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- Author:
- Cheng Zhong-Bin; Lu Xiao; Bao Jing-Mei; Han Qing-Hua; Dong Zhen; Tang Gui-Hua; Gan Li-She; Luo Hai-Bin; Yin Sheng
- Source:
- Journal of natural products 2014 v.77 no.12 pp. 2651-2657
- ISSN:
- 1520-6025
- Subject:
- Alzheimer disease; Torreya; adenosine; diabetes; enantiomers; inhibitory concentration 50; lignans; spectroscopy; tritium
- Abstract:
- ... (±)-Torreyunlignans A–D (1a/1b–4a/4b), four pairs of new 8–9′ linked neolignan enantiomers featuring a rare (E)-2-styryl-1,3-dioxane moiety, were isolated from the trunk of Torreya yunnanensis. The structures were determined by combined spectroscopic and chemical methods, and the absolute configurations were elucidated by ECD calculations. The compounds were screened by using tritium-labeled adeno ...
- DOI:
- 10.1021/np500528u
- https://doi.org/10.1021/np500528u
- Author:
- Hui Lei; Chun-Yang Zhao; Dong-Mei Liu; Yu Zhang; Lin Li; Xiao-Liang Wang; Ying Peng
- Source:
- Journal of Asian natural products research 2014 v.16 no.8 pp. 854-864
- ISSN:
- 1477-2213
- Subject:
- Alzheimer disease; animal models; apoptosis; caspase-3; caspase-9; cytochrome c; death; humans; membrane potential; mitochondrial membrane; mitogen-activated protein kinase; neurodegenerative diseases; neurons; neuroprotective effect; reactive oxygen species; signal transduction; toxicity
- Abstract:
- ... Alzheimer's disease (AD) is a progressive neurodegenerative disease. Amyloid-β protein (Aβ), the hallmark of AD, invokes a cascade of mitochondrial dysfunction and eventually leads to neuronal death. l -3- n -Butylphthalide (l -NBP) has shown the potent neuroprotective effects in stroke and AD animal models. The present study is to evaluate the neuroprotective effect of l -NBP on Aβ ₂₅–₃₅-induced ...
- DOI:
- 10.1080/10286020.2014.939586
- https://doi.org/10.1080/10286020.2014.939586
- Author:
- Dawei Zhang; Mari Pekkanen-Mattila; Mansoureh Shahsavani; Anna Falk; Ana I. Teixeira; Anna Herland
- Source:
- Biomaterials 2014 v.35 no.5 pp. 1420-1428
- ISSN:
- 0142-9612
- Subject:
- Alzheimer disease; actin; induced pluripotent stem cells; models; neurons; phenotype
- Abstract:
- ... The recent progress in stem cell techniques has broadened the horizon for in vitro disease modeling. For desired in vivo like phenotypes, not only correct cell type specification will be critical, the microenvironmental context will be essential to achieve relevant responses. We demonstrate how a three dimensional (3D) culture of stem cell derived neurons can induce in vivo like responses related ...
- DOI:
- 10.1016/j.biomaterials.2013.11.028
- https://doi.org/10.1016/j.biomaterials.2013.11.028
4. 3D Structures and Redox Potentials of Cu2+–Aβ(1–16) Complexes at Different pH: A Computational Study
- Author:
- Alí-Torres Jorge; Mirats Andrea; Maréchal Jean-Didier; Rodríguez-Santiago Luis; Sodupe Mariona
- Source:
- Journal of physical chemistry 2014 v.118 no.18 pp. 4840-4850
- ISSN:
- 1520-5207
- Subject:
- Alzheimer disease; cations; copper; electrodes; geometry; hydrogen; ligands; models; oxidative stress; pH; physical chemistry; redox potential
- Abstract:
- ... Oxidative stress induced by redox-active metal cations such as Cu²⁺ is a key event in the development of Alzheimer’s disease. A detailed knowledge of the structure of Cu²⁺–Aβ complex is thus important to get a better understanding of this critical process. In the present study, we use a computational approach that combines homology modeling with quantum-mechanics-based methods to determine plausib ...
- DOI:
- 10.1021/jp5019718
- https://doi.org/10.1021/jp5019718
- Author:
- Minho Moon; Hyo Geun Kim; Jin Gyu Choi; Hyein Oh; Paula KJ Lee; Sang Keun Ha; Sun Yeou Kim; Yongkon Park; Youngbuhm Huh; Myung Sook Oh
- Source:
- Biochemical and biophysical research communications 2014 v.449 pp. 8-13
- ISSN:
- 0006-291X
- Subject:
- Alzheimer disease; Parkinson disease; animal models; anti-inflammatory activity; antioxidants; astrocytes; cognition; cooking; ginger; herbal medicines; hippocampus; inflammation; ingredients; ischemia; lipopolysaccharides; memory; mice; therapeutics
- Abstract:
- ... Recently, increased attention has been directed towards medicinal extracts as potential new drug candidates for dementia. Ginger has long been used as an important ingredient in cooking and traditional herbal medicine. In particular, ginger has been known to have disease-modifying effects in Alzheimer's disease (AD). However, there is no evidence of which constituents of ginger exhibit therapeutic ...
- DOI:
- 10.1016/j.bbrc.2014.04.121
- https://doi.org/10.1016/j.bbrc.2014.04.121
- Author:
- Warren Davis
- Source:
- BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 168-179
- ISSN:
- 1388-1981
- Subject:
- ABC transporters; Alzheimer disease; atherosclerosis; bile acids; brain; ceramides; cholesterol; energy; esterification; genes; humans; lipid bilayers; loci; metabolism; neurons; oligodendroglia; phospholipids; plasma membrane; rats
- Abstract:
- ... The ATP-binding cassette transporters are a large family (~48 genes divided into seven families A–G) of proteins that utilize the energy of ATP-hydrolysis to pump substrates across lipid bilayers against a concentration gradient. The ABC “A” subfamily is comprised of 13 members and transport sterols, phospholipids and bile acids. ABCA2 is the most abundant ABC transporter in human and rodent brain ...
