PubAg

Main content area

You searched for: Author "Chowdhury, Abhishek Dutta" Remove constraint Author: "Chowdhury, Abhishek Dutta" Publication Year 2014 Remove constraint Publication Year: 2014
Start Over

Search

1  Search Results

1 entry found
Number of results to display per page

Search Results

1. Synthesis, crystal structure, DNA interaction and in vitro anticancer activity of a Cu(ii) complex of purpurin: dual poison for human DNA topoisomerase I and II

Author:
Chowdhury, Abhishek Dutta,   et al.   ; Das, Piyal; Jain, Chetan Kumar; Dey, Sanjoy K.; Saha, Rajat; Roychoudhury, Susanta; Kumar, Sanjay; Majumder, Hemanta Kumar; Das, Saurabh;     Show all 9 Authors
Source:
RSC advances 2014 v.4 no.103 pp. 59344-59357
ISSN:
2046-2069
Subject:
DNA; DNA topoisomerase; DNA topoisomerase (ATP-hydrolysing); NAD (coenzyme); NADH dehydrogenase; antineoplastic activity; cell growth; copper; crystal structure; doxorubicin; growth retardation; humans; models; neoplasm cells; neoplasms; pH; quinones; reactive oxygen species; spectral analysis
Abstract:
... Although generation of reactive oxygen species (ROS) by anthracycline anticancer drugs is essential for anti-tumor activity, they make these drugs cardiotoxic. Metal–anthracyclines that generate relatively fewer ROS are however, effective antitumor agents. Purpurin (LH₃), a hydroxy-9,10-anthraquinone, closely resembles doxorubicin, an established anthracycline drug. This molecule was chosen to stu ...
DOI:
10.1039/c4ra07127a