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- Author:
- Byoung-Seok Lee; Sang-Jin Park; Yong-Bum Kim; Ji-Seok Han; Eun-Ju Jeong; Kyoung-Sik Moon; Hwa-Young Son
- Source:
- Food and chemical toxicology 2015 v.86 pp. 95-103
- ISSN:
- 0278-6915
- Subject:
- alpha-chlorohydrin; body weight; brain; carcinogenicity; cardiomyopathy; females; foods; germ cells; heart; hydrolysis; kidneys; males; mice; microscopy; nerve tissue; no observed adverse effect level; risk assessment; testes; toxicology; vegetable protein
- Abstract:
- ... 3-Monochloro-1,2-propanediol (3-MCPD) is a well-known contaminant of foods containing hydrolyzed vegetable protein. However, limited toxicity data are available for the risk assessment of 3-MCPD and its carcinogenic potential is controversial. To evaluate the potential toxicity and determine the dose levels for a 26-week carcinogenicity test using Tg rasH2 mice, 3-MCPD was administered once daily ...
- DOI:
- 10.1016/j.fct.2015.09.019
- https://doi.org/10.1016/j.fct.2015.09.019
- Author:
- Lucia Ruggiero; Chiara Fiorillo; Sara Gibertini; Francesco De Stefano; Fiore Manganelli; Rosa Iodice; Floriana Vitale; Simona Zanotti; Maurizio Galderisi; Marina Mora; Lucio Santoro
- Source:
- Biochemical and biophysical research communications 2015 v.457 pp. 262-266
- ISSN:
- 0006-291X
- Subject:
- biopsy; cardiomyopathy; genes; genotype-phenotype correlation; muscles; muscular diseases; mutation; phenotype; phenotypic variation
- Abstract:
- ... Mutations in the beta-myosin heavy chain gene (MYH7) cause different muscle disorders. The specific molecular pathobiological processes that cause these different phenotypes remains unexplained. We describe three members of a family with an autosomal dominant mutation in the distal rod of MYH7 [c.5401G> A (p.Glu1801Lys)] displaying a complex phenotype characterized by Laing Distal Myopathy like ph ...
- DOI:
- 10.1016/j.bbrc.2014.12.098
- https://doi.org/10.1016/j.bbrc.2014.12.098
- Author:
- Kruse Tamara N.; Garner Michael M.; Bonar Christopher J.
- Source:
- Journal of zoo and wildlife medicine 2015 v.46 no.4 pp. 798-805
- ISSN:
- 1042-7260
- Subject:
- Procavia; animals; biopsy; cardiomyopathy; colitis; death; enteritis; euthanasia; females; fibrosis; hemosiderosis; islets of Langerhans; males; mortality; necropsy; necrosis; pneumonia; retrospective studies; septicemia; young adults; zoos; United States
- Abstract:
- ... A retrospective examination of gross and histologic reports was performed to find common lesions in young and adult captive rock hyrax (Procavia capensis) from multiple zoo populations. One hundred and thirty-seven reports were analyzed from specimens that were submitted to Northwest ZooPath from 1997 to 2013. Histologic findings from necropsy and biopsy reports and causes of mortality only from n ...
- DOI:
- 10.1638/2014-0248.1
- https://doi.org/10.1638/2014-0248.1
- Author:
- Chisato Hayashi; Gaku Takibuchi; Akinori Shimizu; Takayuki Mito; Kaori Ishikawa; Kazuto Nakada; Jun-Ichi Hayashi
- Source:
- Biochemical and biophysical research communications 2015 v.463 pp. 1021-1027
- ISSN:
- 0006-291X
- Subject:
- cardiomyopathy; genes; lung neoplasms; mice; missense mutation; mitochondria; mitochondrial DNA; patients; polypeptides; sequence analysis; somatic mutation
- Abstract:
- ... Our previous studies provided evidence that mammalian mitochondrial DNA (mtDNA) mutations that cause mitochondrial respiration defects behave in a recessive manner, because the induction of respiration defects could be prevented with the help of a small proportion (10%–20%) of mtDNA without the mutations. However, subsequent studies found the induction of respiration defects by the accelerated acc ...
- DOI:
- 10.1016/j.bbrc.2015.06.052
- https://doi.org/10.1016/j.bbrc.2015.06.052
- Author:
- Thomas Lanzicher; Valentina Martinelli; Carlin S Long; Giorgia Del Favero; Luca Puzzi; Massimo Borelli; Luisa Mestroni; Matthew R G Taylor; Orfeo Sbaizero
- Source:
- Nucleus 2015 v.6 no.5 pp. 394-407
- ISSN:
- 1949-1042
- Subject:
- biomechanics; cardiomyocytes; cell adhesion; cytoskeleton; genes; humans; mutation; spectroscopy
- Abstract:
- ... Previous investigations suggested that lamin A/C gene (LMNA) mutations, which cause a variety of human diseases including muscular dystrophies and cardiomyopathies, alter the nuclear mechanical properties. We hypothesized that biomechanical changes may extend beyond the nucleus. ...
- DOI:
- 10.1080/19491034.2015.1084453
- PubMed:
- 26309016
- PubMed Central:
- PMC4915516
- https://doi.org/10.1080/19491034.2015.1084453
- Author:
- Nicky Van Der Vekens; Marie-Astrid van Dievoet; Hendrik De Puydt; Annelies Decloedt; Sofie Ven; Dominique De Clercq; Piet Deprez; Gunther van Loon
- Source:
- Journal of veterinary diagnostic investigation v.27 no.4 pp. 504-509
- ISSN:
- 1943-4936
- Subject:
- blood serum; cross reaction; crossover interference; ethylenediamines; heart failure; hemolysis; horses; muscular diseases; musculoskeletal system; troponin T
- Abstract:
- ... Although cardiac troponin T (cTnT) assays have been used to detect myocardial damage in horses, a cTnT assay has not been analytically validated, to our knowledge. The aims of this study were to estimate the precision of a high-sensitivity cTnT assay in horses and determine the effect of hemolysis on the measured cTnT concentration. Serum samples from horses were mixed in 3 different pools. Pool 1 ...
- DOI:
- 10.1177/1040638715593601
- https://doi.org/10.1177/1040638715593601
- Author:
- Celine A. Mainville; Genevieve H. Clark; Katherine J. Esty; William M. Foster; Jancy L. Hanscom; Kelly J. Hebert; Helen R. Lyons
- Source:
- Journal of veterinary diagnostic investigation v.27 no.4 pp. 414-421
- ISSN:
- 1040-6387
- Subject:
- biomarkers; blood serum; cardiomyopathy; cats; enzyme-linked immunosorbent assay; heart; natriuretic peptides
- Abstract:
- ... The measurement of N-terminal pro–B-type natriuretic peptide (NT-proBNP), a biomarker for heart stress detectable in blood, has been shown to have clinical utility in cats with heart disease. A second-generation feline enzyme-linked immunosorbent assay (Cardiopet® proBNP, IDEXX Laboratories Inc., Westbrook, Maine) was developed to measure NT-proBNP in routine feline plasma or serum samples with im ...
- DOI:
- 10.1177/1040638715588330
- https://doi.org/10.1177/1040638715588330
- Author:
- I. Biasato; L. Francescone; G. La Rosa; M. Tursi
- Source:
- Research in veterinary science 2015 v.102 pp. 136-141
- ISSN:
- 0034-5288
- Subject:
- cardiomyopathy; cats; coronary artery disease; echocardiography; heart; histopathology; morphometry; phenotype; quantitative analysis
- Abstract:
- ... Diagnosis of feline hypertrophic cardiomyopathy (HCM) is both clinical and anatomopathological. Since standardized echocardiographic parameters have previously been established for its diagnosis and classification, the aim of the present study is to provide an original, complete and repeatable quantitative anatomopathological evaluation of this myocardial disease. Since ES-HCM is a clearly defined ...
- DOI:
- 10.1016/j.rvsc.2015.08.004
- https://doi.org/10.1016/j.rvsc.2015.08.004
- Author:
- R. Kohnken; J.A. Durham; C. Premanandan; B.A. Scansen
- Source:
- Journal of veterinary cardiology 2015 v.17 no.4 pp. 314-320
- ISSN:
- 1760-2734
- Subject:
- Labrador Retriever; aorta; cardiomyopathy; disease course; dogs; heart failure; histopathology; mitosis; necropsy; neoplasms; pathogenesis; phenotype; weight loss
- Abstract:
- ... In the same week, two Labrador Retriever dogs presented to The Ohio State University Veterinary Medical Center for cardiac evaluation. The presenting signs in both dogs included: weight loss, weakness, lethargy, and decreased femoral pulses. The first dog presented in cardiogenic shock and biventricular congestive heart failure, which initially responded to treatment; however, the dog was euthaniz ...
- DOI:
- 10.1016/j.jvc.2015.08.005
- https://doi.org/10.1016/j.jvc.2015.08.005
- Author:
- Martina Calore; Alessandra Lorenzon; Marzia De Bortoli; Giulia Poloni; Alessandra Rampazzo
- Source:
- Cell and tissue research 2015 v.360 no.3 pp. 491-500
- ISSN:
- 0302-766X
- Subject:
- adolescence; cardiomyocytes; cardiomyopathy; clinical trials; death; desmosomes; fibrosis; genes; mutation; pathogenesis; penetrance; proteins; young adults
- Abstract:
- ... Arrhythmogenic cardiomyopathy (ACM) is an acquired progressive disease having an age-related penetrance and showing clinical manifestations usually during adolescence and young adulthood. It is characterized clinically by a high incidence of severe ventricular tachyarrhythmias and sudden cardiac death and pathologically by degeneration of ventricular cardiomyocytes with replacement by fibro-fatty ...
- DOI:
- 10.1007/s00441-014-2015-5
- https://doi.org/10.1007/s00441-014-2015-5
- Author:
- B.M. Kaye; K. Borgeat; P.F. Mõtsküla; V. Luis Fuentes; D.J. Connolly
- Source:
- Journal of veterinary internal medicine 2015 v.29 no.2 pp. 582-588
- ISSN:
- 0891-6640
- Subject:
- Boxer (dog breed); cardiomyopathy; death; dogs; echocardiography; humans; models; retrospective studies; syncope
- Abstract:
- ... BACKGROUND: Tricuspid annular plane systolic excursion (TAPSE) is a useful estimate of right ventricular function in humans. Reference intervals for dogs have been generated, but the value of measuring TAPSE in other diseases, or investigating the association between TAPSE and outcome, is unknown. HYPOTHESIS: TAPSE is lower in Boxer dogs with ≥50 VPCs/24 h on Holter than in dogs with fewer ventric ...
- DOI:
- 10.1111/jvim.12572
- PubMed:
- 25818212
- PubMed Central:
- PMC4895501
- https://doi.org/10.1111/jvim.12572
- Author:
- Matthew D Winter; Robson F Giglio; Clifford R Berry; David J Reese; Herbert W Maisenbacher; Jorge A Hernandez
- Source:
- Journal of feline medicine and surgery v.17 no.6 pp. 447-452
- ISSN:
- 1532-2750
- Subject:
- cardiomyopathy; cats; databases; echocardiography; heart; patients; radiography; radiology; veterinary clinics; Florida
- Abstract:
- ... ‘Valentine’ heart shape is a common qualifier used in veterinary radiology to describe a cardiac silhouette with focal enlargement at the level of the base of the heart in feline patients. Anecdotally, this sign has been thought to be related to biatrial enlargement and also to hypertrophic cardiomyopathy (HCM). However, to our knowledge, there has been no study performed to assess the association ...
- DOI:
- 10.1177/1098612X14546339
- https://doi.org/10.1177/1098612X14546339
- Author:
- Erol Saygili; Fawad Noor-Ebad; Jörg W. Schröder; Karl Mischke; Esra Saygili; Gediminas Rackauskas; Nikolaus Marx; Malte Kelm; Obaida R. Rana
- Source:
- Biochemical and biophysical research communications 2015 v.465 pp. 119-124
- ISSN:
- 0006-291X
- Subject:
- angiogenesis; autoantibodies; blood serum; cardiomyocytes; cardiomyopathy; cell culture; cell proliferation; dose response; fibroblasts; hypertrophy; immunoglobulin G; messenger RNA; neonates; patients; therapeutics; vascular endothelial growth factors
- Abstract:
- ... Autoantibodies have been identified as major predisposing factors for dilated cardiomyopathy (DCM). Patients with DCM show elevated serum levels of vascular endothelial growth factor (VEGF) whose source is unknown. Besides its well-investigated effects on angiogenesis, evidence is present that VEGF signaling is additionally involved in fibroblast proliferation and cardiomyocyte hypertrophy, hence ...
