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1. Effects of Long-Term Exposure to Free Nε-(Carboxymethyl)lysine on Rats Fed a High-Fat Diet

Author:
Li, Mei; Zeng, Maomao; He, Zhiyong; Zheng, Zongping; Qiu, Fang; Tao, Guanjun; Zhang, Shuang; Chen, Jie
Source:
Journal of agricultural and food chemistry 2015 v.63 no.51 pp. 10995-11001
ISSN:
0021-8561
Subject:
rats,   etc   ; advanced glycation end products; binding proteins; blood glucose; blood serum; body weight; chronic diseases; chronic exposure; energy expenditure; fasting; foods; heart; high fat diet; human health; kidneys; liver; long term effects; low density lipoprotein cholesterol; lysine; males; muscles; pancreas; risk factors; risk groups; spleen; tissues;     Show all 26 Subjects
Abstract:
... Recently correlation studies between dietary advanced glycation end products (AGEs) and the progression of chronic diseases have attracted much attention. To explore the impact of dietary AGEs on the health risk of people consuming a high-fat diet (HFD), male Sprague–Dawley rats were used as the research subject. Under HFD, free Nε-(carboxymethyl)lysine (CML, a major AGE, 60 mg/kg body weight/day) ...
DOI:
10.1021/acs.jafc.5b05750

2. LC–ESI–MS/MS analysis of Asparagus racemosus Willd. roots and its protective effects against t-BHP induced oxidative stress in rats

Author:
Jayashree, G.V.; Kumar, Kandikattu Hemanth; Krupashree, K.; Rachitha, P.; Khanum, Farhath
Source:
Industrial crops and products 2015 v.78 pp. 102-109
ISSN:
0926-6690
Subject:
rats,   etc   ; Asparagus racemosus; DNA; alanine transaminase; antioxidants; aspartate transaminase; blood serum; body weight; dietary supplements; flavonoids; gel electrophoresis; hepatoprotective effect; histopathology; leukocytes; lipid peroxidation; liver; oxidative stress; protein products; roots; saponins; superoxide dismutase; tissues;     Show all 22 Subjects
Abstract:
... LC–ESI–MS/MS analysis of Asparagus racemosus roots methanolic extract (AME) showed the presence of flavonoids, saponins and shatavarins. Effectiveness of A. racemosus extract in preventing tert-Butyl hydroperoxide (t-BHP) induced damage was investigated. Wistar rats treated with 1mmol/kg body weight (b/wt) t-BHP induced oxidative stress with an increase in serum alanine aminotransferase (ALT) and ...
DOI:
10.1016/j.indcrop.2015.10.024

3. Flavonoids and phenylethanoid glycosides from Lippia nodiflora as promising antihyperuricemic agents and elucidation of their mechanism of action

Author:
Cheng, Lee-Chuen; Murugaiyah, Vikneswaran; Chan, Kit-Lam
Source:
Journal of ethnopharmacology 2015 v.176 pp. 485-493
ISSN:
0378-8741
Subject:
rats,   etc   ; Oriental traditional medicine; Phyla nodiflora; active ingredients; acute toxicity; blood serum; computers; diuresis; dose response; enzyme inhibition; excretion; flavonoids; glycosides; hyperuricemia; liver; mechanism of action; methanol; molecular models; pain; potassium; uric acid; verbascoside; xanthine dehydrogenase; xanthine oxidase;     Show all 24 Subjects
Abstract:
... Lippia nodiflora has been traditionally used in the Ayurvedic, Unani, and Sidha systems, as well as Traditional Chinese Medicine (TCM) for the treatment of knee joint pain, lithiasis, diuresis, urinary disorder and swelling.The present study aims to investigate the antihyperuricemic effect of the L. nodiflora methanol extract, fractions, and chemical constituents and their mechanism of action in t ...
DOI:
10.1016/j.jep.2015.11.025

4. Li-Gan-Shi-Liu-Ba-Wei-San improves non-alcoholic fatty liver disease through enhancing lipid oxidation and alleviating oxidation stress

