PubAg

Main content area

You searched for: Subject "arachidonic acid" Remove constraint Subject: "arachidonic acid" Publication Year 2015 Remove constraint Publication Year: 2015 Text Availability Citation in PubAg Remove constraint Text Availability: Citation in PubAg
Start Over

Search

160  Search Results

« Previous | 1 - 20 of 160 |
Number of results to display per page

Search Results

1. Abnormalities in Plasma Phospholipid Fatty Acid Profiles of Patients with Hepatocellular Carcinoma

Author:
Qiu, Jian-Feng; Zhang, Ke-Lin; Zhang, Xiao-Jing; Hu, Yuan-Jia; Li, Peng; Shang, Chang-Zhen; Wan, Jian-Bo
Source:
Lipids 2015 v.50 no.10 pp. 977-985
ISSN:
0024-4201
Subject:
arachidonic acid,   etc   ; discriminant analysis; diet; linoleic acid; hepatoma; phospholipid fatty acids; fatty acid composition; biomarkers; least squares; fatty acid metabolism; patients; palmitic acid; death; oleic acid; gas chromatography-mass spectrometry;     Show all 15 Subjects
Abstract:
... Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related death worldwide. In the present study, we aimed to profile the possible changes in plasma phospholipid fatty acid composition of HCC patients, and to identify the fatty acid biomarkers that could distinguish HCC patients from healthy controls. A total of 37 plasma samples from healthy controls and HCC patients were c ...
DOI:
10.1007/s11745-015-4060-6

2. Acceptability of Novel Small-Quantity Lipid-Based Nutrient Supplements for Complementary Feeding in a Peri-Urban South African Community

Author:
Rothman, Marinel; Berti, Cristiana; Smuts, Cornelius M.; Faber, Mieke; Covic, Namukolo
ISSN:
0379-5721
Subject:
arachidonic acid,   etc   ; Africans; complementary feeding; complementary foods; dietary supplements; docosahexaenoic acid; focus groups; hedonic scales; infants; lysine; mothers; pastes; phytases; sensory evaluation; sensory properties;     Show all 15 Subjects
Abstract:
... Small-quantity lipid-based nutritional supplements (SQ-LNS) may potentially be used for home fortification in poor settings, where low nutrient-dense complementary foods are commonly used for infant feeding. However, they need to be acceptable to succeed. This study assessed the acceptability of 2 novel, SQ-LNS (A and B) for supplementing complementary foods among infants aged 6 to 12 months in a ...
DOI:
10.1177/0379572115616057

3. A combination of GC-MS and chemometrics reveals metabolic differences between serum and plasma

Author:
Shi, Shuting; Yi, Lunzhao; Yun, Yonghuan; Zhang, Xiaojuan; Liang, Yizeng
Source:
Analytical methods 2015 v.7 no.5 pp. 1751-1757
ISSN:
1759-9679
Subject:
arachidonic acid,   etc   ; blood serum; chemometrics; citric acid; derivatization; gas chromatography-mass spectrometry; glucose; metabolites; metabolomics; models; phosphates; serine; silylation; volunteers;     Show all 14 Subjects
Abstract:
... Blood serum and plasma are the most frequently used biofluids in metabolomics. The primary aim of this study was to ascertain the feasibility of the commonly used gas chromatography-mass spectrometry (GC-MS)-based methoximation followed by silylation with the BSTFA + 1% TMCS (MeOx-TMS) derivatization method, and to reveal the metabolic differences between serum and plasma. Individual variations we ...
DOI:
10.1039/c4ay02477j

4. A Comparison of Growth, Survival, and Fatty Acid Composition of the Lined Seahorse, Hippocampus erectus, Juveniles Fed Enriched Artemia and a Calanoid Copepod, Schmackeria dubia

Author:
Zhang, Dong; Lin, Tingting; Liu, Xin
Source:
Journal of the World Aquaculture Society 2015 v.46 no.6 pp. 608-616
ISSN:
0893-8849
Subject:
arachidonic acid,   etc   ; Artemia; Copepoda; Hippocampus erectus; adverse effects; docosahexaenoic acid; eicosapentaenoic acid; fatty acid composition; fisheries; growth performance; highly unsaturated fatty acids; juveniles; nauplii; survival rate; China;     Show all 15 Subjects
Abstract:
... The purpose of this study was to evaluate the effect of varying dietary levels of highly unsaturated fatty acids (HUFAs) in live prey (Artemia nauplii and a calanoid copepod, Schmackeria dubia) on the growth performance, survival, and fatty acid composition of the lined seahorse, Hippocampus erectus, juveniles. Artemia nauplii were enriched with a commercial product (SS™ 50DE‐microcapsule as HUFA ...
DOI:
10.1111/jwas.12233

