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- Yang, Jianjing, et al. Show all 8 Authors
- The international journal of biochemistry & cell biology 2014 v.55 pp. 252-263
- NAD(P)H oxidase (H2O2-forming); animal models; astrocytes; catalase; cerebral cortex; dopamine; edema; encephalopathy; immunoblotting; neuronal nitric oxide synthase; oxidative stress; pathogenesis; phosphorylation; precipitin tests; rats; reactive oxygen species; superoxide dismutase; tyrosine; uric acid
- ... We previously demonstrated that dopamine (DA) overload may be a key mechanism behind development of minimal hepatic encephalopathy (MHE) in rats. It has been shown that low-grade cerebral oedema and oxidative stress play important roles in the pathogenesis of MHE. In the current study, DA-triggered oxidative injury in cerebral cortex was studied.An MHE rat model was used. DA was injected intracere ...