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- Barsegov, Valeri, et al. Show all 8 Authors
- Journal of the American Chemical Society 2014 v.136 no.49 pp. 17036-17045
- biomechanics; chromosome segregation; chromosomes; dissociation; elastic deformation; microtubules; models; physicochemical properties; polymers; thermodynamics; tubulin
- ... Microtubules, the primary components of the chromosome segregation machinery, are stabilized by longitudinal and lateral noncovalent bonds between the tubulin subunits. However, the thermodynamics of these bonds and the microtubule physicochemical properties are poorly understood. Here, we explore the biomechanics of microtubule polymers using multiscale computational modeling and nanoindentations ...
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