of two modes of IE1 sub-nuclear localization in baculovirus-infected cells

Author:
Toshihiro Nagamine; Tamio Saito; Hiroyuki Osada; Shogo Matsumoto
Source:
Virus research 2015 v.208 pp. 120-128
ISSN:
0168-1702
Subject:
Bombyx mori nucleopolyhedrovirus; DNA replication; caffeine; cell nucleus; prototypes; viral load; virus replication
Abstract:
... Prior to viral DNA replication, baculovirus IE1 exhibits a focal distribution within the cell nucleus. During DNA replication, the IE1 foci apparently expand and develop into a virus replication center called the virogenic stroma (VS). In our search for chemical compounds capable of modulating Bombyx mori nucleopolyhedrovirus (BmNPV: a prototype of baculovirus) replication, we found an inhibitor ( ...
DOI:
10.1016/j.virusres.2015.06.005

91. Distribution, mass load and environmental impact of multiple-class pharmaceuticals in conventional and upgraded municipal wastewater treatment plants in East China

Author:
Xiangjuan Yuan; Zhimin Qiang; Weiwei Ben; Bing Zhu; Jiuhui Qu
Source:
Environmental science 2015 v.17 no.3 pp. 596-605
ISSN:
2050-7895
Subject:
adsorption; algae; antibiotic residues; anticonvulsants; aquatic environment; azithromycin; beta-adrenergic antagonists; biodegradation; biofilm; biological treatment; caffeine; ciprofloxacin; clarithromycin; dihydrofolate reductase; environmental impact; enzyme inhibitors; lipids; municipal wastewater; norfloxacin; ofloxacin; oxidation; risk; sludge; sulfamethoxazole; tetracyclines; wastewater treatment; China
Abstract:
... The occurrence, fate and environmental impact of 30 pharmaceuticals including sulfonamides, fluoroquinolones, tetracyclines, macrolides, dihydrofolate reductase inhibitors, β-blockers, antiepileptics, lipid regulators, and stimulants were studied in two municipal wastewater treatment plants (WWTPs) located in Wuxi City, East China. A total of 23 pharmaceuticals were detected in wastewater samples, ...
DOI:
10.1039/c4em00596a

92. Does volumetric absorptive microsampling eliminate the hematocrit bias for caffeine and paraxanthine in dried blood samples? A comparative study

Author:
Pieter M.M. De Kesel; Willy E. Lambert; Christophe P. Stove
Source:
Analytica chimica acta 2015 v.881 pp. 65-73
ISSN:
0003-2670
Subject:
analytical chemistry; blood; blood sampling; blood volume; caffeine; dipping; hematocrit; humans; patients
Abstract:
... Volumetric absorptive microsampling (VAMS) is a novel sampling technique that allows the straightforward collection of an accurate volume of blood (approximately 10μL) from a drop or pool of blood by dipping an absorbent polymeric tip into it. The resulting blood microsample is dried and analyzed as a whole. The aim of this study was to evaluate the potential of VAMS to overcome the hematocrit bia ...
DOI:
10.1016/j.aca.2015.04.056

93. Dose-dependent effects of caffeine in human Sertoli cells metabolism and oxidative profile: Relevance for male fertility

Author:
Tânia R. Dias; Marco G. Alves; Raquel L. Bernardino; Ana D. Martins; Ana C. Moreira; Joaquina Silva; Alberto Barros; Mário Sousa; Branca M. Silva; Pedro F. Oliveira
Source:
Toxicology 2015 v.328 pp. 12-20
ISSN:
0300-483X
Subject:
Sertoli cells; aerobiosis; antioxidant activity; beverages; caffeine; dose response; germ cells; glucose transporters; humans; lactic acid; male fertility; males; spermatogenesis
Abstract:
... Caffeine is a widely consumed substance present in several beverages. There is an increasing consumption of energetic drinks, rich in caffeine, among young individuals in reproductive age. Caffeine has been described as a modulator of cellular metabolism. Hence, we hypothesized that it alters human Sertoli cells (hSCs) metabolism and oxidative profile, which are essential for spermatogenesis. For ...
DOI:
10.1016/j.tox.2014.12.003

