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- Wang, Ziyu, et al. Show all 7 Authors
- Biochemical and biophysical research communications 2015 v.464 pp. 774-779
- Allium sativum; apoptosis; garlic; infectious diseases; inflammation; interleukin-1beta; interleukin-6; macrophages; mice; models; reactive oxygen species; respiratory tract diseases; sepsis (infection); spleen; sucrose; survival rate; therapeutics; tumor necrosis factor-alpha
- ... Sepsis is a serious, life-threatening, infectious disease. In this study, we demonstrate that sucrose methyl 3-formyl-4-methylpentanoate (SMFM), a novel natural compound isolated from garlic (Allium sativum L.), markedly enhances survival rates by inhibiting lung inflammation in a cecal ligation and puncture (CLP) experimental polymicrobial sepsis model. SMFM strongly reduced bacterial colony unit ...