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You searched for: Publication year rev 7986-2014 Remove constraint Publication year rev: 7986-2014 Subject term extracellular matrix Remove constraint Subject term: extracellular matrix Text availability Citation in PubAg Remove constraint Text availability: Citation in PubAg
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1. (±)-Aspongamide A, an N-Acetyldopamine Trimer Isolated from the Insect Aspongopus chinensis, Is an Inhibitor of p-Smad3

Author:
Yan Yong-Ming; Ai Jun; Shi Yan-Ni; Zuo Zhi-Li; Hou Bo; Luo Jie; Cheng Yong-Xian
Source:
Organic letters 2014 v.16 no.2 pp. 532-535
ISSN:
1523-7052
Subject:
Aspongopus; enantiomers; extracellular matrix; insects; organic compounds; phosphorylation; rats; spectroscopy; transforming growth factor beta 1
Abstract:
... (±)-Aspongamide A (1), an unusual trimer of N-acetyldopamine (NADA) bearing a novel tetrahydrobenzo[a]dibenzo[b,e][1,4]dioxine structure, and a pair of NADA dimeric enantiomers (2) were isolated from Aspongopus chinensis. The structures of compounds 1 and 2 were assigned using spectroscopic methods. Compound 1 was found to be an inhibitor of Smad3 phosphorylation in transforming growth factor-β1 ( ...
DOI:
10.1021/ol403409v

2. 1H NMR spectroscopic studies establish that heparanase is a retaining glycosidase

Author:
Jennifer C. Wilson; Andrew Elohim Laloo; Sanjesh Singh; Vito Ferro
Source:
Biochemical and biophysical research communications 2014 v.443 pp. 185-188
ISSN:
0006-291X
Subject:
angiogenesis; anti-inflammatory agents; extracellular matrix; glycosides; heparan sulfate; hydrolysis; inflammation; metastasis; mutagenicity; nuclear magnetic resonance spectroscopy; prediction; proteoglycans; sequence analysis; spectral analysis
Abstract:
... Heparanase is an endo-β-glucuronidase that cleaves heparan sulfate side chains of proteoglycans in basement membranes and the extracellular matrix (ECM). Heparanase is implicated in several diverse pathological processes associated with ECM degradation such as metastasis, inflammation and angiogenesis and is thus an important target for anti-cancer and anti-inflammatory drug discovery. Heparanase ...
DOI:
10.1016/j.bbrc.2013.11.079

3. 2,5-Dimethoxy 2,5-dihydrofuran crosslinked chitosan fibers enhance bone regeneration in rabbit femur defects

Author:
Paulomi Ghosh; Arun Prabhu Rameshbabu; Nantu Dogra; Santanu Dhara
Source:
RSC advances 2014 v.4 no.37 pp. 19516-19524
ISSN:
2046-2069
Subject:
adhesion; adsorption; alkaline phosphatase; animal models; bone formation; bone marrow; calcium; cell proliferation; chemical bonding; chitosan; crosslinking; extracellular matrix; femur; glucosamine; histology; humans; hydrophobicity; imines; in vivo studies; mesenchymal stromal cells; neutralization; osteocalcin; pH; polymers; rabbits; secretion; sodium hydroxide; tensile strength; tissue engineering
Abstract:
... Chitosan fibers were fabricated via pH induced neutralization and precipitation in a 5 w/v% NaOH bath. Intermolecular covalent crosslinking of these fibers were performed through imine linkages between the glucosamine units of polymers and the dialdehyde groups of 2,5-dimethoxy-2,5-dihydrofuran at 60 °C, pH 2.2. The covalently crosslinked fibers demonstrated improved tensile strength, stiffness, h ...
DOI:
10.1039/c4ra01971g