- DOI:
- 10.1016/j.bbalip.2013.10.019
- PubMed:
- 24201375
- PubMed Central:
- PMC4437569
- https://doi.org/10.1016/j.bbalip.2013.10.019
- Author:
- Sano Shozo; Tagami Shinji; Hashimoto Yuuki; Yoshizawa-Kumagaye Kumiko; Tsunemi Masahiko; Okochi Masayasu; Tomonaga Takeshi
- Source:
- Journal of Proteome Research 2014 v.13 no.2 pp. 1012-1020
- ISSN:
- 1535-3907
- Subject:
- Alzheimer disease; acetonitrile; albumins; antibodies; blood proteins; blood serum; cation exchange; chromatography; ions; monitoring; peptides; precipitin tests; proteome; spectrometers
- Abstract:
- ... Selected/multiple reaction monitoring (SRM/MRM) has been widely used for the quantification of specific proteins/peptides, although it is still challenging to quantitate low abundant proteins/peptides in complex samples such as plasma/serum. To overcome this problem, enrichment of target proteins/peptides is needed, such as immunoprecipitation; however, this is labor-intense and generation of anti ...
- DOI:
- 10.1021/pr4010103
- https://doi.org/10.1021/pr4010103
- Author:
- Cláudia Seidl; Beatriz L. Correia; Andréa E. M. Stinghen; Cid A. M. Santos
- Source:
- Zeitschrift für Naturforschung 2014 v.65 no.7-8 pp. 440-444
- ISSN:
- 1865-7125
- Subject:
- Alzheimer disease; Apocynaceae; acetylcholinesterase; colorimetry; ethyl acetate; inhibitory concentration 50; methylene chloride; physostigmine; thin layer chromatography
- Abstract:
- ... Application of acetylcholinesterase (AChE) inhibitors is the primary treatment for Alzheimer’s disease. Alkaloids, such as physostigmine, galanthamine, and huperzine A, play an important role as AChE inhibitors. The aim of this work was to evaluate Himatanthus lancifolius (Muell. Arg.) Woodson, a Brazilian species of Apocynaceae, and its main indole alkaloid uleine, in order to identify new AChE i ...
- DOI:
- 10.1515/znc-2010-7-804
- https://doi.org/10.1515/znc-2010-7-804
- Author:
- Hamid-Reza Adhami; Veronika Fitz; Andrea Lubich; Hanspeter Kaehlig; Martin Zehl; Liselotte Krenn
- Source:
- Phytochemistry letters 2014 v.10 pp. lxxxii
- ISSN:
- 1874-3900
- Subject:
- Alzheimer disease; Ferula; acetylcholinesterase; active ingredients; herbal medicines; high performance liquid chromatography; inhibitory concentration 50; physostigmine; solid phase extraction; umbelliferones
- Abstract:
- ... Due to the correlation of Alzheimer's disease with a cholinergic deficit, acetylcholinesterase (AChE) inhibitors from herbal drugs or herbal medicinal preparations have gained a lot of scientific interest.In a previous study, several substances with AChE inhibitory activity were detected in galbanum by TLC bioautography and two of them were identified as auraptene and farnesiferol A. The aim of pr ...
- DOI:
- 10.1016/j.phytol.2014.08.023
- https://doi.org/10.1016/j.phytol.2014.08.023
10. Activation of SIRT1 by curcumin blocks the neurotoxicity of amyloid-β25–35 in rat cortical neurons
- Author:
- Qinru Sun; Ning Jia; Weixi Wang; Hui Jin; Jiehua Xu; Haitao Hu
- Source:
- Biochemical and biophysical research communications 2014 v.448 pp. 89-94
- ISSN:
- 0006-291X
- Subject:
- neuroprotective effect; Alzheimer disease; mitochondrial membrane; neurotoxicity; membrane potential; neurons; cytotoxicity; reactive oxygen species; turmeric; mitochondria; small interfering RNA; rats; curcumin; apoptosis; pigments
- Abstract:
- ... As one of the most important hallmarks of Alzheimer’s disease (AD), β-amyloid (Aβ) plays important roles in inducing reactive oxygen species (ROS) generation, mitochondrial dysfunction and apoptotic cell death in neurons. Curcumin extracted from the yellow pigments spice plant turmeric shows multiplied bioactivities such as antioxidant and anti-apoptosis properties in vitro and in vivo. In the pre ...
- DOI:
- 10.1016/j.bbrc.2014.04.066
- https://doi.org/10.1016/j.bbrc.2014.04.066
- Author:
- Gillman Alan L.; Jang Hyunbum; Lee Joon; Ramachandran Srinivasan; Kagan Bruce L.; Nussinov Ruth; Teran Arce Fernando
- Source:
- Journal of physical chemistry 2014 v.118 no.26 pp. 7335-7344
- ISSN:
- 1520-5207
- Subject:
- Alzheimer disease; cognition; cytotoxicity; elderly; hydrophobicity; lipids; molecular dynamics; patients; peptides; permeability
- Abstract:
- ... Among the family of Aβ peptides, pyroglutamate-modified Aβ (AβₚE) peptides are particularly associated with cytotoxicity in Alzheimer’s disease (AD). They represent the dominant fraction of Aβ oligomers in the brains of AD patients, but their accumulation in the brains of elderly individuals with normal cognition is significantly lower. Accumulation of AβₚE plaques precedes the formation of plaque ...
- DOI:
- 10.1021/jp5040954
- PubMed:
- 24922585
- PubMed Central:
- PMC4096221
- https://doi.org/10.1021/jp5040954
12. Activity-Dependent p25 Generation Regulates Synaptic Plasticity and Aβ-Induced Cognitive Impairment
- Author:
- Jinsoo Seo; Paola Giusti-Rodríguez; Ying Zhou; Andrii Rudenko; Sukhee Cho; Kristie T. Ota; Christine Park; Holger Patzke; Ram Madabhushi; Ling Pan; Alison E. Mungenast; Ji-Song Guan; Ivana Delalle; Li-Huei Tsai
- Source:
- Cell 2014 v.157 pp. 486-498
- ISSN:
- 0092-8674
- Subject:
- Alzheimer disease; animal models; crossing; cyclin-dependent kinase; extinction; memory; mice; mutants; neurodegenerative diseases; neurons; neuroplasticity; neurotoxicity; phosphorylation; proteolysis
- Abstract:
- ... Cyclin-dependent kinase 5 regulates numerous neuronal functions with its activator, p35. Under neurotoxic conditions, p35 undergoes proteolytic cleavage to liberate p25, which has been implicated in various neurodegenerative diseases. Here, we show that p25 is generated following neuronal activity under physiological conditions in a GluN2B- and CaMKIIα-dependent manner. Moreover, we developed a kn ...
