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- Schaffer, David V., et al. Show all 9 Authors
- Biomaterials 2014 v.35 no.3 pp. 941-948
- biocompatible materials; brain; cell differentiation; embryonic stem cells; epilepsy; gamma-aminobutyric acid; humans; ligands; lipids; neurons; patients; receptors
- ... Stem cell differentiation is regulated by complex repertoires of signaling ligands which often use multivalent interactions, where multiple ligands tethered to one entity interact with multiple cellular receptors to yield oligomeric complexes. One such ligand is Sonic hedgehog (Shh), whose posttranslational lipid modifications and assembly into multimers enhance its biological potency, potentially ...