- DOI:
- 10.1016/j.bbrc.2015.07.143
- https://doi.org/10.1016/j.bbrc.2015.07.143
- Author:
- Ying Jiang; Wei Xia; Jie Yang; Yingshuang Zhu; Huailong Chang; Juan Liu; Wenqian Huo; Bing Xu; Xi Chen; Yuanyuan Li; Shunqing Xu
- Source:
- Toxicology 2015 v.329 pp. 21-31
- ISSN:
- 0300-483X
- Subject:
- DNA; adenosine triphosphate; biogenesis; bisphenol A; cardiac output; cardiomyocytes; cardiomyopathy; chronic exposure; corn oil; endocrine-disrupting chemicals; gene expression; genes; hypertrophy; long term effects; males; membrane potential; messenger RNA; methylation; mitochondria; mitochondrial membrane; rats
- Abstract:
- ... Implication of environmental endocrine disruptors, such as bisphenol A (BPA), on the development of cardiopathy has been poorly investigated. The aim of the study was to investigate the effects of long-term exposure to BPA at the reference dose on the myocardium of rats, and the underlying mechanisms.Male rats received corn oil or 50μg/kg/day of BPA since delactation. At 24 and 48 weeks (wk), card ...
- DOI:
- 10.1016/j.tox.2015.01.001
- https://doi.org/10.1016/j.tox.2015.01.001
- Author:
- Bo-Kyoung Kim; Joong-Heui Cho; Pyeonghwa Jeong; Youngjin Lee; Jia Jia Lim; Kyoung Ryoung Park; Soo Hyun Eom; Yong-Chul Kim
- Source:
- FEBS letters 2015 v.589 no.15 pp. 1795-1801
- ISSN:
- 0014-5793
- Subject:
- binding sites; cardiomyopathy; drugs; enzyme kinetics; humans; molecular models; myocarditis; pharmacology; proteinases
- Abstract:
- ... Coxsackievirus B3 is the main cause of human viral myocarditis and cardiomyopathy. Virally encoded Coxsackievirus 3C protease (3Cpro) plays an essential role in viral proliferation. Here, benserazide was discovered as a novel inhibitor from a drug library screen targeting Coxsackievirus 3Cpro using a FRET-based enzyme assay. Benserazide, whose chemical structure has no electrophilic functional gro ...
- DOI:
- 10.1016/j.febslet.2015.05.027
- PubMed:
- 26022398
- PubMed Central:
- PMC7094222
- https://doi.org/10.1016/j.febslet.2015.05.027
- Author:
- Isha Taneja; Kanumuri Siva Rama Raju; Monika Mittal; Kapil Dev; Mohammad Faheem Khan; Rakesh Maurya; Muhammad Wahajuddin
- Source:
- RSC advances 2015 v.5 no.67 pp. 54395-54402
- ISSN:
- 2046-2069
- Subject:
- bioavailability; blood proteins; cardiomyopathy; electrospray ionization mass spectrometry; formic acid; guidelines; heart transplant; intravenous injection; methanol; myocardial infarction; pharmacokinetics; protein binding; rats; reperfusion injury
- Abstract:
- ... Alda-1 is an activator of the enzyme ALDH2. It has been suggested as a novel therapeutic for cardiovascular implications such as myocardial infarction, coronary bypass surgery, heart transplantation, peripheral artery disease, ischemia reperfusion injury, angina and alcoholic cardiomyopathy. Despite its widespread experimental use, no reports are available on its pharmacokinetics or bioanalytical ...
- DOI:
- 10.1039/c5ra06859b
- https://doi.org/10.1039/c5ra06859b
17. Calcium desensitizer catechin reverses diastolic dysfunction in mice with restrictive cardiomyopathy
- Author:
- Lei Zhang; Changlong Nan; Yuan Chen; Jie Tian; Pierre-Yves Jean-Charles; Cecile Getfield; Xiaoqing Wang; Xupei Huang
- Source:
- Archives of biochemistry and biophysics 2015 v.573 pp. 69-76
- ISSN:
- 0003-9861
- Subject:
- animal models; blood; body weight; calcium; cardiomyopathy; catechin; echocardiography; epigallocatechin gallate; green tea; hypersensitivity; mice; mutation; sarcomeres
- Abstract:
- ... Diastolic dysfunction refers to an impaired relaxation and an abnormality in ventricular blood filling during diastole while systolic function is preserved. Cardiac myofibril hypersensitivity to Ca²⁺ is a major factor that causes impaired relaxation of myocardial cells. The present study investigates the effect of the green tea extract catechins on myofibril calcium desensitization and restoration ...
- DOI:
- 10.1016/j.abb.2015.03.015
- https://doi.org/10.1016/j.abb.2015.03.015
- Author:
- K. Borgeat; D.J. Connolly; V. Luis Fuentes
- Source:
- Journal of veterinary cardiology 2015 v.17 pp. S74
- ISSN:
- 1760-2734
- Subject:
- biomarkers; cardiomyopathy; cats; distress; natriuretic peptides; troponin I; urine
- Abstract:
- ... Cardiac biomarkers have been used in cats as part of the clinical assessment of heart disease for over a decade. They are widely available to practitioners through commercial reference laboratories. The evidence base for the use of cardiac biomarkers (primarily N-terminal pro-B type natriuretic peptide and cardiac troponin I) in cats is comprehensively reviewed in this article, focusing on each of ...
- DOI:
- 10.1016/j.jvc.2015.08.001
- https://doi.org/10.1016/j.jvc.2015.08.001
- Author:
- Jianming Jiang; Patrick G. Burgon; Hiroko Wakimoto; Kenji Onoue; Joshua M. Gorham; Caitlin C. O’Meara; Gregory Fomovsky; Bradley K. McConnell; Richard T. Lee; J. G. Seidman; Christine E. Seidman
- Source:
- Proceedings of the National Academy of Sciences of the United States of America 2015 v.112 no.29 pp. 9046-9051
- ISSN:
- 0027-8424
- Subject:
- binding proteins; cardiomyopathy; cytokinesis; homozygosity; mutation; myosin; sarcomeres
- Abstract:
- ... We demonstrate that hearts lacking the sarcomere protein cardiac myosin binding protein C (MYBPC) undergo altered development due to an extra round of postnatal cell division. Normal cardiac myocytes replicate rapidly during fetal life, undergo a final round of cell division shortly after birth, cease dividing, and increase in cell size during prepubescent life. MYBPC has an unexpected function—in ...
- DOI:
- 10.1073/pnas.1511004112
- PubMed:
- 26153423
- PubMed Central:
- PMC4517252
- https://doi.org/10.1073/pnas.1511004112
- Author:
- Lucie Carrier; Giulia Mearini; Konstantina Stathopoulou; Friederike Cuello
- Source:
- Gene 2015 v.573 pp. 188-197
- ISSN:
- 0378-1119
- Subject:
- cardiomyopathy; gene therapy; genes; heart transplant; hypertrophy; inheritance (genetics); mutation; pathophysiology; patients; sarcomeres
- Abstract:
- ... More than 350 individual MYPBC3 mutations have been identified in patients with inherited hypertrophic cardiomyopathy (HCM), thus representing 40–50% of all HCM mutations, making it the most frequently mutated gene in HCM. HCM is considered a disease of the sarcomere and is characterized by left ventricular hypertrophy, myocyte disarray and diastolic dysfunction. MYBPC3 encodes for the thick filam ...
- DOI:
- 10.1016/j.gene.2015.09.008
- PubMed:
- 26358504
- PubMed Central:
- PMC6660134
- https://doi.org/10.1016/j.gene.2015.09.008
- Author:
- L.J. Wilkie; K. Smith; V. Luis Fuentes
- Source:
- Journal of veterinary cardiology 2015 v.17 pp. S329
- ISSN:
- 1760-2734
- Subject:
- analysis of variance; body weight; cardiomyopathy; cats; death; euthanasia; fibrosis; heart; heart failure; histopathology; necropsy; poisoning; veterinary clinics
- Abstract:
- ... To report necropsy and myocardial histopathology in cats with unexpected death and expected death/euthanasia, comparing findings in 4 groups of cats: unexpected death with noncardiac disease (UD-NC); unexpected death with cardiac disease (UD-C); expected death/euthanasia due to noncardiac disease with incidental cardiac disease (OD + HD); and expected death/euthanasia due to congestive heart failu ...
- DOI:
- 10.1016/j.jvc.2015.09.006
- https://doi.org/10.1016/j.jvc.2015.09.006
- Author:
- Gerard J. Gaspard; Christopher R. McMaster
- Source:
- Chemistry and physics of lipids 2015 v.193 pp. 1-10
- ISSN:
- 0009-3084
- Subject:
- adenosine diphosphate; adenosine triphosphate; cardiomyopathy; electron transport chain; etiology; genes; mitochondria; mitochondrial membrane; models; mutation; patients; phenotype; phospholipids; proteins; quality control; reactive oxygen species
- Abstract:
- ... Cardiolipin (CL) is a phospholipid with many unique characteristics. CL is synthesized in the mitochondria and resides almost exclusively within the mitochondrial inner membrane. Unlike most phospholipids that have two fatty acyl chains, CL possesses four fatty acyl chains resulting in unique biophysical characteristics that impact several biological processes including membrane fission and fusion ...
- DOI:
- 10.1016/j.chemphyslip.2015.09.005
- https://doi.org/10.1016/j.chemphyslip.2015.09.005
23. Cardiomyopathy prevalence in 780 apparently healthy cats in rehoming centres (the CatScan study)
- Author:
- Jessie Rose Payne; David Charles Brodbelt; Virginia Luis Fuentes
- Source:
- Journal of veterinary cardiology 2015 v.17 pp. S244
- ISSN:
- 1760-2734
- Subject:
- adults; body condition; body weight; cardiomyopathy; cats; confidence interval; cross-sectional studies; echocardiography; heart; males; regression analysis; systolic blood pressure
- Abstract:
- ... Hypertrophic cardiomyopathy (HCM) appears to be common in cats and, based on pilot data, a prevalence of 15% has been hypothesized. The objectives were to screen a large population of apparently healthy adult cats for cardiac disease, and identify factors associated with a diagnosis of HCM.A total of 1007 apparently healthy cats ≥6 months of age.In this prospective, cross-sectional study, the incl ...
- DOI:
- 10.1016/j.jvc.2015.03.008
- https://doi.org/10.1016/j.jvc.2015.03.008
- Author:
- Jaime A. Costales; Camille N. Kotton; Andrea C. Zurita-Leal; Josselyn Garcia-Perez; Martin S. Llewellyn; Louisa A. Messenger; Tapan Bhattacharyya; Barbara A. Burleigh
- Source:
- Parasites & vectors 2015 v.8 no.1 pp. 435
- ISSN:
- 1756-3305
- Subject:
- Chagas disease; Trypanosoma cruzi; blood; cardiomyopathy; genetic variation; genotype; heart transplant; hosts; human diseases; immunosuppression; microsatellite repeats; monitoring; parasites; patients; polymerase chain reaction; restriction fragment length polymorphism; serology; El Salvador; United States
- Abstract:
- ... BACKGROUND: Trypanosoma cruzi, causative agent of Chagas disease, displays high intraspecific genetic diversity: six genetic lineages or discrete typing units (DTUs) are currently recognized, termed TcI through TcVI. Each DTU presents a particular distribution pattern across the Americas, and is loosely associated with different transmission cycles and hosts. Several DTUs are known to circulate in ...
- DOI:
- 10.1186/s13071-015-1039-3
- PubMed:
- 26303927
- PubMed Central:
- PMC4548706
- https://doi.org/10.1186/s13071-015-1039-3
- Author:
- Vinicius Bermond Marques; Tatiani Botelho Nascimento; Rogério Faustino Ribeiro; Gilson Brás Broseghini-Filho; Emilly Martinelly Rossi; Jones Bernades Graceli; Leonardo dos Santos
- Source:
- Life sciences 2015 v.143 pp. 89-97
- ISSN:
- 0024-3205
- Subject:
- NAD(P)H oxidase (H2O2-forming); NADP (coenzyme); allopurinol; animal models; bioavailability; blood serum; cardiomyopathy; catalase; humans; in vitro studies; iron; iron overload; liver; malondialdehyde; nitric oxide; oxidative stress; rats; renin-angiotensin system; superoxide anion; transferrin
- Abstract:
- ... Iron overload in animal models and humans increases oxidative stress and induces cardiomyopathy. It has been suggested that the vasculature is also damaged, but the impacts on vascular reactivity and the underlying mechanisms remain poorly understood. In this study, we aimed to identify possible changes in the vascular reactivity of aortas from iron overloaded rats and investigate the underlying m ...
- DOI:
- 10.1016/j.lfs.2015.10.034
- https://doi.org/10.1016/j.lfs.2015.10.034
- Author:
- K. Borgeat; J. Dudhia; V. Luis Fuentes; D. J. Connolly
- Source:
- journal of small animal practice 2015 v.56 no.6 pp. 360-365
- ISSN:
- 0022-4510
- Subject:
- biomarkers; blood; cardiomyopathy; cats; collagen; echocardiography; genotype; genotyping; humans; hypertrophy; linear models; metabolism; mutation; natriuretic peptides; regression analysis; screening
- Abstract:
- ... OBJECTIVES: Human carriers of hypertrophic cardiomyopathy associated sarcomeric mutations have abnormal collagen metabolism before overt left ventricular hypertrophy is detectable. This study investigated whether differences in collagen biomarkers were present in blood samples of ragdoll cats positive for the MYBPC3:R820W mutation compared with negative controls. MATERIALS AND METHODS: Cats were r ...
