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1. Engineering immunity: Modulating dendritic cell subsets and lymph node response to direct immune-polarization and vaccine efficacy

Author:
Leleux, Jardin; Atalis, Alexandra; Roy, Krishnendu
Source:
Journal of Controlled Release 2015 v.219 pp. 610-621
ISSN:
0168-3659
Subject:
vaccination,   etc   ; adaptive immunity; dendritic cells; engineering; immune response; lymph nodes; pathogens; vaccines;     Show all 8 Subjects
Abstract:
... While successful vaccines have been developed against many pathogens, there are still many diseases and pathogenic infections that are highly evasive to current vaccination strategies. Thus, more sophisticated approaches to control the type and quality of vaccine-induced immune response must be developed. Dendritic cells (DCs) are the sentinels of the body and play a critical role in immune respon ...
DOI:
10.1016/j.jconrel.2015.09.063
PubMed:
26489733
PubMed Central:
PMC5669361

2. Duration of protective immunity after a single vaccination with a live attenuated bivalent bluetongue vaccine

Author:
Zhugunissov, Kuandyk; Yershebulov, Zakir; Barakbayev, Kainar; Bulatov, Yerbol; Taranov, Dmitriy; Amanova, Zhanat; Abduraimov, Yergali
Source:
Veterinary research communications 2015 v.39 no.4 pp. 203-210
ISSN:
0165-7380
Subject:
vaccination,   etc   ; Bluetongue virus; antibodies; bluetongue; fever; immune response; seroconversion; serotypes; sheep; vaccines; viruses;     Show all 11 Subjects
Abstract:
... The prevention of bluetongue is typically achieved with mono- or polyvalent modified- live-attenuated virus (MLV) vaccines. MLV vaccines typically elicit a strong antibody response that correlates directly with their ability to replicate in the vaccinated animal. They are inexpensive, stimulate protective immunity after a single inoculation, and have been proven effective in preventing clinical bl ...
DOI:
10.1007/s11259-015-9643-4
PubMed:
26280208
PubMed Central:
PMC4643103

3. Improvement of BCG protective efficacy with a novel chimpanzee adenovirus and a modified vaccinia Ankara virus both expressing Ag85A

Author:
Stylianou, E.; Griffiths, K.L.; Poyntz, H.C.; Harrington-Kandt, R.; Dicks, M.D.; Stockdale, L.; Betts, G.; McShane, H.
Source:
Vaccine 2015 v.33 no.48 pp. 6800-6808
ISSN:
0264-410X
Subject:
vaccination,   etc   ; Mycobacterium tuberculosis; Pan troglodytes; Vaccinia virus; aerosols; immune response; lungs; mice; vaccines;     Show all 9 Subjects
Abstract:
... A replication-deficient chimpanzee adenovirus expressing Ag85A (ChAdOx1.85A) was assessed, both alone and in combination with modified vaccinia Ankara also expressing Ag85A (MVA85A), for its immunogenicity and protective efficacy against a Mycobacterium tuberculosis (M.tb) challenge in mice. Naïve and BCG-primed mice were vaccinated or boosted with ChAdOx1.85A and MVA85A in different combinations. ...
DOI:
10.1016/j.vaccine.2015.10.017
PubMed:
26478198
PubMed Central:
PMC4678294

4. New approaches to understanding the immune response to vaccination and infection

Author:
Furman, David; Davis, Mark M.
Source:
Vaccine 2015 v.33 no.40 pp. 5271-5281
ISSN:
0264-410X
Subject:
vaccination,   etc   ; antibodies; blood; cytokines; direct contact; immune response; immune system; pathogens; tissues; vaccine development; vaccines;     Show all 11 Subjects
Abstract:
... The immune system is a network of specialized cell types and tissues that communicates via cytokines and direct contact, to orchestrate specific types of defensive responses. Until recently, we could only study immune responses in a piecemeal, highly focused fashion, on major components like antibodies to the pathogen. But recent advances in technology and in our understanding of the many componen ...
DOI:
10.1016/j.vaccine.2015.06.117
PubMed:
26232539
PubMed Central:
PMC4581990