5. Altered secretion of selected arachidonic acid metabolites during subclinical endometritis relative to estrous cycle stage and grade of fibrosis in mares

Author:
Gajos, Katarzyna; Kozdrowski, Roland; Nowak, Marcin; Siemieniuch, Marta J.
Source:
Theriogenology 2015 v.84 no.3 pp. 457-466
ISSN:
0093-691X
Subject:
arachidonic acid,   etc   ; breeding; cytokines; diestrus; endometritis; endometrium; fibrosis; histopathology; inflammation; mares; metabolites; neutrophils; pathogens; prostacyclin; secretion; staining;     Show all 16 Subjects
Abstract:
... Mares that fail to become pregnant after repeated breeding, without showing typical signs of clinical endometritis, should be suspected of subclinical endometritis (SE). Contact with infectious agents results in altered synthesis and secretion of inflammatory mediators, including cytokines and arachidonic acid metabolites, and disturbs endometrial functional balance. To address the hypothesis that ...
DOI:
10.1016/j.theriogenology.2015.03.038

6. Analysis of cytochrome P450 metabolites of arachidonic acid by stable isotope probe labeling coupled with ultra high-performance liquid chromatography/mass spectrometry A

Author:
Zhu, Quan-Fei; Hao, Yan-Hong; Liu, Ming-Zhou; Yue, Jiang; Ni, Jian; Yuan, Bi-Feng; Feng, Yu-Qi
Source:
Journal of chromatography 2015 v.1410 pp. 154-163
ISSN:
0021-9673
Subject:
arachidonic acid,   etc   ; blood serum; brain; cytochrome P-450; eicosanoids; heart; inflammation; isomers; liver; mass spectrometry; metabolites; myeloid leukemia; pathogenesis; patients; quantitative analysis; rats; stable isotopes; tissues; ultra-performance liquid chromatography;     Show all 19 Subjects
Abstract:
... Cytochrome P450 metabolites of arachidonic acid (AA) belong to eicosanoids and are potent lipid mediators of inflammation. It is well-known that eicosanoids play an important role in numerous pathophysiological processes. Therefore, quantitative analysis of cytochrome P450 metabolites of AA, including hydroxyeicosatetraenoic acids (HETEs), epoxyeicosatreinoic acids (EETs), and dihydroxyeicosatrien ...
DOI:
10.1016/j.chroma.2015.07.100

7. An in vitro investigation of the actions of reproductive hormones on the cervix of the ewe in the follicular stage: The effects of 17β-estradiol, oxytocin, FSH, and arachidonic acid on the cervical pathway for the synthesis of prostaglandin E2

Author:
Falchi, L.; Scaramuzzi, R.J.
Source:
Theriogenology 2015 v.83 no.6 pp. 1007-1014
ISSN:
0093-691X
Subject:
arachidonic acid,   etc   ; cervix; estradiol; estrous cycle; ewes; explants; follicle-stimulating hormone; immunoblotting; oxytocin; oxytocin receptors; phospholipase A2; prostaglandin synthase; prostaglandins; radioimmunoassays;     Show all 14 Subjects
Abstract:
... During the periovulatory period, the cervix of the ewe relaxes and this mechanism is thought to be mediated by oxytocin and prostaglandin E2 (PGE2) in response to increased concentrations of 17β-estradiol and perhaps FSH. The aim of the study was to determine the in vitro effects of 17β-estradiol, FSH, oxytocin, and arachidonic acid (AA) on the synthesis of PGE2 and on the expression of oxytocin r ...
DOI:
10.1016/j.theriogenology.2014.12.003

8. A novel method for the synthesis of symmetrical triacylglycerols by enzymatic transesterification

Author:
Tang, Wenjia; Wang, Xiaosan; Huang, Jianhua; Jin, Qingzhe; Wang, Xingguo
Source:
Bioresource technology 2015 v.196 pp. 559-565
ISSN:
0960-8524
Subject:
arachidonic acid,   etc   ; enzymatic treatment; ethanolysis; free fatty acids; methodology; palmitates; palmitic acid; temperature; transesterification; triacylglycerols;     Show all 10 Subjects
Abstract:
... A novel two-step enzymatic method is described in this study to synthesize symmetrical triacylglycerols (TAGs) with arachidonic acid (ARA) at the sn-2 position. The processes included the synthesis of 2-monoacylglycerols (2-MAGs) rich in 2-arachidonoylglycerol (2-AG) by enzymatic ethanolysis and the synthesis of symmetrical TAGs by enzymatic transesterification between 2-MAGs and vinyl palmitate. ...
DOI:
10.1016/j.biortech.2015.08.024

