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- Deng, Lingquan; Song, Jeongmin; Gao, Xiang; Wang, Jiawei; Yu, Hai; Chen, Xi; Varki, Nissi; Naito-Matsui, Yuko; Galán, Jorge E.; Varki, Ajit
- Cell 2014 v.159 pp. 1290-1299
- typhoid fever, etc ; Salmonella Typhi; bacterial toxins; glycoproteins; host specificity; humans; laboratory animals; mice; pathogens; polysaccharides; tissues; toxicity; virulence; Show all 13 Subjects
- ... Salmonella Typhi is an exclusive human pathogen that causes typhoid fever. Typhoid toxin is a S. Typhi virulence factor that can reproduce most of the typhoid fever symptoms in experimental animals. Toxicity depends on toxin binding to terminally sialylated glycans on surface glycoproteins. Human glycans are unusual because of the lack of CMAH, which in other mammals converts N-acetylneuraminic ac ...
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