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- McCarron, Pearse, et al. Show all 3 Authors
- Toxicon 2014 v.92 pp. 75-80
- detection limit; domoic acid; food safety; ionization; liquid chromatography; monitoring; mussels; neurotoxins; quantitative analysis; rapid methods; safety testing; shellfish; tandem mass spectrometry; tissue analysis
- ... Eliminating sample extraction or liquid chromatography steps from methods for analysis of the neurotoxin Domoic Acid (DA) in shellfish could greatly increase throughput in food safety testing laboratories worldwide. To this end, we have investigated the use of Laser Ablation Electrospray Ionization (LAESI) with tandem mass spectrometry (MS/MS) detection for DA analysis directly from mussel tissue ...
- McCarron, Pearse, et al. Show all 4 Authors
- Aquatic biosystems 2014 v.10 no.1 pp. 57
- Arthrospira; amino acids; derivatization; detection limit; dietary supplements; environmental exposure; environmental factors; hydrophilic interactions; mass spectrometry; neurodegenerative diseases; public health; quality control; raw materials; risk; stable isotopes; water supply
- ... Over the last decade the amino acid beta-N-methylamino-L-alanine (BMAA) has come under intense scrutiny. International laboratory and epidemiological research continues to support the hypothesis that environmental exposure to BMAA (e.g., through dietary practices, water supply) can promote the risk of various neurodegenerative diseases. A wide variety of cyanobacteria spp. have previously been rep ...
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- McCarron, Pearse, et al. Show all 12 Authors
- Journal of natural products 2014 v.77 no.11 pp. 2465-2474
- Azadinium spinosum; T-lymphocytes; cytotoxicity; liquid chromatography; mass spectrometry; models; molecular weight; mussels; nuclear magnetic resonance spectroscopy; seawater; structure-activity relationships; toxicity testing
- ... We identified three new azaspiracids (AZAs) with molecular weights of 715, 815, and 829 (AZA33 (3), AZA34 (4), and AZA35, respectively) in mussels, seawater, and Azadinium spinosum culture. Approximately 700 μg of 3 and 250 μg of 4 were isolated from a bulk culture of A. spinosum, and their structures determined by MS and NMR spectroscopy. These compounds differ significantly at the carboxyl end o ...