Author:
Jiang, Youzhao; Chen, Liu; Wang, Hui; Narisi, Bao; Chen, Bing
Source:
Journal of ethnopharmacology 2015 v.176 pp. 499-507
ISSN:
0378-8741
Subject:
rats,   etc   ; IKappaB kinase; Oriental traditional medicine; animal models; aspartate transaminase; beta oxidation; blood serum; cholesterol; fatty liver; free fatty acids; high fat diet; human cell lines; inducible nitric oxide synthase; lipid peroxidation; liver; liver function; malondialdehyde; oxidative stress; peroxisome proliferator-activated receptors; superoxide dismutase; transcription factor NF-kappa B; triacylglycerols;     Show all 22 Subjects
Abstract:
... Mongolian medicine is an important constituent of traditional Chinese medicine. Its representative prescription, Li-Gan-Shi-Liu-Ba-Wei-San (LGSLBWS), is widely used for long-term treatment of chronic liver disease and nonalcoholic fatty liver disease (NAFLD).This study explored the effects and mechanism of LGSLBWS on NAFLD.NAFLD rat model was established with high-fat diet. The effects of LGSLBWS ...
DOI:
10.1016/j.jep.2015.11.019

5. Chronic iron overload in rats increases vascular reactivity by increasing oxidative stress and reducing nitric oxide bioavailability

Author:
Marques, Vinicius Bermond; Nascimento, Tatiani Botelho; Ribeiro, Rogério Faustino; Broseghini-Filho, Gilson Brás; Rossi, Emilly Martinelly; Graceli, Jones Bernades; dos Santos, Leonardo
Source:
Life sciences 2015 v.143 pp. 89-97
ISSN:
0024-3205
Subject:
rats,   etc   ; NAD(P)H oxidase (H2O2-forming); NADP (coenzyme); allopurinol; animal models; bioavailability; blood serum; cardiomyopathy; catalase; humans; in vitro studies; iron; iron overload; liver; malondialdehyde; nitric oxide; oxidative stress; renin-angiotensin system; superoxide anion; transferrin;     Show all 20 Subjects
Abstract:
... Iron overload in animal models and humans increases oxidative stress and induces cardiomyopathy. It has been suggested that the vasculature is also damaged, but the impacts on vascular reactivity and the underlying mechanisms remain poorly understood. In this study, we aimed to identify possible changes in the vascular reactivity of aortas from iron overloaded rats and investigate the underlying m ...
DOI:
10.1016/j.lfs.2015.10.034

6. Ethyl acetate fraction of Aframomum melegueta fruit ameliorates pancreatic β-cell dysfunction and major diabetes-related parameters in a type 2 diabetes model of rats

Author:
Mohammed, Aminu; Koorbanally, Neil Anthony; Islam, Md. Shahidul
Source:
Journal of ethnopharmacology 2015 v.175 pp. 518-527
ISSN:
0378-8741
Subject:
rats,   etc   ; Aframomum melegueta; blood glucose; blood lipids; blood serum; body weight; ethyl acetate; fructose; fruits; glucose tolerance; glycemic effect; glycogen; histopathology; insulin; insulin resistance; intraperitoneal injection; islets of Langerhans; leaves; liver; models; noninsulin-dependent diabetes mellitus; streptozotocin; traditional medicine; Western Africa;     Show all 24 Subjects
Abstract:
... In West Africa, various preparations of the fruit, seed and leaf of Aframomum melegueta K. Schum. are reputably used for the management of diabetes mellitus (DM) and other metabolic disorders. The present study evaluated the anti-diabetic effects of A. melegueta ethyl acetate fraction (AMEF) from fruit ethanolic extract in a type 2 diabetes (T2D) model of rats.T2D was induced in rats by feeding a ...
DOI:
10.1016/j.jep.2015.10.011

7. Extract of Woodfordia fruticosa flowers ameliorates hyperglycemia, oxidative stress and improves β-cell function in streptozotocin–nicotinamide induced diabetic rats

Author:
Arya, Aditya; Jamil Al-Obaidi, Mazen M.; Karim, Rustini Binti; Taha, Hairin; Khan, Ataul Karim; Shahid, Nayiar; Sayem, Abu Sadat; Looi, Chung Yeng; Mustafa, Mohd Rais; Mohd, Mustafa Ali; Ali, Hapipah Mohd
Source:
Journal of ethnopharmacology 2015 v.175 pp. 229-240
ISSN:
0378-8741
Subject:
rats,   etc   ; Ayurvedic medicine; Western blotting; Woodfordia fruticosa; acute toxicity; animal disease models; antioxidants; apoptosis; blood glucose; blood serum; body weight; c-peptide; diabetes; flowers; glibenclamide; glucose; glucose transporters; glycemic effect; glycogen; histopathology; hyperglycemia; immunohistochemistry; islets of Langerhans; kidneys; liver; oxidative stress; protein synthesis; streptozotocin; tissues; India;     Show all 30 Subjects
Abstract:
... The art of Ayurveda and the traditional healing system in India have reflected the ethnomedicinal importance of the plant Woodfordia fruticosa Kurtz, which demonstrates its vast usage in the Ayurvedic preparations as well as in the management of diabetes by the traditional healers.The study aimed to ascertain the antidiabetic potential of W. fruticosa flower methanolic extract (WF) on Streptozotoc ...
DOI:
10.1016/j.jep.2015.08.057