4. A 3-D in vitro co-culture model of mammary gland involution

Author:
Jonathan J. Campbell; Laur-Alexandru Botos; Timothy J. Sargeant; Natalia Davidenko; Ruth E. Cameron; Christine J. Watson
Source:
Integrative biology 2014 v.6 no.6 pp. 618-626
ISSN:
1757-9708
Subject:
adipose tissue; autophagy; breast neoplasms; breasts; cell lines; coculture; collagen; cytokines; drugs; epithelial cells; epithelium; extracellular matrix; high-throughput screening methods; hyaluronic acid; macrophages; mammary glands; models; monocytes; phenotype; progeny; prolactin; signal transduction; therapeutics; tissue repair; weaning
Abstract:
... Involution is a process whereby the mammary gland undergoes extensive tissue remodelling involving exquisitely coordinated cell death, extracellular matrix degradation and adipose tissue regeneration following the weaning of offspring. These processes are mediated in part through Jak/Stat signalling pathways, which can be deregulated in breast cancer. Synthetic in vitro analogues of the breast cou ...
DOI:
10.1039/c3ib40257f

5. 3D Tissue Engineered Supramolecular Hydrogels for Controlled Chondrogenesis of Human Mesenchymal Stem Cells

Author:
Jung Hyuntae; Park Ji Sun; Yeom Junseok; Selvapalam Narayanan; Park Kyeng Min; Oh Kyunghoon; Yang Jeong-A; Park Keun Hong; Hahn Sei Kwang; Kim Kimoon
Source:
Biomacromolecules 2014 v.15 no.3 pp. 707-714
ISSN:
1526-4602
Subject:
cartilage; chondrogenesis; crosslinking; dexamethasone; extracellular matrix; glycosaminoglycans; humans; hydrogels; immunohistochemistry; mechanical properties; quantitative polymerase chain reaction; stem cells; tissue engineering; transforming growth factor beta 3
Abstract:
... Despite a wide investigation of hydrogels as an artificial extracellular matrix, there are few scaffold systems for the facile spatiotemporal control of mesenchymal stem cells (MSCs). Here, we report 3D tissue engineered supramolecular hydrogels prepared with highly water-soluble monofunctionalized cucurbit[6]uril–hyaluronic acid (CB[6]-HA), diaminohexane conjugated HA (DAH-HA), and drug conjugate ...
DOI:
10.1021/bm401123m

6. Absence of feedback regulation in the synthesis of COL1A1

Author:
Kevin Dzobo; Virna D. Leaner; M. Iqbal Parker
Source:
Life sciences 2014 v.103 no.1 pp. 25-33
ISSN:
0024-3205
Subject:
Western blotting; cell growth; collagen; extracellular matrix; fibroblasts; gene expression; messenger RNA; metalloproteinases; polypeptides; protein content; quantitative polymerase chain reaction; transforming growth factor beta
Abstract:
... Recent studies have emphasized the importance of the extracellular microenvironment in modulating cell growth, motility, and signalling. In this study we have evaluated the ability of a fibroblast derived-extracellular matrix (fd-ECM) to regulate type I collagen synthesis and degradation in fibroblasts.Fibroblasts were plated on plastic (control) or on fd-ECM and type I collagen synthesis and degr ...
DOI:
10.1016/j.lfs.2014.03.006

7. Adhesive properties of Clostridium perfringens to extracellular matrix proteins collagens and fibronectin

Author:
Yasuo Hitsumoto; Naomi Morita; Ryosuke Yamazoe; Mika Tagomori; Tsutomu Yamasaki; Seiichi Katayama
Source:
Anaerobe 2014 v.25 pp. 67-71
ISSN:
1075-9964
Subject:
Clostridium perfringens; bacterial adhesion; collagen; dose response; extracellular matrix; fibronectins; gelatin
Abstract:
... The adhesive properties of Clostridium perfringens to collagens, gelatin, fibronectin (Fn), Fn-prebound collagens, and Fn-prebound gelatin were investigated. C. perfringens could bind to Fn-prebound collagen type II, type III, and gelatin, but not to gelatin or collagens except for collagen type I directly. Recombinant Fn-binding proteins of C. perfringens, rFbpA and rFbpB, were used to examine Fn ...
DOI:
10.1016/j.anaerobe.2013.11.002

8. Age-related disruption of autophagy in dermal fibroblasts modulates extracellular matrix components

Author:
Kanae Tashiro; Mayumi Shishido; Keiko Fujimoto; Yuko Hirota; Kazuyuki Yo; Takamasa Gomi; Yoshitaka Tanaka
Source:
Biochemical and biophysical research communications 2014 v.443 pp. 167-172
ISSN:
0006-291X
Subject:
Western blotting; autophagy; collagen; elastin; extracellular matrix; fibroblasts; fluorescence microscopy; humans; hyaluronic acid; proteinase inhibitors; transmission electron microscopy; vacuoles; women
Abstract:
... Autophagy is an intracellular degradative system that is believed to be involved in the aging process. The contribution of autophagy to age-related changes in the human skin is unclear. In this study, we examined the relationship between autophagy and skin aging. Transmission electron microscopy and immunofluorescence microscopy analyses of skin tissue and cultured dermal fibroblasts derived from ...
DOI:
10.1016/j.bbrc.2013.11.066

