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1. Unimolecular micelles of camptothecin-bonded hyperbranched star copolymers via β-thiopropionate linkage: synthesis and drug delivery

Author:
Pan, Cai-Yuan,   et al.   ; Qiu, Liang; Liu, Qing; Hong, Chun-Yan;     Show all 4 Authors
Source:
Journal of materials chemistry B 2015 v.4 no.1 pp. 141-151
ISSN:
2050-7518
Subject:
composite polymers; drugs; micelles; neoplasm cells; pH; polymerization
Abstract:
... In order to develop pH- and redox-responsive unimolecular micelles composed of camptothecin (CPT)-conjugated hyperbranched star copolymers via acid-labile β-thiopropionate linkage, a new monomer, methacryloyloxy-3-thiohexanoyl–CPT, is synthesized through conjugation of CPT with methacrylate via β-thiopropionate linkage, and then used in synthesis of the CPT-conjugated hyperbranched star copolymers ...
DOI:
10.1039/c5tb01905b