5. Systems vaccinology: Enabling rational vaccine design with systems biological approaches

Author:
Hagan, Thomas; Nakaya, Helder I.; Subramaniam, Shankar; Pulendran, Bali
Source:
Vaccine 2015 v.33 no.40 pp. 5294-5301
ISSN:
0264-410X
Subject:
vaccination,   etc   ; Human immunodeficiency virus; immune response; malaria; morbidity; mortality; researchers; systems engineering; vaccine development; vaccines;     Show all 10 Subjects
Abstract:
... Vaccines have drastically reduced the mortality and morbidity of many diseases. However, vaccines have historically been developed empirically, and recent development of vaccines against current pandemics such as HIV and malaria has been met with difficulty. The advent of high-throughput technologies, coupled with systems biological methods of data analysis, has enabled researchers to interrogate ...
DOI:
10.1016/j.vaccine.2015.03.072
PubMed:
25858860
PubMed Central:
PMC4581890

6. Beyond adjuvants: Immunomodulation strategies to enhance T cell immunity

Author:
Kamphorst, Alice O.; Araki, Koichi; Ahmed, Rafi
Source:
Vaccine 2015 v.33 pp. B21
ISSN:
0264-410X
Subject:
vaccination,   etc   ; T-lymphocytes; adjuvants; immune response; immunosuppression; interleukin-2; monitoring; neoplasms; pathogens; receptors; vaccines;     Show all 11 Subjects
Abstract:
... Engagement of CD8T cells is a crucial aspect of immune responses to pathogens and in tumor surveillance. Nonetheless most vaccination strategies with common adjuvants fail to elicit long-term memory CD8T cells. Increased knowledge on the cellular and molecular requirements for CD8T cell activation has unveiled new opportunities to directly modulate CD8T cells to generate optimal responses. During ...
DOI:
10.1016/j.vaccine.2014.12.082
PubMed:
26022562
PubMed Central:
PMC4449453

7. Infrared thermography detects febrile and behavioural responses to vaccination of weaned piglets

Author:
Cook, N. J.; Chabot, B.; Lui, T.; Bench, C. J.; Schaefer, A. L.
Source:
Animal 2015 v.9 no.2 pp. 339-346
ISSN:
1751-732X
Subject:
vaccination,   etc   ; barns; biomarkers; cameras; immune response; models; monitoring; piglets; screening; swine diseases; temperature; thermography; thermoregulation; vaccines;     Show all 14 Subjects
Abstract:
... An automated, non-invasive system for monitoring of thermoregulation has the potential to mitigate swine diseases through earlier detection. Measurement of radiated temperature of groups of animals by infrared thermography (IRT) is an essential component of such a system. This study reports on the feasibility of monitoring the radiated temperature of groups of animals as a biomarker of immune resp ...
DOI:
10.1017/S1751731114002481
PubMed:
25274013
PubMed Central:
PMC4299536

8. Evaluation of phenotypic factors for anti-rabies antibody in vaccinated pet dogs

Author:
Savaliya, Bhumika F.; Mathakiya, R. A.; Bhanderi, B. B.; Jhala, M. K.
Source:
VirusDis. 2015 v.26 no.4 pp. 282-287
ISSN:
2347-3584
Subject:
vaccination,   etc   ; analysis of variance; antibodies; blood serum; dogs; enzyme-linked immunosorbent assay; humans; immune response; pets; phenotype; rabies; vaccines;     Show all 12 Subjects
Abstract:
... The aims of this study were to investigate various factors associated with protective anti-rabies antibody status (0.5 EU/ml) in vaccinated pet dogs and anti-rabies antibody status in unvaccinated stray dogs. One hundred and seven serum samples were collected from vaccinated pet dogs, out of these 58 (62.36 %) dogs showed antibody titre above 0.5 EU/ml. All the dogs were divided into different gro ...
DOI:
10.1007/s13337-015-0284-6
PubMed:
26645039
PubMed Central:
PMC4663715

9. Prospects in Mycobacterium bovis Bacille Calmette et Guérin (BCG) vaccine diversity and delivery: Why does BCG fail to protect against tuberculosis?

Author:
Moliva, Juan I.; Turner, Joanne; Torrelles, Jordi B.
Source:
Vaccine 2015 v.33 no.39 pp. 5035-5041
ISSN:
0264-410X
Subject:
vaccination,   etc   ; Mycobacterium bovis; Mycobacterium tuberculosis; adults; childhood; clinical trials; drug resistance; drug therapy; humans; immune response; sterilizing; tuberculosis; vaccines;     Show all 13 Subjects
Abstract:
... Mycobacterium tuberculosis (M.tb) infection leads to active tuberculosis (TB), a disease that kills one human every 18s. Current therapies available to combat TB include chemotherapy and the preventative vaccine Mycobacterium bovis Bacille Calmette et Guérin (BCG). Increased reporting of drug resistant M.tb strains worldwide indicates that drug development cannot be the primary mechanism for eradi ...
DOI:
10.1016/j.vaccine.2015.08.033
PubMed:
26319069
PubMed Central:
PMC4577463

