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- Pappa, Aglaia, et al. Show all 7 Authors
- The Journal of nutritional biochemistry 2013 v.24 pp. 586-594
- DNA fragmentation; Silybum marianum; antioxidant activity; atrial natriuretic peptide; cell viability; heart; hydrogen peroxide; hypertrophy; in vivo studies; mitogen-activated protein kinase; oxidative stress; phosphorylation; rats
- ... Cardiac hypertrophy is the main response of the heart to various extrinsic and intrinsic stimuli, and it is characterized by specific molecular and phenotypic changes. Recent in vitro and in vivo studies indicate the involvement of reactive oxygen species in the hypertrophic response. In this study, silibinin, a plant flavonolignan extracted from milk thistle with potent antioxidant activity, was ...