- DOI:
- 10.1016/j.cell.2014.01.065
- PubMed:
- 24725413
- PubMed Central:
- PMC4327772
- https://doi.org/10.1016/j.cell.2014.01.065
- Author:
- Tadas Ragaliauskas; Mindaugas Mickevicius; Rima Budvytyte; Gediminas Niaura; Benjamin Carbonnier; Gintaras Valincius
- Source:
- Journal of colloid and interface science 2014 v.425 pp. 159-167
- ISSN:
- 0021-9797
- Subject:
- Alzheimer disease; absorption; adsorption; amino acids; amyloid; atomic force microscopy; gold; quartz; spectroscopy; surface plasmon resonance
- Abstract:
- ... β-Amyloid oligomers of different aggregation and physiological functions exhibit distinct adsorption behavior allowing them to be discriminated in preparations.Two forms of amyloid oligomers, small 1–4nm and large 5–10nm were formulated using synthetic 42 amino acids β-amyloid peptide. Forms differ in their size and physiological function. A systematic study of adsorption of these amyloid species ...
- DOI:
- 10.1016/j.jcis.2014.03.042
- https://doi.org/10.1016/j.jcis.2014.03.042
- Author:
- Marie Hennebelle; Mélanie Plourde; Raphaël Chouinard-Watkins; Christian-Alexandre Castellano; Pascale Barberger-Gateau; Stephen C. Cunnane
- Source:
- Proceedings of the Nutrition Society 2014 v.73 no.1 pp. 80-86
- ISSN:
- 1475-2719
- Subject:
- Alzheimer disease; beta oxidation; blood; brain; docosahexaenoic acid; elderly; epidemiological studies; fatty fish; fish consumption; homeostasis; humans; isotope labeling; omega-3 fatty acids; risk; risk reduction; young adults
- Abstract:
- ... Epidemiological studies fairly convincingly suggest that higher intakes of fatty fish and n-3 fatty acids are associated with reduced risk of Alzheimer's disease (AD). DHA in plasma is normally positively associated with DHA intake. However, despite being associated with lower fish and DHA intake, unexpectedly, plasma (or brain) DHA is frequently not lower in AD. This review will highlight some me ...
- DOI:
- 10.1017/S0029665113003625
- PubMed:
- 24103099
- https://doi.org/10.1017/S0029665113003625
- Author:
- Sang-Wook Yi; Jae-Seok Hong; Heechoul Ohrr; Jee-Jeon Yi
- Source:
- Environmental Research 2014 v.133 pp. 56-65
- ISSN:
- 0013-9351
- Subject:
- 2,4,5-T; 2,4-D; Alzheimer disease; amyloidosis; asthma; bronchitis; diabetes mellitus; disease prevalence; epidemiological studies; health insurance; hypothyroidism; liver cirrhosis; military veterans; models; morbidity; muscular atrophy; nervous system; odds ratio; peptic ulcers; pituitary gland; spatial data; stroke; tetrachlorodibenzo-p-dioxin; Korean Peninsula; United States; Vietnam
- Abstract:
- ... Between 1961 and 1971, military herbicides were used by the United States and allied forces for military purposes. Agent Orange, the most-used herbicide, was a mixture of 2,4-dichlorophenoxyacetic acid (2,4-D) and 2,4,5-trichlorophenoxyacetic acid, and contained an impurity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Many Korean Vietnam veterans were exposed to Agent Orange during the Vietnam W ...
- DOI:
- 10.1016/j.envres.2014.04.027
- https://doi.org/10.1016/j.envres.2014.04.027
- Author:
- Yoshiaki Shimoda; Kiyonari Matsuo; Kazunori Ono; Yuka Soma; Tomomi Ueyama; Satoaki Matoba; Hiroyuki Yamada; Koji Ikeda
- Source:
- Biochemical and biophysical research communications 2014 v.446 pp. 1243-1249
- ISSN:
- 0006-291X
- Subject:
- Alzheimer disease; adipocytes; angiogenesis; blood vessels; diabetes; elderly; endoplasmic reticulum; gene expression regulation; genes; heart failure; homeostasis; hypoxia; mice; morbidity; myotubes; skeletal muscle; white adipose tissue
- Abstract:
- ... Organ functions are altered and impaired during aging, thereby resulting in increased morbidity of age-related diseases such as Alzheimer’s disease, diabetes, and heart failure in the elderly. Angiogenesis plays a crucial role in the maintenance of tissue homeostasis, and aging is known to reduce the angiogenic capacity in many tissues. Here, we report the differential effects of aging on the expr ...
- DOI:
- 10.1016/j.bbrc.2014.03.098
- https://doi.org/10.1016/j.bbrc.2014.03.098
- Author:
- J. -M. Lecerf
- Source:
- Phytothérapie 2014 v.12 no.2 pp. 84-88
- ISSN:
- 1624-8597
- Subject:
- Alzheimer disease; anti-inflammatory activity; antioxidants; citrus fruits; cognition; epidemiological studies; humans; neurodegenerative diseases; nutrition; polyphenols; vitamins
- Abstract:
- ... Some data from pathophysiological and epidemiological studies are consistent with the role of nutritional factors in the occurrence of neurodegenerative diseases such as Alzheimer disease and age-related cognitive decline. Citrus fruits rich in polyphenols and some vitamins are candidates for this role of nutrition, through their antioxidant and antiinflammatory effects. Some data in animals and h ...
- DOI:
- 10.1007/s10298-014-0846-6
- https://doi.org/10.1007/s10298-014-0846-6
- Author:
- Liliya Georgievaa; Strahil Berkov; Violeta Kondakova; Jaume Bastida; Francesc Viladomat; Atanas Atanassov; Carles Codina
- Source:
- Zeitschrift für Naturforschung 2014 v.62 no.9-10 pp. 627-635
- ISSN:
- 1865-7125
- Subject:
- Alzheimer disease; Leucojum aestivum; acetylcholinesterase; bulbs; gas chromatography-mass spectrometry; lycorine; summer; Bulgaria
- Abstract:
- ... Leucojum aestivum (summer snowflake) is a plant species used for the extraction of galanthamine, an acetylcholinesterase inhibitor for the treatment of Alzheimer’s disease. Extracts from bulbs collected from 18 Bulgarian populations and from shoot-clumps obtained in vitro from 8 different populations showed variations in their alkaloid composition. Nineteen alkaloids were detected in the studied s ...
