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- Vann, Kendra
R.; Sedgeman, Carl A.; Gopas, Jacob; Golan-Goldhirsh, Avi; Osheroff, Neil
- Biochemistry 2015 v.54 no.29 pp. 4531-4541
- Olea europaea, etc ; DNA; DNA damage; DNA topoisomerase (ATP-hydrolysing); Phillyrea latifolia; antineoplastic activity; bark; caffeic acid; chemoprevention; extra-virgin olive oil; humans; leaves; metabolites; metabolomics; oleuropein; olives; oxidants; phytopharmaceuticals; plant extracts; polyphenols; reducing agents; trees; verbascoside; Show all 23 Subjects
- ... Several naturally occurring dietary polyphenols with chemopreventive or anticancer properties are topoisomerase II poisons. To identify additional phytochemicals that enhance topoisomerase II-mediated DNA cleavage, a library of 341 Mediterranean plant extracts was screened for activity against human topoisomerase IIα. An extract from Phillyrea latifolia L., a member of the olive tree family, displ ...
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