Jump to Main Content
- Kobayashi, Yasushi, et al. Show all 8 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2015 v.112 no.22 pp. E2891
- allergens; asthma; chitin; chitinase; dust; dust mites; enzyme activity; exoskeleton; hypersensitivity; immune response; mice; people; polymers
- ... Chitinases are enzymes that cleave chitin, a component of the exoskeleton of many organisms including the house dust mite (HDM). Here we show that knockin mice expressing an enzymatically inactive acidic mammalian chitinase (AMCase), the dominant true chitinase in mouse lung, showed enhanced type 2 immune responses to inhaled HDM. We found that uncleaved chitin promoted the release of IL-33, where ...
- PubMed Central: