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- Khalil, Zeinab
G.; Raju, Ritesh; Piggott, Andrew M.; Salim, Angela
A.; Blumenthal, Antje; Capon, Robert J.
- Journal of natural products 2015 v.78 no.4 pp. 949-952
- anthracyclines, etc ; Gram-negative bacteria; Gram-positive bacteria; Mycobacterium tuberculosis; Streptomyces; antibiotics; chemical analysis; cytotoxicity; fungi; humans; inhibitory concentration 50; neoplasms; spectral analysis; Show all 13 Subjects
- ... Chemical analysis of an Australian marine-derived Streptomyces sp. (CMB-M0150) yielded two new anthracycline antibiotics, aranciamycins I (1) and J (2), as well as the previously reported aranciamycin A (3) and aranciamycin (4). The aranciamycins 1–4, identified by detailed spectroscopic analysis, were noncytotoxic when tested against selected Gram-negative bacteria and fungi (IC₅₀ >30 μM) and exh ...