8. Reduced Fgf10/Fgfr2 and androgen receptor (AR) in anorectal malformations male rats induced by di-n-butyl phthalate (DBP): A study on the local and systemic toxicology of DBP

Author:
Jiang, Jun-Tao; Xu, Hong-Li; Zhu, Yi-Ping; Wood, Kristofer; Li, En-Hui; Sun, Wen-Lan; Yuan, Quan; Xu, Dong-Liang; Liu, Zhi-Hong; Zhao, Wei; Xia, Shu-Jie
Source:
Toxicology 2015 v.338 pp. 77-85
ISSN:
0300-483X
Subject:
rats,   etc   ; abnormal development; androgen receptors; blood serum; body weight; congenital abnormalities; dibutyl phthalate; heart; histopathology; kidneys; liver; males; messenger RNA; models; neonates; pathogenesis; photographs; progeny; rectum; spleen; staining; testosterone; toxicology;     Show all 23 Subjects
Abstract:
... Previous study have demonstrated that not only the anorectal development but also the general conditions of anorectal malformations (ARMs) male rats are severely affected by di-n-butyl phthalate (DBP) maternal exposure. However, the mechanisms underlying DBP-induced congenital defects remain elusive. Reportedly, Fgf10/Fgfr2 and androgen receptor (AR) are pivotal for the development of multiple org ...
DOI:
10.1016/j.tox.2015.10.006

9. Antihyperlipidaemic effects of oxyresveratrol-containing Ramulus mori ethanol extract in rats fed a high-cholesterol diet

Author:
Hwang, Dahyun; Jo, Sung-Pil; Lee, Jiyun; Kim, Jeong-Keun; Kim, Ki-Hyun; Lim, Young-Hee
Source:
Journal of functional foods 2015 v.19 pp. 353-362
ISSN:
1756-4646
Subject:
rats,   etc   ; Western blotting; animal models; blood lipids; blood serum; cholesterol; cholesterol 7alpha-monooxygenase; cholesterol acyltransferase; coronary vessels; droplets; ethanol; foam cells; functional foods; genes; high fat diet; hyperlipidemia; liver; low density lipoprotein; reverse transcriptase polymerase chain reaction; risk; tissues;     Show all 21 Subjects
Abstract:
... The antihyperlipidaemic effect of an ethanol extract of Ramulus mori containing a high concentration of oxyresveratrol (ERMO) was investigated in a high-cholesterol diet (HCD)-fed rat model. Cholesterol metabolism-related genes and proteins, such as lecithin cholesterol acyltransferase (LCAT), low-density lipoprotein receptor (LDLR), cholesterol 7α-hydroxylase (CYP7A1), 3-hydroxy-3-methylglutaryl ...
DOI:
10.1016/j.jff.2015.09.039

10. Control of liver glucokinase activity: A potential new target for incretin hormones?

Author:
Francini, Flavio; Massa, María Laura; Polo, Mónica Patricia; Villagarcía, Hernán; Castro, María Cecilia; Gagliardino, Juan José
Source:
Peptides 2015 v.74 pp. 57-63
ISSN:
0196-9781
Subject:
rats,   etc   ; agonists; blood glucose; blood serum; enzyme activity; fructose; glucagon-like peptide 1; glucokinase; glucose tolerance; hepatocytes; human cell lines; hyperinsulinemia; hypertriglyceridemia; insulin; liver; messenger RNA; pathogenesis; protein content; protein synthesis; secretin; triacylglycerols;     Show all 21 Subjects
Abstract:
... We tested the exendin-4 and des-fluoro-sitagliptin effects on fructose-induced increase in liver glucokinase activity in rats with impaired glucose tolerance and the exendin-4 effect on glucokinase activity in HepG2 cells incubated with fructose in the presence/absence of exendin-9-39. After 3 weeks of in vivo fructose administration we measured: (1) serum glucose, insulin and triglyceride levels; ...
DOI:
10.1016/j.peptides.2015.10.006