- DOI:
- 10.1111/jsap.12332
- https://doi.org/10.1111/jsap.12332
- Author:
- Hui-Lin Wang; Jian-Ping Gao; Yu-Liang Han; Xu Xu; Rong Wu; Yan Gao; Xiao-Hua Cui
- Source:
- Phytomedicine 2015 v.22 pp. 553-559
- ISSN:
- 0944-7113
- Subject:
- Reynoutria japonica; antioxidant activity; antioxidants; blood serum; cardiomyopathy; catalase; doxorubicin; glutathione; glutathione peroxidase; glycosides; high performance liquid chromatography; intragastric administration; mice; oral administration; oxidative stress; rats; resveratrol; superoxide dismutase
- Abstract:
- ... Polydatin and resveratrol are extractives of radix or rhizoma of Polygonum cuspidatum, and as the glycoside forms, it is a natural precursor of resveratrol.In this study, we aimed to explore the mutual transformation between polydatin and resveratrol in rats, and to compare the antioxidative effect of them in vivo.In this study, we analyzed the serum molar concentration of polydatin and resveratro ...
- DOI:
- 10.1016/j.phymed.2015.03.014
- https://doi.org/10.1016/j.phymed.2015.03.014
- Author:
- Lissa Cruz; Angie Vivas; Marleny Montilla; Carolina Hernández; Carolina Flórez; Edgar Parra; Juan David Ramírez
- Source:
- Infection, genetics, and evolution 2015 v.29 pp. 110-117
- ISSN:
- 1567-1348
- Subject:
- Chagas disease; Trypanosoma cruzi; animal models; antibodies; cardiomyopathy; endemic diseases; genetic variation; genotype; geographical distribution; histopathology; immune response; immunoglobulin G; mice; parasitemia; parasites; prepatent period; sympatry; tissue tropism; zoonoses; Latin America
- Abstract:
- ... Chagas disease is an endemic zoonosis in Latin America and caused by the parasite Trypanosoma cruzi. This kinetoplastid displays remarkable genetic variability, allowing its classification into six Discrete Typing Units (DTUs) from TcI to TcVI. T. cruzi I presents the broadest geographical distribution in the continent and has been associated to severe forms of cardiomyopathies. Recently, a partic ...
- DOI:
- 10.1016/j.meegid.2014.11.012
- https://doi.org/10.1016/j.meegid.2014.11.012
- Author:
- Wang Xinzhu; West James A.; Murray Andrew J.; Griffin Julian L.
- Source:
- Journal of Proteome Research 2015 v.14 no.7 pp. 2849-2862
- ISSN:
- 1535-3907
- Subject:
- cardiomyopathy; diacylglycerols; diet; heart; lipotoxicity; liquid chromatography; mass spectrometry; metabolomics; mice; mitochondria; oxidative stress; proteome; triacylglycerols
- Abstract:
- ... The ectopic deposition of fat is thought to lead to lipotoxicity and has been associated with mitochondrial dysfunction and diabetic cardiomyopathy. We have measured mitochondrial respiratory capacities in the hearts of ob/ob and wild-type mice on either a regular chow (RCD) or high-fat (HFD) diet across four age groups to investigate the impact of diet and age on mitochondrial function alongside ...
- DOI:
- 10.1021/acs.jproteome.5b00128
- https://doi.org/10.1021/acs.jproteome.5b00128
- Author:
- Chen-Ching Yuan; Priya Muthu; Katarzyna Kazmierczak; Jingsheng Liang; Wenrui Huang; Thomas C. Irving; Rosemeire M. Kanashiro-Takeuchi; Joshua M. Hare; Danuta Szczesna-Cordary
- Source:
- Proceedings of the National Academy of Sciences of the United States of America 2015 v.112 no.30 pp. E4138
- ISSN:
- 0027-8424
- Subject:
- cardiomyopathy; heart; heart failure; mice; mutants; mutation; myosin; phenotype; phosphorylation; therapeutics
- Abstract:
- ... Genetic hypertrophic cardiomyopathy (HCM) is a debilitating disease affecting 1 in 500 of the general population, and there is no effective therapy to reverse or prevent its development and/or progression to heart failure. To inhibit a detrimental HCM phenotype induced by the D166V mutation of cardiac myosin regulatory light chain (RLC) in mice that also show reduced phosphorylation of endogenous ...
- DOI:
- 10.1073/pnas.1505819112
- PubMed:
- 26124132
- PubMed Central:
- PMC4522794
- https://doi.org/10.1073/pnas.1505819112
- Author:
- Rieko Ajima; Joseph A. Bisson; Jay-Christian Helt; Masa-Aki Nakaya; Raymond Habas; Lino Tessarollo; Xi He; Edward E. Morrisey; Terry P. Yamaguchi; Ethan David Cohen
- Source:
- Developmental biology 2015 v.408 pp. 126-139
- ISSN:
- 0012-1606
- Subject:
- actin; cardiac output; cardiomyopathy; cytoskeleton; heterozygosity; homozygosity; ligands; mice; morphogenesis; null alleles; sarcomeres
- Abstract:
- ... Wnt ligands regulate heart morphogenesis but the underlying mechanisms remain unclear. Two Formin-related proteins, DAAM1 and 2, were previously found to bind the Wnt effector Disheveled. Here, since DAAM1 and 2 nucleate actin and mediate Wnt-induced cytoskeletal changes, a floxed-allele of Daam1 was used to disrupt its function specifically in the myocardium and investigate Wnt-associated pathway ...
- DOI:
- 10.1016/j.ydbio.2015.10.003
- PubMed:
- 26526197
- PubMed Central:
- PMC4765503
- https://doi.org/10.1016/j.ydbio.2015.10.003
- Author:
- Elaine R. Miller; Pedro L. Moro; Maria Cano; Tom T. Shimabukuro
- Source:
- Vaccine 2015 v.33 no.29 pp. 3288-3292
- ISSN:
- 0264-410X
- Subject:
- Internet; Variola virus; Yellow fever virus; adults; adverse effects; anaphylaxis; cardiomyopathy; case studies; children; death; eczema; encephalitis; influenza; live vaccines; monitoring; myocarditis; people; public health; risk; syncope; vaccination; United States
- Abstract:
- ... Vaccines are rigorously tested and monitored and are among the safest medical products we use. Millions of vaccinations are given to children and adults in the United States each year. Serious adverse reactions are rare. However, because of the high volume of use, coincidental adverse events including deaths, that are temporally associated with vaccination, do occur. When death occurs shortly foll ...
- DOI:
- 10.1016/j.vaccine.2015.05.023
- PubMed:
- 26004568
- PubMed Central:
- PMC4599698
- https://doi.org/10.1016/j.vaccine.2015.05.023
- Author:
- Kevin M. Bonney; Joann M. Taylor; Edward B. Thorp; Conrad L. Epting; David M. Engman
- Source:
- Parasitology research 2015 v.114 no.3 pp. 1167-1178
- ISSN:
- 0932-0113
- Subject:
- CD4-positive T-lymphocytes; Chagas disease; Trypanosoma cruzi; cardiomyopathy; edema; fibrosis; immune response; inflammation; mice; myocardium; parasitemia; parasites; parasitology
- Abstract:
- ... Infection with the protozoan parasite Trypanosoma cruzi may lead to a potentially fatal cardiomyopathy known as Chagas heart disease. This disease is characterized by infiltration of the myocardium by mononuclear cells, including CD4+ T cells, together with edema, myofibrillary destruction, and fibrosis. A multifaceted systemic immune response develops that ultimately keeps parasitemia and tissue ...
- DOI:
- 10.1007/s00436-014-4300-3
- PubMed:
- 25576191
- PubMed Central:
- PMC4336812
- https://doi.org/10.1007/s00436-014-4300-3
- Author:
- Cristiane Cecatto; Fernanda H. Hickmann; Marília D. N. Rodrigues; Alexandre U. Amaral; Moacir Wajner
- Source:
- FEBS journal 2015 v.282 no.24 pp. 4714-4726
- ISSN:
- 1742-464X
- Subject:
- 3-hydroxyacyl-CoA dehydrogenase; NAD (coenzyme); adenosine diphosphate; adenosine triphosphate; beta oxidation; brain; calcium; cardiomyopathy; cyclosporine; energy; heart; homeostasis; long chain fatty acids; membrane potential; metabolites; mitochondria; mitochondrial membrane; oxidative phosphorylation; pathogenesis; patients; permeability; rats; ruthenium red
- Abstract:
- ... Mitochondrial trifunctional protein and long‐chain 3‐hydroxyacyl‐CoA dehydrogenase deficiencies are fatty acid oxidation disorders biochemically characterized by tissue accumulation of long‐chain fatty acids and derivatives, including the monocarboxylic long‐chain 3‐hydroxy fatty acids (LCHFAs) 3‐hydroxytetradecanoic acid (3HTA) and 3‐hydroxypalmitic acid (3HPA). Patients commonly present severe c ...
- DOI:
- 10.1111/febs.13526
- https://doi.org/10.1111/febs.13526
- Author:
- Karim Hnia; Caroline Ramspacher; Julien Vermot; Jocelyn Laporte
- Source:
- Cell and tissue research 2015 v.360 no.3 pp. 591-608
- ISSN:
- 0302-766X
- Subject:
- animal models; cardiomyopathy; desmin; humans; muscles; muscular diseases; mutation; patients; phenotype; signal transduction
- Abstract:
- ... Desmin is a muscle-specific type III intermediate filament essential for proper muscular structure and function. In human, mutations affecting desmin expression or promoting its aggregation lead to skeletal (desmin-related myopathies), or cardiac (desmin-related cardiomyopathy) phenotypes, or both. Patient muscles display intracellular accumulations of misfolded proteins and desmin-positive insolu ...
- DOI:
- 10.1007/s00441-014-2016-4
- https://doi.org/10.1007/s00441-014-2016-4
- Author:
- Philip F. Solter; Mark A. Oyama; Maggie C. Machen; Dennis J. Trafny; D. David Sisson
- Source:
- veterinary journal 2015 v.206 no.2 pp. 213-217
- ISSN:
- 1090-0233
- Subject:
- antibody detection; binding capacity; cardiomyopathy; cats; confidence interval; disease course; enzyme-linked immunosorbent assay; epitope mapping; heart failure; humans; monoclonal antibodies; natriuretic peptides; patients; proteinase inhibitors; rabbits
- Abstract:
- ... The B-type natriuretic peptide prohormone (proBNP) is enzymatically cleaved into an inactive N-terminal peptide and a biologically active C-terminal peptide with many beneficial cardiorenal effects. The purpose of this study was to develop and test in cats with cardiomyopathy an immunoassay to quantify the concentrations of C-terminal proBNP in feline plasma.An anti-canine proBNP monoclonal antibo ...
- DOI:
- 10.1016/j.tvjl.2015.07.015
- https://doi.org/10.1016/j.tvjl.2015.07.015
- Author:
- Tae-Mi Kim; Jong-Hyuk Baek; Jeong Hee Kim; Myung Sook Oh; Joungmok Kim
- Source:
- Analytical biochemistry 2015 v.480 pp. 21-27
- ISSN:
- 0003-2697
- Subject:
- autophagy; cardiomyopathy; catalytic activity; diabetes; disease control; monitoring; neoplasms; neurodegenerative diseases; screening; therapeutics
- Abstract:
- ... Autophagy is an important catabolic program to respond to a variety of cellular stresses by forming a double membrane vesicle, autophagosome. Autophagy plays key roles in various cellular functions. Accordingly, dysregulation of autophagy is closely associated with diseases such as diabetes, neurodegenerative diseases, cardiomyopathy, and cancer. In this sense, autophagy is emerging as an importan ...
- DOI:
- 10.1016/j.ab.2015.04.004
- https://doi.org/10.1016/j.ab.2015.04.004
- Author:
- Meng Xun; Chao-Feng Ma; Quan-Li Du; Yan-Hong Ji; Ji-Ru Xu
- Source:
- Virology journal 2015 v.12 no.1 pp. 288
- ISSN:
- 1743-422X
- Subject:
- Enterovirus A; adhesion; algorithms; apoptosis; bioinformatics; cardiomyopathy; endocytosis; foot-and-mouth disease; gene expression regulation; genes; hand, foot and mouth disease; humans; immune response; melanogenesis; microRNA; microarray technology; mitogen-activated protein kinase; non-coding RNA; pathogenesis; pathogens; protein phosphorylation; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; signal transduction
- Abstract:
- ... BACKGROUND: Enterovirus 71 (EV71) is one of the major etiological pathogens of hand, foot and mouth disease (HFMD) and can cause severe cerebral and pulmonary complications and even fatality. MicroRNAs (miRNAs), a class of small non-coding RNA molecules, play an important role in post-transcriptional regulation of gene expression and thereby influencing various physiological and pathological proce ...
