Jump to Main Content
- Hoshii, Takayuki, et al. Show all 20 Authors
- Molecular cell 2013 v.51 pp. 618-631
- autophagy; binding capacity; biochemical pathways; carcinoma; human growth; humans; organelles; oxidative stress; phosphorylation; ubiquitin-protein ligase
- ... The Keap1-Nrf2 system and autophagy are both involved in the oxidative-stress response, metabolic pathways, and innate immunity, and dysregulation of these processes is associated with pathogenic processes. However, the interplay between these two pathways remains largely unknown. Here, we show that phosphorylation of the autophagy-adaptor protein p62 markedly increases p62’s binding affinity for ...