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Lydia C. Soydan; Heidi B. Kellihan; Melissa L. Bates; Rebecca L. Stepien; Daniel W. Consigny; Alessandro Bellofiore; Christopher J. Francois; Naomi C. Chesler
... To compare noninvasive estimates of pulmonary artery pressure (PAP) obtained via echocardiography (ECHO) to invasive measurements of PAP obtained during right heart catheterization (RHC) across a range of PAP. To examine the accuracy of estimating right atrial pressure via ECHO (RAPECHO) compared to RAP measured by RHC (RAPRHC), and determine if adding RAPECHO improves the accuracy of noninvasive ...
... A 12-month-old Thoroughbred filly was admitted for poor weight gain, intermittent fever, and distal limb edema. Initial clinical examination revealed tachycardia, tachypnea, and pyrexia. A loud holosystolic murmur was identified by cardiac auscultation, and thoracic auscultation identified bilateral diffuse crackles. Echocardiography demonstrated severe extrinsic pulmonic stenosis, enlargement of ...
... Placement of an endocardial VDD pacing lead in small dogs (<12 kg) may necessitate a redundant lead remaining looped in the right atrium for appropriate sensing and pacing. This report documented acquired tricuspid valve stenosis in two small dogs between 8 months and 4 years after VDD pacemaker placement for third-degree atrioventricular block. Echocardiography and Doppler echocardiography identi ...
... Aryl hydrocarbon receptor (AhR) agonists are known to cause lethal cardiovascular deformities in fish after developmental exposure. Acute adult fish toxicity of AhR agonists is thought to be minimal, but limited evidence suggests sublethal effects may also involve the cardiac system in fish. In the present study, adult zebrafish (Danio rerio) were aqueously exposed to solvent control or three nomi ...
... We investigated the effect of α-linolenic acid (ALA) in protecting the heart from injury caused by β-adrenergic overstimulation. ALA's role either in isoproterenol (ISO)-treated isolated rat cardiomyocytes (H9c2 cells) or in in vivo rat hearts was studied. In isolated cardiomyocytes in vitro, the involvement of kinases (Src and PI3K) in protection was tested using the specific inhibitors (PP2 or L ...
... A three-month-old female Rottweiler puppy was referred for intravascular correction of a previously identified cor triatriatum dexter. Echocardiography confirmed the presence of a hyperechoic membrane that divided the right atrium into a cranial and caudal chamber. A foramen in this membrane allowed the blood to flow from the caudal to the cranial chamber. Balloon dilation of the defect under tran ...
... Diagnosis of feline hypertrophic cardiomyopathy (HCM) is both clinical and anatomopathological. Since standardized echocardiographic parameters have previously been established for its diagnosis and classification, the aim of the present study is to provide an original, complete and repeatable quantitative anatomopathological evaluation of this myocardial disease. Since ES-HCM is a clearly defined ...
... Obesity is a chronic metabolic disorder that is associated with numerous diseases including hyperlipidemia, diabetes mellitus, hypertension, atherosclerosis, cardiovascular disease, and cancer. Cinnamic acid is a phytochemical compound having many biological effects and could be considered for the management of obesity. This study is aimed to assess the possible anti-obesity and cardioprotective p ...
... Depression is a predictor of poor prognosis in patients with heart failure. Selective serotonin (5-HT) reuptake inhibitors (SSRIs) may improve these outcomes. Left ventricular volume overload induced hypertrophy that is associated with aortic regurgitation (AR) leads to ventricular dysfunction and heart failure. The aim of this study was to verify the effects of the SSRI paroxetine on cardiac func ...
... Brebes is an agricultural village in north coastal area of Central Java that is exposed to organophosphate pesticides. Organophosphate could cause mechanical damage of artery such as increasing the stiffness and leading to arteriosclerosis in early life. Aortic (Ao) elasticity profiles of children who are living in those polluted area have never been studied. The aim of study was to determine Ao w ...
dogs; echocardiography; heart valve diseases; magnetic resonance imaging; nervous system diseases; quantitative analysis; surface area
Abstract:
... OBJECTIVES: Echocardiography is used routinely to assess mitral regurgitation severity, but echocardiographic measures of mitral regurgitation in dogs have not been compared with other quantitative methods. The study aim was to compare echocardiographic measures of mitral regurgitation with cardiac magnetic resonance imaging‐derived mitral regurgitant fraction in small‐breed dogs. METHODS: Dogs wi ...