- DOI:
- 10.1515/znc-2007-9-1002
- https://doi.org/10.1515/znc-2007-9-1002
- Author:
- Shu Yang; Qihai Gong; Qin Wu; Fei Li; Yuanfu Lu; Jingshan Shi
- Source:
- Phytomedicine 2014 v.21 pp. 712-716
- ISSN:
- 0944-7113
- Subject:
- Alzheimer disease; Dendrobium nobile; Western blotting; alkaloids; apoptosis; hippocampus; lipopolysaccharides; medicinal plants; protective effect; rats; therapeutics
- Abstract:
- ... Neurofibrillary tangles, one of the characteristic pathological features of Alzheimer's disease (AD), are composed of paired helical filaments mainly with hyperphosphorylated tau protein. Inhibition of the hyperphosphorylation of tau protein is an effective therapy for AD. The current study was designed to investigate the protective effects of alkaloids enriched extract from Dendrobium Nobile Lind ...
- DOI:
- 10.1016/j.phymed.2013.10.026
- https://doi.org/10.1016/j.phymed.2013.10.026
- Author:
- Hongjie Wang; Adel Nefzi; Gregg B. Fields; Madepalli K. Lakshmana; Dmitriy Minond
- Source:
- Analytical biochemistry 2014 v.459 pp. 24-30
- ISSN:
- 0003-2697
- Subject:
- Alzheimer disease; amyloid; chemotypes; drugs; screening
- Abstract:
- ... Activation of nonamyloidogenic processing of amyloid precursor protein (APP) has been hypothesized to be a viable approach for Alzheimer’s disease drug discovery. However, until recently, the lack of HTS-compatible assay technologies precluded large scale screening efforts to discover molecules that potentiate nonamyloidogenic pathways. We have developed an HTS-compatible assay based on AlphaLISA ...
- DOI:
- 10.1016/j.ab.2014.05.007
- https://doi.org/10.1016/j.ab.2014.05.007
- Author:
- Diogo Ribeiro Demartini; Lucas Porcello Schilling; Jaderson Costa da Costa; Célia Regina Carlini
- Source:
- Journal of proteomics 2014 v.104 pp. 24-36
- ISSN:
- 1874-3919
- Subject:
- Alzheimer disease; Parkinson disease; biomarkers; etiology; proteomics
- Abstract:
- ... Alzheimer's and Parkinson's diseases are severe neurodegenerative conditions triggered by complex biochemical routes. Many groups are currently pursuing the search for valuable biomarkers to either perform early diagnostic or to follow the disease's progress. Several studies have reported relevant findings regarding environmental issues and the progression of such diseases. Here the etiology and m ...
- DOI:
- 10.1016/j.jprot.2014.04.014
- https://doi.org/10.1016/j.jprot.2014.04.014
- Author:
- Vincent T. Marchesi
- Source:
- Cellular and molecular life sciences 2014 v.71 no.6 pp. 949-955
- ISSN:
- 1420-682X
- Subject:
- Alzheimer disease; amyloid; blood flow; blood vessels; brain; cell death; disease course; genes; germ cells; inflammation; mutants; mutation; neurons; nuclear magnetic resonance spectroscopy; pathogenesis; patients; peptides; protein aggregates
- Abstract:
- ... This essay explores an alternative pathway to Alzheimer’s dementia that focuses on damage to small blood vessels rather than late-stage toxic amyloid deposits as the primary pathogenic mechanism that leads to irreversible dementia. While the end-stage pathology of AD is well known, the pathogenic processes that lead to disease are often assumed to be due to toxic amyloid peptides that act on neuro ...
- DOI:
- 10.1007/s00018-013-1542-7
- https://doi.org/10.1007/s00018-013-1542-7
- Author:
- Kate E. Lawlor; James E. Vince
- Source:
- BBA - General Subjects 2014 v.1840 pp. 1433-1440
- ISSN:
- 0304-4165
- Subject:
- Alzheimer disease; apoptosis; atherosclerosis; calcium; caspase-1; immune response; interleukin-18; interleukin-1beta; mitochondria; mitochondrial DNA; models; mutation; neoplasms; noninsulin-dependent diabetes mellitus; pathogens; reactive oxygen species
- Abstract:
- ... The NLRP3 inflammasome is a sensor of specific pathogen, host and environmental danger molecules. Upon activation NLRP3 recruits caspase-1, which cleaves and thereby activates precursor interleukin-1β (IL-1β) and IL-18 to initiate immune responses. Several recent studies have posited that the mitochondria are a central regulator of NLRP3 function.Mitochondrial reactive oxygen species (mtROS) produ ...
- DOI:
- 10.1016/j.bbagen.2013.08.014
- https://doi.org/10.1016/j.bbagen.2013.08.014
- Author:
- Meyer Virginia; Dinkel Paul D.; Rickman Hager Emily; Margittai Martin
- Source:
- Biochemistry 2014 v.53 no.36 pp. 5804-5809
- ISSN:
- 1520-4995
- Subject:
- Alzheimer disease; brain; heparin; prions; protein folding; seeds
- Abstract:
- ... The propagation of Tau pathology in Alzheimer’s disease (AD) is thought to proceed through templated conversion of Tau protein into fibrils and cell-to-cell transfer of elongation-competent seeds. To investigate the efficiency of Tau conversion, we adapted the protein misfolding cyclic amplification assay used for the conversion of prions. Utilizing heparin as a cofactor and employing repetitive c ...
- DOI:
- 10.1021/bi501050g
- PubMed:
- 25153692
- PubMed Central:
- PMC4165214
- https://doi.org/10.1021/bi501050g
- Author:
- Mulaj Mentor; Foley Joseph; Muschol Martin
- Source:
- Journal of the American Chemical Society 2014 v.136 no.25 pp. 8947-8956
- ISSN:
- 1520-5126
- Subject:
- Alzheimer disease; amyloid; humans; lysozyme; pathogenesis; polymerization; temperature
- Abstract:
- ... Self-assembly of amyloid fibrils is the molecular mechanism best known for its connection with debilitating human disorders such as Alzheimer’s disease but is also associated with various functional cellular responses. There is increasing evidence that amyloid formation proceeds along two distinct assembly pathways involving either globular oligomers and protofibrils or rigid monomeric filaments. ...
