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- Doherty, Margaret; Bones, Jonathan; McLoughlin, Niaobh; Telford, Jayne E.; Harmon, Bryan; DeFelippis, Michael R.; Rudd, Pauline M.
- Analytical biochemistry 2013 v.442 no.1 pp. 10-18
- automation; bioprocessing; bioreactors; capillary electrophoresis; cell culture; fluorescent labeling; innate immunity; mass spectrometry; monoclonal antibodies; oligosaccharides; receptors; ultra-performance liquid chromatography
- ... Oligosaccharides attached to Asn297 in each of the CH2 domains of monoclonal antibodies play an important role in antibody effector functions by modulating the affinity of interaction with Fc receptors displayed on cells of the innate immune system. Rapid, detailed, and quantitative N-glycan analysis is required at all stages of bioprocess development to ensure the safety and efficacy of the thera ...