Author: hashii / Publication Year: 2013 / Subject: amino acids and humans

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Author:: Hashii, Noritaka, et al. ; Nakazawa, Shiori; Ahn, Joomi; Hirose, Kenji; Kawasaki, Nana; Show all 5 Authors
Source:: BBA - Proteins and Proteomics 2013 v.1834 pp. 1210-1214
ISSN:: 1570-9639
Subject:: amino acids; deuterium; dimerization; humans; insulin; mass spectrometry; mutation; peptide mapping
Abstract:: ... Human insulin and insulin lispro (lispro), a rapid-acting insulin analog, have identical primary structures, except for the transposition of a pair of amino acids. This mutation results in alterations in their higher order structures, with lispro dissociating more easily than human insulin. In our previous study performed using hydrogen/deuterium exchange mass spectrometry (HDX/MS), differences we ...
DOI:: 10.1016/j.bbapap.2012.11.012
: http://dx.doi.org/10.1016/j.bbapap.2012.11.012