94. Draft Genome Sequence of the Bacterium Pseudomonas putida CBB5, Which Can Utilize Caffeine as a Sole Carbon and Nitrogen Source

Author:
Erik M. Quandt; Ryan M. Summers; Mani V. Subramanian; Jeffrey E. Barrick
Source:
Genome Announcements 2015 v.3 no.3 pp. e00640-15
ISSN:
2169-8287
Subject:
Pseudomonas putida; bacteria; caffeine; carbon; enzymes; multigene family; nitrogen; nucleotide sequences; soil
Abstract:
... Pseudomonas putida CBB5 was isolated from soil by enriching for growth on caffeine (1,3,7-trimethylxanthine). The draft genome of this strain is 6.9 Mb, with 5,941 predicted coding sequences. It includes the previously studied Alx gene cluster encoding alkylxanthine N -demethylase enzymes and other genes that enable the degradation of purine alkaloids. ...
DOI:
10.1128/genomeA.00640-15
PubMed:
26067973
PubMed Central:
PMC4463537

95. Drug cross-contamination of latent fingermarks during routine powder dusting detected by SALDI TOF MS

Author:
Latha Sundar; Frederick Rowell
Source:
Analytical methods 2015 v.7 no.9 pp. 3757-3763
ISSN:
1759-9679
Subject:
acetaminophen; aspirin; brushes; caffeine; cocaine; cross contamination; desorption; dusting; illicit drugs; ionization; magnetism; mass spectrometry; methadone; powders; squirrels; therapeutics
Abstract:
... The process of dusting powders over latent fingermarks was shown to transfer drug contact residues between adjacent marks. This was seen for marks contaminated after contact with two drugs of abuse (cocaine and methadone) and three therapeutic drugs (caffeine, aspirin and paracetamol). The powders used were a commercial black powder, and α-cyano-4-hydroxycinnamic acid both of which also act as ion ...
DOI:
10.1039/c5ay00598a

96. Eating behavior by sleep duration in the Hispanic Community Health Study/Study of Latinos

Author:
Yasmin Mossavar-Rahmani; Molly Jung; Sanjay R. Patel; Daniela Sotres-Alvarez; Raanan Arens; Alberto Ramos; Susan Redline; Cheryl L. Rock; Linda Van Horn
Source:
Appetite 2015 v.95 pp. 275-284
ISSN:
0195-6663
Subject:
Hispanics; Latinos; body mass index; caffeine; calcium; cities; cohort studies; community health; diabetes; diet recall; eating habits; education; employment; healthy diet; income; linear models; nutrient intake; nutrients; nutritional adequacy; obesity; potassium; regression analysis; risk factors; saturated fats; sleep; stroke; United States
Abstract:
... Sleep is an important pillar of health and a modifiable risk factor for diabetes, stroke and obesity. Little is known of diet and sleep patterns of Hispanics/Latinos in the US. Here we examine eating behavior as a function of sleep duration in a sub-sample of 11,888 participants from the Hispanic Community Health Study/Study of Latinos, a community-based cohort study of Hispanics aged 18–74 years ...
DOI:
10.1016/j.appet.2015.07.014
PubMed:
26189885
PubMed Central:
PMC4589504

