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- Gu, Peng, et al. Show all 7 Authors
- Genomics Data 2015 v.5 pp. 27-29
- cell proliferation; cisplatin; epigenetics; gene expression; gene expression regulation; genes; microarray technology; neoplasm cells; tissues; transcription (genetics); urinary bladder neoplasms
- ... WD repeat domain 5 (WDR5) plays an important role in various biological functions through the epigenetic regulation of gene transcription (Wysocka et al., 2005 ; Sandstrom et al., 2014; Ang et al., 2011). Recently, our study found that WDR5 was upregulated in bladder cancer tissues, promoted bladder cancer cell proliferation, self-renewal and chemoresistance to cisplatin in bladder cancer ...
- Gu, Peng, et al. Show all 9 Authors
- Biochemical and biophysical research communications 2015 v.460 pp. 380-385
- apoptosis; autophagy; binding proteins; cell proliferation; cell viability; drug resistance; drug therapy; flow cytometry; genes; humans; immunoblotting; neoplasm cells; patients; protein-serine-threonine kinases; serine; signal transduction; small interfering RNA; threonine; urinary bladder neoplasms
- ... Pirarubicin is widely used in intravesical chemotherapy for bladder cancer, but its efficacy is limited due to drug resistance; the mechanism has not been well studied. Emerging evidence shows that autophagy can be a novel target for cancer therapy. This study aimed to investigate the role of autophagy in pirarubicin-treated bladder cancer cells. Bladder cancer cells EJ and J82 were treated with p ...