9. Ageing related periostin expression increase from cardiac fibroblasts promotes cardiomyocytes senescent

Author:
Qing Li; Xin Liu; Jin Wei
Source:
Biochemical and biophysical research communications 2014 v.452 pp. 497-502
ISSN:
0006-291X
Subject:
blood serum; cardiomyocytes; extracellular matrix; fibroblasts; fibrosis; humans; interleukin-4; interleukin-6; rats
Abstract:
... Periostin, as an extracellular matrix (ECM) protein, plays a critical role in myocardial fibrosis and also might be involved in the heart inflammatory process since it is a downstream molecule of IL4 and IL13. Considering the possible important role of periostin in heart aging, this study explored periostin expression pattern in both rat and human, the effect of periostin expression on cardiomyocy ...
DOI:
10.1016/j.bbrc.2014.08.109

10. Akt induces down regulation of MUC5AC production in NCI-H292 human airway epithelial cells cultured on extracellular matrix

Author:
Jun Iwashita; Yuho Ito; Mari Yokoo; Sunao Takahashi; Jun Murata
Source:
Bioscience, biotechnology, and biochemistry 2014 v.78 no.2 pp. 212-221
ISSN:
1347-6947
Subject:
asthma; biotechnology; collagen; epithelium; extracellular matrix; humans; integrins; laminin; mucins; signal transduction
Abstract:
... MUC5AC mucin overproduction is a key feature of asthma as contributes to airway obstruction. The production of MUC5AC is regulated in part by signals from extracellular matrix via integrin pathways, but it remains largely unclear. We investigated the role of Akt, a typical signal transducer in the integrin pathway, in the regulation of MUC5AC production. When NCI-H292 human airway epithelial cells ...
DOI:
10.1080/09168451.2014.877829

11. Aligning cells in arbitrary directions on a membrane sheet using locally formed microwrinkles

Author:
Akira C. Saito; Tsubasa S. Matsui; Masaaki Sato; Shinji Deguchi
Source:
Biotechnology letters 2014 v.36 no.2 pp. 391-396
ISSN:
0141-5492
Subject:
adhesion; deformation; equipment; extracellular matrix; medicine; tissue repair
Abstract:
... Sheets of cells can be used for tissue regenerative medicine. Cell alignment within the sheet is now a key factor in the next generation of this technology. Anisotropic cell sheets without random cell orientations have been conventionally produced with photolithographically, microfabricated substrates using special facilities and equipment. Here we demonstrate a more accessible approach to the fab ...
DOI:
10.1007/s10529-013-1368-2
PubMed:
24101251

12. Alteration of energy metabolism gene expression in cumulus cells affects oocyte maturation via MOS–mitogen-activated protein kinase pathway in dairy cows with an unfavorable “Fertil−” haplotype of one female fertility quantitative trait locus

Author:
Daphné Brisard; Alice Desmarchais; Jean-Luc Touzé; Lionel Lardic; Sandrine Freret; Sebastien Elis; Fabienne Nuttinck; Sylvaine Camous; Joelle Dupont; Svetlana Uzbekova
Source:
Theriogenology 2014 v.81 no.4 pp. 599-612
ISSN:
0093-691X
Subject:
dairy cows; embryogenesis; energy metabolism; extracellular matrix; fatty-acid synthase; female fertility; gene expression; gene expression regulation; genes; haplotypes; heifers; lipid metabolism; mitogen-activated protein kinase; oocytes; pregnancy; prostaglandin synthase; quantitative polymerase chain reaction; quantitative trait loci; reverse transcription
Abstract:
... Prim'Holstein heifers selected for the “Fertil−” homozygous haplotype of QTL-Female-Fert ility-BTA3 showed a greater rate of early pregnancy failure and slower embryo development after IVM suggesting lower oocyte quality than those selected for “Fertile+”. We aimed to ascertain intrafollicular factors related to lower oocyte quality in “Fertil−” cows. Analysis of individual oocytes showed meiotic ...
DOI:
10.1016/j.theriogenology.2013.11.013

