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You searched for: Publication year rev 7986-2014 Remove constraint Publication year rev: 7986-2014 Subject term Alzheimer disease Remove constraint Subject term: Alzheimer disease
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1. 3D Structures and Redox Potentials of Cu2+–Aβ(1–16) Complexes at Different pH: A Computational Study

Author:
Alí-Torres Jorge; Mirats Andrea; Maréchal Jean-Didier; Rodríguez-Santiago Luis; Sodupe Mariona
Source:
Journal of physical chemistry 2014 v.118 no.18 pp. 4840-4850
ISSN:
1520-5207
Subject:
Alzheimer disease; cations; copper; electrodes; geometry; hydrogen; ligands; models; oxidative stress; pH; physical chemistry; redox potential
Abstract:
... Oxidative stress induced by redox-active metal cations such as Cu²⁺ is a key event in the development of Alzheimer’s disease. A detailed knowledge of the structure of Cu²⁺–Aβ complex is thus important to get a better understanding of this critical process. In the present study, we use a computational approach that combines homology modeling with quantum-mechanics-based methods to determine plausib ...
DOI:
10.1021/jp5019718

2. A 3D Alzheimer's disease culture model and the induction of P21-activated kinase mediated sensing in iPSC derived neurons

Author:
Dawei Zhang; Mari Pekkanen-Mattila; Mansoureh Shahsavani; Anna Falk; Ana I. Teixeira; Anna Herland
Source:
Biomaterials 2014 v.35 no.5 pp. 1420-1428
ISSN:
0142-9612
Subject:
Alzheimer disease; actin; induced pluripotent stem cells; models; neurons; phenotype
Abstract:
... The recent progress in stem cell techniques has broadened the horizon for in vitro disease modeling. For desired in vivo like phenotypes, not only correct cell type specification will be critical, the microenvironmental context will be essential to achieve relevant responses. We demonstrate how a three dimensional (3D) culture of stem cell derived neurons can induce in vivo like responses related ...
DOI:
10.1016/j.biomaterials.2013.11.028

3. A Complex Equilibrium among Partially Unfolded Conformations in Monomeric Transthyretin

Author:
Conti Simona; Li Xinyi; Gianni Stefano; Ghadami Seyyed Abolghasem; Buxbaum Joel; Cecchi Cristina; Chiti Fabrizio; Bemporad Francesco
Source:
Biochemistry 2014 v.53 no.27 pp. 4381-4392
ISSN:
1520-4995
Subject:
Alzheimer disease; isomerization; pH; prealbumin; proline; protective effect
Abstract:
... Aggregation of transthyretin (TTR) is known to be linked to the development of systemic and localized amyloidoses. It also appears that TTR exerts a protective role against aggregation of the Aβ peptide, a process linked to Alzheimer’s disease. In vitro, both processes correlate with the ability of TTR to populate a monomeric state, yet a complete description of the possible conformational states ...
DOI:
10.1021/bi500430w

4. A Nutrient Combination that Can Affect Synapse Formation

Author:
Richard J. Wurtman
Source:
Nutrients 2014 v.6 no.4 pp. 1701-1710
ISSN:
2072-6643
Subject:
Alzheimer disease; RNA; adults; bioavailability; blood plasma; brain; choline; infant formulas; infants; longevity; milk; mothers; neurons; nutrients; omega-3 fatty acids; synapse; synaptogenesis; uridine; uridine monophosphate
Abstract:
... Brain neurons form synapses throughout the life span. This process is initiated by neuronal depolarization, however the numbers of synapses thus formed depend on brain levels of three key nutrients—uridine, the omega-3 fatty acid DHA, and choline. Given together, these nutrients accelerate formation of synaptic membrane, the major component of synapses. In infants, when synaptogenesis is maximal, ...
DOI:
10.3390/nu6041701
PubMed:
24763080
PubMed Central:
PMC4011061

5. A Review of Thermo‐Oxidative Degradation of Food Lipids Studied by ¹H NMR Spectroscopy: Influence of Degradative Conditions and Food Lipid Nature

