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- Lin, Win-Li, et al. Show all 6 Authors
- Biomaterials 2014 v.35 no.13 pp. 4066-4081
- adverse effects; blood-brain barrier; brain neoplasms; cell viability; doxorubicin; drug therapy; folic acid; ghrelin; ligands; medicine; mice; models; nanocarriers; tissues; viability assays
- ... Chemotherapy for brain cancer tumors remains a big challenge for clinical medicine due to the inability to transport sufficient drug across the blood–brain barrier (BBB) and the poor penetration of drug into the tumors. To effectively treat brain tumors and reduce side effects on normal tissues, both des-octanoyl ghrelin and folate conjugated with polymersomal doxorubicin (GFP-D) was developed in ...