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- Chowdhury, Abhishek Dutta, et al. Show all 9 Authors
- RSC advances 2014 v.4 no.103 pp. 59344-59357
- DNA; DNA topoisomerase; DNA topoisomerase (ATP-hydrolysing); NAD (coenzyme); NADH dehydrogenase; antineoplastic activity; cell growth; copper; crystal structure; doxorubicin; growth retardation; humans; models; neoplasm cells; neoplasms; pH; quinones; reactive oxygen species; spectral analysis
- ... Although generation of reactive oxygen species (ROS) by anthracycline anticancer drugs is essential for anti-tumor activity, they make these drugs cardiotoxic. Metal–anthracyclines that generate relatively fewer ROS are however, effective antitumor agents. Purpurin (LH₃), a hydroxy-9,10-anthraquinone, closely resembles doxorubicin, an established anthracycline drug. This molecule was chosen to stu ...