9. A novel NAD(P)H‐dependent carbonyl reductase specifically expressed in the thyroidectomized chicken fatty liver: catalytic properties and crystal structure

Author:
Fukuda, Yudai; Sone, Takeki; Sakuraba, Haruhiko; Araki, Tomohiro; Ohshima, Toshihisa; Shibata, Takeshi; Yoneda, Kazunari
Source:
The FEBS journal 2015 v.282 no.20 pp. 3918-3928
ISSN:
1742-464X
Subject:
arachidonic acid,   etc   ; Escherichia coli; NAD (coenzyme); NADP (coenzyme); active sites; amino acid sequences; chickens; crystal structure; ethylene glycol; fatty liver; gene overexpression; genes; mutants; substrate specificity;     Show all 14 Subjects
Abstract:
... A gene encoding a functionally unknown protein that is specifically expressed in the thyroidectomized chicken fatty liver and has a predicted amino acid sequence similar to that of NAD(P)H‐dependent carbonyl reductase was overexpressed in Escherichia coli; its product was purified and characterized. The expressed enzyme was an NAD(P)H‐dependent broad substrate specificity carbonyl reductase and wa ...
DOI:
10.1111/febs.13385

10. Anti-inflammatory activity and phenolic profile of propolis from two locations in Región Metropolitana de Santiago, Chile

Author:
Valenzuela-Barra, Gabriela; Castro, Consuelo; Figueroa, Catalina; Barriga, Andrés; Silva, Ximena; de las Heras, Beatriz; Hortelano, Sonsoles; Delporte, Carla
Source:
Journal of ethnopharmacology 2015 v.168 pp. 37-44
ISSN:
0378-8741
Subject:
arachidonic acid,   etc   ; aluminum chloride; anti-inflammatory activity; anti-inflammatory agents; ears; edema; ethanol; flavonoids; inflammation; lipopolysaccharides; macrophages; methylene chloride; mice; nitric oxide; nitrites; phenols; propolis; traditional medicine; Chile;     Show all 19 Subjects
Abstract:
... Propolis has long been used as a popular folk medicine due to its wide spectrum of alleged biological and pharmaceutical properties. In Chile, propolis is widely used by folklore medicine as an anti-inflammatory agent; however, this property has not been demonstrated by scientific methods.The objective of this study was to determine the anti-inflammatory activity in vivo and in vitro and to establ ...
DOI:
10.1016/j.jep.2015.03.050

11. Anti-inflammatory and antioxidative activity of anthocyanins from purple basil leaves induced by selected abiotic elicitors

Author:
Szymanowska, Urszula; Złotek, Urszula; Karaś, Monika; Baraniak, Barbara
Source:
Food chemistry 2015 v.172 pp. 71-77
ISSN:
0308-8146
Subject:
arachidonic acid,   etc   ; anthocyanins; inhibitory concentration 50; anti-inflammatory activity; jasmonic acid; basil; Ocimum basilicum; iron; elicitors; linoleate 13S-lipoxygenase; prostaglandin synthase; antioxidant activity; leaves;     Show all 13 Subjects
Abstract:
... This paper investigates changes in the anti-inflammatory and antioxidative activity of anthocyanins from purple basil (Ocimum basilicum L.) leaves induced by arachidonic acid (AA), jasmonic acid (JA) and β-aminobutyric acid (BABA). The anthocyanins content was significantly increased by all elicitors used in this study; however, no increase was observed in the antioxidant activity of the analyzed ...
DOI:
10.1016/j.foodchem.2014.09.043

12. Antioxidant supplementation and obesity have independent effects on hepatic oxylipin profiles in insulin resistant, obese-prone rats

Author:
Picklo Sr., Matthew J.; Newman, John W.
Source:
Free Radical Biology and Medicine 2015 v.89 pp. 182-191
ISSN:
0891-5849
Subject:
arachidonic acid,   etc   ; alpha-linolenic acid; antioxidants; ascorbic acid; cytochrome P-450; dietary supplements; enzyme activity; epoxides; insulin resistance; laboratory animals; linoleic acid; lipid metabolism; lipoxygenases; liver; obesity; oxylipins; phenotype; rats; vitamin E;     Show all 19 Subjects
Abstract:
... Obesity-induced changes in lipid metabolism are mechanistically associated with the development of insulin resistance and prediabetes. Recent studies have focused on the extent to which obesity-induced insulin resistance is mediated through oxylipins, derived from enzymatic and nonenzymatic lipid per-oxidation. Vitamin E and vitamin C are widely used antioxidant supplements, but conflicting data e ...
Handle:
10113/61628
DOI:
10.1016/j.freeradbiomed.2015.07.152

