Jump to Main Content
Did you mean to type: brian?
- Dickinson, Bryan C., et al. Show all 4 Authors
- Journal of the American Chemical Society 2015 v.137 no.51 pp. 15996-15999
- RNA; engineering; gene expression; gene regulatory networks; mammals; proteolysis
- ... RNA is an attractive biomolecule for biosensing and engineering applications due to its information storage capacity and ability to drive gene expression or knockdown. However, methods to link chemical signals to the production of specific RNAs are lacking. Here, we develop protease-responsive RNA polymerases (PRs) as a strategy to encode multiple specific proteolytic events in defined sequences o ...
- PubMed Central:
- Dickinson, Bryan C., et al. Show all 5 Authors
- Biochemical and biophysical research communications 2015 v.458 pp. 896-900
- Caenorhabditis elegans; RNA interference; animals; fluorescence; genes; heat stress; hydrogen peroxide; image analysis; longevity; statistical analysis
- ... Reactive oxygen species (ROS) are important factors mediating aging according to the free radical theory of aging. Few studies have systematically measured ROS levels in relationship to aging, partly due to the lack of tools for detection of specific ROS in live animals. By using the H2O2-specific fluorescence probe Peroxy Orange 1, we assayed the H2O2 levels of live Caenorhabditis elegans with 41 ...
- Dickinson, Bryan C., et al. Show all 8 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2015 v.112 no.5 pp. E497
- Schwann cells; animals; hydrogen peroxide; motor neurons; muscle fibers; muscles; nerve tissue; neurotoxins; patients; signal transduction; synapse
- ... An acute and highly reproducible motor axon terminal degeneration followed by complete regeneration is induced by some animal presynaptic neurotoxins, representing an appropriate and controlled system to dissect the molecular mechanisms underlying degeneration and regeneration of peripheral nerve terminals. We have previously shown that nerve terminals exposed to spider or snake presynaptic neurot ...
- PubMed Central: