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1. Synergistic anabolic actions of hyaluronic acid and platelet-rich plasma on cartilage regeneration in osteoarthritis therapy

Author:
Tina Chen, Szu-Yu,   et al.   ; Chen, Wei-Hong; Lo, Wen-Cheng; Hsu, Wei-Che; Wei, Hong-Jian; Liu, Hen-Yu; Lee, Chian-Her; Shieh, Ying-Hua; Williams, David F.; Deng, Win-Ping;     Show all 10 Authors
Source:
Biomaterials 2014 v.35 no.36 pp. 9599-9607
ISSN:
0142-9612
Subject:
cartilage; chemokines; chondrocytes; genes; homeostasis; hyaluronic acid; immunoblotting; inflammation; models; osteoarthritis; patients; phenotype; receptors; reverse transcriptase polymerase chain reaction; signal transduction; therapeutics; tissue repair; transcription factors
Abstract:
... Osteoarthritis (OA) is a common disease associated with tissue inflammation, physical disability and imbalanced homeostasis in cartilage. For advanced treatments, biological approaches are currently focused on tissue regeneration and anti-inflammation. This study was undertaken to evaluate the therapeutic efficacies of hyaluronic acid (HA) and platelet-rich plasma (PRP) (HA+PRP) on OA. Articular c ...
DOI:
10.1016/j.biomaterials.2014.07.058