Author:
Andrea Martínez‐Yusta; Encarnación Goicoechea; María D. Guillén
Source:
Comprehensive reviews in food science and food safety 2014 v.13 no.5 pp. 838-859
ISSN:
1541-4337
Subject:
Alzheimer disease; alcohols; aldehydes; animal fats and oils; atherosclerosis; cooking fats and oils; cytotoxicity; epoxides; food spoilage; genotoxicity; hydroperoxides; hydroxides; ketones; lipids; metabolomics; nuclear magnetic resonance spectroscopy; oxidation; oxygen; protons; temperature; vegetables
Abstract:
... This review summarizes present‐day knowledge provided by proton nuclear magnetic resonance (¹H NMR) concerning food lipid thermo‐oxidative degradation. The food lipids considered include edible oils and fats of animal and vegetable origin. The thermo‐oxidation processes of food lipids of very different composition, occurring at low, intermediate, or high temperatures, with different food lipid sur ...
DOI:
10.1111/1541-4337.12090

6. A Synchrotron-Based Hydroxyl Radical Footprinting Analysis of Amyloid Fibrils and Prefibrillar Intermediates with Residue-Specific Resolution

Author:
Klinger Alexandra L.; Kiselar Janna; Ilchenko Serguei; Komatsu Hiroaki; Chance Mark R.; Axelsen Paul H.
Source:
Biochemistry 2014 v.53 no.49 pp. 7724-7734
ISSN:
1520-4995
Subject:
Alzheimer disease; amino acids; amyloid; electron microscopy; hydroxyl radicals; mass spectrometry; models; neurotoxicity; polypeptides; solvents; topology
Abstract:
... Structural models of the fibrils formed by the 40-residue amyloid-β (Aβ40) peptide in Alzheimer’s disease typically consist of linear polypeptide segments, oriented approximately perpendicular to the long axis of the fibril, and joined together as parallel in-register β-sheets to form filaments. However, various models differ in the number of filaments that run the length of a fibril, and in the t ...
DOI:
10.1021/bi5010409
PubMed:
25382225
PubMed Central:
PMC4270378

7. A glucan isolated from flowers of Lonicera japonica Thunb. inhibits aggregation and neurotoxicity of Aβ42

Author:
Peipei Wang; Wenfeng Liao; Jianping Fang; Qin Liu; Jian Yao; Minghua Hu; Kan Ding
Source:
Carbohydrate polymers 2014 v.110 pp. 142-147
ISSN:
0144-8617
Subject:
Alzheimer disease; Lonicera japonica; atomic force microscopy; cytotoxicity; flowers; glucans; methylation; monosaccharides; neurotoxicity; nuclear magnetic resonance spectroscopy; therapeutics
Abstract:
... Inhibition of Aβ aggregation and attenuation of its cytotoxicity are considered to valuable therapeutics for Alzheimer's disease (AD). Here, a glucan named as LJW0F2 was purified from flowers of Lonicera japonica Thunb. Using monosaccharides composition analysis, methylation analysis, IR and NMR spectroscopy, this polysaccharide was elucidated to be an α-d-(1→4)-glucan with an α-(1→4) linked branc ...
DOI:
10.1016/j.carbpol.2014.03.060

8. A review of analytical methods for eicosanoids in brain tissue

Author:
Michael Puppolo; Deepti Varma; Susan A. Jansen
Source:
Journal of Chromatography B 2014 v.964 pp. 50-64
ISSN:
1570-0232
Subject:
Alzheimer disease; arachidonic acid; atherosclerosis; brain; chromatography; derivatization; eicosanoids; hypertension; inflammation; mass spectrometry; metabolites; neoplasms; rheumatoid arthritis; solid phase extraction
Abstract:
... Eicosanoids are potent lipid mediators of inflammation and are known to play an important role in numerous pathophysiological processes. Furthermore, inflammation has been proven to be a mediator of diseases such as hypertension, atherosclerosis, Alzheimer's disease, cancer and rheumatoid arthritis. Hence, these lipid mediators have gained significant attention in recent years. This review focuses ...
DOI:
10.1016/j.jchromb.2014.03.007

