Jump to Main Content
- Bujnicki, Janusz M., et al. Show all 5 Authors
- FEBS letters 2015 v.589 pp. 2603-2610
- RNA editing; RNA folding; Trypanosoma brucei; amino acid composition; bioinformatics; messenger RNA; mitochondria; models; prediction; proteins; uridine
- ... Mitochondrial pre-mRNAs in trypanosomatids undergo RNA editing to be converted into translatable mRNAs. The reaction is characterized by the insertion and deletion of uridine residues and is catalyzed by a macromolecular protein complex called the editosome. Despite intensive research, structural information for the majority of editosome proteins is still missing and no high resolution structure f ...
- Bujnicki, Janusz M., et al. Show all 9 Authors
- Journal of Molecular Biology 2015 v.427 pp. 3001-3022
- RNA; alternative splicing; exons; metabolism; ribonucleoproteins; structure-activity relationships
- ... The RNA recognition motif (RRM) is the far most abundant RNA binding domain. In addition to the typical β1α1β2β3α2β4 fold, various sub-structural elements have been described and reportedly contribute to the high functional versatility of RRMs. The heterogeneous nuclear ribonucleoprotein L (hnRNP L) is a highly abundant protein of 64kDa comprising four RRM domains. Involved in many aspects of RNA ...