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- Eyer, Joel, et al. Show all 7 Authors
- Biochemistry 2015 v.54 no.23 pp. 3660-3669
- amino acids; mechanism of action; microtubules; molecular dynamics; nuclear magnetic resonance spectroscopy; tubulin
- ... NFL-TBS.40–63 is a 24 amino acid peptide corresponding to the tubulin-binding site located on the light neurofilament subunit, which selectively enters glioblastoma cells, where it disrupts their microtubule network and inhibits their proliferation. We investigated its structural variability and binding modes on a tubulin heterodimer using a combination of NMR experiments, docking, and molecular d ...