- DOI:
- 10.1186/s12985-015-0288-2
- PubMed:
- 25889836
- PubMed Central:
- PMC4416288
- https://doi.org/10.1186/s12985-015-0288-2
- Author:
- Frame David D.; Kelly E. Jane; Van Wettere Arnaud
- Source:
- Journal of wildlife diseases 2015 v.51 no.3 pp. 790-792
- ISSN:
- 0090-3558
- Subject:
- Meleagris gallopavo; cardiomyopathy; emaciation; flocks; heart; liver; males; necropsy; turkeys; Utah
- Abstract:
- ... A male Rio Grande Wild Turkey (Meleagris gallopavo intermedia) living in semidomestication was submitted for necropsy. Emaciation, a greatly enlarged heart, and chronic passive congestion of the liver were present. Dilated cardiomyopathy occurs in domestic turkey flocks but has not been reported in Wild Turkeys. ...
- DOI:
- 10.7589/2014-09-228
- https://doi.org/10.7589/2014-09-228
- Author:
- Shirin Akhter; J.-P. Jin
- Source:
- FEBS Open Bio 2015 v.5 pp. 64-75
- ISSN:
- 2211-5463
- Subject:
- assays; binding capacity; cardiomyopathy; epitopes; gels; humans; mice; monoclonal antibodies; mutants; phosphorylation; point mutation; polyacrylamide gel electrophoresis; protein binding; protein conformation; transgenic animals; troponin C; troponin I; troponin T
- Abstract:
- ... The α-helix in troponin I (TnI) at the interface with troponin T (TnT) is a highly conserved structure. A point mutation in this region, A116G, was found in human cardiac TnI in a case of cardiomyopathy. An adjacent dominantly negative mutation found in turkey cardiac TnI (R111C, equivalent to K117C in human and K118C in mouse) decreased diastolic function and blunted beta-adrenergic response in t ...
- DOI:
- 10.1016/j.fob.2015.01.001
- PubMed:
- 25685665
- PubMed Central:
- PMC4325132
- https://doi.org/10.1016/j.fob.2015.01.001
- Author:
- Jonggul Kim; Larry R. Masterson; Alessandro Cembran; Raffaello Verardi; Lei Shi; Jiali Gao; Susan S. Taylor; Gianluigi Veglia
- Source:
- Proceedings of the National Academy of Sciences of the United States of America 2015 v.112 no.12 pp. 3716-3721
- ISSN:
- 0027-8424
- Subject:
- active sites; cAMP-dependent protein kinase; calcium; cardiac output; cardiomyopathy; death; heart; muscles; mutants; phosphorylation
- Abstract:
- ... The dynamic interplay between kinases and substrates is crucial for the formation of catalytically committed complexes that enable phosphoryl transfer. However, a clear understanding on how substrates modulate kinase structural dynamics to control catalytic efficiency is still missing. Here, we used solution NMR spectroscopy to study the conformational dynamics of two complexes of the catalytic su ...
- DOI:
- 10.1073/pnas.1502299112
- PubMed:
- 25775607
- PubMed Central:
- PMC4378435
- https://doi.org/10.1073/pnas.1502299112
42. Early onset cardiomyopathy associated with the mitochondrial tRNALeu(UUR) 3271T>C MELAS mutation
- Author:
- Giacomo Brisca; Chiara Fiorillo; Claudia Nesti; Federica Trucco; Maria Derchi; Antonio Andaloro; Stefania Assereto; Guido Morcaldi; Marina Pedemonte; Carlo Minetti; Filippo M. Santorelli; Claudio Bruno
- Source:
- Biochemical and biophysical research communications 2015 v.458 pp. 601-604
- ISSN:
- 0006-291X
- Subject:
- acidosis; cardiomyopathy; children; genes; mitochondria; mitochondrial DNA; mutation; oxidative phosphorylation; patients; phenotype
- Abstract:
- ... Mitochondrial disorders are a heterogeneous group of diseases sharing a defect of the oxidative phosphorylation system.Point mutations in the mitochondrial DNA are a common cause of mitochondrial disorders and frequently affect the sequences encoding mitochondrial transfer RNAs.The m.3271T>C mutation in the mitochondrial tRNALeu(UUR) is traditionally reported in patients with clinical features of ...
- DOI:
- 10.1016/j.bbrc.2015.01.157
- https://doi.org/10.1016/j.bbrc.2015.01.157
- Author:
- Karsten E. Schober; Valérie Chetboul
- Source:
- Journal of veterinary cardiology 2015 v.17 pp. S102
- ISSN:
- 1760-2734
- Subject:
- cardiomyopathy; cats; compliance; diagnostic techniques; echocardiography; epidemiological studies; exercise; field experimentation; functional properties; heart failure; hemodynamics
- Abstract:
- ... Left ventricular (LV) diastolic dysfunction is highly prevalent in cats and is a functional hallmark of feline cardiomyopathy. The majority of cats with hypertrophic, restrictive, and dilated cardiomyopathy have echocardiographic evidence of abnormal LV filling, even during the occult (preclinical) phase. Moderate and severe diastolic dysfunction is an indicator of advanced myocardial disease, is ...
- DOI:
- 10.1016/j.jvc.2015.02.002
- https://doi.org/10.1016/j.jvc.2015.02.002
- Author:
- Bethany L. Jackson; Darcy B. Adin; Linda B. Lehmkuhl
- Source:
- Journal of veterinary cardiology 2015 v.17 pp. S296
- ISSN:
- 1760-2734
- Subject:
- arrhythmia; cardiomyopathy; cats; death; echocardiography; electrocardiography; heart rate; monitoring; systolic blood pressure; therapeutics
- Abstract:
- ... To investigate the negative chronotropic, antiarrhythmic, and obstruction-relieving effects of atenolol in cats with subclinical hypertrophic cardiomyopathy (HCM).Seventeen cats with HCM.Results for echocardiography, electrocardiography, Doppler blood pressure, and 24 h Holter monitoring were compared in cats before and 2–4 weeks after atenolol therapy (6.25–12.5 mg PO q 12 h).The left ventricular ...
- DOI:
- 10.1016/j.jvc.2015.03.002
- https://doi.org/10.1016/j.jvc.2015.03.002
45. Effective Top-Down LC/MS+ Method for Assessing Actin Isoforms as a Potential Cardiac Disease Marker
- Author:
- Chen Yi-Chen; Ayaz-Guner Serife; Peng Ying; Lane Nicole M.; Locher Matthew R.; Kohmoto Takushi; Larsson Lars; Moss Richard L.; Ge Ying
- Source:
- Analytical chemistry 2015 v.87 no.16 pp. 8399-8406
- ISSN:
- 1520-6882
- Subject:
- actin; cardiomyopathy; cytoskeleton; humans; liquid chromatography; mass spectrometry; multigene family; muscles; myocardium; purification methods; rapid methods; sequence homology; skeletal muscle
- Abstract:
- ... Actin is the major component of the cytoskeleton, playing an essential role in the structure and motility of both muscle and nonmuscle cells. It is highly conserved and encoded by a multigene family. α-Cardiac actin (αCAA) and α-skeletal actin (αSKA), encoded by two different genes, are the primary actin isoforms expressed in striated muscles. The relative expression levels of αSKA and αCAA have b ...
- DOI:
- 10.1021/acs.analchem.5b01745
- PubMed:
- 26189812
- PubMed Central:
- PMC4965275
- https://doi.org/10.1021/acs.analchem.5b01745
- Author:
- A. M. Debela; S. Thorimbert; B. Hasenknopf; C. K. O'SullivanThese authors share corresponding authorship equally.; M. Ortiz
- Source:
- Chemical communications 2015 v.52 no.4 pp. 757-759
- ISSN:
- 1364-548X
- Subject:
- cardiomyopathy; chemical compounds; chemical reactions; cost effectiveness; electrochemistry; genes; nucleotides; screening; single nucleotide polymorphism
- Abstract:
- ... We report the labelling of dideoxy nucleotides (ddNTPs) for use in electrochemical array based primer extension for the detection of single nucleotide polymorphisms (SNPs). The results confirm the extension of the immobilised primers for each of the four ddNTPs, representing a significant advance in achieving a cost-effective platform for screening of disease-specific SNPs. ...
- DOI:
- 10.1039/c5cc07762a
- https://doi.org/10.1039/c5cc07762a
- Author:
- Catherine K. Hathaway; Ruriko Grant; John R. Hagaman; Sylvia Hiller; Feng Li; Longquan Xu; Albert S. Chang; Victoria J. Madden; C. Robert Bagnell; Mauricio Rojas; Hyung-Suk Kim; Bingruo Wu; Bin Zhou; Oliver Smithies; Masao Kakoki
- Source:
- Proceedings of the National Academy of Sciences of the United States of America 2015 v.112 no.16 pp. 5141-5146
- ISSN:
- 0027-8424
- Subject:
- cardiac output; cardiomyopathy; collagen; gelatinase B; genes; heart failure; laboratory animals; mice; myocardium; patients
- Abstract:
- ... We have generated low-expressing and high-expressing endothelin-1 genes (L and H) and have bred mice with four levels of expression: L/L, ∼20%; L/+, ∼65%; +/+ (wild type), 100%; and H/+, ∼350%. The hypomorphic L allele can be spatiotemporally switched to the hypermorphic H allele by Cre-loxP recombination. Young adult L/L and L/+ mice have dilated cardiomyopathy, hypertension, and increased plasma ...
- DOI:
- 10.1073/pnas.1504557112
- PubMed:
- 25848038
- PubMed Central:
- PMC4413291
- https://doi.org/10.1073/pnas.1504557112
- Author:
- Almesh Kadakol; Vajir Malek; Santosh Kumar Goru; Anuradha Pandey; Anil Bhanudas Gaikwad
- Source:
- Journal of functional foods 2015 v.17 pp. 127-136
- ISSN:
- 1756-4646
- Subject:
- acetylation; animal disease models; cardiomyocytes; cardiomyopathy; cell proliferation; diabetic complications; fibrosis; histones; hypertension; hypertrophy; insulin resistance; noninsulin-dependent diabetes mellitus; oxidative stress; pathogenesis; phosphorylation; rats; renin-angiotensin system; translation (genetics); ubiquitination
- Abstract:
- ... Post translational histone modifications (PTHMs) play a pivotal role in pathogenesis of diabetic complications. Esculetin is reported to prevent glomerulosclerosis by reversing PTHMs in diabetic rats, but until now its cardioprotective role is unexplored. Hence, the present study aimed to investigate the effect of esculetin on diabetic cardiomyopathy (DCM) and its associated PTHMs. Insulin resista ...
- DOI:
- 10.1016/j.jff.2015.05.017
- https://doi.org/10.1016/j.jff.2015.05.017
- Author:
- G. Stanzani; R. Cowlam; K. English; D.J. Connolly
- Source:
- Journal of veterinary cardiology 2015 v.17 pp. S233
- ISSN:
- 1760-2734
- Subject:
- cardiomyopathy; cats; clinical examination; death; echocardiography; erythrocytes; heart; heart failure; hematocrit; hematology; hospitals; human diseases; mortality; prognosis; veterinarians
- Abstract:
- ... Red blood cell distribution width (RDW) is a measurement of variability in circulating erythrocytes size, and has recently been shown to correlate with prognosis in a variety of human diseases, including acute and chronic heart failure.To determine if RDW differs between healthy controls, cats with hypertrophic cardiomyopathy (HCM) without congestive heart failure (CHF) and cats with HCM and CHF, ...
- DOI:
- 10.1016/j.jvc.2015.09.001
- https://doi.org/10.1016/j.jvc.2015.09.001
- Author:
- Yue Zhou; Xin He; Yili Chen; Yiyi Huang; Lingling Wu; Jiangui He
- Source:
- Biochemical and biophysical research communications 2015 v.468 pp. 394-399
- ISSN:
- 0006-291X
- Subject:
- agonists; antagonists; cardiomyopathy; coronary artery disease; diabetes mellitus; glucagon-like peptide 1; glucagon-like peptide receptors; heart; heart failure; hypertension; hypertrophy; morbidity; mortality; phenylephrine; risk factors; secretin; signal transduction; surface area
- Abstract:
- ... Diabetes mellitus is a prominent risk factor for cardiovascular diseases. Diabetic cardiomyopathy is an important complication of the heart independent of hypertension and coronary artery disease and is accompanied by cardiac hypertrophy. Cardiac hypertrophy easily leads to heart failure, which is a leading cause of morbidity and mortality. Glucagon-like peptide 1 (GLP-1) is an incretin hormone, w ...
- DOI:
- 10.1016/j.bbrc.2015.09.179
- https://doi.org/10.1016/j.bbrc.2015.09.179
- Author:
- Imke März; Lois J Wilkie; Norelene Harrington; Jessie R Payne; Ruthnea A L Muzzi; Jens Häggström; Ken Smith; Virginia Luis Fuentes
- Source:
- Journal of feline medicine and surgery v.17 no.8 pp. 681-691
- ISSN:
- 1532-2750
- Subject:
- cardiomyopathy; cat breeds; cats; databases; echocardiography; fibrosis; forests; histopathology; hypertrophy; necropsy; pedigree; screening
- Abstract:
- ... Norwegian Forest cats (NFCs) are often listed as a breed predisposed to cardiomyopathy, but the characteristics of cardiomyopathy in this breed have not been described. The aim of this preliminary study was to report the features of NFC cardiomyopathy based on prospective echocardiographic screening of affected family groups; necropsy findings; and open-source breed screening databases. Prospectiv ...
- DOI:
- 10.1177/1098612X14553686
- https://doi.org/10.1177/1098612X14553686
- Author:
- S. Granström; M.T.N. Godiksen; M. Christiansen; C.B. Pipper; T. Martinussen; R. Møgelvang; P. Søgaard; J.L. Willesen; J. Koch
- Source:
- Journal of veterinary cardiology 2015 v.17 pp. S268
- ISSN:
- 1760-2734
- Subject:
- Maine coon; binding proteins; cardiomyopathy; cats; death; echocardiography; genes; genotype-phenotype correlation; heterozygosity; homozygosity; image analysis; longitudinal studies; missense mutation; myosin; penetrance; risk
- Abstract:
- ... A missense mutation (A31P) in the cardiac myosin binding protein C gene has been associated with hypertrophic cardiomyopathy (HCM) in Maine Coon cats. The aim of this study was to investigate the effect of A31P on development of HCM, myocardial diastolic dysfunction detected by color tissue Doppler imaging and occurrence of cardiac death during longitudinal follow-up in a cohort of Maine Coon cats ...
- DOI:
- 10.1016/j.jvc.2015.10.005
- https://doi.org/10.1016/j.jvc.2015.10.005
- Author:
- Xiaohui Zhang; Xiao Ma; Meng Zhao; Bo Zhang; Jinyu Chi; Wenxiu Liu; Wenjia Chen; Yu Fu; Yue Liu; Xinhua Yin
- Source:
- Biochimie 2015 v.108 pp. 59-67
- ISSN:
- 0300-9084
- Subject:
- apoptosis; autophagy; cardiomyocytes; cardiomyopathy; caspase-12; caspase-3; caspase-8; endoplasmic reticulum; glucose; humans; hydrogen; protein synthesis; rats; relaxin
- Abstract:
- ... High concentrations of glucose induce cardiomyocyte apoptosis, and contribute to diabetic cardiomyopathy. Relaxin-2 and relaxin-3 are two members of the relaxin peptide family that are cardioprotective. However, it remains unknown whether relaxin-2 or relaxin-3 can regulate apoptosis in high glucose treated-neonatal rat ventricular myocytes (NRVMs). In cultured NRVMs, 33 mmol/l high glucose (HG) i ...
- DOI:
- 10.1016/j.biochi.2014.11.004
- https://doi.org/10.1016/j.biochi.2014.11.004
- Author:
- Yuehong Wang; Jinjun Zhao; Wei Yang; Yayan Bi; Jing Chi; Juanjuan Tian; Weimin Li
- Source:
- Biochemical and biophysical research communications 2015 v.456 pp. 656-661
- ISSN:
- 0006-291X
- Subject:
- alcohol drinking; alcohols; apoptosis; cardiomyocytes; cardiomyopathy; cytochrome c; dose response; membrane potential; mice; mitochondrial membrane; oxidative stress; oxygen; phosphorylation; protein kinase C; reactive oxygen species
- Abstract:
- ... Cardiac dysfunction caused by excessive alcohol consumption is a specific disease, alcoholic cardiomyopathy (ACM). High-dose alcohol has been found to induce oxidation stress and apoptosis in cardiomyocytes, but the signaling link between alcohol-induced oxidation stress and apoptosis in cardiomyocytes remains to be elucidated. To address the issue, we exposed primary cardiomyocytes from neonatal ...
- DOI:
- 10.1016/j.bbrc.2014.12.012
- https://doi.org/10.1016/j.bbrc.2014.12.012
- Author:
- Yun Hak Lee; Wen Xiu Ren; Jiyou Han; Kyoung Sunwoo; Ja-Yun Lim; Jong-Hoon Kim; Jong Seung Kim
- Source:
- Chemical communications 2015 v.51 no.76 pp. 14401-14404
- ISSN:
- 1364-548X
- Subject:
- cardiomyopathy; chemical reactions; cysteine; fluorescent dyes; glutathione; homocysteine; image analysis; neoplasm cells; neoplasms; peripheral nervous system diseases
- Abstract:
- ... Abnormal concentrations of Cys have been reported to be implicated in various health problems, including cancer, neuropathy, and cardiomyopathy. We present a novel two-photon fluorescent probe for the specific recognition of cysteine over homocysteine and glutathione, and the bioapplication of this probe for the imaging of live cancerous cells and thick tissues. ...
- DOI:
- 10.1039/c5cc06038a
- https://doi.org/10.1039/c5cc06038a
- Author:
- Barry J. Maron; Philip R. Fox
- Source:
- Journal of veterinary cardiology 2015 v.17 pp. S6
- ISSN:
- 1760-2734
- Subject:
- Boxer (dog breed); animal diseases; binding proteins; cardiomyopathy; cats; disease control; domestic animals; fibrosis; genes; heart failure; histopathology; humans; hypertrophy; mutation; myosin; pathophysiology; phenotype
- Abstract:
- ... To highlight similarities in hypertrophic cardiomyopathy (HCM) that are shared between humans and domestic cats.Contemporary clinical and scientific findings were selected from the literature. Evidence is provided to support the concept that HCM in humans and felines are fundamentally the same disease.A number of remarkable similarities have been reported in certain spontaneously occurring myocard ...
- DOI:
- 10.1016/j.jvc.2015.03.007
- https://doi.org/10.1016/j.jvc.2015.03.007
- Author:
- Gustav Holmgren; Jane Synnergren; Yalda Bogestål; Caroline Améen; Karolina Åkesson; Sandra Holmgren; Anders Lindahl; Peter Sartipy
- Source:
- Toxicology 2015 v.328 pp. 102-111
- ISSN:
- 0300-483X
- Subject:
- apoptosis; biomarkers; cardiomyocytes; cardiomyopathy; cytotoxicity; doxorubicin; drug therapy; embryonic stem cells; gene expression regulation; genes; humans; lactate dehydrogenase; leukemia; lymphoma; transcription (genetics); troponin T
- Abstract:
- ... Doxorubicin is a chemotherapeutic agent indicated for the treatment of a variety of cancer types, including leukaemia, lymphomas, and many solid tumours. The use of doxorubicin is, however, associated with severe cardiotoxicity, often resulting in early discontinuation of the treatment. Importantly, the toxic symptoms can occur several years after the termination of the doxorubicin administration. ...
- DOI:
- 10.1016/j.tox.2014.12.018
- PubMed:
- 25529476
- PubMed Central:
- PMC4326176
- https://doi.org/10.1016/j.tox.2014.12.018
- Author:
- Joshua A. Stern; Sunshine Lahmers; Kathryn M. Meurs
- Source:
- Research in veterinary science 2015 v.102 pp. 182-183
- ISSN:
- 0034-5288
- Subject:
- basement membrane; brain; cardiomyopathy; cell adhesion; cornea; corneal diseases; desmosomes; dogs; epithelial cells; etiology; genes; heart; immunohistochemistry; models; mutation; scaffolding proteins
- Abstract:
- ... Striatin is a scaffolding protein expressed in brain and cardiac tissues. In the heart, striatin has been localized to the region of the cardiac desmosome. A causal mutation within the gene encoding for this scaffolding protein has been described as the etiology for arrhythmogenic right ventricular cardiomyopathy, a disease of the cardiac desmosome, in a canine model. Hemidesmosomes are cell adhes ...
- DOI:
- 10.1016/j.rvsc.2015.08.009
- https://doi.org/10.1016/j.rvsc.2015.08.009
- Author:
- Yotam Blech-Hermoni; Andrea N. Ladd
- Source:
- Genomics data 2015 v.6 pp. 74-76
- ISSN:
- 2213-5960
- Subject:
- RNA-binding proteins; alternative splicing; cardiomyocytes; cardiomyopathy; cytoplasm; diabetes; embryogenesis; gene expression; messenger RNA; pathogenesis; sequence analysis; transcriptome; translation (genetics)
- Abstract:
- ... CUG-BP, Elav-like family member 1 (CELF1) is a multi-functional RNA binding protein that regulates pre-mRNA alternative splicing in the nucleus, as well as polyadenylation status, mRNA stability, and translation in the cytoplasm [1]. Dysregulation of CELF1 has been implicated in cardiomyopathies in myotonic dystrophy type 1 and diabetes [2–5], but the targets of CELF1 regulation in the heart have ...
- DOI:
- 10.1016/j.gdata.2015.08.014
- PubMed:
- 26366374
- PubMed Central:
- PMC4563868
- https://doi.org/10.1016/j.gdata.2015.08.014
60. Imaging diagnosis—acute mesenteric ischemia associated with hypertrophic cardiomyopathy in a cat
- Author:
- Miyoung Lee; Nohwon Park; Jaehwan Kim; Donghyun Kim; Hyunsoo Kim; Kidong Eom
- Source:
- Veterinary radiology & ultrasound 2015 v.56 no.4 pp. E44
- ISSN:
- 1058-8183
- Subject:
- aorta; cardiomyopathy; case studies; cats; diarrhea; image analysis; ischemia; mesenteric arteries; middle-aged adults; paresis; radiography; vena cava; vomiting
- Abstract:
- ... A middle‐aged cat was presented with vomiting, diarrhea, and pelvic limb paresis. Radiography showed cardiomegaly, interstitial pulmonary infiltration, distended intestinal loops, and portal venous gas. Hypertrophic cardiomyopathy (HCM) was confirmed. On CT, thrombi were identified at the abdominal aorta, superior mesenteric artery, bilateral renal arteries, and cauda vena cava at the level of the ...
- DOI:
- 10.1111/vru.12199
- https://doi.org/10.1111/vru.12199
- Author:
- T. Haffar; F. Bérubé-Simard; N. Bousette
- Source:
- Biochemical and biophysical research communications 2015 v.468 pp. 73-78
- ISSN:
- 0006-291X
- Subject:
- Western blotting; beta oxidation; cardiomyocytes; cardiomyopathy; carnitine; carnitine palmitoyltransferase; fluorescence; lipotoxicity; membrane potential; mitochondria; mitochondrial membrane; oleic acid; oxidation; palmitates; pretreatment; rats; saturated fatty acids; small interfering RNA; toxicity
- Abstract:
- ... A major cause for diabetic cardiomyopathy is excess lipid accumulation. To elucidate mechanisms of lipotoxicity mediated diabetic heart disease we need to further our understanding of how lipid metabolism is altered in the diabetic heart. Here we investigated the role of lipid clearance by oxidation as a regulator of lipid-mediated toxicity (lipotoxicity).We evaluated the effect of pre-treating ra ...
- DOI:
- 10.1016/j.bbrc.2015.10.162
- https://doi.org/10.1016/j.bbrc.2015.10.162
- Author:
- Manel Ben M’hadheb; Amira Souii; Myriam Harrabi; Nadia Jrad-Battikh; Jawhar Gharbi
- Source:
- Current microbiology 2015 v.70 no.5 pp. 756-761
- ISSN:
- 0343-8651
- Subject:
- RNA; binding capacity; cardiomyopathy; genome; mutants; mutation; myocarditis; ribosomes; translation (genetics); vaccines
- Abstract:
- ... Coxsackievirus B3 (CVB3) causes viral myocarditis and can ultimately result in dilated cardiomyopathy. There is no vaccine available for clinical use. Translation initiation of CVB3 RNA is directed by an internal ribosome entry site within the 5′-untranslated region. We have previously described that Sabin3-like mutation (U⁴⁷³to C) introduced in CVB3 genome led to a defective mutant with a serious ...
- DOI:
- 10.1007/s00284-015-0784-z
- https://doi.org/10.1007/s00284-015-0784-z
- Author:
- Andrea Streitberger; Peter Modler; Jens Häggström
- Source:
- Journal of veterinary cardiology 2015 v.17 no.1 pp. 25-33
- ISSN:
- 1760-2734
- Subject:
- blood; blood volume; cardiomyopathy; cats; echocardiography; heart; heart failure; ultrasonics
- Abstract:
- ... To estimate heart rate-normalized pulmonary transit times (nPTTs) in cardiomyopathic cats with or without congestive heart failure (CHF). To assess potential associations of echocardiographic variables and nPTT and to evaluate nPTT as a test for the presence of CHF.Forty-eight privately owned cats.nPTT was measured using echocardiography and the ultrasound contrast media SonoVue® in 3 groups of ca ...