13. Amelioration of diabetic nephropathy by orange peel extract in rats

Author:
Nishad Parkar; Veeranjaneyulu Addepalli
Source:
Natural product research 2014 v.28 no.23 pp. 2178-2181
ISSN:
1478-6427
Subject:
blood; creatinine; diabetic nephropathy; fibrosis; kidneys; orange peels; rats; urea; urea nitrogen
Abstract:
... This study was aimed to evaluate the effect of alcoholic orange peel extract (OPE) on streptozotocin-induced diabetic nephropathy. Four weeks after the induction of diabetes, treatment with OPE (100 and 200 mg/kg) was further given for 4 weeks. Treatment with OPE 200 improved renal functions and significantly prevented the increase in creatinine, urea and blood urea nitrogen levels. Histological a ...
DOI:
10.1080/14786419.2014.925894

14. Angiogenesis in Bone Regeneration: Tailored Calcium Release in Hybrid Fibrous Scaffolds

Author:
Castaño Oscar; Sachot Nadège; Xuriguera Elena; Engel Elisabeth; Planell Josep A.; Park Jeong-Hui; Jin Guang-Zhen; Kim Tae-Hyun; Kim Joong-Hyun; Kim Hae-Won
Source:
ACS applied materials 2014 v.6 no.10 pp. 7512-7522
ISSN:
1944-8252
Subject:
angiogenesis; blood vessels; calcium; calcium phosphates; extracellular matrix; ions; scanning electron microscopy; silica; silicon; titanium dioxide; zeta potential
Abstract:
... In bone regeneration, silicon-based calcium phosphate glasses (Bioglasses) have been widely used since the 1970s. However, they dissolve very slowly because of their high amount of Si (SiO₂ > 45%). Recently, our group has found that calcium ions released by the degradation of glasses in which the job of silicon is done by just 5% of TiO₂ are effective angiogenic promoters, because of their stimula ...
DOI:
10.1021/am500885v

15. AngiotensinII induces HuR shuttling by post-transcriptional regulated CyclinD1 in human mesangial cells

Author:
Yu Che; Liu Yi; Javed Akhtar; Chen Bing; Zhang Ruiyu; Wan Qiang; Wang Rong
Source:
Molecular biology reports 2014 v.41 no.2 pp. 1141-1150
ISSN:
0301-4851
Subject:
RNA interference; cell proliferation; extracellular matrix; humans; in vitro studies; kidney diseases; kidneys; messenger RNA; sclerosis; translation (genetics)
Abstract:
... Abnormal proliferation of human mesangial cells was the earliest pathological character in chronic kidney disease and linked to the accumulation of extracellular matrix and glomerular sclerosis. Multifunctional Angiotensin (AngII) had been emerged as a key player in initiation and progression of fibrogenic processes in kidney. In mesangial cells, treatment with the proliferation stimulus AngII tri ...
DOI:
10.1007/s11033-013-2960-1

16. Anti-fibrotic effect of thymoquinone on hepatic stellate cells

Author:
Mohammed Ghazwani; Yifei Zhang; Xiang Gao; Jie Fan; Jiang Li; Song Li
Source:
Phytomedicine 2014 v.21 pp. 254-260
ISSN:
0944-7113
Subject:
animal models; extracellular matrix; gene expression; gene expression regulation; genes; humans; in vitro studies; in vivo studies; inflammation; interleukin-6; liver; liver cirrhosis; mechanism of action; messenger RNA; mice; protective effect; rats; transcription factor NF-kappa B
Abstract:
... Hepatic stellate cells (HSCs) are the major cell type involved in the production of extracellular matrix in liver. After liver injury, HSCs undergo transdifferentiation process from quiescent state to activated state, which plays an important role in liver fibrosis. Previous studies have shown that thymoquinone (TQ) might have protective effect against liver fibrosis in animal models; however, the ...
DOI:
10.1016/j.phymed.2013.09.014

