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- Shin, Chan Young, et al. Show all 7 Authors
- Biochemical and biophysical research communications 2013 v.438 pp. 420-426
- astrocytes; brain; cell culture; cell death; cytokines; general anesthetics; inducible nitric oxide synthase; lipopolysaccharides; mitogen-activated protein kinase; neurons; nitric oxide; rats
- ... Despite the extensive use of propofol in general anesthetic procedures, the effects of propofol on glial cell were not completely understood. In lipopolysaccharide (LPS)-stimulated rat primary astrocytes and BV2 microglial cell lines, co-treatment of propofol synergistically induced inflammatory activation as evidenced by the increased production of NO, ROS and expression of iNOS, MMP-9 and severa ...