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- Gryko, Dorota, et al. Show all 4 Authors
- Journal of organic chemistry 2014 v.79 no.16 pp. 7532-7542
- chemical structure; cobalt; cycloaddition reactions; drug carriers; organic chemistry; organic compounds; photostability; vitamin B12
- ... The synthesis of vitamin B₁₂ derivatives for selective orthogonal conjugation at both the Co center and 5′-OH is reported. Newly developed, reduction-free, direct alkynylation of vitamin B₁₂ at the central cobalt ion proved to be versatile, with the formed acetylides, unlike other metalloorganic derivatives, showing remarkable heat and light stability, thus making them promising candidates as a dr ...