10. A microneedle patch containing measles vaccine is immunogenic in non-human primates

Author:
Edens, Chris; Collins, Marcus L.; Goodson, James L.; Rota, Paul A.; Prausnitz, Mark R.
Source:
Vaccine 2015 v.33 no.37 pp. 4712-4718
ISSN:
0264-410X
Subject:
vaccination,   etc   ; Macaca mulatta; erythema; freeze drying; immune response; neutralization; neutralizing antibodies; subcutaneous injection; temperature; thermal stability; vaccines;     Show all 11 Subjects
Abstract:
... Very high vaccination coverage is required to eliminate measles, but achieving high coverage can be constrained by the logistical challenges associated with subcutaneous injection. To simplify the logistics of vaccine delivery, a patch containing micron-scale polymeric needles was formulated to encapsulate the standard dose of measles vaccine (1000 TCID50) and the immunogenicity of the microneedle ...
DOI:
10.1016/j.vaccine.2015.02.074
PubMed:
25770786
PubMed Central:
PMC4554796

11. The weight of obesity on the human immune response to vaccination

Author:
Painter, Scott D.; Ovsyannikova, Inna G.; Poland, Gregory A.
Source:
Vaccine 2015 v.33 no.36 pp. 4422-4429
ISSN:
0264-410X
Subject:
vaccination,   etc   ; adipocytes; adipose tissue; body mass index; humans; immune response; immune system; infectious diseases; lipids; obesity; patients; risk; vaccines;     Show all 13 Subjects
Abstract:
... Despite the high success of protection against several infectious diseases through effective vaccines, some sub-populations have been observed to respond poorly to vaccines, putting them at increased risk for vaccine-preventable diseases. In particular, the limited data concerning the effect of obesity on vaccine immunogenicity and efficacy suggests that obesity is a factor that increases the like ...
DOI:
10.1016/j.vaccine.2015.06.101
PubMed:
26163925
PubMed Central:
PMC4547886

12. Self-administration of intranasal influenza vaccine: Immunogenicity and volunteer acceptance

Author:
Burgess, Timothy H.; Murray, Clinton K.; Bavaro, Mary F.; Landrum, Michael L.; O’Bryan, Thomas A.; Rosas, Jessica G.; Cammarata, Stephanie M.; Martin, Nicholas J.; Ewing, Daniel; Raviprakash, Kanakatte; Mor, Deepika; Zell, Elizabeth R.; Wilkins, Kenneth J.; Millar, Eugene V.
Source:
Vaccine 2015 v.33 no.32 pp. 3894-3899
ISSN:
0264-410X
Subject:
vaccination,   etc   ; antibodies; geometry; health promotion; health services; humans; immune response; influenza; military personnel; randomized clinical trials; vaccines;     Show all 11 Subjects
Abstract:
... In outbreak settings, mass vaccination strategies could maximize health protection of military personnel. Self-administration of live attenuated influenza vaccine (LAIV) may be a means to vaccinate large numbers of people and achieve deployment readiness while sparing the use of human resources.A phase IV, open-label, randomized controlled trial evaluating the immunogenicity and acceptance of self ...
DOI:
10.1016/j.vaccine.2015.06.061
PubMed:
26117150
PubMed Central:
PMC5828152

13. In situ vaccination by radiotherapy to improve responses to anti-CTLA-4 treatment

Author:
Vanpouille-Box, Claire; Pilones, Karsten A.; Wennerberg, Erik; Formenti, Silvia C.; Demaria, Sandra
Source:
Vaccine 2015 v.33 no.51 pp. 7415-7422
ISSN:
0264-410X
Subject:
vaccination,   etc   ; T-lymphocytes; adhesion; animal models; antibodies; antigens; chemokines; cytotoxicity; death; dendritic cells; immune response; ionizing radiation; irradiation; neoplasm cells; neoplasms; patients; radiotherapy; receptors; vaccines;     Show all 19 Subjects
Abstract:
... Targeting immune checkpoint receptors has emerged as an effective strategy to induce immune-mediated cancer regression in the subset of patients who have significant pre-existing anti-tumor immunity. For the remainder, effective anti tumor responses may require vaccination. Radiotherapy, traditionally used to achieve local tumor control, has acquired a new role, that of a partner for immunotherapy ...
DOI:
10.1016/j.vaccine.2015.05.105
PubMed:
26148880
PubMed Central:
PMC4684480