... BACKGROUND: Tricuspid annular plane systolic excursion (TAPSE) is a useful estimate of right ventricular function in humans. Reference intervals for dogs have been generated, but the value of measuring TAPSE in other diseases, or investigating the association between TAPSE and outcome, is unknown. HYPOTHESIS: TAPSE is lower in Boxer dogs with ≥50 VPCs/24 h on Holter than in dogs with fewer ventric ...
... ‘Valentine’ heart shape is a common qualifier used in veterinary radiology to describe a cardiac silhouette with focal enlargement at the level of the base of the heart in feline patients. Anecdotally, this sign has been thought to be related to biatrial enlargement and also to hypertrophic cardiomyopathy (HCM). However, to our knowledge, there has been no study performed to assess the association ...
animal models; blood; body weight; calcium; cardiomyopathy; catechin; echocardiography; epigallocatechin gallate; green tea; hypersensitivity; mice; mutation; sarcomeres
Abstract:
... Diastolic dysfunction refers to an impaired relaxation and an abnormality in ventricular blood filling during diastole while systolic function is preserved. Cardiac myofibril hypersensitivity to Ca²⁺ is a major factor that causes impaired relaxation of myocardial cells. The present study investigates the effect of the green tea extract catechins on myofibril calcium desensitization and restoration ...
... OBJECTIVE: To describe a case of cardiac malposition in a cat, and the successful management of the anomaly. CASE DESCRIPTION: A 2‐year‐old male neutered male British Shorthair cat weighing 7.58 kg was referred for bicavitary effusion. Ultrasonography and echocardiography demonstrated displacement of the heart into the abdomen through a diaphragmatic defect. Clinical signs of right‐sided congestiv ...
... Compromised cardiac fatty acid oxidation (FAO) induced energy deprivation is a critical cause of cardiac dysfunction in sepsis. Acyl-CoA thioesterase 1 (ACOT1) is involved in regulating cardiac energy production via altering substrate metabolism. This study aims to clarify whether ACOT1 has a potency to ameliorate septic myocardial dysfunction via enhancing cardiac FAO. Transgenic mice with cardio ...
adults; body condition; body weight; cardiomyopathy; cats; confidence interval; cross-sectional studies; echocardiography; heart; males; regression analysis; systolic blood pressure
Abstract:
... Hypertrophic cardiomyopathy (HCM) appears to be common in cats and, based on pilot data, a prevalence of 15% has been hypothesized. The objectives were to screen a large population of apparently healthy adult cats for cardiac disease, and identify factors associated with a diagnosis of HCM.A total of 1007 apparently healthy cats ≥6 months of age.In this prospective, cross-sectional study, the incl ...
... To evaluate the physiological variables, arterial blood gas values, induction of anesthesia quality, and recovery quality using the combination of butorphanol, midazolam and alfaxalone in dogs.Ten healthy adult Beagle dogs weighing 8.3 ± 3.1 kg.Rectal temperature (T), pulse rate (PR), respiratory rate (fR), mean arterial pressure (MAP), and arterial blood gases were measured and recorded prior to ...
... Wet beriberi-induced pericardial effusion has rarely been previously described. Little is known about the effect of beriberi-induced pericardial effusion on hemodynamics. Here we present a case of wet beriberi with pericardial effusion that exhibited constrictive physiology, which was dramatically improved after treatment. A 61-year-old male patient was admitted to our hospital for progressive leg ...
... Deleted in colorectal cancer (DCC), a large transmembrane receptor of netrin-1, is critical for mediating netrin-1’s cardioprotective function. In the present study we investigated novel mechanisms underlying netrin-1–induced, rapid, and feed-forward up-regulation of DCC, which is believed to sustain nitric oxide (NO) production to potentiate cardioprotection. Intriguingly, NO markedly reduced exp ...