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You searched for: Subject "trypsin inhibitors" Remove constraint Subject: "trypsin inhibitors" Publication Year 2014 Remove constraint Publication Year: 2014 Text Availability Full Text Remove constraint Text Availability: Full Text
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1. Correlation as a Determinant of Configurational Entropy in Supramolecular and Protein Systems

Author:
Fenley, Andrew T.; Killian, Benjamin J.; Hnizdo, Vladimir; Fedorowicz, Adam; Sharp, Dan S.; Gilson, Michael K.
Source:
The Journal of physical chemistry 2014 v.118 no.24 pp. 6447-6455
ISSN:
1520-5207
Subject:
trypsin inhibitors,   etc   ; biochemical compounds; cattle; entropy; models; molecular dynamics; nuclear magnetic resonance spectroscopy;     Show all 7 Subjects
Abstract:
... For biomolecules in solution, changes in configurational entropy are thought to contribute substantially to the free energies of processes like binding and conformational change. In principle, the configurational entropy can be strongly affected by pairwise and higher-order correlations among conformational degrees of freedom. However, the literature offers mixed perspectives regarding the contrib ...
DOI:
10.1021/jp411588b
PubMed:
24702693
PubMed Central:
PMC4067153

2. Cytoprotective effects of urinary trypsin inhibitor on astrocytes injured by sustained compression

Author:
Zhang, Shuang; Yu, Rongguo; Zhang, Yingrui; Chen, Kai
Source:
Molecular biology reports 2014 v.41 no.3 pp. 1311-1316
ISSN:
0301-4851
Subject:
trypsin inhibitors,   etc   ; astrocytes; brain; cell membranes; lactate dehydrogenase; models; protective effect; pups; rats;     Show all 9 Subjects
Abstract:
... Decreased cell membrane integrity is a primary pathological change observed in traumatic brain injury (TBI) that activates a number of complex intercellular and intracellular pathological events, leading to further neural injury. In this paper, we assessed the effects of urinary trypsin inhibitor (UTI) on astrocyte membrane integrity by determining the percentage of lactate dehydrogenase (LDH) rel ...
DOI:
10.1007/s11033-013-2976-6
PubMed:
24385305
PubMed Central:
PMC3933746

3. Fatty acid-amino acid conjugates are essential for systemic activation of salicylic acid-induced protein kinase and accumulation of jasmonic acid in Nicotiana attenuata

Author:
Hettenhausen, Christian; Heinrich, Maria; Baldwin, Ian T; Wu, Jianqiang
Source:
BMC plant biology 2014 v.14 no.1 pp. 326
ISSN:
1471-2229
Subject:
trypsin inhibitors,   etc   ; Manduca sexta; Nicotiana attenuata; elicitors; herbivores; jasmonic acid; leaves; metabolites; mitogen-activated protein kinase; tobacco;     Show all 10 Subjects
Abstract:
... BACKGROUND: Herbivory induces the activation of mitogen-activated protein kinases (MAPKs), the accumulation of jasmonates and defensive metabolites in damaged leaves and in distal undamaged leaves. Previous studies mainly focused on individual responses and a limited number of systemic leaves, and more research is needed for a better understanding of how different plant parts respond to herbivory. ...
DOI:
10.1186/s12870-014-0326-z
PubMed:
25430398
PubMed Central:
PMC4263023

4. Efficient Separations of Intact Proteins Using Slip-Flow with Nano-Liquid Chromatography–Mass Spectrometry

Author:
Wu, Zhen; Wei, Bingchuan; Zhang, Ximo; Wirth, Mary J.
Source:
Analytical chemistry 2014 v.86 no.3 pp. 1592-1598
ISSN:
1520-6882
Subject:
trypsin inhibitors,   etc   ; ambient temperature; carbonate dehydratase; mass spectrometry; proteomics; reversed-phase liquid chromatography; ribonucleases; silica; statistical analysis; superoxide dismutase; ubiquitin;     Show all 11 Subjects
Abstract:
... A capillary with a pulled tip, densely packed with silica particles of 0.47 μm in diameter, is shown to provide higher peak capacity and sensitivity in the separation of intact proteins by reversed-phase liquid chromatography–mass spectrometry (LC–MS). For a C18 bonded phase, slip flow gave a 10-fold flow enhancement to allow for stable nanospray with a 4-cm column length. Model proteins were stud ...
DOI:
10.1021/ac403233d
PubMed:
24383398
PubMed Central:
PMC3982985