11. Evaluation of serum and liver toxicokinetics for furan and liver DNA adduct formation in male Fischer 344 rats

Author:
Churchwell, M.I.; Scheri, R.C.; Von Tungeln, L.S.; Gamboa da Costa, G.; Beland, F.A.; Doerge, D.R.
Source:
Food and chemical toxicology 2015 v.86 pp. 1-8
ISSN:
0278-6915
Subject:
rats,   etc   ; DNA; amino acids; animal models; blood serum; cooked foods; food processing; genotoxicity; hepatotoxicity; liver; liver neoplasms; males; nucleotides; pharmacokinetics; portal vein; toxicology;     Show all 16 Subjects
Abstract:
... Furan is a food processing contaminant found in many common cooked foods that induces liver toxicity and liver cancer in animal models treated with sufficient doses. The metabolism of furan occurs primarily in the liver where CYP 2E1 produces a highly reactive bis-electrophile, cis-2-butene-1,4-dial (BDA). BDA reacts with nucleophilic groups in amino acids and DNA in vitro to form covalent adducts ...
DOI:
10.1016/j.fct.2015.08.029

12. Metabolic response to subacute and subchronic iron overload in a rat model

Author:
Adham, Khadiga G.; Farhood, Manal H.; Daghestani, Maha H.; Aleisa, Nadia A.; Alkhalifa, Ahlam A.; El Amin, Maha H.; Virk, Promy; Al-Obeid, Mai A.; Al-Humaidhi, Eman M. H.
Source:
Acta biologica Hungarica 2015 v.66 no.4 pp. 361-373
ISSN:
1588-256X
Subject:
rats,   etc   ; alanine transaminase; anemia; animal models; aspartate transaminase; binding capacity; blood serum; corticosterone; energy metabolism; enzyme activity; erythrocytes; erythropoiesis; glycolysis; hematocrit; hemoglobin; iron; iron overload; lactic acid; leukocytes; liver; metabolites; risk; toxicity; transferrin;     Show all 24 Subjects
Abstract:
... One of the common causes of iron overload is excessive iron intake in cases of iron-poor anemia, where iron saccharate complex (ISC) is routinely used to optimize erythropoiesis. However, non-standardized ISC administration could entail the risk of iron overload. To induce iron overload, Wistar rats were intraperitoneally injected with subacute (0.2 mg kg ⁻¹) and subchronic (0.1 mg kg ⁻¹) overdose ...
DOI:
10.1556/018.66.2015.4.1

13. Oxidative stress associated with pathological lesions in the liver of rats experimentally infected by Fasciola hepatica

Author:
Bottari, Nathieli B.; Mendes, Ricardo E.; Lucca, Neuber J.; Schwertz, Claiton I.; Henker, Luan C.; Olsson, Débora C.; Piva, Manoela M.; Sangoi, Manuela; Campos, Luízi P.; Moresco, Rafael N.; Jaques, Jeandre A.; Da silva, Aleksandro S.
Source:
Experimental parasitology 2015 v.159 pp. 24-28
ISSN:
0014-4894
Subject:
rats,   etc   ; Fasciola hepatica; advanced oxidation protein products; antioxidant activity; antioxidants; bile ducts; blood serum; free radicals; hepatitis; histopathology; hyperplasia; lipid peroxidation; liver; nitrates; nitrites; nitrogen oxides; oxidation; oxidative stress; parasites; thiobarbituric acid-reactive substances;     Show all 20 Subjects
Abstract:
... The aim of this study was to analyze the antioxidant status and oxidative profile in serum and liver of rats experimentally infected with Fasciola hepatica and its relationship with pathological findings. Twenty-four rats were divided into two groups: group A consisted of 12 healthy rats and group B of 12 rats infected orally with 20 metacercaria of F. hepatica. At days 20 and 150 post-infection ( ...
DOI:
10.1016/j.exppara.2015.08.008