- DOI:
- 10.1021/ja502529m
- PubMed:
- 24884889
- PubMed Central:
- PMC4227717
- https://doi.org/10.1021/ja502529m
26. Amyloid beta receptors responsible for neurotoxicity and cellular defects in Alzheimer’s disease
- Author:
- Tae-In Kam; Youngdae Gwon; Yong-Keun Jung
- Source:
- Cellular and molecular life sciences 2014 v.71 no.24 pp. 4803-4813
- ISSN:
- 1420-682X
- Subject:
- Alzheimer disease; amyloid; endoplasmic reticulum; models; neurodegenerative diseases; neurons; neurotoxicity; receptors
- Abstract:
- ... Alzheimer’s disease (AD) is the most common neurodegenerative disease. Although a major cause of AD is the accumulation of amyloid-β (Aβ) peptide that induces neuronal loss and cognitive impairments, our understanding of its neurotoxic mechanisms is limited. Recent studies have identified putative Aβ-binding receptors that mediate Aβ neurotoxicity in cells and models of AD. Once Aβ interacts with ...
- DOI:
- 10.1007/s00018-014-1706-0
- https://doi.org/10.1007/s00018-014-1706-0
- Author:
- Pascal Saidlitz; T. Voisin; B. Vellas; P. Payoux; A. Gabelle; M. Formaglio; J. Delrieu
- Source:
- journal of nutrition, health & aging 2014 v.18 no.7 pp. 723-740
- ISSN:
- 1279-7707
- Subject:
- Alzheimer disease; amyloid; drugs; image analysis; immunotherapy; marketing; tracer techniques
- Abstract:
- ... Therapies targeting amyloid-β peptide currently represent approximately 50% of drugs now being developed for Alzheimer’s disease. Some, including active and passive anti-Aβ immunotherapy, directly target the amyloid plaques. The new amyloid tracers are increasingly being included in the proposed updated diagnostic criteria, and may allow earlier diagnosis. Those targeting amyloid-β peptide allow i ...
- DOI:
- 10.1007/s12603-014-0485-5
- PubMed:
- 25226113
- https://doi.org/10.1007/s12603-014-0485-5
- Author:
- Toshiaki Miyazaki; Kazuhiro Ikeda; Kuniko Horie-Inoue; Satoshi Inoue
- Source:
- Biochemical and biophysical research communications 2014 v.452 pp. 828-833
- ISSN:
- 0006-291X
- Subject:
- Alzheimer disease; amyloid; gene expression; gene expression regulation; genes; humans; microarray technology; neoplasm cells; patients; prognosis; prostatic neoplasms; small interfering RNA; transmembrane proteins
- Abstract:
- ... Amyloid precursor protein (APP) is a type I transmembrane protein, and one of its processed forms, β-amyloid, is considered to play a central role in the development of Alzheimer’s disease. We previously showed that APP is a primary androgen-responsive gene in prostate cancer and that its increased expression is correlated with poor prognosis for patients with prostate cancer. APP has also been im ...
- DOI:
- 10.1016/j.bbrc.2014.09.010
- https://doi.org/10.1016/j.bbrc.2014.09.010
- Author:
- Charlotte Regitz; Lisa Marie Dußling; Uwe Wenzel
- Source:
- Molecular nutrition & food research 2014 v.58 no.10 pp. 1931-1940
- ISSN:
- 1613-4125
- Subject:
- Alzheimer disease; Caenorhabditis elegans; RNA interference; amyloid; endoplasmic reticulum; genetically modified organisms; histopathology; humans; lysosomes; mitochondria; models; paralysis; phenotype; polyphenols; protein degradation; quercetin; unfolded protein response
- Abstract:
- ... SCOPE: Dietary polyphenols are suggested to play a role in the prevention of Alzheimer's disease, of which accumulation of aggregated beta amyloid (Aβ) is a key histopathological hallmark. We used the transgenic Caenorhabditis elegans strain CL2006, which expresses human Aβ₁–₄₂ under control of a muscle‐specific promoter and responds to Aβ₁–₄₂ aggregation with paralysis, to test effects of the pol ...
- DOI:
- 10.1002/mnfr.201400014
- https://doi.org/10.1002/mnfr.201400014
- Author:
- J. M. Haro; Kristin Kahle-Wrobleski; G. Bruno; M. Belger; G. Dell’Agnello; R. Dodel; R. W. Jones; C. C. Reed; B. Vellas; A. Wimo; J. M. Argimon
- Source:
- journal of nutrition, health & aging 2014 v.18 no.7 pp. 677-684
- ISSN:
- 1279-7707
- Subject:
- Alzheimer disease; caregivers; disease severity; distress; funding; linear models; observational studies; patients; regression analysis; France; Germany; United Kingdom
- Abstract:
- ... OBJECTIVES: This study aimed to describe the baseline characteristics of informal carers of community-living Alzheimer’s disease (AD) patients by AD severity group and to identify factors associated with two measures of caregiver burden. DESIGN AND SETTING: GERAS is a prospective observational study in France, Germany, and the UK, designed to assess costs and resource use associated with AD, for p ...
- DOI:
- 10.1007/s12603-014-0036-0
- PubMed:
- 25226106
- https://doi.org/10.1007/s12603-014-0036-0
- Author:
- Alison Burgess; Tam Nhan; Clare Moffatt; A.L. Klibanov; Kullervo Hynynen
- Source:
- Journal of controlled release 2014 v.192 pp. 243-248
- ISSN:
- 0168-3659
- Subject:
- Alzheimer disease; acoustics; amyloid; animal models; blood-brain barrier; brain; drugs; dyes; fluorescence; mice; microscopy; permeability; skull; therapeutics; transgenic animals
- Abstract:
- ... Transcranial focused ultrasound (FUS) can cause temporary, localized increases in blood–brain barrier (BBB) permeability for effective drug delivery to the brain. In pre-clinical models of Alzheimer's disease, FUS has successfully been used to deliver therapeutic agents and endogenous therapeutic molecules to the brain leading to plaque reduction and improved behavior. However, prior to moving to ...
- DOI:
- 10.1016/j.jconrel.2014.07.051
- https://doi.org/10.1016/j.jconrel.2014.07.051
- Author:
- Abu M. T. Islam; Jina Kwak; Yoo Jung Jung; Yun Kee
- Source:
- Genes & genomics 2014 v.36 no.4 pp. 399-413
- ISSN:
- 1976-9571
- Subject:
- Alzheimer disease; Danio rerio; Drosophila; Parkinson disease; animal models; disease course; mice; mutants; phenotype; proteins; sclerosis; transgenic animals
- Abstract:
- ... Amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD) are debilitating neurodegenerative conditions for which there is no effective cure. Genetic determinants of both diseases have been identified, providing insight into neuropathological mechanisms and opportunities for therapeutic intervention. Aggregation of mutant proteins is the most prominent phenotype of these neurodegenerative ...