9. A review study on medicinal plants used in the treatment of learning and memory impairments

Author:
Nahid Jivad; Zahra Rabiei
Source:
Asian Pacific Journal of Tropical Biomedicine 2014 v.4 pp. 780-789
ISSN:
2221-1691
Subject:
Alzheimer disease; acetylcholine; amyloid; anxiety; brain; cognitive disorders; elderly; herbal medicines; herbs; medicinal plants; memory; memory disorders; neurodegenerative diseases; neurotoxicity; neurotransmitters; oxidative stress; oxygen; patients; personality
Abstract:
... Alzheimer's disease (AD) is a progressive brain disorder that gradually impairs the person's memory and ability to learn, reasoning, judgment, communication and daily activities. AD is characterized clinically by cognitive impairment and pathologically by the deposition of β amyloid plaques and neurofibrillary tangles, and the degeneration of the cholinergic basal forebrain. During the progression ...
DOI:
10.12980/APJTB.4.2014APJTB-2014-0412

10. A small molecule that displays marked reactivity toward copper– versus zinc–amyloid-β implicated in Alzheimer's disease

Author:
Masha G. Savelieff; Yuzhong Liu; Russell R. P. Senthamarai; Kyle J. Korshavn; Hyuck Jin Lee; Ayyalusamy Ramamoorthy; Mi Hee Lim
Source:
Chemical communications 2014 v.50 no.40 pp. 5301-5303
ISSN:
1364-548X
Subject:
Alzheimer disease; chemical communication; chemical reactions; copper; etiology; neurodegenerative diseases; zinc
Abstract:
... Alzheimer's disease (AD) is a complex, multifactorial, neurodegenerative disease that poses tremendous difficulties in pinpointing its precise etiology. A toolkit, which specifically targets and modulates suggested key players, may elucidate their roles in disease onset and progression. We report high-resolution insights on the activity of a small molecule (L2-NO) which exhibits reactivity toward ...
DOI:
10.1039/c3cc48473d
PubMed:
24326305
PubMed Central:
PMC3999264

11. Absolute Quantitation of Low Abundance Plasma APL1β peptides at Sub-fmol/mL Level by SRM/MRM without Immunoaffinity Enrichment

Author:
Sano Shozo; Tagami Shinji; Hashimoto Yuuki; Yoshizawa-Kumagaye Kumiko; Tsunemi Masahiko; Okochi Masayasu; Tomonaga Takeshi
Source:
Journal of Proteome Research 2014 v.13 no.2 pp. 1012-1020
ISSN:
1535-3907
Subject:
Alzheimer disease; acetonitrile; albumins; antibodies; blood proteins; blood serum; cation exchange; chromatography; ions; monitoring; peptides; precipitin tests; proteome; spectrometers
Abstract:
... Selected/multiple reaction monitoring (SRM/MRM) has been widely used for the quantification of specific proteins/peptides, although it is still challenging to quantitate low abundant proteins/peptides in complex samples such as plasma/serum. To overcome this problem, enrichment of target proteins/peptides is needed, such as immunoprecipitation; however, this is labor-intense and generation of anti ...
DOI:
10.1021/pr4010103

12. Activity and Architecture of Pyroglutamate-Modified Amyloid-β (AβpE3-42) Pores

Author:
Gillman Alan L.; Jang Hyunbum; Lee Joon; Ramachandran Srinivasan; Kagan Bruce L.; Nussinov Ruth; Teran Arce Fernando
Source:
Journal of physical chemistry 2014 v.118 no.26 pp. 7335-7344
ISSN:
1520-5207
Subject:
Alzheimer disease; cognition; cytotoxicity; elderly; hydrophobicity; lipids; molecular dynamics; patients; peptides; permeability
Abstract:
... Among the family of Aβ peptides, pyroglutamate-modified Aβ (AβₚE) peptides are particularly associated with cytotoxicity in Alzheimer’s disease (AD). They represent the dominant fraction of Aβ oligomers in the brains of AD patients, but their accumulation in the brains of elderly individuals with normal cognition is significantly lower. Accumulation of AβₚE plaques precedes the formation of plaque ...
DOI:
10.1021/jp5040954
PubMed:
24922585
PubMed Central:
PMC4096221

