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- Chen, Lei, et al. Show all 52 Authors
- Cell 2015 v.161 pp. 1280-1292
- Human immunodeficiency virus 1; antibodies; antibody binding sites; geometry; glycoproteins; neutralization; ontogeny
- ... The site on the HIV-1 gp120 glycoprotein that binds the CD4 receptor is recognized by broadly reactive antibodies, several of which neutralize over 90% of HIV-1 strains. To understand how antibodies achieve such neutralization, we isolated CD4-binding-site (CD4bs) antibodies and analyzed 16 co-crystal structures –8 determined here– of CD4bs antibodies from 14 donors. The 16 antibodies segregated b ...
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