5. Stem Nematode Counteracts Plant Resistance of Aphids in Alfalfa, Medicago Sativa

Author:
Ramirez, Ricardo A.; Spears, Lori R.
Source:
Journal of chemical ecology 2014 v.40 no.10 pp. 1099-1109
ISSN:
0098-0331
Subject:
trypsin inhibitors,   etc   ; Acyrthosiphon pisum; Ditylenchus dipsaci; Medicago sativa; alfalfa; cross resistance; greenhouse experimentation; herbivores; insect communities; insects; nematode infections; nutrient availability; peroxidases; plant pathogens; proteins; saponins; signal transduction;     Show all 17 Subjects
Abstract:
... Plants are exploited by a diverse community of insect herbivores and phytopathogens that interact indirectly through plant-mediated interactions. Generally, plants are thought to respond to insects and pathogens through different defensive signaling pathways. As plants are selected for resistance to one phytophagous organism type (insect vs. pathogen) in managed systems, it is not clear how this s ...
DOI:
10.1007/s10886-014-0504-3
PubMed:
25261892
PubMed Central:
PMC4244557

6. Conservation of sequence and function in fertilization of the cortical granule serine protease in echinoderms

Author:
Oulhen, Nathalie; Xu, Dongdong; Wessel, Gary M.
Source:
Biochemical and biophysical research communications 2014 v.450 pp. 1135-1141
ISSN:
0006-291X
Subject:
trypsin inhibitors,   etc   ; Asteroidea; Echinoidea; conserved sequences; cortical granules; eggs; enzyme activity; germplasm conservation; polyspermy; serine proteinases; soybeans; spermatozoa; surface proteins; transcriptome;     Show all 14 Subjects
Abstract:
... Conservation of the cortical granule serine protease during fertilization in echinoderms was tested both functionally in sea stars, and computationally throughout the echinoderm phylum. We find that the inhibitor of serine protease (soybean trypsin inhibitor) effectively blocks proper transition of the sea star fertilization envelope into a protective sperm repellent, whereas inhibitors of the oth ...
DOI:
10.1016/j.bbrc.2014.05.098
PubMed:
24878526
PubMed Central:
PMC4133295

7. Susceptibility of sweetpotato (Ipomoea batatas) peel proteins to digestive enzymes

Author:
Maloney, Katherine P.; Truong, Van-Den; Allen, Jonathan C.
Source:
Food science & nutrition 2014 v.2 no.4 pp. 351-360
ISSN:
2048-7177
Subject:
trypsin inhibitors,   etc   ; Ipomoea batatas; amylases; antioxidants; chymotrypsin; digestion; enzyme inhibition; orange peels; oranges; pepsin; potato protein; protein sweeteners; sporamin; sweet potatoes; trypsin;     Show all 15 Subjects
Abstract:
... Sweet potato proteins have been shown to possess antioxidant and antidiabetic properties in vivo. The ability of a protein to exhibit systemic effects is somewhat unusual as proteins are typically susceptible to digestive enzymes. This study was undertaken to better understand how digestive enzymes affect sweet potato proteins. Two fractions of industrially processed sweet potato peel, containing ...
Handle:
10113/60301
DOI:
10.1002/fsn3.110
PubMed:
25473492
PubMed Central:
PMC4221833
CHORUS:
10.1002/fsn3.110
Chorus Open Access:
10.1002/fsn3.110

8. Decoy Plasminogen Receptor Containing a Selective Kunitz-Inhibitory Domain

Author:
Kumar, Yogesh; Vadivel, Kanagasabai; Schmidt, Amy E.; Ogueli, Godwin I.; Ponnuraj, Sathya M.; Rannulu, Nalaka; Loo, Joseph A.; Bajaj, Madhu S.; Bajaj, S. Paul
Source:
Biochemistry 2014 v.53 no.3 pp. 505-517
ISSN:
1520-4995
Subject:
trypsin inhibitors,   etc   ; active sites; blood; cattle; fibrinolysis; lysine; mice; models; mutants; plasmin; plasminogen; surface plasmon resonance; t-plasminogen activator; thrombin; valine;     Show all 15 Subjects
Abstract:
... Kunitz domain 1 (KD1) of tissue factor pathway inhibitor-2 in which P2′ residue Leu17 (bovine pancreatic trypsin inhibitor numbering) is mutated to Arg selectively inhibits the active site of plasmin with ∼5-fold improved affinity. Thrombin cleavage (24 h extended incubation at a 1:50 enzyme-to-substrate ratio) of the KD1 mutant (Leu17Arg) yielded a smaller molecule containing the intact Kunitz do ...
DOI:
10.1021/bi401584b
PubMed:
24383758
PubMed Central:
PMC3985851