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- Heuts, Frank, et al. Show all 10 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2015 v.112 no.2 pp. 524-529
- CD4-positive T-lymphocytes; antibodies; antigen-presenting cells; autoimmunity; cytotoxicity; ligands; mechanism of action
- ... Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) is an essential regulator of T-cell responses, and its absence precipitates lethal T-cell hyperactivity. However, whether CTLA-4 acts simply to veto the activation of certain clones or plays a more nuanced role in shaping the quality of T-cell responses is not clear. Here we report that T cells in CTLA-4–deficient mice show spontaneous T-follicu ...
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