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- Cheatham, S. Christian, et al. Show all 7 Authors
- International journal of antimicrobial agents 2013 v.41 no.1 pp. 52-56
- Monte Carlo method; beta-lactamase; blood; body mass index; demographic statistics; drugs; patients; pharmacokinetics; piperacillin; probability; therapeutics
- ... The study objective was to evaluate steady-state pharmacokinetics and pharmacodynamics of piperacillin and tazobactam administered by prolonged infusion in obese patients. Fourteen hospitalised patients weighing >120kg received piperacillin/tazobactam 4.5g every 8h (q8h) or 6.75g q8h infused over 4h. Blood samples were collected at steady-state and drug concentrations were determined. Pharmacokine ...