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- Yang, Zhibo, et al. Show all 6 Authors
- Analytical chemistry 2014 v.86 no.19 pp. 9376-9380
- doxorubicin; eukaryotic cells; ionization; mass spectrometry; metabolites; metabolomics; neoplasm cells; paclitaxel; spectrometers; technology; uterine cervical neoplasms
- ... We have developed a new mass spectrometry (MS) technology, the Single-probe MS, capable of real-time, in situ metabolomic analysis of individual living cells. The Single-probe is a miniaturized multifunctional sampling and ionization device that is directly coupled to the mass spectrometer. With a sampling tip smaller than individual eukaryotic cells (<10 μm), the Single-probe can be inserted into ...