14. Development of vaccine-induced immunity against TRT in turkeys depends remarkably on the level of maternal antibodies and the age of birds on the day of vaccination

Author:
Smialek, Marcin; Pestka, Daria; Tykalowski, Bartlomiej; Stenzel, Tomasz; Koncicki, Andrzej
Source:
BMC veterinary research 2015 v.11 no.1 pp. 28
ISSN:
1746-6148
Subject:
vaccination,   etc   ; Avian metapneumovirus; antibodies; blood serum; immune response; immunoglobulin Y; lymphocytes; maternal immunity; mucosa; poultry industry; poults; turkeys; vaccines; virus replication;     Show all 14 Subjects
Abstract:
... BACKGROUND: Avian Metapneumovirus (aMPV) infections are a huge economical issue for the poultry industry worldwide. Although maternal antibodies do not protect turkey poults against turkey rhinotracheitis (TRT), almost no studies have been conducted so far regarding the impact of these antibodies on vaccine induced immunity development against aMPV infection. We conducted four experiments on comme ...
DOI:
10.1186/s12917-015-0345-5
PubMed:
25889279
PubMed Central:
PMC4326515

15. Evaluation of biological safety in vitro and immunogenicity in vivo of recombinant Escherichia coli Shiga toxoids as candidate vaccines in cattle

Author:
Kerner, Katharina; Bridger, Philip S; Köpf, Gabriele; Fröhlich, Julia; Barth, Stefanie; Willems, Hermann; Bauerfeind, Rolf; Baljer, Georg; Menge, Christian
Source:
Veterinary research 2015 v.46 no.1 pp. 38
ISSN:
1297-9716
Subject:
vaccination,   etc   ; T-lymphocytes; calves; enterohemorrhagic Escherichia coli; humans; ileum; immune response; infectious diseases; interleukin-4; macrophages; messenger RNA; neutralizing antibodies; site-directed mutagenesis; toxoids; vaccines; verotoxins;     Show all 16 Subjects
Abstract:
... Cattle are the most important reservoir for enterohemorrhagic Escherichia coli (EHEC), a subset of shigatoxigenic E. coli (STEC) capable of causing life-threatening infectious diseases in humans. In cattle, Shiga toxins (Stx) suppress the immune system thereby promoting long-term STEC shedding. First infections of animals at calves’ age coincide with the lack of Stx-specific antibodies. We hypothe ...
DOI:
10.1186/s13567-015-0175-2
PubMed:
25889651
PubMed Central:
PMC4391668

16. What’s in SWAP? Abundance of the principal constituents in a soluble extract of Schistosoma mansoni revealed by shotgun proteomics

Author:
Neves, Leandro Xavier; Sanson, Ananda Lima; Wilson, R. Alan; Castro-Borges, William
Source:
Parasites & vectors 2015 v.8 no.1 pp. 337
ISSN:
1756-3305
Subject:
vaccination,   etc   ; Schistosoma mansoni; adults; antigens; cytoskeletal proteins; databases; disease diagnosis; immune response; pH; parasites; peptides; protein synthesis; proteomics; spectral analysis; spectrometers; synergism; trypsin; ultra-performance liquid chromatography; vaccines;     Show all 19 Subjects
Abstract:
... BACKGROUND: The soluble antigen preparation of adult schistosomes (SWAP) has often been used to probe host responses against these blood-dwelling parasites. Despite its long-established use there is limited knowledge about its composition. The information we provide here on the molecular composition of SWAP may contribute as a guide for a rational selection of antigenic targets. METHODS: Label-fre ...
DOI:
10.1186/s13071-015-0943-x
PubMed:
26088647
PubMed Central:
PMC4484702

17. Methylglycol chitosan and a synthetic TLR4 agonist enhance immune responses to influenza vaccine administered sublingually