13. Ageing and apoE change DHA homeostasis: relevance to age-related cognitive decline

Author:
Marie Hennebelle; Mélanie Plourde; Raphaël Chouinard-Watkins; Christian-Alexandre Castellano; Pascale Barberger-Gateau; Stephen C. Cunnane
Source:
Proceedings of the Nutrition Society 2014 v.73 no.1 pp. 80-86
ISSN:
1475-2719
Subject:
Alzheimer disease; beta oxidation; blood; brain; docosahexaenoic acid; elderly; epidemiological studies; fatty fish; fish consumption; homeostasis; humans; isotope labeling; omega-3 fatty acids; risk; risk reduction; young adults
Abstract:
... Epidemiological studies fairly convincingly suggest that higher intakes of fatty fish and n-3 fatty acids are associated with reduced risk of Alzheimer's disease (AD). DHA in plasma is normally positively associated with DHA intake. However, despite being associated with lower fish and DHA intake, unexpectedly, plasma (or brain) DHA is frequently not lower in AD. This review will highlight some me ...
DOI:
10.1017/S0029665113003625
PubMed:
24103099

14. Alkaloids enriched extract from Dendrobium nobile Lindl. attenuates tau protein hyperphosphorylation and apoptosis induced by lipopolysaccharide in rat brain

Author:
Shu Yang; Qihai Gong; Qin Wu; Fei Li; Yuanfu Lu; Jingshan Shi
Source:
Phytomedicine 2014 v.21 pp. 712-716
ISSN:
0944-7113
Subject:
Alzheimer disease; Dendrobium nobile; Western blotting; alkaloids; apoptosis; hippocampus; lipopolysaccharides; medicinal plants; protective effect; rats; therapeutics
Abstract:
... Neurofibrillary tangles, one of the characteristic pathological features of Alzheimer's disease (AD), are composed of paired helical filaments mainly with hyperphosphorylated tau protein. Inhibition of the hyperphosphorylation of tau protein is an effective therapy for AD. The current study was designed to investigate the protective effects of alkaloids enriched extract from Dendrobium Nobile Lind ...
DOI:
10.1016/j.phymed.2013.10.026

15. AlphaLISA-based high-throughput screening assay to measure levels of soluble amyloid precursor protein α

Author:
Hongjie Wang; Adel Nefzi; Gregg B. Fields; Madepalli K. Lakshmana; Dmitriy Minond
Source:
Analytical biochemistry 2014 v.459 pp. 24-30
ISSN:
0003-2697
Subject:
Alzheimer disease; amyloid; chemotypes; drugs; screening
Abstract:
... Activation of nonamyloidogenic processing of amyloid precursor protein (APP) has been hypothesized to be a viable approach for Alzheimer’s disease drug discovery. However, until recently, the lack of HTS-compatible assay technologies precluded large scale screening efforts to discover molecules that potentiate nonamyloidogenic pathways. We have developed an HTS-compatible assay based on AlphaLISA ...
DOI:
10.1016/j.ab.2014.05.007

16. Alzheimer’s disease and CADASIL are heritable, adult-onset dementias that both involve damaged small blood vessels

Author:
Vincent T. Marchesi
Source:
Cellular and molecular life sciences 2014 v.71 no.6 pp. 949-955
ISSN:
1420-682X
Subject:
Alzheimer disease; amyloid; blood flow; blood vessels; brain; cell death; disease course; genes; germ cells; inflammation; mutants; mutation; neurons; nuclear magnetic resonance spectroscopy; pathogenesis; patients; peptides; protein aggregates
Abstract:
... This essay explores an alternative pathway to Alzheimer’s dementia that focuses on damage to small blood vessels rather than late-stage toxic amyloid deposits as the primary pathogenic mechanism that leads to irreversible dementia. While the end-stage pathology of AD is well known, the pathogenic processes that lead to disease are often assumed to be due to toxic amyloid peptides that act on neuro ...
DOI:
10.1007/s00018-013-1542-7

