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- Smith, Craig S., et al. Show all 6 Authors
- Developmental biology 2014 v.392 no.2 pp. 344-357
- cell death; cell differentiation; cell lines; genes; giant cells; mice; transcription factors; trophoblast
- ... In mice the transcription factor Elf5 is necessary for correct trophoblast development. Upon knockdown of Elf5, TS cells display neither a decrease in proliferation nor an increase in cell death but rather an increased propensity to differentiate. Such cells rapidly lose Sox2 and 3 expression, while transiently upregulating the giant cell differentiation determinant gene Hand1. Other genes affecte ...