17. Anti-inflammatory and Chondroprotective Activity of (+)-α-Pinene: Structural and Enantiomeric Selectivity

Author:
Rufino Ana T.; Ribeiro Madalena; Judas Fernando; Salgueiro Lígia; Lopes Maria C.; Cavaleiro Carlos; Mendes Alexandrina F.
Source:
Journal of natural products 2014 v.77 no.2 pp. 264-269
ISSN:
1520-6025
Subject:
alpha-pinene; anti-inflammatory activity; beta-pinene; chondrocytes; cytotoxicity; drugs; extracellular matrix; genes; humans; inducible nitric oxide synthase; inflammation; metabolites; mitogen-activated protein kinase; physicochemical properties; transcription factor NF-kappa B
Abstract:
... Previous studies have suggested that α-pinene, a common volatile plant metabolite, may have anti-inflammatory effects in human chondrocytes, thus exhibiting potential antiosteoarthritic activity. The objective of this study was to further characterize the potential antiosteoarthritic activity of selected pinene derivatives by evaluating their ability to modulate inflammation and extracellular matr ...
DOI:
10.1021/np400828x

18. Antibiotic resistance in Pseudomonas aeruginosa biofilms: Towards the development of novel anti-biofilm therapies

Author:
Patrick K. Taylor; Amy T.Y. Yeung; Robert E.W. Hancock
Source:
Journal of biotechnology 2014 v.191 pp. 121-130
ISSN:
0168-1656
Subject:
Pseudomonas aeruginosa; antibiotic resistance; antibiotics; bacteria; biofilm; environmental factors; extracellular matrix; health services; hospitals; nutrient availability; quorum sensing; resistance mechanisms
Abstract:
... The growth of bacteria as structured aggregates termed biofilms leads to their protection from harsh environmental conditions such as physical and chemical stresses, shearing forces, and limited nutrient availability. Because of this highly adapted ability to survive adverse environmental conditions, bacterial biofilms are recalcitrant to antibiotic therapies and immune clearance. This is particul ...
DOI:
10.1016/j.jbiotec.2014.09.003

19. Association of prohibitin-1 and 2 with oxidative stress in rats with renal interstitial fibrosis

Author:
Tian-Biao Zhou; Yuan-Han Qin; Feng-Ying Lei; Wei-Fang Huang; Gregor P. C. Drummen
Source:
Molecular biology reports 2014 v.41 no.5 pp. 3033-3043
ISSN:
0301-4851
Subject:
correlation; protein folding; anaerobic conditions; glutathione; fibrosis; oxidative stress; malondialdehyde; proteins; extracellular matrix; reactive oxygen species; superoxide dismutase; animal models; transforming growth factor beta 1; rats; antioxidant activity; apoptosis
Abstract:
... Prohibitins PHB1 and PHB2 are evolutionary conserved and pleiotropic proteins, which have been shown to be important factors in various cellular functions, including proliferation, tumour suppression, apoptosis, transcription, and mitochondrial protein folding. Recently, we demonstrated that down-regulation promoted renal interstitial fibrosis (RIF) in ureteral obstructed rats. Furthermore, the hy ...
DOI:
10.1007/s11033-014-3162-1
PubMed:
24595445

20. Association of the SNP rs2623047 in the HSPG modification enzyme SULF1 with an Australian Caucasian Breast Cancer Cohort

Author:
Rachel K. Okolicsanyi; Marion Faure; Jose M.E. Jacinto; Diego Chacon-Cortes; Suzanne Chambers; Philippa H. Youl; Larisa M. Haupt; Lyn R. Griffiths
Source:
Gene 2014 v.547 pp. 50-54
ISSN:
0378-1119
Subject:
alleles; breast neoplasms; cell proliferation; death; developed countries; disease detection; early diagnosis; enzymes; extracellular matrix; genotype; growth factors; heparan sulfate; ligands; patients; prognosis; proteoglycans; receptors; risk; single nucleotide polymorphism; survival rate; women
Abstract:
... Breast cancer is the second most common cancer worldwide and the most common cancer reported in women. This malignant tumour is characterised by a number of specific features including uncontrolled cell proliferation. It ranks fifth in the world as a cause of cancer death overall in developed countries and is the second most frequent cause of cancer death in women. Early diagnosis increases 5-year ...
DOI:
10.1016/j.gene.2014.06.009