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1. Gene flow from North Africa contributes to differential human genetic diversity in southern Europe

Author:
Gignoux, Christopher R.,   et al.   ; Botigué, Laura R.; Henn, Brenna M.; Gravel, Simon; Maples, Brian K.; Corona, Erik; Atzmon, Gil; Burns, Edward; Ostrer, Harry; Flores, Carlos; Bertranpetit, Jaume; Comas, David; Bustamante, Carlos D.;     Show all 13 Authors
Source:
Proceedings of the National Academy of Sciences of the United States of America 2013 v.110 no.29 pp. 11791-11796
ISSN:
0027-8424
Subject:
Africans; alleles; ancestry; gene flow; genetic variation; genome-wide association study; humans; risk; sclerosis; single nucleotide polymorphism; Europe; Middle East; Northern Africa; Southern European region; Sub-Saharan Africa
Abstract:
... Human genetic diversity in southern Europe is higher than in other regions of the continent. This difference has been attributed to postglacial expansions, the demic diffusion of agriculture from the Near East, and gene flow from Africa. Using SNP data from 2,099 individuals in 43 populations, we show that estimates of recent shared ancestry between Europe and Africa are substantially increased wh ...
DOI:
10.1073/pnas.1306223110
PubMed:
23733930
PubMed Central:
PMC3718088