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- Bogdanov, Alexey A., et al. Show all 18 Authors
- Molecular cell 2014 v.56 pp. 531-540
- antibiotics; binding sites; crystal structure; messenger RNA; mutation; nucleotides; protein subunits; protein synthesis inhibitors; ribosomal RNA; ribosomal proteins; ribosomes; translation (genetics)
- ... We demonstrate that the antibiotic amicoumacin A (AMI) is a potent inhibitor of protein synthesis. Resistance mutations in helix 24 of the 16S rRNA mapped the AMI binding site to the small ribosomal subunit. The crystal structure of bacterial ribosome in complex with AMI solved at 2.4 Å resolution revealed that the antibiotic makes contacts with universally conserved nucleotides of 16S rRNA in the ...
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