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- Hashii, Noritaka, et al. Show all 5 Authors
- BBA - Proteins and Proteomics 2013 v.1834 pp. 1210-1214
- amino acids; deuterium; dimerization; humans; insulin; mass spectrometry; mutation; peptide mapping
- ... Human insulin and insulin lispro (lispro), a rapid-acting insulin analog, have identical primary structures, except for the transposition of a pair of amino acids. This mutation results in alterations in their higher order structures, with lispro dissociating more easily than human insulin. In our previous study performed using hydrogen/deuterium exchange mass spectrometry (HDX/MS), differences we ...