- DOI:
- 10.1016/j.jvc.2014.09.005
- https://doi.org/10.1016/j.jvc.2014.09.005
- Author:
- Yanfei Xia; Luwei Gong; Hui Liu; Beibei Luo; Bo Li; Rui Li; Beibei Li; Mei Lv; Jinyu Pan; Fengshuang An
- Source:
- Molecular and Cellular Endocrinology 2015 v.403 pp. 21-29
- ISSN:
- 0303-7207
- Subject:
- RNA; animal disease models; apoptosis; cardiomyocytes; cardiomyopathy; fibrosis; glucose; high fat diet; hypoxia; intraperitoneal injection; mechanism of action; mitogen-activated protein kinase; noninsulin-dependent diabetes mellitus; procollagen-proline dioxygenase; rats; streptozotocin
- Abstract:
- ... Prolyl hydroxylase 3 (PHD3) is a member of the prolyl hydroxylases (PHDs) family and is induced by hypoxia. It plays a critical role in regulating the abundance of hypoxia-inducible factor (HIF). Its expression is increased in diabetic rat hearts; however, its role remains unclear. We investigated the potential role and mechanism of action of PHD3 in the setting of diabetes-induced myocardial dysf ...
- DOI:
- 10.1016/j.mce.2015.01.014
- https://doi.org/10.1016/j.mce.2015.01.014
- Author:
- Philip R. Fox; Karsten E. Schober
- Source:
- Journal of veterinary cardiology 2015 v.17 pp. S150
- ISSN:
- 1760-2734
- Subject:
- cardiomyopathy; cats; clinical trials; cost effectiveness; death; drugs; echocardiography; etiology; heart failure; monitoring; morbidity; mutation; natural history; pathophysiology; patients; phenotype; prediction; risk factors; siblings; therapeutics; uncertainty
- Abstract:
- ... Cardiomyopathy distinguishes a heterogeneous group of myocardial disorders that represent the most prevalent cause of feline heart disease. Etiology is uncertain and the natural history is presently unresolved. Hypertrophic cardiomyopathy is the most common of these conditions, and while the majority of affected cats are asymptomatic, a proportion is at risk to develop serious morbidities – the mo ...
- DOI:
- 10.1016/j.jvc.2015.03.004
- https://doi.org/10.1016/j.jvc.2015.03.004
- Author:
- Zeynep A. Oztug Durer; Rebecca M. McGillivary; Hyeran Kang; W. Austin Elam; Christina L. Vizcarra; Dorit Hanein; Enrique M. De La Cruz; Emil Reisler; Margot E. Quinlan
- Source:
- Journal of molecular biology 2015 v.427 no.17 pp. 2782-2798
- ISSN:
- 0022-2836
- Subject:
- actin; binding capacity; cardiomyopathy; fluorescence microscopy; fluorescent dyes; microfilaments; muscle contraction; muscles; mutagenesis; proteolysis
- Abstract:
- ... Vinculin is an abundant protein found at cell–cell and cell–extracellular matrix junctions. In muscles, a longer splice isoform of vinculin, metavinculin, is also expressed. The metavinculin-specific insert is part of the C-terminal tail domain, the actin-binding site of both isoforms. Mutations in the metavinculin-specific insert are linked to heart disease such as dilated cardiomyopathies. Vincu ...
- DOI:
- 10.1016/j.jmb.2015.07.005
- PubMed:
- 26168869
- PubMed Central:
- PMC4540644
- https://doi.org/10.1016/j.jmb.2015.07.005
- Author:
- Andrés F. Henao-Martínez; Gabriel Parra-Henao
- Source:
- Genomics data 2015 v.4 pp. 76-77
- ISSN:
- 2213-5960
- Subject:
- Chagas disease; Trypanosoma cruzi; acute course; cardiomyopathy; gene activation; gene expression; heart; infectious diseases; mice; myocarditis; non-specific serine/threonine protein kinase; nucleotide sequences; parasites; patients; ubiquitin
- Abstract:
- ... Chagas disease is transmitted by the parasite, Trypanosoma cruzi. Acute infection is characterized by acute myocarditis, although it is largely asymptomatic. Initial cardiac insult could be a determinant to the posterior development of chronic Chagasic cardiomyopathy, usually after 10years in only approximately 30% of chronically infected patients. Herein, we characterized the acute gene expressio ...
- DOI:
- 10.1016/j.gdata.2015.03.009
- PubMed:
- 26484182
- PubMed Central:
- PMC4535623
- https://doi.org/10.1016/j.gdata.2015.03.009
- Author:
- Elizabeth Vafiadaki; Demetrios A. Arvanitis; Despina Sanoudou
- Source:
- Gene 2015 v.566 pp. 1-7
- ISSN:
- 0378-1119
- Subject:
- cardiomyopathy; cysteine; genes; heart; humans; muscle development; muscle physiology; muscles; muscular diseases; mutation; pathophysiology; skeletal muscle; striated muscle
- Abstract:
- ... Muscle LIM Protein (MLP) has emerged as a key regulator of striated muscle physiology and pathophysiology. Mutations in cysteine and glycine-rich protein 3 (CSRP3), the gene encoding MLP, are causative of human cardiomyopathies, whereas altered expression patterns are observed in human failing heart and skeletal myopathies. In vitro and in vivo evidences reveal a complex and diverse functional rol ...
- DOI:
- 10.1016/j.gene.2015.04.077
- PubMed:
- 25936993
- PubMed Central:
- PMC6660132
- https://doi.org/10.1016/j.gene.2015.04.077
- Author:
- Mingchang Zhang; Aimin Xue; Yiwen Shen; Joao Bosco Oliveira; Ling Li; Ziqin Zhao; Allen Burke
- Source:
- Forensic science international 2015 v.255 pp. 85-88
- ISSN:
- 0379-0738
- Subject:
- DNA; arrhythmia; cadherins; cardiomyopathy; computer software; death; exons; heart; mutation; necropsy; patients; prediction; tissues
- Abstract:
- ... Desmoglein-2 (DSG2), a member of the desmosomal cadherin superfamily, has been linked to arrhythmogenic right ventricular cardiomyopathy (ARVC)which may cause life-threatening ventricular arrhythmias and sudden death. Fatal arrhythmias resulting in sudden death also occur in the absence of morphologic cardiac abnormalities at autopsy. We sequenced all 15 exons of DSG2 in DNA extracted from post-mo ...
- DOI:
- 10.1016/j.forsciint.2015.07.052
- https://doi.org/10.1016/j.forsciint.2015.07.052
- Author:
- K.H. Khor; F.E. Campbell; H. Owen; I.A. Shiels; P.C. Mills
- Source:
- veterinary journal 2015 v.203 no.2 pp. 161-168
- ISSN:
- 1090-0233
- Subject:
- cardiomyocytes; cardiomyopathy; cats; collagen; echocardiography; etiology; fibrosis; hypertrophy; lymphocytes; neutrophils
- Abstract:
- ... The histological features of feline hypertrophic cardiomyopathy (HCM) have been well documented, but there are no reports describing the histological features in mild pre-clinical disease, since cats are rarely screened for the disease in the early stages before clinical signs are apparent. Histological changes at the early stage of the disease in pre-clinical cats could contribute to an improved ...
- DOI:
- 10.1016/j.tvjl.2014.11.018
- https://doi.org/10.1016/j.tvjl.2014.11.018
- Author:
- Shuyuan Chen; Jiaxi Chen; Pintong Huang; Xing-Li Meng; Sandra Clayton; Jin-Song Shen; Paul A. Grayburn
- Source:
- Biochemical and biophysical research communications 2015 v.458 pp. 823-829
- ISSN:
- 0006-291X
- Subject:
- cardiomyocytes; cardiomyopathy; cardioprotective effect; cell proliferation; cyclins; cytoplasm; doxorubicin; embryonic stem cells; gene overexpression; gene therapy; genes; genetically modified organisms; glucagon-like peptide 1; microbubbles; phosphorylation; plasmids; rats; transposons; ultrasonics
- Abstract:
- ... Recently GLP-1 was found to have cardioprotective effects independent of those attributable to tight glycemic control.We employed ultrasound targeted microbubble destruction (UTMD) to deliver piggybac transposon plasmids encoding the GLP-1 gene with a nuclear localizing signal to rat hearts with adriamycin cardiomyopathy. After a single UTMD treatment, overexpression of transgenic GLP-1 was found ...
- DOI:
- 10.1016/j.bbrc.2015.02.038
- https://doi.org/10.1016/j.bbrc.2015.02.038
- Author:
- Gülhan Belgin; Kanık-Yüksek Saliha; Çetin İbrahim İlker; Özkaya-Parlakay Aslınur; Tezer Hasan
- Source:
- Vector borne and zoonotic diseases 2015 v.15 no.9 pp. 565-567
- ISSN:
- 1557-7759
- Subject:
- Crimean-Congo hemorrhagic fever; adults; boys; cardiomyopathy; children; myocarditis; patients; pericardial effusion; viruses
- Abstract:
- ... Crimean-Congo hemorrhagic fever (CCHF) is a viral, tick-borne disease that can be fatal, especially in the adult patient population. CCHF involves multiple organ systems. Pericardial effusion, cardiac hypokinesia, T-wave changes, bundle branch block, and myocardial involvement can be seen as a cardiac complication of CCHF. Several different viruses like Coxsackie A/B and adenovirus may cause myoca ...
- DOI:
- 10.1089/vbz.2015.1769
- https://doi.org/10.1089/vbz.2015.1769
73. Myosin regulatory light chain phosphorylation enhances cardiac β-myosin in vitro motility under load
- Author:
- Anastasia Karabina; Katarzyna Kazmierczak; Danuta Szczesna-Cordary; Jeffrey R. Moore
- Source:
- Archives of biochemistry and biophysics 2015 v.580 pp. 14-21
- ISSN:
- 0003-9861
- Subject:
- actin; cardiomyopathy; death; humans; hypertrophy; mutants; mutation; myosin; phenotype; phosphorylation; swine
- Abstract:
- ... Familial hypertrophic cardiomyopathy (HCM) is characterized by left ventricular hypertrophy and myofibrillar disarray, and often results in sudden cardiac death. Two HCM mutations, N47K and R58Q, are located in the myosin regulatory light chain (RLC). The RLC mechanically stabilizes the myosin lever arm, which is crucial to myosin’s ability to transmit contractile force. The N47K and R58Q mutation ...
- DOI:
- 10.1016/j.abb.2015.06.014
- PubMed:
- 26116789
- PubMed Central:
- PMC4790447
- https://doi.org/10.1016/j.abb.2015.06.014
- Author:
- S. Kesdangsakonwut; Y. Sunden; K. Yamada; A. Nishizono; H. Sawa; T. Umemura
- Source:
- Veterinary pathology v.52 no.3 pp. 573-575
- ISSN:
- 1544-2217
- Subject:
- rabbits; animal pathology; anesthesia; cardiomyopathy; Rabies lyssavirus; fibrosis; brain stem; hypothalamus; necrosis; rabies; thalamus; cerebral cortex; viral antigens; heart
- Abstract:
- ... Cardiomyopathies have been rarely described in rabbits. Here we report myocardial necrosis of the ventricular wall in rabbits with experimentally induced rabies. Myocardial lesions were found only in rabbits with brain lesions, and the severity of the cardiac lesions was proportional to that of the brain lesions. Neither the frequency nor the cumulative dose of anesthesia was related to the incide ...
- DOI:
- 10.1177/0300985814543197
- https://doi.org/10.1177/0300985814543197
- Author:
- Guochang Luo; Xuehua Xu; Wei Guo; Chengliang Luo; Hao Wang; Xiangzhi Meng; Shaohua Zhu; Yan Wei
- Source:
- Peptides 2015 v.71 pp. 162-169
- ISSN:
- 0196-9781
- Subject:
- Western blotting; adenosine triphosphate; bioluminescence assay; cardiomyocytes; cardiomyopathy; dose response; energy balance; energy metabolism; gene expression regulation; heart failure; hypertension; membrane potential; messenger RNA; mitochondria; mitochondrial membrane; neuropeptide Y; protein synthesis; quantitative polymerase chain reaction; staining; transmission electron microscopy
- Abstract:
- ... Neuropeptide Y (NPY) plays an important role in cardiovascular diseases including stress cardiomyopathy, hypertrophic cardiomyopathy, heart failure, diabetic cardiomyopathy, hypertension, and so on. However, inconsistent results related to the role of NPY in the different types of cardiomyopathies make the exact involvement of the peptide elusive. Considering these effects are known to be involved ...
