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- Qin, Lingyun, et al. Show all 6 Authors
- Journal of the American Chemical Society 2014 v.136 no.52 pp. 18023-18033
- antagonists; apoptosis; drugs; humans; models; neoplasm cells; neoplasms
- ... The aberrant interaction between p53 and Mdm2/MdmX is an attractive target for cancer drug discovery because the overexpression of Mdm2 and/or MdmX ultimately impairs the function of p53 in approximately half of all human cancers. Recent studies have shown that inhibition of both Mdm2 and MdmX is more efficient than that of a single target in promoting cellular apoptosis in cancers. In this study, ...