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- Chen, Szu-Yu, et al. Show all 3 Authors
- The Journal of physical chemistry 2015 v.119 no.12 pp. 4359-4370
- Methanocaldococcus jannaschii; denaturation; dissociation; models; nitrogen; nuclear magnetic resonance spectroscopy; polypeptides; proteins; stable isotopes
- ... Understanding the mechanism by which polypeptide chains thread themselves into topologically knotted structures has emerged to be a challenging subject not least because of the additional complexity associated with the spontaneous and efficient knotting and folding events. While recent theoretical calculations have made significant progress in establishing the atomistic folding pathways for a numb ...
- Chen, Szu-Yu, et al. Show all 10 Authors
- The Journal of physical chemistry 2015 v.119 no.17 pp. 5437-5443
- X-radiation; physical chemistry; polypeptides; proteins; stereoisomerism; topology
- ... Recent studies on the mechanisms by which topologically knotted proteins attain their natively knotted structures have intrigued theoretical and experimental biophysicists. Of particular interest is the finding that YibK and YbeA, two small trefoil knotted proteins, remain topologically knotted in their chemically denatured states. Using small-angle X-ray scattering (SAXS), we examine whether thes ...