- DOI:
- 10.1016/j.peptides.2015.07.001
- https://doi.org/10.1016/j.peptides.2015.07.001
- Author:
- Laëtitia Pereira; Holger Rehmann; Dieu Hung Lao; Jeffrey R. Erickson; Julie Bossuyt; Ju Chen; Donald M. Bers
- Source:
- Proceedings of the National Academy of Sciences of the United States of America 2015 v.112 no.13 pp. 3991-3996
- ISSN:
- 0027-8424
- Subject:
- arrhythmia; calcium; cardiomyocytes; cardiomyopathy; cyclic AMP; fluorescence; signal transduction; therapeutics
- Abstract:
- ... Exchange proteins directly activated by cAMP (Epac1 and Epac2) have been recently recognized as key players in β-adrenergic–dependent cardiac arrhythmias. Whereas Epac1 overexpression can lead to cardiac hypertrophy and Epac2 activation can be arrhythmogenic, it is unknown whether distinct subcellular distribution of Epac1 vs. Epac2 contributes to differential functional effects. Here, we characte ...
- DOI:
- 10.1073/pnas.1416163112
- PubMed:
- 25829540
- PubMed Central:
- PMC4386405
- https://doi.org/10.1073/pnas.1416163112
- Author:
- Lauro Thiago Turaça; Douglas Oliveira Soares de Faria; Sandra Obikawa Kyosen; Valber Dias Teixeira; Fabiana Louise Motta; Juliana Gilbert Pessoa; Marina Rodrigues e Silva; Sandro Soares de Almeida; Vânia D'Almeida; Maria Verônica Munoz Rojas; Ana Maria Martins; João Bosco Pesquero
- Source:
- Gene 2015 v.561 pp. 124-131
- ISSN:
- 0378-1119
- Subject:
- cardiomyopathy; counseling; African Americans; humans; glycogen; early diagnosis; nonsense mutation; children; Whites; missense mutation; exons; Asians; pathogenicity; genotype-phenotype correlation; patients; blood; Brazil
- Abstract:
- ... Pompe disease is an autosomal recessive disorder linked to GAA gene that leads to a multi-system intralysosomal accumulation of glycogen. Mutation identification in the GAA gene can be very important for early diagnosis, correlation between genotype–phenotype and therapeutic intervention. For this purpose, peripheral blood from 57 individuals susceptible to Pompe disease was collected and all exon ...
- DOI:
- 10.1016/j.gene.2015.02.023
- https://doi.org/10.1016/j.gene.2015.02.023
- Author:
- Wenrui Huang; Jingsheng Liang; Chen‐Ching Yuan; Katarzyna Kazmierczak; Zhiqun Zhou; Ana Morales; Kim L. McBride; Sara M. Fitzgerald‐Butt; Ray E. Hershberger; Danuta Szczesna‐Cordary
- Source:
- FEBS journal 2015 v.282 no.12 pp. 2379-2393
- ISSN:
- 1742-464X
- Subject:
- adenosinetriphosphatase; adults; alanine; aspartic acid; calcium; cardiomyopathy; humans; in vitro studies; muscles; mutagenesis; mutants; myocardium; myosin heavy chains; myosin light chain kinase; phenotype; phosphorylation; sequence analysis; swine
- Abstract:
- ... Dilated cardiomyopathy (DCM) is a disease of the myocardium characterized by left ventricular dilatation and diminished contractile function. Here we describe a novel DCM mutation in the myosin regulatory light chain (RLC), in which aspartic acid at position 94 is replaced by alanine (D94A). The mutation was identified by exome sequencing of three adult first‐degree relatives who met formal criter ...
- DOI:
- 10.1111/febs.13286
- PubMed:
- 25825243
- PubMed Central:
- PMC4472530
- https://doi.org/10.1111/febs.13286
79. Novel remodeling of the mouse heart mitochondrial proteome in response to acute insulin stimulation
- Author:
- B.A. Pedersen; P.G. Yazdi; J.F. Taylor; O.S. Khattab; Y.-H. Chen; Y. Chen; P.H. Wang
- Source:
- Nutrition, metabolism, and cardiovascular diseases 2015 v.25 no.12 pp. 1152-1158
- ISSN:
- 0939-4753
- Subject:
- adenosine diphosphate; cardiomyopathy; enzymes; fluorescence; gel electrophoresis; heart; insulin; matrix-assisted laser desorption-ionization mass spectrometry; metabolism; mice; mitochondria; pathophysiology; proteome; proteomics; structural proteins
- Abstract:
- ... Mitochondrial dysfunction contributes to the pathophysiology of diabetic cardiomyopathy. The aim of this study was to investigate the acute changes in the mitochondrial proteome in response to insulin stimulation.Cardiac mitochondria from C57BL/6 mice after insulin stimulation were analyzed using two-dimensional fluorescence difference gel electrophoresis. MALDI-TOF MS/MS was utilized to identify ...
- DOI:
- 10.1016/j.numecd.2015.09.011
- PubMed:
- 26610654
- PubMed Central:
- PMC4684478
- https://doi.org/10.1016/j.numecd.2015.09.011
- Author:
- Alexandre Chojnowski; Peh Fern Ong; Oliver Dreesen
- Source:
- Cell and tissue research 2015 v.360 no.3 pp. 621-631
- ISSN:
- 0302-766X
- Subject:
- cardiomyopathy; genetic disorders; human diseases; loci; mutation; nuclear membrane; tissues
- Abstract:
- ... The intermediate filament A- and B-type lamins are key architectural components of the nuclear lamina, a proteinaceous meshwork that lies underneath the inner nuclear membrane. In the past decade, many different monogenic human diseases have been linked to mutations in various components of the nuclear lamina. Mutations in LMNA (encoding lamin A and C) cause a variety of human diseases, collective ...
- DOI:
- 10.1007/s00441-014-2069-4
- https://doi.org/10.1007/s00441-014-2069-4
- Author:
- Jan Galuszka; Jitka Vostalova; Blanka Cervena; Dana Galuszkova; Vilim Simanek; Michal Holcapek; Eva Cifkova; Miroslav Lisa; Jana Vrbkova; Martina Bancirova; Milos Taborsky; Dalibor Novotny
- Source:
- European journal of lipid science and technology 2015 v.117 no.5 pp. 601-607
- ISSN:
- 1438-7697
- Subject:
- blood lipids; body mass index; cardiomyopathy; coronary disease; docosahexaenoic acid; eicosapentaenoic acid; erythrocytes; fish consumption; flame ionization; guidelines; heart failure; males; marine fish; men; myocardial infarction; omega-3 fatty acids; overweight; patients; relative risk
- Abstract:
- ... The aim of this study was to evaluate the fatty acid (FA) profile in the plasma and erythrocyte membranes of apparently healthy men compared to male patients with various cardiovascular diseases (CVD). The plasma FA profiles were analyzed in five groups of subjects aged 37–57 years: groups 1 and 2 were male voluntary blood donors with a body mass index (BMI) 25.1 ± 1.6, (Group 1, N = 12) and a BMI ...
- DOI:
- 10.1002/ejlt.201400213
- https://doi.org/10.1002/ejlt.201400213
- Author:
- R. Urban-Chmiel; R. Pyz-Łukasik; A. Dudzic; A. Wernicki
- Source:
- Polish journal of veterinary sciences 2015 v.17 no.3 pp. 433-439
- ISSN:
- 2300-2557
- Subject:
- Western blotting; cardiomyopathy; death; heart; heat shock proteins; infarction; ions; muscles; myocardial infarction; nitric oxide; nitrites; oxidative stress; polyacrylamide gel electrophoresis; slaughter; swine; thiobarbituric acid-reactive substances
- Abstract:
- ... In view of the significant role of Hsp70 in protecting the organism against the destructive effects of stress, and the possibility of using this protein as a marker of the infarction process in the heart, the aim of this study was to conduct an evaluation of the expression of 70kDa heat shock proteins (Hsp70) and the concentration of TBARS (thiobarbituric acid reactive substances) and nitric oxide ...
- DOI:
- 10.2478/pjvs-2014-0062
- https://doi.org/10.2478/pjvs-2014-0062
- Author:
- Tara A. Sime; Lisa L. Powell; Julie C. Schildt; Erik J. Olson
- Source:
- Journal of veterinary emergency and critical care 2015 v.25 no.6 pp. 765-769
- ISSN:
- 1479-3261
- Subject:
- Carnivore protoparvovirus 1; Dachshund; cardiac arrest; cardiomyopathy; distress; dogs; immunohistochemistry; males; myocarditis; myocardium; necropsy; radiography
- Abstract:
- ... OBJECTIVE: To describe a case of myocarditis associated with naturally occurring canine parvovirus type 2 (CPV‐2). CASE SUMMARY: A 5‐week‐old male intact Dachshund dog presented for acute respiratory distress. Limited diagnostic tests prior to the dog experiencing cardiopulmonary arrest included a lateral thoracic radiograph, which indicated cardiomegaly and diffuse unstructured pulmonary infiltra ...
- DOI:
- 10.1111/vec.12347
- https://doi.org/10.1111/vec.12347
- Author:
- Michelle S. Parvatiyar; Jose Renato Pinto
- Source:
- BBA - General Subjects 2015 v.1850 pp. 365-372
- ISSN:
- 0304-4165
- Subject:
- actin; cAMP-dependent protein kinase; calcium; cardiomyopathy; circular dichroism spectroscopy; fluorescence; mutants; mutation; pathogenesis; phosphorylation; spectral analysis; swine; troponin I; troponin T
- Abstract:
- ... Dilated and hypertrophic cardiomyopathy mutations in troponin can blunt effects of protein kinase A (PKA) phosphorylation of cardiac troponin I (cTnI), decreasing myofilament Ca2+-sensitivity; however this effect has never been tested for restrictive cardiomyopathy (RCM) mutants. This study explores whether an RCM cardiac troponin T mutant (cTnT-ΔE96) interferes with convergent PKA regulation and ...
- DOI:
- 10.1016/j.bbagen.2014.09.029
- PubMed:
- 25450489
- PubMed Central:
- PMC4276470
- https://doi.org/10.1016/j.bbagen.2014.09.029
85. Pathologic and Cardiovascular Characterization of Pheochromocytoma-Associated Cardiomyopathy in Dogs
- Author:
- E. F. Edmondson; J. M. Bright; C. H. Halsey; E. J. Ehrhart
- Source:
- Veterinary pathology v.52 no.2 pp. 338-343
- ISSN:
- 1544-2217
- Subject:
- Primates; animal pathology; arrhythmia; blood pressure; cardiomyocytes; cardiomyopathy; dogs; echocardiography; electrocardiography; fibrosis; hemorrhage; humans; hypertension; hypertrophy; medical treatment; mice; morbidity; mortality; myocarditis; necrosis; retrospective studies
- Abstract:
- ... Pheochromocytoma-associated catecholamine-induced cardiomyopathy is a well-known entity in man, nonhuman primates, and mice but has not been described in dogs. In this retrospective study, 9 dogs were identified with pheochromocytomas and concurrent cardiovascular pathology observed histologically (n = 6), echocardiographically (n = 4), and/or electrocardiographically (n = 5). Cardiac lesions incl ...
- DOI:
- 10.1177/0300985814533805
- https://doi.org/10.1177/0300985814533805
- Author:
- Mohammed H. Rahman; G.K. Aning; P. Addo; G. Assare; M.I. Hossain; M.M. Hossain; B.K. Ahunu
- Source:
- Indian journal of veterinary pathology 2015 v.39 no.3 pp. 277-281
- ISSN:
- 0973-970X
- Subject:
- Thryonomys swinderianus; animal pathology; blood; cardiomyopathy; edema; endothelial cells; females; heart; heart failure; liver; males; mortality; neck; necropsy; necrosis; pathogenesis; pneumonia; Ghana
- Abstract:
- ... Hepatorenal syndrome and clinical signs of heart failure occurred sporadically in 3- to 12-month-old Grasscutter(Thryonomys swinderianus) in captive colonies originally derived from in-bred male and female littermates. Macroscopic lesions in severely affected animals included subcutaneous edema, cervical swelling, pneumonia and hepatomegaly. 43 Grasscutters that were found dead and or were euthana ...
- DOI:
- 10.5958/0973-970X.2015.00069.3
- https://doi.org/10.5958/0973-970X.2015.00069.3
- Author:
- Izabela Janus; Marcin Nowak; Janusz A. Madej
- Source:
- Bulletin of the Veterinary Institute in Puławy = 2015 v.59 no.1 pp. 135-142
- ISSN:
- 2300-3235
- Subject:
- cardiomyopathy; dogs; fibrosis; heart failure; hypertrophy; muscles; myocardium
- Abstract:
- ... The study was conducted on ventricular and atrial wall preparations from 11 dogs with clinically diagnosed dilated cardiomyopathy. After fixation, the specimens were stained with haematoxylin and eosin and Masson-Goldner trichrome technique. Parenchymal changes (fibrosis and fatty infiltration), vascular changes (congestion and coronary vessel wall hypertrophy), degenerative changes (loss of stria ...