- DOI:
- 10.1007/s13258-014-0188-7
- https://doi.org/10.1007/s13258-014-0188-7
- Author:
- Neha; Rupinder K. Sodhi; Amteshwar S. Jaggi; Nirmal Singh
- Source:
- Life sciences 2014 v.109 no.2 pp. 73-86
- ISSN:
- 0024-3205
- Subject:
- Alzheimer disease; animal models; cognition; cognitive disorders; drugs; prognosis; therapeutics
- Abstract:
- ... Recent advances in the understanding of the pathophysiological mechanisms underlying Alzheimer's disease and other cognitive deficits have pointed to novel strategies for drug development. Animal models have contributed noticeably to these advances and are an indispensible part in the evaluation of therapeutics. This review is an exhaustive study of animal models of dementia and cognitive dysfunct ...
- DOI:
- 10.1016/j.lfs.2014.05.017
- https://doi.org/10.1016/j.lfs.2014.05.017
- Author:
- Jessié M. Gutierres; Fabiano B. Carvalho; Maria Rosa C. Schetinger; Patrícia Marisco; Paula Agostinho; Marília Rodrigues; Maribel A. Rubin; Roberta Schmatz; Cassia R. da Silva; Giana de P. Cognato; Julia G. Farias; Cristiane Signor; Vera M. Morsch; Cinthia M. Mazzanti; Mauricio Bogo; Carla D. Bonan; Roselia Spanevello
- Source:
- Life sciences 2014 v.96 no.1-2 pp. 7-17
- ISSN:
- 0024-3205
- Subject:
- Alzheimer disease; Ca2-transporting ATPase; acetylcholinesterase; anthocyanins; anxiety; cerebral cortex; enzyme activity; hippocampus; memory; memory disorders; nitrates; nitrites; nitrogen oxides; rats; receptors; sodium-potassium-exchanging ATPase; streptozotocin; tranquilizers; tritium
- Abstract:
- ... The aim of this study was to analyze if the pre-administration of anthocyanin on memory and anxiety prevented the effects caused by intracerebroventricular streptozotocin (icv-STZ) administration-induced sporadic dementia of Alzheimer's type (SDAT) in rats. Moreover, we evaluated whether the levels of nitrite/nitrate (NOx), Na⁺,K⁺-ATPase, Ca²⁺-ATPase and acethylcholinesterase (AChE) activities in ...
- DOI:
- 10.1016/j.lfs.2013.11.014
- https://doi.org/10.1016/j.lfs.2013.11.014
- Author:
- Filomena Altieri; Chiara Stella Di Stadio; Valeria Severino; Annamaria Sandomenico; Giuseppina Minopoli; Giuseppina Miselli; Antimo Di Maro; Menotti Ruvo; Angela Chambery; Vincenzo Quagliariello; Mariorosario Masullo; Emilia Rippa; Paolo Arcari
- Source:
- Biochimie 2014 v.106 pp. 91-100
- ISSN:
- 0300-9084
- Subject:
- Alzheimer disease; amino acids; amyloid; confocal microscopy; dissociation; distress; gastric mucosa; gel chromatography; human diseases; humans; hydrolysis; mass spectrometry; polyacrylamide gel electrophoresis; polymerization; polypeptides; stomach neoplasms; surfactants
- Abstract:
- ... Gastrokine 1 (GKN1) is a stomach-specific protein expressed in normal gastric tissue but absent in gastric cancer. GKN1 plays a major role in maintaining gastric mucosa integrity and is characterized by the presence of a BRICHOS domain consisting of about 100 amino acids also found in several unrelated proteins associated with major human diseases like BRI2, related to familial British and Danish ...
- DOI:
- 10.1016/j.biochi.2014.08.004
- https://doi.org/10.1016/j.biochi.2014.08.004
- Author:
- M. Chinsamy; J.F. Finnie; J. Van Staden
- Source:
- South African journal of botany 2014 v.91 pp. 88-98
- ISSN:
- 0254-6299
- Subject:
- Alzheimer disease; Bulbophyllum; Salmonella; anti-inflammatory activity; antioxidant activity; coasts; electron transfer; free radical scavengers; genotoxicity; hydrogen; leaf extracts; leaves; markets; mutagenicity; oxidative stress; patients; prostaglandin synthase; traditional medicine; tubers; South Africa
- Abstract:
- ... While the role of various processes in inflammatory-related degenerative disorders is still being researched, many avenues of research have concentrated on the treatment and/or prevention of these disorders. Inflammatory-responses, the cholinergic system and oxidative stress have often been linked to the symptoms prevalent in aged persons and Alzheimer's patients. The current research explored the ...
- DOI:
- 10.1016/j.sajb.2013.12.004
- https://doi.org/10.1016/j.sajb.2013.12.004
- Author:
- Erwin De Genst; Anne Messer; Christopher M. Dobson
- Source:
- BBA - Proteins and Proteomics 2014 v.1844 pp. 1907-1919
- ISSN:
- 1570-9639
- Subject:
- Alzheimer disease; Parkinson disease; antibodies; cellular microenvironment; engineering; protein folding; spectroscopy; toxicity
- Abstract:
- ... Protein misfolding disorders, including the neurodegenerative conditions Alzheimer's disease (AD) and Parkinson's disease (PD) represent one of the major medical challenges or our time. The underlying molecular mechanisms that govern protein misfolding and its links with disease are very complex processes, involving the formation of transiently populated but highly toxic molecular species within t ...
- DOI:
- 10.1016/j.bbapap.2014.08.016
- https://doi.org/10.1016/j.bbapap.2014.08.016
38. Antiglycative and carbonyl trapping properties of the water soluble fraction of coffee silverskin
- Author:
- M. Mesías; M. Navarro; N. Martínez-Saez; M. Ullate; M.D. del Castillo; F.J. Morales
- Source:
- Food research international 2014 v.62 pp. 1120-1126
- ISSN:
- 0963-9969
- Subject:
- Alzheimer disease; Coffea canephora; advanced glycation end products; antioxidant activity; atherosclerosis; caffeine; chlorogenic acid; diabetic complications; dietary fiber; dose response; inhibitory concentration 50; melanoidins; models; phenolic compounds; protective effect; tissues
- Abstract:
- ... Carbonyl stress and accumulation of advanced glycation end-products (AGEs) in human tissues are involved in diabetic complications, atherosclerosis, Alzheimer's disease and aging. The objective of this study was to evaluate the in vitro protective effect of aqueous extracts of coffee silverskin (CS) in the formation of AGEs and trapping of carbonyl reactive species such as methylglyoxal (MGO). Aqu ...