17. Amplification of Tau Fibrils from Minute Quantities of Seeds

Author:
Meyer Virginia; Dinkel Paul D.; Rickman Hager Emily; Margittai Martin
Source:
Biochemistry 2014 v.53 no.36 pp. 5804-5809
ISSN:
1520-4995
Subject:
Alzheimer disease; brain; heparin; prions; protein folding; seeds
Abstract:
... The propagation of Tau pathology in Alzheimer’s disease (AD) is thought to proceed through templated conversion of Tau protein into fibrils and cell-to-cell transfer of elongation-competent seeds. To investigate the efficiency of Tau conversion, we adapted the protein misfolding cyclic amplification assay used for the conversion of prions. Utilizing heparin as a cofactor and employing repetitive c ...
DOI:
10.1021/bi501050g
PubMed:
25153692
PubMed Central:
PMC4165214

18. Amyloid Oligomers and Protofibrils, but Not Filaments, Self-Replicate from Native Lysozyme

Author:
Mulaj Mentor; Foley Joseph; Muschol Martin
Source:
Journal of the American Chemical Society 2014 v.136 no.25 pp. 8947-8956
ISSN:
1520-5126
Subject:
Alzheimer disease; amyloid; humans; lysozyme; pathogenesis; polymerization; temperature
Abstract:
... Self-assembly of amyloid fibrils is the molecular mechanism best known for its connection with debilitating human disorders such as Alzheimer’s disease but is also associated with various functional cellular responses. There is increasing evidence that amyloid formation proceeds along two distinct assembly pathways involving either globular oligomers and protofibrils or rigid monomeric filaments. ...
DOI:
10.1021/ja502529m
PubMed:
24884889
PubMed Central:
PMC4227717

19. Amyloid‐beta (Aβ₁–₄₂)‐induced paralysis in Caenorhabditis elegans is inhibited by the polyphenol quercetin through activation of protein degradation pathways

Author:
Charlotte Regitz; Lisa Marie Dußling; Uwe Wenzel
Source:
Molecular nutrition & food research 2014 v.58 no.10 pp. 1931-1940
ISSN:
1613-4125
Subject:
Alzheimer disease; Caenorhabditis elegans; RNA interference; amyloid; endoplasmic reticulum; genetically modified organisms; histopathology; humans; lysosomes; mitochondria; models; paralysis; phenotype; polyphenols; protein degradation; quercetin; unfolded protein response
Abstract:
... SCOPE: Dietary polyphenols are suggested to play a role in the prevention of Alzheimer's disease, of which accumulation of aggregated beta amyloid (Aβ) is a key histopathological hallmark. We used the transgenic Caenorhabditis elegans strain CL2006, which expresses human Aβ₁–₄₂ under control of a muscle‐specific promoter and responds to Aβ₁–₄₂ aggregation with paralysis, to test effects of the pol ...
DOI:
10.1002/mnfr.201400014

20. Analysis of focused ultrasound-induced blood–brain barrier permeability in a mouse model of Alzheimer's disease using two-photon microscopy

Author:
Alison Burgess; Tam Nhan; Clare Moffatt; A.L. Klibanov; Kullervo Hynynen
Source:
Journal of controlled release 2014 v.192 pp. 243-248
ISSN:
0168-3659
Subject:
Alzheimer disease; acoustics; amyloid; animal models; blood-brain barrier; brain; drugs; dyes; fluorescence; mice; microscopy; permeability; skull; therapeutics; transgenic animals
Abstract:
... Transcranial focused ultrasound (FUS) can cause temporary, localized increases in blood–brain barrier (BBB) permeability for effective drug delivery to the brain. In pre-clinical models of Alzheimer's disease, FUS has successfully been used to deliver therapeutic agents and endogenous therapeutic molecules to the brain leading to plaque reduction and improved behavior. However, prior to moving to ...
DOI:
10.1016/j.jconrel.2014.07.051