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You searched for: Author "Connaris, Helen" Remove constraint Author: "Connaris, Helen" Publication Year 2014 Remove constraint Publication Year: 2014 Subject carbohydrate binding Remove constraint Subject: carbohydrate binding
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1. Prevention of influenza by targeting host receptors using engineered proteins

Author:
Connaris, Helen,   et al.   ; Govorkova, Elena A.; Ligertwood, Yvonne; Dutia, Bernadette M.; Yang, Lei; Tauber, Sandra; Taylor, Margaret A.; Alias, Nadiawati; Hagan, Robert; Nash, Anthony A.; Webster, Robert G.; Taylor, Garry L.;     Show all 12 Authors
Source:
Proceedings of the National Academy of Sciences of the United States of America 2014 v.111 no.17 pp. 6401-6406
ISSN:
0027-8424
Subject:
Influenza A virus; antiviral agents; carbohydrate binding; immune response; influenza; mice; pandemic; pathogens; receptors; sialic acids; virus replication; viruses
Abstract:
... There is a need for new approaches for the control of influenza given the burden caused by annual seasonal outbreaks, the emergence of viruses with pandemic potential, and the development of resistance to current antiviral drugs. We show that multivalent biologics, engineered using carbohydrate-binding modules specific for sialic acid, mask the cell-surface receptor recognized by the influenza vir ...
DOI:
10.1073/pnas.1404205111
PubMed:
24733924
PubMed Central:
PMC4035977