13. Anti‐Platelet Activity of Water Dispersible Curcuminoids in Rat Platelets

Author:
Maheswaraiah, Anikisetty; Jaganmohan Rao, Lingamallu; Naidu, Kamatham Akhilender
Source:
Phytotherapy research 2015 v.29 no.3 pp. 450-458
ISSN:
0951-418X
Subject:
arachidonic acid,   etc   ; adenosine diphosphate; agonists; collagen; curcumin; nitric oxide; platelet aggregation; rats; serotonin; superoxide anion; turmeric;     Show all 11 Subjects
Abstract:
... Curcuminoids are active principle of turmeric with plethora of health beneficial properties. In this study, we have evaluated for the first time the effect of water dispersible curcuminoids on rat platelet aggregation. Curcuminoids (10–30 µg/mL) significantly inhibited platelet aggregation induced by agonists viz., collagen, ADP and arachidonic acid. Curcuminoids were found to be two‐fold more pot ...
DOI:
10.1002/ptr.5274

14. A Pharmacometabonomic Approach To Predicting Metabolic Phenotypes and Pharmacokinetic Parameters of Atorvastatin in Healthy Volunteers

Author:
Huang, Qing; Aa, Jiye; Jia, Huning; Xin, Xiaoqing; Tao, Chunlei; Liu, Linsheng; Zou, Bingjie; Song, Qinxin; Shi, Jian; Cao, Bei; Yong, Yonghong; Wang, Guangji; Zhou, Guohua
Source:
Journal of Proteome Research 2015 v.14 no.9 pp. 3970-3981
ISSN:
1535-3907
Subject:
arachidonic acid,   etc   ; alanine; cholesterol; drug therapy; drugs; gas chromatography-mass spectrometry; genetic polymorphism; isoleucine; least squares; liquid chromatography; metabolites; metabolomics; models; pharmacokinetics; phenotype; prediction; proteome; tandem mass spectrometry; toxicity; tryptophan;     Show all 20 Subjects
Abstract:
... Genetic polymorphism and environment each influence individual variability in drug metabolism and disposition. It is preferable to predict such variability, which may affect drug efficacy and toxicity, before drug administration. We examined individual differences in the pharmacokinetics of atorvastatin by applying gas chromatography–mass spectrometry-based metabolic profiling to predose plasma sa ...
DOI:
10.1021/acs.jproteome.5b00440

15. A quantitiative LC-MS/MS method for the measurement of arachidonic acid, prostanoids, endocannabinoids, N-acylethanolamines and steroids in human plasma

Author:
Gachet, María Salomé; Rhyn, Peter; Bosch, Oliver G.; Quednow, Boris B.; Gertsch, Jürg
Source:
Journal of Chromatography B 2015 v.976-977 pp. 6-18
ISSN:
1570-0232
Subject:
arachidonic acid,   etc   ; acetonitrile; aldosterone; blood lipids; chromatography; cortisol; humans; ionization; prasterone; progesterone; prostaglandins; solid phase extraction; testosterone; thromboxanes;     Show all 14 Subjects
Abstract:
... Free arachidonic acid is functionally interlinked with different lipid signaling networks including those involving prostanoid pathways, the endocannabinoid system, N-acylethanolamines, as well as steroids. A sensitive and specific LC-MS/MS method for the quantification of arachidonic acid, prostaglandin E2, thromboxane B2, anandamide, 2-arachidonoylglycerol, noladin ether, lineoyl ethanolamide, o ...
DOI:
10.1016/j.jchromb.2014.11.001

16. Arachidonic acid impairs hypothalamic leptin signaling and hepatic energy homeostasis in mice

Author:
Cheng, Licai; Yu, Yinghua; Zhang, Qingsheng; Szabo, Alexander; Wang, Hongqin; Huang, Xu-Feng
Source:
Molecular and Cellular Endocrinology 2015 v.412 pp. 12-18
ISSN:
0303-7207
Subject:
arachidonic acid,   etc   ; cholesterol; diet; energy; gene expression; gluconeogenesis; glucose; homeostasis; hydroxymethylglutaryl-CoA reductases; hypothalamus; inflammation; leptin; lipogenesis; messenger RNA; mice; non-specific protein-tyrosine kinase; nutrient transport; obesity; omega-6 fatty acids;     Show all 19 Subjects
Abstract:
... Epidemiological evidence suggests that the consumption of a diet high in n-6 polyunsaturated fatty acids (PUFA) is associated with the development of leptin resistance and obesity. We aim to examine the central effect of n-6 PUFA, arachidonic acid (ARA) on leptin sensitivity and leptin-regulated hepatic glucose and lipid metabolism. We found that intracerebroventricular injection of ARA (25 nmol/d ...
DOI:
10.1016/j.mce.2015.04.025