14. Pharmacological and histological examination of atorvastatin-PVP K30 solid dispersions

Author:
Jahangiri, Azin; Barzegar-Jalali, Mohammad; Garjani, Alireza; Javadzadeh, Yousef; Hamishehkar, Hamed; Afroozian, Arash; Adibkia, Khosro
Source:
Powder technology 2015 v.286 pp. 538-545
ISSN:
0032-5910
Subject:
rats,   etc   ; X-ray diffraction; blood lipids; blood serum; cholesterol; crystal structure; differential scanning calorimetry; dispersions; drugs; evaporation; fatty liver; high fat diet; histology; hypercholesterolemia; in vivo studies; liver; oral administration; polyvinylpyrrolidone; powders; scanning electron microscopy; solubility; solvents; therapeutics;     Show all 23 Subjects
Abstract:
... The objective of the present study was to investigate the pharmacological efficiency of orally administered atorvastatin calcium (ATV) solid dispersions (SDs). SDs of ATV were prepared using polyvinylpyrrolidone K30 (PVP) through the solvent evaporation method. Physicochemical characteristics of the prepared formulations were assessed benefitting scanning electron microscopy (SEM), differential sc ...
DOI:
10.1016/j.powtec.2015.08.047

15. Protective effect of gastrodin on bile duct ligation-induced hepatic fibrosis in rats

Author:
Zhao, Shuangshuang; Li, Naren; Zhen, Yongzhan; Ge, Maoxu; Li, Yi; Yu, Bin; He, Hongwei; Shao, Rong-guang
Source:
Food and chemical toxicology 2015 v.86 pp. 202-207
ISSN:
0278-6915
Subject:
rats,   etc   ; alanine transaminase; apoptosis; aspartate transaminase; bile; bile acids; bile ducts; bilirubin; blood serum; collagen; drinking water; drugs; fibrosis; high density lipoprotein; histopathology; hydroxyproline; immunohistochemistry; inflammation; liver; liver cirrhosis; necrosis; nitric oxide; oxidation; oxidative stress; protective effect; superoxide dismutase; tissues; toxicology; transcription factor NF-kappa B; urine;     Show all 30 Subjects
Abstract:
... Gastrodin has been showed to possess many beneficial physiological functions, including protection against inflammation and oxidation and apoptosis. Studies showed inflammation and oxidation play important roles in producing liver damage and initiating hepatic fibrogenesis. However, it has not been reported whether gastrodin has a protective effect against hepatic fibrosis or not. This is first ev ...
DOI:
10.1016/j.fct.2015.10.010

16. Protective effect of peppermint and parsley leaves oils against hepatotoxicity on experimental rats

Author:
Khalil, Ayman F.; Elkatry, Haiam O.; El Mehairy, Hanaa F.
Source:
Annals of agricultural science 2015 v.60 no.2 pp. 353-359
ISSN:
0570-1783
Subject:
rats,   etc   ; Mentha piperita nothosubsp. piperita; Petroselinum crispum; adverse effects; alpha-pinene; antioxidant activity; blood serum; carbon tetrachloride; creatinine; free radical scavengers; gas chromatography-mass spectrometry; glutathione; hepatoprotective effect; hepatotoxicity; high density lipoprotein cholesterol; kidney function tests; lipid peroxidation; liver; low density lipoprotein cholesterol; malondialdehyde; menthol; menthone; oils; parsley; peppermint oil; superoxide dismutase; triacylglycerols; urea nitrogen; uric acid;     Show all 29 Subjects
Abstract:
... In the present study, the protective effect of peppermint (Mentha piperita) and parsley (Petroselinum crispum) leaves oils against hepatotoxicity is induced by carbon tetrachloride (CCl4) in experimental rats. GC/MS results indicated that the main components in peppermint oil were menthol (35.9%) and menthone (25.6%), while in parsley oil were α-Pinene (26.6%) and Myristicin (20.3%). Hepatotoxicit ...
DOI:
10.1016/j.aoas.2015.11.004

17. Kojibiose ameliorates arachidic acid-induced metabolic alterations in hyperglycaemic rats

Author:
Moisés Laparra, José; Díez-Municio, Marina; Javier Moreno, F.; Herrero, Miguel
Source:
The British journal of nutrition 2015 v.114 no.9 pp. 1395-1402
ISSN:
1475-2662
Subject:
rats,   etc   ; T-lymphocytes; biomarkers; blood serum; body weight; cholesterol; enzymes; flow cytometry; glucose; liver; macrophages; messenger RNA; phospholipids; prebiotics;     Show all 14 Subjects
Abstract:
... Herein we hypothesise the positive effects of kojibiose (KJ), a prebiotic disaccharide, selected for reducing hepatic expression of inflammatory markers in vivo that could modulate the severity of saturated arachidic acid (ARa)-induced liver dysfunction in hyperglycaemic rats. Animals were fed daily (20 d) with ARa (0·3 mg) together or not with KJ (22 mg approximately 0·5 %, w/w diet). Glucose, to ...
DOI:
10.1017/S0007114515003153
PubMed:
26344377