- DOI:
- 10.1016/j.foodres.2014.05.058
- https://doi.org/10.1016/j.foodres.2014.05.058
- Author:
- Ningna Zhou; Yang Tang; Richard F. Keep; Xiaoxia Ma; Jianming Xiang
- Source:
- Phytomedicine 2014 v.21 pp. 1189-1195
- ISSN:
- 0944-7113
- Subject:
- Alzheimer disease; Panax notoginseng; astrocytes; cell death; heme oxygenase (biliverdin-producing); humans; glucose; glutathione transferase; oxidative stress; brain; reactive oxygen species; saponins; stroke; lactate dehydrogenase; rats; antioxidant activity; oxygen; leaves; protective effect
- Abstract:
- ... Oxidative stress resulting from accumulation of reactive oxygen species (ROS) is involved in cell death associated with neurological disorders such as stroke, Alzheimer's disease and traumatic brain injury. Antioxidant compounds that improve endogenous antioxidant defenses have been proposed for neural protection. The purpose of this study was to investigate the potential protective effects of tot ...
- DOI:
- 10.1016/j.phymed.2014.05.004
- PubMed:
- 24916704
- PubMed Central:
- PMC4111966
- https://doi.org/10.1016/j.phymed.2014.05.004
- Author:
- Fiona E. Harrison; Gene L. Bowman; Maria Cristina Polidori
- Source:
- Nutrients 2014 v.6 no.4 pp. 1752-1781
- ISSN:
- 2072-6643
- Subject:
- Alzheimer disease; animal models; ascorbic acid; brain; cognition; cognitive disorders; comorbidity; humans; metabolism; neurodegenerative diseases; neurons; risk factors; tissues
- Abstract:
- ... This review is focused upon the role of ascorbic acid (AA, vitamin C) in the promotion of healthy brain aging. Particular attention is attributed to the biochemistry and neuronal metabolism interface, transport across tissues, animal models that are useful for this area of research, and the human studies that implicate AA in the continuum between normal cognitive aging and age-related cognitive de ...
- DOI:
- 10.3390/nu6041752
- PubMed:
- 24763117
- PubMed Central:
- PMC4011065
- https://doi.org/10.3390/nu6041752
- Author:
- Nurgun Kucukboyacı; Ilkay Orhan; Bilge Şener; S. Ahmad Nawaz; M. Iqbal Choudhary
- Source:
- Zeitschrift für Naturforschung 2014 v.65 no.3-4 pp. 187-194
- ISSN:
- 1865-7125
- Subject:
- Alzheimer disease; acetylcholinesterase; ions; Taxus baccata; 2,2-diphenyl-1-picrylhydrazyl; iron; linoleate 13S-lipoxygenase; chromatography; pathogenesis; lignans; cholinesterase; chlorogenic acid; antioxidant activity
- Abstract:
- ... Phytochemical investigations of Taxus baccata L. by successive chromatographic methods resulted in the isolation of the lignans lariciresinol (1), taxiresinol (2), 3´-demethylisolariciresinol- 9´-hydroxyisopropylether (3), isolariciresinol (4), and 3-demethylisolariciresinol (5) as well as taxoids. Compounds 1 - 5 were evaluated for their acetylcholinesterase (AChE), butyrylcholinesterase (BChE), ...
- DOI:
- 10.1515/znc-2010-3-404
- https://doi.org/10.1515/znc-2010-3-404
- Author:
- Martínez-Morillo Eduardo; Nielsen Henrietta M.; Batruch Ihor; Drabovich Andrei P.; Begcevic Ilijana; Lopez Mary F.; Minthon Lennart; Bu Guojun; Mattsson Niklas; Portelius Erik; Hansson Oskar; Diamandis Eleftherios P.
- Source:
- Journal of Proteome Research 2014 v.13 no.2 pp. 1077-1087
- ISSN:
- 1535-3907
- Subject:
- Alzheimer disease; apolipoprotein E; central nervous system; cerebrospinal fluid; clinical trials; coronary artery disease; deamidation; enzyme-linked immunosorbent assay; genotype; glutamine; lipid metabolism; mass spectrometry; methionine; monitoring; oxidation; peptides; phenotype
- Abstract:
- ... Apolipoprotein E (ApoE) is a polymorphic protein that plays a major role in lipid metabolism in the central nervous system and periphery. It has three common allelic isoforms, ApoE2, ApoE3, and ApoE4, that differ in only one or two amino acids. ApoE isoforms have been associated with the occurrence and progression of several pathological conditions, such as coronary atherosclerosis and Alzheimer’s ...
- DOI:
- 10.1021/pr401060x
- https://doi.org/10.1021/pr401060x
- Author:
- Hyesook Kim; Ggotpin Kim; Won Jang; Seong Yoon Kim; Namsoo Chang
- Source:
- Nutrition journal 2014 v.13 no.1 pp. 118
- ISSN:
- 1475-2891
- Subject:
- Alzheimer disease; Koreans; blood; cognition; correlation; dietary supplements; elderly; folic acid; food intake; homocysteine; memory; nutrient intake; patients; pyridoxine; radioimmunoassays; regression analysis; riboflavin; vitamin B12; South Korea
- Abstract:
- ... BACKGROUND: It is possible that blood B vitamins level and cognitive function may be affected by dietary intake of these vitamins, no study however has yet been conducted on relationships between B vitamins intake and cognitive function among elderly population in Korea. This study examined the relationship between B vitamins intake and cognitive function among elderly in South Korea. METHODS: Par ...
- DOI:
- 10.1186/1475-2891-13-118
- PubMed:
- 25516359
- PubMed Central:
- PMC4290102
- https://doi.org/10.1186/1475-2891-13-118
- Author:
- Marie Fanelli Kuczmarski; Deanne Allegro; Emily Stave
- Source:
- Journal of nutrition in gerontology and geriatrics 2014 v.33 no.2 pp. 69-90
- ISSN:
- 2155-1200
- Subject:
- Alzheimer disease; Mediterranean diet; cognition; elderly; researchers; risk
- Abstract:
- ... The association of diet with mild cognitive impairment has not been extensively studied. Consumption of a healthful diet may help to attenuate age-related decline in older adults. Published studies have suggested that greater adherence to a Mediterranean-style dietary pattern is associated with a lower risk of developing Alzheimer's disease and with a slower rate of cognitive decline with age. How ...