17. A ‘soft spot’ for drug transport: modulation of cell stiffness using fatty acids and its impact on drug transport in lung model

Author:
Haghi, Mehra; Traini, Daniela; Wood, Lisa G.; Oliver, Brian; Young, Paul M.; Chrzanowski, Wojciech
Source:
Journal of materials chemistry B 2015 v.3 no.13 pp. 2583-2589
ISSN:
2050-7518
Subject:
arachidonic acid,   etc   ; asthma; cell membranes; chemistry; dietary fat; drugs; epithelial cells; humans; lungs; membrane fluidity; microscopy; models; sulfates;     Show all 13 Subjects
Abstract:
... The impact of a polyunsaturated fatty acid, arachidonic acid (AA), on membrane fluidity of epithelial cells and subsequent modulation of the drug transport was investigated. Membrane fluidity was assessed using molecular force microscopy. Calu-3 human bronchial epithelial cells were cultured on Transwell® inserts and the cell stiffness was assessed in the absence of fatty acids or in the presence ...
DOI:
10.1039/c4tb01928h

18. Assessment of platelet function in healthy sedated cats using three whole blood platelet function tests

Author:
Ho, Kimberly K.; Abrams-Ogg, Anthony C. G.; Wood, R. Darren; O’Sullivan, M. Lynne; Kirby, Gordon M.; Blois, Shauna L.
ISSN:
1943-4936
Subject:
arachidonic acid,   etc   ; adenosine diphosphate; agonists; blood platelets; cats; collagen; confidence interval; flow cytometry; hematology; platelet aggregation;     Show all 10 Subjects
Abstract:
... The objectives of this study were to establish feline references intervals for 3 commercial whole blood platelet function test analyzer systems: Multiplate analyzer (MP; Roche Diagnostics International Ltd., Rotkreuz, Switzerland), Platelet Function Analyzer-100 (PF: Siemens Canada, Mississauga, Ontario, Canada), and Plateletworks Combo-25 kit (PW; Helena Laboratories, Beaumont, TX). Venipuncture ...
DOI:
10.1177/1040638715584994

19. Biodiesel Production by Direct In Situ Transesterification of an Oleaginous Tropical Mangrove Fungus Grown on Untreated Agro-Residues and Evaluation of Its Fuel Properties

Author:
Kakkad, Hardik; Khot, Mahesh; Zinjarde, Smita; RaviKumar, Ameeta
Source:
BioEnergy research 2015 v.8 no.4 pp. 1788-1799
ISSN:
1939-1234
Subject:
arachidonic acid,   etc   ; Aspergillus candidus; bananas; biodiesel; coconut meal; corn cobs; fatty acid methyl esters; feedstocks; fuel production; fungi; glucose; glycerol; grapes; iodine value; lignocellulose; microbial biomass; microbial growth; oleic acid; production costs; saturated fatty acids; sugarcane; sugarcane bagasse; transesterification; viscosity; wastes; wetlands;     Show all 26 Subjects
Abstract:
... Recent research has focused on use of waste agro- residues for growth of oleaginous microbial biomass as renewable feedstock for biodiesel. However, pretreatment of lignocellulosic biomass into fermentable sugar is necessary for microbial growth, increasing production costs. An oleaginous fungal isolate from the tropical mangrove wetlands, IBB G4, identified as Aspergillus candidus was assessed fo ...
DOI:
10.1007/s12155-015-9626-x

20. Bringing PGE₂ in from the cold

Author:
FitzGerald, Garret A.
Source:
Science 2015 v.348 no.6240 pp. 1208-1209
ISSN:
0036-8075
Subject:
arachidonic acid,   etc   ; animal models; cell membranes; cell transplantation; cold; drugs; hematopoietic stem cells; inflammation; pain; phospholipases; prostaglandins; tissue repair; tissues;     Show all 13 Subjects
Abstract:
... Prostaglandins (PGs) are evanescent, locally acting lipids. They are not stored within cells, but are generated when their precursor, arachidonic acid, is mobilized from cellular membranes by rather nonspecific activation of phospholipases. Most cells generate one or two dominant PGs, each with a remarkable diversity of effects. Prostaglandin E ₂ (PGE ₂) is a vasodilator that acts with other PGs a ...
DOI:
10.1126/science.aac5515