Author:
Spinner, Justin L.; Oberoi, Hardeep S.; Yorgensen, Yvonne M.; Poirier, Danielle S.; Burkhart, David J.; Plante, Martin; Evans, Jay T.
Source:
Vaccine 2015 v.33 no.43 pp. 5845-5853
ISSN:
0264-410X
Subject:
vaccination,   etc   ; Orthomyxoviridae; Toll-like receptor 4; adjuvants; agonists; blood serum; chitosan; death; immune response; immunoglobulin A; immunoglobulin G; influenza; mice; mucosal immunity; vaccines; viruses;     Show all 16 Subjects
Abstract:
... Influenza is a vaccine-preventable contagious respiratory illness caused by influenza (flu) viruses which can lead to hospitalization and sometimes even death. Current flu vaccines delivered intramuscularly (IM) or intradermally (ID) are less effective at eliciting protective mucosal immune responses and vaccines delivered intranasally (IN) possess potential safety concerns. Sublingual (SL) vaccin ...
DOI:
10.1016/j.vaccine.2015.08.086
PubMed:
26392012
PubMed Central:
PMC4609623

18. Sex difference in immune response to vaccination: A participant-level meta-analysis of randomized trials of IMVAMUNE® smallpox vaccine

Author:
Troy, Jesse D.; Hill, Heather R.; Ewell, Marian G.; Frey, Sharon E.
Source:
Vaccine 2015 v.33 no.41 pp. 5425-5431
ISSN:
0264-410X
Subject:
vaccination,   etc   ; Variola virus; bioterrorism; enzyme-linked immunosorbent assay; geometry; immune response; men; meta-analysis; models; research programs; vaccines; women; United States;     Show all 13 Subjects
Abstract:
... Previous research shows immune response to vaccination differs by sex but this has not been explored for IMVAMUNE®, a replication-deficient smallpox vaccine developed in response to the potential for bioterrorism using smallpox.We conducted a participant-level meta-analysis (N=275, 136 men, 139 women) of 3 randomized trials of IMVAMUNE conducted at 13 centers in the US through a federally-funded e ...
DOI:
10.1016/j.vaccine.2015.08.032
PubMed:
26319063
PubMed Central:
PMC4581981

19. Recombinant Bacillus subtilis Spores Elicit Th1/Th17-Polarized Immune Response in a Murine Model of Helicobacter pylori Vaccination

Author:
Stasiłojć, Małgorzata; Hinc, Krzysztof; Peszyńska-Sularz, Grażyna; Obuchowski, Michał; Iwanicki, Adam
Source:
Molecular biotechnology 2015 v.57 no.8 pp. 685-691
ISSN:
1073-6085
Subject:
vaccination,   etc   ; Bacillus subtilis; Helicobacter acinonychis; Helicobacter pylori; adjuvants; aluminum hydroxide; animal models; antigens; germination; immune response; interleukin-2; mice; oral administration; splenocytes; spores; vaccines; vegetative cells;     Show all 17 Subjects
Abstract:
... Current progress in research on vaccines against Helicobacter pylori emphasizes the significance of eliciting the Th1/Th17-polarized immune response. Such polarization can be achieved by selection of appropriate antigen and adjuvant. In this study, we wanted to check the polarization of the immune response elicited by UreB protein of Helicobacter acinonychis delivered by recombinant Bacillus subti ...
DOI:
10.1007/s12033-015-9859-0
PubMed:
25779639
PubMed Central:
PMC4503858

20. Safety and immunogenicity of candidate vaccine M72/AS01E in adolescents in a TB endemic setting

Author:
Penn-Nicholson, Adam; Geldenhuys, Hennie; Burny, Wivine; van der Most, Robbert; Day, Cheryl L.; Jongert, Erik; Moris, Philippe; Hatherill, Mark; Ofori-Anyinam, Opokua; Hanekom, Willem; Bollaerts, Anne; Demoitie, Marie-Ange; Kany Luabeya, Angelique Kany; De Ruymaeker, Evi; Tameris, Michele; Lapierre, Didier; Scriba, Thomas J.
Source:
Vaccine 2015 v.33 no.32 pp. 4025-4034
ISSN:
0264-410X
Subject:
vaccination,   etc   ; CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; Mycobacterium tuberculosis; adolescents; antibodies; immune response; interferon-gamma; interleukin-17; natural killer cells; placebos; staining; tuberculosis; vaccines;     Show all 14 Subjects
Abstract:
... Vaccination that prevents tuberculosis (TB) disease, particularly in adolescents, would have the greatest impact on the global TB epidemic. Safety, reactogenicity and immunogenicity of the vaccine candidate M72/AS01E was evaluated in healthy, HIV-negative adolescents in a TB endemic region, regardless of Mycobacterium tuberculosis (M.tb) infection status.In a phase II, double-blind randomized, con ...
DOI:
10.1016/j.vaccine.2015.05.088
PubMed:
26072017
PubMed Central:
PMC5845829