- DOI:
- 10.1515/bvip-2015-0020
- https://doi.org/10.1515/bvip-2015-0020
- Author:
- Sonya G. Gordon; Etienne Côté
- Source:
- Journal of veterinary cardiology 2015 v.17 pp. S159
- ISSN:
- 1760-2734
- Subject:
- cardiomyopathy; cats; drug therapy; heart failure
- Abstract:
- ... The natural progression of cardiomyopathy in cats can lead to congestive heart failure. This review enumerates commonly and uncommonly used medications that can be used for the long-term treatment of cats that have positively responded to initial management of acute heart failure. The advantages, drawbacks, and authors' preferred approach are presented for each medication. ...
- DOI:
- 10.1016/j.jvc.2015.03.009
- https://doi.org/10.1016/j.jvc.2015.03.009
- Author:
- Carina Frykholm; Joakim Klar; Hanna Arnesson; Anna-Carin Rehnman; Marianne Lodahl; Ulla Wedén; Niklas Dahl; Lisbeth Tranebjærg; Nanna D. Rendtorff
- Source:
- Gene 2015 v.563 pp. 10-16
- ISSN:
- 0378-1119
- Subject:
- cardiomyopathy; etiology; frameshift mutation; gender; genome; hearing; hearing disorders; heterozygosity; loci; phenotypic variation
- Abstract:
- ... Linkage to an interval overlapping the DFNA10 locus on chromosome 6q22–23 was found through genome wide linkage analysis in a seven-generation Swedish family segregating postlingual, autosomal dominant nonsyndromic sensorineural hearing impairment. A novel heterozygous frame-shift mutation (c.579_580insTACC, p.(Asp194Tyrfs*52)) in EYA4 was identified that truncates the so-called variable region of ...
- DOI:
- 10.1016/j.gene.2015.02.022
- https://doi.org/10.1016/j.gene.2015.02.022
- Author:
- Suraiya Rasheed; Rahim Hashim; Jasper S. Yan
- Source:
- Computational and Structural Biotechnology Journal 2015 v.13 pp. 145-152
- ISSN:
- 2001-0370
- Subject:
- CD4-positive T-lymphocytes; HIV infections; Human immunodeficiency virus; antiretroviral agents; arrhythmia; bioinformatics; biomarkers; calcium; cardiomyopathy; cell growth; early diagnosis; enzymes; heart; heart failure; immune response; microorganisms; myosin heavy chains; prediction; proteomics; statistical analysis; translation (genetics); viral load; virus replication
- Abstract:
- ... The frequency of cardiovascular disorders is increasing in HIV-infected individuals despite a significant reduction in the viral load by antiretroviral therapies (ART). Since the CD4⁺ T-cells are responsible for the viral load as well as immunological responses, we hypothesized that chronic HIV-infection of T-cells produces novel proteins/enzymes that cause cardiac dysfunctions. To identify specif ...
- DOI:
- 10.1016/j.csbj.2015.02.001
- PubMed:
- 25750702
- PubMed Central:
- PMC4348431
- https://doi.org/10.1016/j.csbj.2015.02.001
- Author:
- G. Remmers; D. W. Hayden; M. A. Jaeger; J. M. Ervasti; S. J. Valberg
- Source:
- Veterinary pathology v.52 no.1 pp. 186-188
- ISSN:
- 1544-2217
- Subject:
- Western blotting; anesthesia; anesthetics; animal pathology; cardiomyopathy; cats; death; diaphragm; domestic animals; dystrophin; fibrosis; fluorescence microscopy; histology; hypertrophy; males; mineralization; muscular dystrophy; necrosis; surgery
- Abstract:
- ... There are few reports of naturally occurring muscular dystrophy in domestic animals. Herein, we describe a case of muscular dystrophy in a 4-year-old neutered male American domestic shorthair cat that died unexpectedly following anesthesia for an elective surgical procedure. Macroscopic muscular hypertrophy and histologic evidence of myofiber size variation, mineralization, myofiber degeneration, ...
- DOI:
- 10.1177/0300985814524797
- https://doi.org/10.1177/0300985814524797
- Author:
- Ting-Wei Lee; Ting-I Lee; Chun-Jen Chang; Gi-Shih Lien; Yu-Hsun Kao; Tze-Fan Chao; Yi-Jen Chen
- Source:
- Nutrition research 2015 v.35 no.4 pp. 269-279
- ISSN:
- 0271-5317
- Subject:
- advanced glycation end products; cardiomyopathy; cardiovascular system; databases; diabetes mellitus; hypercalcemia; metabolism; morbidity; mortality; patients; pleiotropy; randomized clinical trials; renin-angiotensin system; risk; vitamin D
- Abstract:
- ... Cardiovascular disease is the leading cause of morbidity and mortality in patients with diabetes mellitus (DM), and patients with DM frequently develop diabetic cardiomyopathy. Currently, effective treatments for diabetic cardiomyopathy are limited. Vitamin D exerts pleiotropic effects on the cardiovascular system and is associated with DM. The purpose of this review was to evaluate published rese ...
- DOI:
- 10.1016/j.nutres.2015.02.005
- https://doi.org/10.1016/j.nutres.2015.02.005
- Author:
- Donald P. Schrope
- Source:
- Journal of veterinary cardiology 2015 v.17 no.3 pp. 192-202
- ISSN:
- 1760-2734
- Subject:
- cardiomyopathy; cats; disease prevalence; dogs; females; males; mixed breeds; patent ductus arteriosus; pulmonary artery; purebreds
- Abstract:
- ... Assess the prevalence of congenital heart disease (CHD) in a large population of mixed-breed dogs and cats.76,301 mixed-breed dogs and 57,025 mixed-breed cats.Retrospective review of records and examinations based on specified diagnostic criteria.Among mixed-breed dogs, the prevalence of CHD was 0.13% (51.4% female) and of innocent murmurs was 0.10% (53.0% male). Pulmonic stenosis was the most com ...
- DOI:
- 10.1016/j.jvc.2015.06.001
- https://doi.org/10.1016/j.jvc.2015.06.001
- Author:
- Sabrina Lento; Maura Brioschi; Simona Barcella; Md. Talat Nasim; Stefania Ghilardi; Silvia Stella Barbieri; Elena Tremoli; Cristina Banfi
- Source:
- Journal of proteomics 2015 v.119 pp. 75-89
- ISSN:
- 1874-3919
- Subject:
- blood coagulation; cardiomyopathy; coagulation; gene silencing; hemostasis; human diseases; immunity; inflammation; messenger RNA; metabolism; myocardium; patients; proteins; proteome; proteomics; risk; spliceosomes
- Abstract:
- ... It has long been known that Tissue Factor (TF) plays a role in blood coagulation and has a direct thrombotic action that is closely related to cardiovascular risk, but it is becoming increasingly clear that it has a much wider range of biological functions that range from inflammation to immunity. It is also involved in maintaining heart haemostasis and structure, and the observation that it is do ...
- DOI:
- 10.1016/j.jprot.2015.01.021
- https://doi.org/10.1016/j.jprot.2015.01.021
- Author:
- Jothi Ranjani; Muthuirulan Pushpanathan; Ayyavu Mahesh; Marimuthu Niraimathi; Paramasamy Gunasekaran; Jeyaprakash Rajendhran
- Source:
- Journal of basic microbiology 2015 v.55 no.10 pp. 1191-1202
- ISSN:
- 0233-111X
- Subject:
- Pseudomonas aeruginosa; apoptosis; bacterial infections; cardiac arrest; cardiomyopathy; cell cycle; flow cytometry; image analysis; mitochondria; myocarditis; myocardium; pathogens; patients
- Abstract:
- ... Bacterial infections in myocardium may lead to the myocardial damage, which may progress to dilated cardiomyopathy and cardiac arrest. Pseudomonas aeruginosa has been reported to cause myocarditis and other systemic infections especially in immunocompromised patients. To understand the cellular responses during the establishment of infection in myocardium, we challenged differentiated H9C2 cells w ...
- DOI:
- 10.1002/jobm.201500037
- https://doi.org/10.1002/jobm.201500037
- Author:
- Jing Lv; Yi-Xin Zhu; Ying-Qun Liu; Xin Xue
- Source:
- Molecular biology reports 2015 v.42 no.2 pp. 441-449
- ISSN:
- 0301-4851
- Subject:
- algorithms; cardiomyopathy; cluster analysis; computer software; data collection; endothelial cells; gene expression; gene expression regulation; genes; microarray technology; mitogen-activated protein kinase; pathogens; topology
- Abstract:
- ... The study aimed to compare the molecular mechanism of Porphuromonas gingivalis (P. gingivalis) and Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans). With microarray dataset (GSE9723) from Gene Expression Omnibus, differentially expressed genes (DEGs) were identified comparing normal cell samples with A. actinomycetemcomitans-infected and P. gingivalis-infected periodontitis cell sa ...
- DOI:
- 10.1007/s11033-014-3785-2
- PubMed:
- 25351486
- https://doi.org/10.1007/s11033-014-3785-2
- Author:
- Yichuan Liu; Michael Morley; Jeffrey Brandimarto; Sridhar Hannenhalli; Yu Hu; Euan A. Ashley; W.H. Wilson Tang; Christine S. Moravec; Kenneth B. Margulies; Thomas P. Cappola; Mingyao Li
- Source:
- Genomics 2015 v.105 pp. 83-89
- ISSN:
- 0888-7543
- Subject:
- adults; binding sites; cardiomyopathy; data collection; gene expression; genes; genome-wide association study; heart failure; microarray technology; myocardial ischemia; patients; promoter regions; sequence analysis; transcription factors
- Abstract:
- ... Heart failure is a complex clinical syndrome and has become the most common reason for adult hospitalization in developed countries. Two subtypes of heart failure, ischemic heart disease (ISCH) and dilated cardiomyopathy (DCM), have been studied using microarray platforms. However, microarray has limited resolution. Here we applied RNA sequencing (RNA-Seq) to identify gene signatures for heart fai ...
- DOI:
- 10.1016/j.ygeno.2014.12.002
- PubMed:
- 25528681
- PubMed Central:
- PMC4684258
- https://doi.org/10.1016/j.ygeno.2014.12.002
- Author:
- Gautam Rekha; Vanga Sandeep; Madan Aditi; Gayathri Narayanappa; Nongthomba Upendra; Umapathy Siva
- Source:
- Analytical chemistry 2015 v.87 no.4 pp. 2187-2194
- ISSN:
- 1520-6882
- Subject:
- Drosophila; Raman spectroscopy; cardiomyopathy; carotenoids; discriminant analysis; flight muscles; glycogen; humans; models; mortality; muscular diseases; mutants; myosin; nucleic acids; pathophysiology; protein content; screening; spectral analysis; therapeutics
- Abstract:
- ... Myopathies are among the major causes of mortality in the world. There is no complete cure for this heterogeneous group of diseases, but a sensitive, specific, and fast diagnostic tool may improve therapy effectiveness. In this study, Raman spectroscopy is applied to discriminate between muscle mutants in Drosophila on the basis of associated changes at the molecular level. Raman spectra were coll ...
- DOI:
- 10.1021/ac503647x
- https://doi.org/10.1021/ac503647x
- Author:
- Brian A. Scansen; Kyla L. Morgan
- Source:
- Journal of veterinary cardiology 2015 v.17 pp. S282
- ISSN:
- 1760-2734
- Subject:
- allometry; body weight; cardiomyopathy; cats; echocardiography; equations; females; hybrids; males; prediction; regression analysis
- Abstract:
- ... The Bengal is a relatively new hybrid breed, reported to develop hypertrophic cardiomyopathy. The aim of this study was to determine reference intervals for echocardiographic measurements in Bengal cats.Sixty-six apparently healthy Bengal cats.The study included a retrospective review of echocardiograms from 39 Bengal cats evaluated from March 2004 to June 2012 and reported to be normal by a board ...
- DOI:
- 10.1016/j.jvc.2015.02.001
- https://doi.org/10.1016/j.jvc.2015.02.001
- Author:
- Adele Stewart; Biswanath Maity; Simon P. Anderegg; Chantal Allamargot; Jianqi Yang; Rory A. Fisher
- Source:
- Proceedings of the National Academy of Sciences of the United States of America 2015 v.112 no.7 pp. E786
- ISSN:
- 0027-8424
- Subject:
- accidents; alcohol abuse; alcohol drinking; alcohols; cardiomyopathy; drugs; endotoxemia; fatty liver; gastrointestinal system; heart; liver; men; mice; mortality; toxicity; traffic; women; United States
- Abstract:
- ... Alcohol is the most commonly abused drug worldwide, and chronic alcohol consumption is a major etiological factor in the development of multiple pathological sequelae, including alcoholic cardiomyopathy and hepatic cirrhosis. Here, we identify regulator of G protein signaling 6 (RGS6) as a critical regulator of both alcohol-seeking behaviors and the associated cardiac and hepatic morbidities throu ...
- DOI:
- 10.1073/pnas.1418795112
- PubMed:
- 25646431
- PubMed Central:
- PMC4343156
- https://doi.org/10.1073/pnas.1418795112