18. Chronic central leptin infusion modulates the glycemia response to insulin administration in male rats through regulation of hepatic glucose metabolism

Author:
Burgos-Ramos, Emma; Canelles, Sandra; Rodríguez, Amaia; Gómez-Ambrosi, Javier; Frago, Laura M.; Chowen, Julie A.; Frühbeck, Gema; Argente, Jesús; Barrios, Vicente
Source:
Molecular and Cellular Endocrinology 2015 v.415 pp. 157-172
ISSN:
0303-7207
Subject:
rats,   etc   ; blood glucose; blood serum; cytokines; glucose; glucose transporters; glycogen; glycogen synthase kinases; insulin; insulin receptors; leptin; liver; males; metabolism;     Show all 14 Subjects
Abstract:
... Leptin and insulin use overlapping signaling mechanisms to modify hepatic glucose metabolism, which is critical in maintaining normal glycemia. We examined the effect of an increase in central leptin and insulin on hepatic glucose metabolism and its influence on serum glucose levels. Chronic leptin infusion increased serum leptin and reduced hepatic SH-phosphotyrosine phosphatase 1, the associatio ...
DOI:
10.1016/j.mce.2015.08.014

19. Activity and mRNA Levels of Enzymes Involved in Hepatic Fatty Acid Synthesis in Rats Fed Naringenin

Author:
Hashimoto, Toru; Ide, Takashi
Source:
Journal of agricultural and food chemistry 2015 v.63 no.43 pp. 9536-9542
ISSN:
0021-8561
Subject:
rats,   etc   ; blood serum; cholesterol; diet; enzymes; fatty acids; gene expression; lipogenesis; liver; messenger RNA; naringenin; phospholipids; signal transduction; triacylglycerols;     Show all 14 Subjects
Abstract:
... We investigated the physiological activity of naringenin in affecting hepatic lipogenesis and serum and liver lipid levels in rats. Rats were fed diets containing 0, 1, or 2.5 g/kg naringenin for 15 d. Naringenin at a dietary level of 2.5 g/kg significantly decreased the activities and the mRNA levels of various lipogenic enzymes and sterol regulatory element binding protein-1c (SREBP-1c) mRNA lev ...
DOI:
10.1021/acs.jafc.5b03734

20. Hepatoprotective activity of flavonoids from Cichorium glandulosum seeds in vitro and in vivo carbon tetrachloride-induced hepatotoxicity

Author:
Tong, Jing; Yao, Xincheng; Zeng, Hong; Zhou, Gao; Chen, Yuxin; Ma, Bingxin; Wang, Youwei
Source:
Journal of ethnopharmacology 2015 v.174 pp. 355-363
ISSN:
0378-8741
Subject:
rats,   etc   ; Cichorium glandulosum; aerial parts; alanine transaminase; alkaline phosphatase; antioxidant activity; aspartate transaminase; beta-carotene; bilirubin; bleaching; blood serum; carbon; carbon tetrachloride; cytotoxicity; dose response; enzyme activity; ethanol; flavonoids; glutathione; hepatoma; hepatoprotective effect; hepatotoxicity; inhibitory concentration 50; jaundice; lactate dehydrogenase; lipid peroxidation; liver; malondialdehyde; oral administration; porous media; roots; seeds; thiobarbituric acid; thiobarbituric acid-reactive substances; traditional medicine; triacylglycerol lipase; typhoid fever; viability; China;     Show all 39 Subjects
Abstract:
... Cichorium glandulosum Boiss. et Huet was used historically in Uyghur folk medicine. Its roots, seeds, and aerial parts are extensively used by Uyghur residents in Xinjiang to eliminate savda typhoid, dredge and cure obstructive jaundice variety liver disorders.To evaluate the hepatoprotective activity of total flavonoids (TFs) obtained from C. glandulosum seeds against carbon tetrachloride (CCl4)- ...
DOI:
10.1016/j.jep.2015.08.045