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- McKee, Christopher J.; Hines, Harry B.; Ulrich, Robert G.
- Analytical biochemistry 2013 v.442 no.1 pp. 62-67
- desorption; enzyme activity; gold; image analysis; ionization; mass spectrometry; microarray technology; protein-protein interactions; protein-tyrosine-phosphatase; recombinant proteins; surface plasmon resonance; tyrosine
- ... Microarrays of peptide and recombinant protein libraries are routinely used for high-throughput studies of protein–protein interactions and enzymatic activities. Imaging mass spectrometry (IMS) is currently applied as a method to localize analytes on thin tissue sections and other surfaces. Here, we have applied IMS as a label-free means to analyze protein–peptide interactions in a microarray-base ...
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