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- Lin, Win-Li, et al. Show all 6 Authors
- Journal of controlled release 2015 v.211 pp. 53-62
- antineoplastic activity; brain; brain neoplasms; doxorubicin; drug therapy; endothelium; mice; microbubbles; nanomedicine; nanoparticles; permeability; sonication; transforming growth factor beta 1; ultrasonics
- ... The clinical application of chemotherapy for brain cancer tumors remains a challenge due to difficulties in the transport of therapeutic agents across the blood–brain barrier/blood–tumor barrier (BBB/BTB). In this study, we developed des-octanoyl ghrelin-conjugated microbubbles (GMB) loaded with TGFβ1 inhibitor (LY364947) (GMBL) to induce BBB/BTB disruption for ultrasound (US) sonication with GMBL ...