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- Connaris, Helen, et al. Show all 12 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2014 v.111 no.17 pp. 6401-6406
- Influenza A virus; antiviral agents; carbohydrate binding; immune response; influenza; mice; pandemic; pathogens; receptors; sialic acids; virus replication; viruses
- ... There is a need for new approaches for the control of influenza given the burden caused by annual seasonal outbreaks, the emergence of viruses with pandemic potential, and the development of resistance to current antiviral drugs. We show that multivalent biologics, engineered using carbohydrate-binding modules specific for sialic acid, mask the cell-surface receptor recognized by the influenza vir ...
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