- DOI:
- 10.1080/21551197.2014.907101
- https://doi.org/10.1080/21551197.2014.907101
- Author:
- V. Pouyet; A. Giboreau; L. Benattar; G. Cuvelier
- Source:
- Food quality and preference 2014 v.34 pp. 62-69
- ISSN:
- 0950-3293
- Subject:
- Alzheimer disease; elderly; food choices; foods; ingredients; interviews; nurses; nursing homes; patients
- Abstract:
- ... Finger foods are helpful for patients with Alzheimer’s disease because they enable them to eat alone with their fingers rather than with cutlery, once this has become too difficult to use. By applying this solution, patients with Alzheimer’s disease can gain in autonomy and rediscover the pleasure of eating on their own. However, the provision of attractive finger foods is essential to ensuring th ...
- DOI:
- 10.1016/j.foodqual.2013.12.011
- https://doi.org/10.1016/j.foodqual.2013.12.011
- Author:
- Xin R. Cheng; Ben Y.H. Hau; Tatsuro Endo; Kagan Kerman
- Source:
- Biosensors & bioelectronics 2014 v.53 pp. 513-518
- ISSN:
- 0956-5663
- Subject:
- Alzheimer disease; DNA; apolipoprotein E; biosensors; dielectric spectroscopy; genes; glass; gold; indium tin oxide; nanogold; nucleic acid hybridization; point mutation; potassium chloride; surface plasmon resonance
- Abstract:
- ... Electrochemical impedance spectroscopy (EIS) and localized surface plasmon resonance (LSPR) were performed on the same Au nanoparticle (AuNP)-modified indium tin oxide (ITO) coated glass surfaces. Cyclic voltammetry was applied to electrodeposit AuNPs on ITO surface directly. The surface plasmon band characterization of AuNPs was initially studied by controlling the electrodeposition conditions. I ...
- DOI:
- 10.1016/j.bios.2013.10.003
- https://doi.org/10.1016/j.bios.2013.10.003
- Author:
- Jimena Baleriola; Chandler A. Walker; Ying Y. Jean; John F. Crary; Carol M. Troy; Peter L. Nagy; Ulrich Hengst
- Source:
- Cell 2014 v.158 pp. 1159-1172
- ISSN:
- 0092-8674
- Subject:
- Alzheimer disease; axons; brain; gene expression regulation; messenger RNA; mice; neurodegenerative diseases; patients; protein synthesis; small interfering RNA; transcription (genetics); transcription factors; translation (genetics)
- Abstract:
- ... In Alzheimer’s disease (AD) brain, exposure of axons to Aβ causes pathogenic changes that spread retrogradely by unknown mechanisms, affecting the entire neuron. We found that locally applied Aβ1-42 initiates axonal synthesis of a defined set of proteins including the transcription factor ATF4. Inhibition of local translation and retrograde transport or knockdown of axonal Atf4 mRNA abolished Aβ-i ...
- DOI:
- 10.1016/j.cell.2014.07.001
- PubMed:
- 25171414
- PubMed Central:
- PMC4149755
- https://doi.org/10.1016/j.cell.2014.07.001
- Author:
- Anzelle Delport; Brian H. Harvey; Anél Petzer; Jacobus P. Petzer
- Source:
- Life sciences 2014 v.117 no.2 pp. 56-66
- ISSN:
- 0024-3205
- Subject:
- Alzheimer disease; amine oxidase (flavin-containing); antidepressants; chlorides; cultured cells; humans; inhibitory concentration 50; metabolites; methylene blue; nitric oxide; rats; toxicity
- Abstract:
- ... The phenothiazinium compound, methylene blue (MB), possesses diverse pharmacological actions and is attracting attention for the treatment of bipolar disorder and Alzheimer's disease. MB acts on both monoamine oxidase (MAO) and the nitric oxide (NO)-cGMP pathway, and possesses antidepressant activity in rodents. The goal of this study was to synthesise a structural analogue of MB, ethylthioninium ...
- DOI:
- 10.1016/j.lfs.2014.10.005
- https://doi.org/10.1016/j.lfs.2014.10.005
- Author:
- Hui Jin; Weixi Wang; Shanshan Zhao; Weina Yang; Yihua Qian; Ning Jia; Gaifeng Feng
- Source:
- Vaccine 2014 v.32 no.35 pp. 4450-4456
- ISSN:
- 0264-410X
- Subject:
- Alzheimer disease; T-lymphocytes; adjuvants; adverse effects; amyloid; antibodies; antiserum; behavior change; cortex; epitopes; hippocampus; immune response; immunization; immunohistochemistry; memory; meningoencephalitis; mice; neuroglia; toxicity; transgenic animals; vaccines; virus-like particles
- Abstract:
- ... β-Amyloid peptide (Aβ) immunization is regarded as a promising therapy to Alzheimer's disease. The full length Aβ as antigen might induce meningoencephalitis adverse effect since the middle and C-terminal fragments of Aβ contain T cell epitopes. While N-terminal fragment of Aβ, containing B cell epitope, has weak or no immunogenicity. To improve the immunogenicity, in the previous study, we used H ...
- DOI:
- 10.1016/j.vaccine.2014.06.051
- https://doi.org/10.1016/j.vaccine.2014.06.051
- Author:
- Gunjan Joshi; Youjian Chi; Zheping Huang; Yanzhuang Wang
- Source:
- Proceedings of the National Academy of Sciences of the United States of America 2014 v.111 no.13 pp. E1230
- ISSN:
- 0027-8424
- Subject:
- Alzheimer disease; amyloid; cell biology; drugs; mice; models; mutants; neurons; patients; peptides; phosphorylation; protein transport; secretion; structural proteins; tissue culture; transgenic animals
- Abstract:
- ... Golgi fragmentation occurs in neurons of patients with Alzheimer’s disease (AD), but the underlying molecular mechanism causing the defects and the subsequent effects on disease development remain unknown. In this study, we examined the Golgi structure in APPswe/PS1E9 transgenic mouse and tissue culture models. Our results show that accumulation of amyloid beta peptides (Aβ) leads to Golgi fragmen ...
- DOI:
- 10.1073/pnas.1320192111
- PubMed:
- 24639524
- PubMed Central:
- PMC3977293
- https://doi.org/10.1073/pnas.1320192111