97. Effect of a high and low dose of caffeine on human lymphocyte activation in response to antigen stimulation

Author:
Deborah K. Dulson; Nicolette C. Bishop
Source:
Applied Physiology, Nutrition, and Metabolism 2015 v.41 no.2 pp. 224-227
ISSN:
1715-5320
Subject:
T-lymphocytes; antigens; caffeine; fluorescence; geometry; humans; lymphocyte proliferation; males; metabolism; nutrition
Abstract:
... This study investigated the effect of caffeine on antigen-stimulated lymphocyte activation. Six males rested for 3.5 h after ingesting 0 (PLA), 2, or 6 (6CAF) mg·kg⁻¹ body mass of caffeine. The number of antigen-stimulated NK CD69⁺ cells increased in 6CAF at 1 h compared with PLA (P = 0.021). Caffeine did not influence the number of antigen-stimulated CD69⁺ T cells or the geometric mean fluorescen ...
DOI:
10.1139/apnm-2015-0456

98. Effect of extraction time on antioxidants and bioactive volatile components of green tea (Camellia sinensis), using GC/MS

Author:
Mudasir Ahmad; Waqas N. Baba; Adil Gani; Touseef Ahmed Wani; Asir Gani; F.A. Masoodi; Fatih Yildiz
Source:
Cogent food & agriculture 2015 v.1 no.1 pp. 1106387
ISSN:
2331-1932
Subject:
Camellia sinensis; acetic acid; agriculture; caffeine; green tea; leaves; linoleic acid; myristic acid; oleic acid; palmitic acid; polyphenols; stearic acid; temperature
Abstract:
... Two green tea types, leaf grade and sanding, were extracted at different time intervals: 20, 40, and 120 min at a constant temperature of 50°C. The extracts were analyzed by GC/MS technique. The major compounds identified were myristic acid, palmitic acid, stearic acid, oleic acid, 1H-purine-2,6-dione, caffeine, linoleic acid, diethyl ester, and 1H-purine-6-amine. Stearic acid, palmitic acid, lino ...
DOI:
10.1080/23311932.2015.1106387

99. Effect of post-exercise caffeine and green coffee bean extract consumption on blood glucose and insulin concentrations

Author:
Jason R. Beam; Ann L. Gibson; Chad M. Kerksick; Carole A. Conn; Ailish C. White; Christine M. Mermier
Source:
Nutrition 2015 v.31 no.2 pp. 292-297
ISSN:
0899-9007
Subject:
bicycling; blood glucose; blood sampling; body mass index; body weight; caffeine; chlorogenic acid; coffee beans; diet therapy; exercise; glucose; glucose tolerance; humans; insulin; males; placebos
Abstract:
... The aim of this study was to investigate the effects of ingesting caffeine and green coffee bean extract on blood glucose and insulin concentrations during a post-exercise oral glucose tolerance test.Ten male cyclists (age: 26 ± 5 y; height: 179.9 ± 5.4 cm; weight: 77.6 ± 13.3 kg; body mass index: 24 ± 4.3 kg/m²; VO2 peak: 55.9 ± 8.4 mL·kg·min⁻¹) participated in this study. In a randomized order, ...
DOI:
10.1016/j.nut.2014.07.012

100. Effects of Pu-erh tea aqueous extract (PTAE) on blood lipid metabolism enzymes

Author:
Liang Zeng; Jingna Yan; Liyong Luo; Dongying Zhang
Source:
Food & function 2015 v.6 no.6 pp. 2008-2016
ISSN:
2042-650X
Subject:
active ingredients; blood lipids; caffeine; cholesterol acyltransferase; coenzyme A; dose response; drugs; flavanols; free amino acids; gallic acid; hematologic diseases; hydroxymethylglutaryl-CoA reductases; lecithins; lipid metabolism; phospholipase A2; phospholipases; risk factors; sugars; synergism; tea; therapeutics; triacylglycerol lipase
Abstract:
... Disorders of blood lipid metabolism are the primary risk factors for many diseases. Recently, the effect of Pu-erh tea on blood lipid metabolism has received increasing attention. However, the mechanism underlying its ability to regulate blood lipid metabolism is unclear. We set out to study this through assessing the effects of Pu-erh tea aqueous extract (PTAE) on the central enzymes of blood lip ...
DOI:
10.1039/c5fo00362h